Irreversible inhibitors of pyruvate kinase M2 and the use thereof
The invention provides a novel class of propiolylamide-based irreversible inhibitors of PKM2 compounds of the general formula I, pharmaceutical compositions, and methods of inducing an anti-tumor effect in a subject suffering from tumor comprising administering to the subject a pharmaceutical composition comprising an effective amount of compound of formula I.
CHINA MEDICAL UNIVERSITY
A C C C
A61P C07D C07D C07D
inventional inventional inventional inventional
Ching-Shih Po-Chen Chih-Shiang Hsiang-Wen
Chen Chu Chang Lin