McAndrews, Held & Malloy, Ltd.
Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
Abbott Research B.V.
A C C A C C C A C C C A A A C A A
A61P C07K C07K A61P C07K C07K C07K A61K C07K C07K C07K A61K A61P A61P C07K A61P A61P
inventional additional additional inventional additional inventional additional additional additional additional additional additional inventional inventional additional inventional inventional
John Duncan Mark Wei Andrea Sandeep Jerry A.
Powell Casson Maginn Liu Best Dutta Hall