Christie, Parker & Hale, LLP
Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof
A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences China Pharmaceutical University Yangtze River Pharmaceutical Group Co., Ltd.
A A A A A A A A A A A C C
A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D C07D
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Tianjiang Ting Yungen Dechuan Jinggen Hongguo
Sun Guo Xu Wang Liu Lu