Prolylcarboxypeptidase inhibitors
Compounds of structural formulas I-1 and I-2 are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
Merck Sharp & Dohme Corp
A A A C A C
A61K A61K A61K C07D A61K C07D
inventional inventional inventional inventional inventional inventional
Wensheng Zhi-Cai Iyassu K. Thomas H. Dong-Ming
Liu Shi Sebhat Graham Shen