7-oxo-pyridopyrimidines (II)
The present invention provides compounds of the formula: wherein R1, R3, and Ar1 are those defined herein, and R2 is &#8212;CR&#8242;R&#8243;&#8212;Ra (where R&#8242; and R&#8243; are hydrogen, hydroxyalkyl or alkyl with at least one being alkyl or hydroxyalkyl and Ra is hydroxyalkyl), Rx&#8212;S&#8212;Ry&#8212; (where Rx is alkyl and Ry is alkylene), alkoxy-substituted alkyl, heterocyclylalkyl or C4-C5 cycloalkyl, wherein each of the hydroxy group present in R2 can be independently Ra&#8212;C(&boxH;O)&#8212;O, RaRbN&#8212;C(&boxH;O)&#8212;O, or Ra&#8212;S(O)2&#8212;O&#8212;, wherein Ra and Rb are independently hydrogen, alkyl, aryl, or aralkyl, and methods for preparation and uses thereof.
Syntex (U.S.A.) LLC
C A A A C
C07D A61P A61P A61P C07D
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Julie Anne James Patrick David Michael Humberto Bartolome Jian Jeffrey
Lim Dunn Goldstein Arzeno Chen