Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1
Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.
Janssen Pharmaceutica NV
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Alec D. Wei J. Guy Bryan James Jason C Jing
Lebsack Xiao Breitenbucher Branstetter Rech Liu