Fish & Richardson P.C.
Macrocyclic compounds as TRK kinase inhibitors
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Array BioPharma, Inc.
A A C C C A A A Y C A C A A A A A
A61P A61P C07D C07D C07D A61P A61P A61P Y02A C07D A61K C07D A61P A61P A61P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional
Gabrielle R. Kevin Ronald Hong-Woon Jeongbeob Julia Steven W. Yutong Qian
Kolakowski Condroski Yang Seo Haas Andrews Jiang Zhao