Polsinelli PC
Soft tissue mimetics and thermoplastic elastomer hydrogels
Provided herein is a soft tissue mimetic formed from a block copolymer hydrogel and methods of making such. The hydrogel comprises a glass formed from a dry blend of polystyrene-poly(ethylene oxide) diblock copolymer (SO) and polystyrene-poly(ethylene oxide)-polystyrene triblock copolymer (SOS) in a molar ratio from between 95:5 and 1:99 SO/SOS and a liquid medium at a concentration between about 32:1 and about 2:1 liquid medium/SO-SOS by weight. The soft tissue mimetic has a fatigue resistance to at least 500,000 compression cycles.
Colorado State University Research Foundation
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Jackson T. Kristine Travis S. Tammy Haut Chen
Lewis Fischenich Bailey Donahue Guo