Nixon Peabody LLP
Regulators of NFAT and/or store-operated calcium entry
Embodiments of the inventions relate to modulating NFAT activity, modulating store-operated Ca2+ entry into a cell and treating and/or preventing hyperactivity or inappropriate immune response by inhibiting the expression or activities of septin 4 (SEPT 4) and septin 5 (SEPT 5) proteins involved in the calcineurin/NFAT axis and T-cell activation.
C C
C12N C12N
inventional additional
Patrick Anjana Sonia
Hogan Rao Sharma