Holtz, Holtz, Goodman & Chick, P.C.
1,2-dihydroquinoline derivative having substituted phenylchalcogeno lower alkyl group and ester-introduced phenyl group as substituents
The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator.The R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or a nitro group; X represents —C(O)—, —C(O)NR8—, —S(O)2— and the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; Z represents a chalcogen atom; and P represents 0, 1, 2 or 3.
Santen Pharmaceutical Co., Ltd.
A A C A A A A A A A C A A A A A A A A C A A A A A C A A C A A A A C A
A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Mamoru Toshiyuki Masato Sachiko Miwa Masatomo
Matsuda Mori Nagatsuka Kobayashi Takai Kato