Procoagulant antibodies
The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or parts thereof and methods and composition for treating subjects suffering from a coagulopathy such as haemophilia A as well as kits, methods of manufacture and methods of use.
Novo Nordisk A/S
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Per J. Mikkel Nors Haisun Jianhe Morten Groenbech Anders Zhiru Henrik Bjarne Gram Prafull S. Eva Karina Rong Laust Bruun
Greisen Harndahl Zhu Chen Rasch Svensson Yang Oestergaard Hansen Gandhi Johansson Thorn Zhou Johnsen