Seed Intellectual Property Law Group LLP
PKM2 modulators and methods for their use
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. 
Tolero Pharmaceuticals, Inc.
C C A C C C C C C C A C C C C C C A A
C07D C07D A61P C07D C07D C07D C07D C07D C07F C07D A61K C07D C07D C07D C07D C07D C07D A61P A61P
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Kenneth Mark Yong Scott Albert Xiaohui Jason Marc Jihua Michael David Koc-Kan Steven Brian Kevin Bret David Lee
Parnell Xu Pearce Liu Foulks Liu Saunders Ho Kanner Wright Vollmer