Purdue Pharma L.P.
Substituted pyridines as sodium channel blockers
The invention relates to substituted pyridine compounds of Formula I: (I) and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein R1a, R1b, R2a, R2b, R2c, A1, A2, and X are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
Purdue Pharma L.P.
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Xiaoming Mark A. Chiyou Minnie Bin Laykea Jiangchao
Zhou Youngman Ni Park Shao Tafesse Yao