Oblon, Fisher, Spivak, McClelland & Maier
Hemoglobin combined with a poly(alkylene oxide)
 There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure: EQU --CH.sub.2 --O--(CH.sub.2)--CONH--Hb wherein Hb represents said hemoglobin and n represents a positive integer, preferably 1 to 7. The modified hemoglobin is an effective oxygen carrier and can therefore be used as a blood substitute. 
Ajinomoto Co., Inc.
A C A
A61P C07K A61K
inventional inventional additional
Taketoshi Yuji Keiji
Okami Iwashita Iwasaki