Fish & Richardson P.C.
Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases
Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein—protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
The CBR Institute for Biomedical Research, Inc.
A C
A61K C07K
additional inventional
Patrick G. Jose Anjana
Hogan Aramburu Rao