Beusse Wolter Sanks Mora & Maire
Herpesvirus ribozymes and vectors
Hammerhead ribozymes that target components critical to HSV replication (ICP4, UL20, UL30, and UL54) were synthesized and shown to efficiently cleave target RNA encoding a portion of these components in in vitro assays. Several cloned cell lines stably expressing these ribozymes were established. HSV-mediated plaque formation was dramatically reduced in cells stably transfected with an anti-HSV ribozyme compared to non-transfected cells.
University of Florida Research Foundation, Inc.
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C12N C12N C07K
additional additional inventional
Gregory Scott David Clair Sonal Sanjeen Jia Alfred Samuel
Schultz Bloom Tuli Liu Lewin