Fox Rothschild LLP
Enantioselective process for cycloalkenyl β-substituted alanines
A process for preparing an enantiomerically enriched cycloalkene-substituted alanine compound having the structure:by asymmetrically hydrogenating a dehydro amino acid compound having the structure:in a suitable reaction media in the presence of a catalyst having a transition metal moiety complexed to a chiral phosphine ligand to prepare enantiomerically enriched cycloalkene substituted alanine compounds having the structure of Formula (IA) or (IB), which are key intermediates for the ACE inhibitors ramipril and perindolpril:
Chiral Quest, Inc.
C C C C C C C C C
C07C C07C C07D C07C C07C C07C C07D C07C C07C
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Xinjun Zijun Hui Xiaojuan Jingyang Fei Sanhui Zhongwei Wenge
Liu Liu Lu Zhang Zhu Xiong Lin Tian Li