N-substituted tricyclic 1-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders
The invention is directed to N-substituted tricyclic 3-AMINOPYRAZOLE derivatives, which are useful as inhibitors of platelet-derived growth factor receptor (PDGF-R) kinase, and methods for the preparation of said derivatives. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as tumors and other cell proliferative disorders.
Janssen Pharmaceutica NV
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Dana L. Hwa Kwo Donald W. Umar Jan L. Chih Yung Robert W. Eric D. Stuart Robert A. Bengt Anders Jay M.
Johnson Yen Ludovici Maharoof Sechler Ho Tuman Strobel Emanuel Galemmo, Jr. Brunmark Mei