Armstrong, Westerman, Hattori, McLeland & Naughton
Synergistic antimicrobial compositions containing 1-hydroxymethylpyrazole and a preservative
Compositions comprising a compound of formula I ##STR1## where R and R' are independently selected from hydrogen and alkyl of 1 to 4 carbon atoms, R" is a moiety selected from the group consisting of (a) hydrogen, (b) a halogen atom selected from the group consisting of F, Cl, Br, and I, and (c) a nitro group, or the hydrochloride salt of said compound; and at least one preservative are disclosed which are synergistically effective compared to the respective components alone in controlling and/or reducing the growth of microorganisms in or on a material or medium. Methods to control and/or reduce the growth of microorganisms and prevent spoilage caused by microorganisms with the use of the compositions of the present invention are also disclosed.
Buckman Laboratories International, Inc.
A
A01N
inventional
Xiangdong Vanja M.
Zhou King