C-3 alkyl and alkenyl modified betulinic acid derivatives
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:a compound of Formula I            The compounds are useful for the treatment of HIV and AIDS.
Bristol-Myers Squibb Company
A C C A A
A61K C07J C07J A61P A61K
inventional inventional inventional inventional inventional
Zheng Sing-Yuen Li Nicholas A. Richard A. Yan Jie Jacob Alicia
Liu Sit Xu Meanwell Hartz Chen Chen Swidorski Regueiro-Ren