Birch, Stewart, Kolasch & Birch, LLP
Process for preparing piperazine derivatives
A process for preparing a piperazine derivative represented by the formula (V): comprising reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in an aprotic polar organic solvent in the presence of a base and an alkali metal halide. The piperazine derivative and its oxalate are compounds useful as preparation intermediates of mirtazapine.
Sumika Fine Chemicals Co., Ltd.
C C C C
C07C C07C C07D C07C
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Chiharu Weiqi Eiichi Yoshiyuki
Maeda Wang Iishi Imamiya