Wilmer Cutler Pickering Hale and Dorr LLP
Methods of treating volume depletion and kidney injury
The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TACSTD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.
The Trustees of Columbia University in the City of New York
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Katherine Jonathan Paul Paolo
Xu Barasch Rosenstiel Guarnieri