Choate, Hall & Stewart, LLP
Exocrine gland tight junction-constituting protein jeap family
A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
Eisai Co., Ltd.
C C
C07K C07K
inventional inventional
Koji Yoshimi Mayumi Masakazu Yuichi Toshio Yoko Miyuki
Morimoto Takai Asano Takeuchi Ono Imai Inoue Nishimura