Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates. 
Bristol-Myers Squibb Company
A C C A C A A A A A A
A61K C07D C07D A61K C07K A61K A61K A61K A61K A61P A61K
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Fukang Qian Lawrence B. Dale L. Sanjeev
Yang Zhang Snyder Boger Gangwar