Wallenstein & Wagner
Process for the preparation of a solid pharmaceutical dosage form
A process for the preparation of a solid pharmaceutical dosage form comprising a carrier and, as active ingredient, a compound which exists, in solution, in an equilibrium between a free acid or free base form and a salt form, and for which there is a difference in volatility between the free acid or free base form and the salt form. The process includes the steps of solidifying a mixture of the compound and carrier in a solvent, and subsequently removing the solvent from the solidified mixture. A pH modifier is added to the mixture prior to solidification to shift the equilibrium to favor the less volatile form of the active ingredient.
R. P. Scherer Corporation
A A A A
A61P A61K A61P A61K
inventional inventional inventional inventional
Joy Elaine Patrick Andrew William
Saunders Kearney Jordan