Marshall, Gerstein & Borun LLP
N-(phenylsulfonyl)benzamides and related compounds as BCL-2 inhibitors
The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b, E, and  are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer. 
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
A A C
A61P A61P C07D
inventional inventional inventional
Jianyong Shaomeng
Chen Wang