Christie, Parker & Hale, LLP
Triazolo-1,4-diazepine compounds and medicinal composition containing the same
A triazolo-1,4-diazepine compound having the formula (I): wherein A represents CO, CO&#8212;B, or B, B represents a C1 to C6 alkylene group or a C2 to C6 alkylene group having an oxygen atom interposed in the middle thereof, X represents N&#8212;O or CH, n represents an integer of 2 to 6, R represents a hydroxyl group, a C1 to C6 lower alkyloxy group or a C1 to C6 lower alkylamino group, provided that these groups may be substituted with an N,N-dimethylamino group, an N,N-diethylamino group, a phenyl group, or a heterocyclic group, and R1 represents a hydrogen atom or a C1 to C3 lower alkyl group having both a PAF antagonistic action and a thromboxane synthesis inhibiting action, and a pharmaceutical composition containing the same as an active ingredient.
Nikken Chemicals Co., Ltd.
C
C07D
inventional
Tetsuro Masakazu Taketsugu Haruaki
Sano Fujita Seki Inada