Schwegman Lundberg & Woessner, P.A.
Anti-LAG-3 antibody
The present invention provides an anti-LAG-3 antibody capable of repeated administration even to animals other than rat. An anti-LAG-3 antibody comprising (a) a light chain comprising a light chain variable region containing CDR1 having the amino acid sequence of QSLLDSDGNTY (SEQ ID NO: 16), CDR2 having the amino acid sequence of SVS and CDR3 having the amino acid sequence of MQATHVPFT (SEQ ID NO: 17) and the light chain constant region of an antibody of an animal other than rat; and (b) a heavy chain comprising a heavy chain variable region containing CDR1 having the amino acid sequence of GFDFDTYP (SEQ ID NO: 18), CDR2 having the amino acid sequence of ITIKTHNYAT (SEQ ID NO: 19) and CDR3 having the amino acid sequence of NREDFDY (SEQ ID NO: 20) and the heavy chain constant region of an antibody of an animal other than rat. A pharmaceutical composition comprising the above anti-LAG-3 antibody as an active ingredient. A method for preparing the above anti-LAG-3 antibody is also provided.
Fuso Pharmaceutical Industries, Ltd. National University Corporation Hokkaido University
A A C C A C A C A C A A C C A A C C
A61P A61P C12N C07K A61K C07K A61P C12N A61P C07K A61P A61P C12N C07K A61P A61P C12N C07K
inventional inventional additional additional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional
Yasuhiko Satoru Tomohiro Naoya Asami Shiro Kazuhiko Chie
Suzuki Konnai Okagawa Maekawa Nishimori Murata Ohashi Nakajima