WPAT, P.C.
Use of outer membrane protein A (OMPA) in treatment/prevention/diagnosis of infections caused by Klebsiella pneumoniae and other gram-negative bacteria
The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
Taipei Medical University
A Y G G A
A61K Y02A G01N G01N A61K
inventional additional inventional additional inventional
Yueh-Lun Hsueh-Hsia Sy-Jye Ko-Jiunn Neng-Yao Yuan-Soon Wen-Shyang Chi-Hsin Yi-Yuan I-Jen Shih-Yi Ching-Yu Shih-Lan
Lee Wu Leu Liu Shih Ho Hsieh Lee Yang Huang Huang Lin Hsu