Clark & Elbing LLP
Methods and compositions for the treatment of proliferative disorders
The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.
Beth Israel Deaconess Medical Center, Inc.
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Xiao Zhen Shuo Kun Ping
Zhou Wei Lu