Wood, Phillips, Katz, Clark & Mortimer
Propanoic acid derivatives that inhibit the binding of integrins to their receptors
A compound of the structure A method for the inhibition of the binding of &agr;4&bgr;1 integrin to its receptors, for example VCAM-1(vascular cell adhesion molecule-1) and fibronectin; pharmaceutically active compositions comprising these compounds; and the use of these compounds for the control or prevention of diseases states in which &agr;4&bgr;1 is involved are also disclosed.
Texas Biotechnology Corporation
C A A C C C
C07D A61P A61P C07D C07D C07D
inventional inventional inventional inventional inventional inventional
Ronald J. Noel Brian Wen Jamal M. Robert V. Chengde George W. E. Radford Linda K. Ian L.
Biediger Nguyen Dupre Li Kassir Market Wu Holland Decker Hamaker Scott