Browdy and Neimark, P.L.L.C.
Indole derivative having heterocycle and mono- or diazaindole derivative
There is provided a compound represented by the general formula (1): wherein Het represents an optional substituted heterocylic group A1 and A2 each independently represent —CH═, etc.; A3 represents —CH2—, etc.; R1 represents a 4-fluorophenyl group, etc.; R2 represents an alkyl group; n represents 0, 1 or 2, provided that when A1 and A2 both are —CH═, A3 represents —CH2— or —SO2—, which is an indole derivative or a mono- or diazaindole derivative that has COX-2 inhibitory activity and is useful as a pharmaceutical, such as an anti-inflammatory agent, or addition salts thereof with a pharmaceutically acceptable acid or base, or hydrates thereof.
Chugai Seiyaku Kabushiki Kaisha
C A C C C C C C C C C A
C07D A61P C07D C07D C07D C07D C07D C07D C07D C07D C07D A61P
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Tadakatsu Noriaki Takenori Hiroharu Nobuaki Yukio
Takahashi Maruyama Ishizawa Matsuoka Kato Suzuki