Greenblum & Bernstein, P.L.C.
Phospholipid derivatives and process for the production there
A phospholipid derivative represented by the following formula (1):wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1≦k1≦(k+2)/2, 0≦k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
NOF Corporation DAIICHI Pharmaceutical Co., Ltd.
C A A A C C C A A A A A
C08G A61K A61K A61Q C07F C08G C08G A61K A61K A61K A61P A61K
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Syunsuke Hiroshi Norio Hitoshi Yusuke Miho Chika Tohru Kazuhiro
Ohhashi Kikuchi Suzuki Yamauchi Ohkawa Takahashi Itoh Yasukohchi Kubo