Scully, Scott, Murphy & Presser
Alkanoarachidonic acids
 A series of alkanoarachidonic acids have been prepared as modulators of the arachidonic acid cascade to increase the production of biologically desirable compounds and minimize the production of biologically undesirable compounds. Examples of desirable compounds in this respect comprise postaglandins and thromboxanes whereas undesirable compounds comprise the mono- and polyhydroxyarachidonic acids and leukotrienes. The alkanoarachidonic acids and their intermediates are of the general formula: ##STR1## and at least one of X, Y, and Z is lower alkano and is hydrogen when not lower alkano; the esters and salts of the acids are also prepared. The acids, esters and salts may be used as anti-anaphylaxis or anti-thrombosis agents. 
Research Corporation
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Nicos A. Wen-Sen Jared L. Kyriacos C. Pedro E. Stephen E. Tamara
Petasis Li Randall Nicolaou Hernandez Webber Ladduwahetty