Mintz Levin Cohn Ferris Glovsky and Popeo PC
2,4-disubstituted phenylene-1,5-diamine derivatives and applications thereof, and pharmaceutical compositions and pharmaceutically acceptable compositions prepared therefrom
The present invention provides a class of 2,4-substituted phenylene-1,5-diamine derivatives, having an inhibiting effect on EGFR tyrosine kinases, and pharmaceutically acceptable salt, stereoisomer, solvate or prodrug of said derivatives. See the description for the definition of each group in the formula. In addition, the present invention also discloses pharmaceutical compositions, pharmaceutically acceptable compositions and applications thereof.
YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD. SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO. LTD.
A A A A C A A C A C A C A C A A C A
A61P A61K A61K A61P C07D A61P A61P C07D A61P C07D A61K C07D A61K C07D A61P A61K C07D A61K
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Jiong Yunzhou Sida Qiang Jing Yi Wei Fusheng
Lan Jin Shen Lv Xie Hu Liu Zhou