Abelman, Frayne & Schwab
Antipsychotic agents and standardized antipsychotic fractions from Rauwolfia tetraphylla and process of their isolation
The present invention relates to bioactive extracts its fractions and isolation of compound from Rauwolfia tetraphylla. The extracts and fractions are useful for the treatment of psychosis based on in-vivo validation on animal model and proportional binding affinities for dopaminergic-D2, Cholinergic (muscarinic) and Serotonergic (5HT2A) receptors for antipsychotic activity. The present invention relates to novel antipsychotic activity in the leaf alkaloids of Formula 1 and 2 named tetrahydroalstonine, 10-methoxytetrahydroalstonine, isoreserpiline, 10-demethoxyreserpiline, 11-demethoxyreserpiline, reserpiline and α-yohimbine. The present invention also relates to processes for obtaining antipsychotic extracts as well as for the isolation of alkaloids of formula 1 and 2 from the leaves of Rauwolfia tetraphylla. The present invention particularly relates to significant antipsychotic activity in the MeOH extract, ethylacetate and chloroform fractions of R. tetraphylla and in the isolated compounds α-yohimbine, reserpiline and in a mixture 10-demethoxyreserpiline and 11-demethoxyreserpiline in 1:1.5 ratios for treating psychosis without any extra pyramidal symptoms (EPS).
Council of Scientific & Industrial Research
A A
A61P A61K
inventional inventional
Dnyaneshwar Umrao Madan Mohan Ram Kishor Vinay Kumar Dharmendra Subhash Chandra Chandeshwar Suman Preet Singh Anirban Ashok Kumar Janardan Anil Kumar Anupam Santosh Kumar Shikha
Bawankule Gupta Verma Khanna Saikia Singh Nath Khanuja Pal Agrawal Singh Gupta Maurya Srivastava Gupta