Chalker Flores, LLP
System and method for solution phase gap peptide synthesis
Disclosed is a system and method for Fmoc/tBu solution-phase peptide synthesis including the development of a new benzyl-type GAP protecting group, and related uses thereto. This novel GAP protecting group is utilized in place of a polymer support, facilitating C to N Fmoc peptide synthesis without chromatography, recrystallization, or polymer supports. The GAP group can be added and removed in high yield.
Texas Tech University System
C C C Y
C07K C07K C07F Y02P
inventional inventional inventional additional
Guigen Cole
Li Seifert