Substituted piperazines as KRAS G12C inhibitors
Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers. 
AMGEN INC.
A A C A A C C C C A C A
A61P A61K C07D A61K A61K C07D C07D C07D C07D A61K C07D A61K
inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional
Hui-Ling Jennifer Rebecca Vu Van Margaret Victor J. Shon Albert Alexander J. Brian Alan Mary Anthony B. Jian Thomas T. Nobuko Nuria A. Kevin C. Qiufen Longbin Ning Jonathan D. Youngsook John Gordon Patricia Aaron C. Clifford Ryan Paul Ana Elena
Wang Allen Ma Chu-Moyer Cee Booker Amegadzie Pickrell Lanman Walton Reed Chen Nguyen Nishimura Tamayo Yang Xue Liu Chen Low Shin Allen Lopez Siegmund Goodman Wurz Minatti