Muncy, Geissler, Olds & Lowe, P.C.
Deglycosylated hemagglutinin and manufacture thereof
The invention provides a deglycosylated hemagglutinin, wherein the glycosylation site(s) on the stem region is removed. The deglycosylated hemagglutinin may induce neutralizing antibody against influenza virus, and cross-reactive protection against different virus. The invention also provides a method for manufacturing deglycosylated hemagglutinin, comprising aligning two or more hemagglutinin stem sequences of influenza virus, identifying the high conserved N-glycosylation site, and removing the high conserved N-glycosylation site. Thus, the N-glycosylation site cannot be glycosylated.
National Tsing Hua University
C C C A C C C
C12N C12N C12N A61K C12N C12N C07K
additional additional inventional inventional additional additional inventional
Suh-Chin Wen-Chun Yun-Ju
Wu Liu Huang