Cohen Pontani Lieberman & Pavane LLP
Tiacumicin production
Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
Optimer Pharmaceuticals, Inc.
C C A C A C
C12P C12N A61P C12N A61P C12R
inventional inventional inventional inventional inventional additional
Yuan-Ting Ming-Hsi Jonathan James Franklin W. Youe-Kong Mei-Chiao Chi-Jen Frank
Chen Chiou Duffield Okumu Shue Wu Du