Holtz, Holtz, Goodman & Chick, PC
1-2-dihydroquinoline derivative having glucocorticoid receptor binding activity
An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S(O)R8 or S(O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.
Santen Pharmaceutical Co., Ltd.
C C A A A A A C A C A A A A C A A C A A A A A A A C A C A A A A A A A A A A
C07D C07D A61P A61P A61P A61P A61P C07D A61P C07D A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Tomoko Masatomo Toshiyuki Mamoru Miwa Minoru Masato Kenji Sachiko
Oda Kato Mori Matsuda Takai Yamamoto Nagatsuka Kawashima Kobayashi