Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caused by microorganisms having a neuraminidase, processes for preparing the compounds and synthetic intermediates used in these processes.
Abbott Laboratories
C C C C C A C C C C C C C C C
C07D C07C C07C C07C C07C A61P C07C C07D C07D C07D C07D C07C C07C C07B C07B
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Zhen Chen Steven W. Kent D. Vincent L. Darold L. Ming C. Vincent S. Clarence J. Gary T. Allan C. Yu Gui Dale J. Hing L. David A. April Sheldon Yuanwei Minghua Warren M. David J.
Lin Zhao Muchmore Stewart Giranda Madigan Yeung Stoll Maring Wang Krueger Gu Kempf Sham Degoey Kennedy Wang Chen Sun Kati Grampovnik