Fitch, Even, Tabin & Flannery
Method for the enantiomoeric separation of optical active amlodipine
The present invention relates to the preparation of the (S)-(−)-amlodipine and (R)-(+)-amlodipine by means of enantiomeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butanone is used as solvent. The 2-butanone used in the present invention has the advantage of low boiling point, low toxicity, litter pollution, and the method is suitable for large-scaled production.
Shijiazhuang Pharmaceutical Group Ouyl Pharma. Co., Ltd.
A C
A61P C07D
inventional inventional
Nanping Yujie Hui Xianfeng
Zhong Chen Ma Zhao