Benzenesulfonamide derivatives and their use as MEK inhibitors
Benzenesulfonamides of formula (I), in which W is OR1, NR2OR1, NRARB, NR2NRARB, or NR2(CH2)2-4NRARB and the other variables as defined in the claims, are inhibitors of MEK and are effective in the treatment of proliferative diseases, cancer, stroke, heart failure, xenograft rejection, arthritis, cystic fibrosis, hepatomegaly, cardiomegaly, Alzheimer's disease, complications of diabetes, septic shock, and viral infection.
Warner-Lambert Company
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A61P A61P A61P A61P A61P C07C A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07C
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Stephen Douglas Richard John Haile
Barrett Booth Tecle