McCarter & English, LLP
Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
Disclosed are compounds represented by Formula (I):or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof and methods of inhibiting 11 β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I) or pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Values for the variables of Formula (I) are defined herein.
Vitae Pharmaceuticals, Inc.
C A A A C A A A A A A C A A C A A A A A A A A A A A A C A A A
C07D A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Linghang Colin M. David A. Zhenrong Yuanjie Wei Suresh B. Wei Salvacion
Zhuang Tice Claremon Xu Ye Zhao Singh He Cacatian