Wolf, Greenfield & Sacks, P.C.
Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents
 Certain novel aminoacyl adenylate mimics are described. An exemplary compound of this invention is S-(R*,R*)!-3,6-anhydro-1,2-dideoxy-1-5-4-(5-nitro-2-thienyl)ethynyl!ph enyl!-2H-tetrazol-2-yl!-D-allo-heptitol 7-(2-amino-3-methyl-1-oxopentyl)sulfamate. These compounds inhibit isoleucyl-tRNA synthetases and are useful as antimicrobial and antiparasitic agents. 
Cubist Pharmaceuticals, Inc.
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Guixue Thomas M. Youe-Kong Julius Jason M.
Yu Zydowsky Shue Rebek Hill