Quinolone derivatives as antibacterials
This invention is in the field of medicinal chemistry and relates to compounds, and pharmaceutical compositions thereof, that inhibit bacterial gyrase. The compounds are useful as inhibitors of bacterial gyrase activity and bacterial infections, and have the structure of Formula (I) as further described herein. The invention further provides pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compounds and compositions to treat bacterial infections. 
Novartis AG
A C C C Y A A C C A C C C C C A A C A
A61K C07D C07D C07D Y02A A61K A61P C07D C07D A61K C07D C07D C07D C07D C07D A61P A61K C07D A61K
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Xiaolin Cheng Jianhua Colin Keith Peichao Xiaojing Michael Wosenu Alexey Haiying Javier de Vicente Folkert Zhigan Yongjin Daniel
Li Hu Xia Skepper Lu Wang Mergo Rivkin He Fidalgo Reck Jiang Xu Mutnick