Antidiabetic tricyclic compounds
Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Merck Sharp & Dohme Corp.
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A61P C07B C07D A61P C07D C07C A61P C07C A61P A61P
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Songnian Paul E. Xibin Lihu Dooseop Weiguo Gui-Bai
Lin Finke Liao Yang Kim Liu Liang