Wolf, Greenfield & Sacks, P.C.
Wnt pathway modulators
The present invention relates to dihydropyrazolo[1,5-a]pyrimidine compounds of formula I, defined herein, as WNT pathways modulators, processes for making them, and pharmaceutical compositions comprising them. Methods of treatment of conditions mediated by WNT pathway signalling including cancer, fibrosis, stem cell and diabetic retinopathy, rheumatoid arthritis, psoriasis and myocardial infarction, comprising the compounds of formula I are also provided.
Agency for Science, Technology and Research
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Soo Yei Wei Ling Jenefer Athisayamani Jeyaraj
Ho Wang Alam Duraiswamy