DLA Piper LLP (US)
Hybrid cyclic libraries and screens thereof
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
The Johns Hopkins University
C C C C A C A A G C C A
C07K C07D C07K C07D A61K C07D A61P A61K G01N C07D C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Zufeng Jingxin Wei Manisha Shridhar Jun O.
Guo Wang Li Das Bhat Liu