Nikaido, Marmelstein, Murray & Oram
Hydantoin derivatives for treating complications of diabetes
 Hydantoin derivatives and salts thereof, intermediates therefor, process for the preparation thereof, and medicines containing the derivative, wherein said derivatives have the formula ##STR1## wherein one of V and W is hydrogen and the other is a halogenomethyl group, 1H-tetrazol-5-yl radical, --COOR group, PA2 in which R is hydrogen atom, an alkyl group, --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n is an integer of 1 to 113) or substituted phenyl, ##STR2## in which R.sub.1 and R.sub.2 are same or different independently, each is hydrogen atom, an alkyl group, substituted phenyl or --(CH.sub.2 CH.sub.2 O)nCH.sub.3 group (n has the meaning as referred to) or R.sub.1 may form a heterocyclic ring together with R.sub.2 and nitogen or oxygen atom, --CH.sub.2 OH.sub.3 group or ##STR3## group, in which R.sub.3 and R.sub.4 are same or different independently and each is hydrogen atom or an alkyl group, PA1 X is oxygen or sulfur atom, and Y and Z are same or different independently and each is hydrogen atom, a halogen atom, alkyl group, alkoxy group, alkylmercapto group, nitro radical or --NHR.sub.5 group, in which R.sub.5 is hydrogen atom or an acyl group. The derivatives and salts thereof are useful for the treatment of complications of diabetes. 
Sanwa Kagaku Kenkyusho Co., Ltd.
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inventional inventional inventional
Kuniharu Toshinao Masato Kiichi Takuji Noriaki Hiroshi Masayasu Kyoichi Naofumi Kenji Yasuaki Ryoichi Akira
Mizuno Usui Fukushima Sawai Yamaguchi Kato Ozawa Kurono Asano Terada Miura Kondo Unno Matsubara