Kilpatrick Townsend & Stockton LLP
GPR84 receptor antagonist and use thereof
The present invention relates to a GPR84 receptor antagonist and use thereof. The GPR84 receptor antagonist of the present invention has a structure as represented by formula (I), the definitions of R1, R2, R3, R4, L1, L2, L3, L4, L5, L6, Y, Z, and rings A, B, C, and D are as described in the description and claims. The GPR84 receptor antagonist of the present invention can competitively inhibit the activation of the receptor caused by an agonist of GPR84, and can be used in the preparation of a medicament for treating related diseases caused by high expression or high excitability of GPR84 receptor, the diseases including multiple sclerosis, inflammatory bowel disease, arthritis and the like.
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
C C A C C A C C C A C A
C07F C07F A61P C07F C07F A61P C07F C07F C07F A61P C07F A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Xin Fajun Qing Hui Yufeng Linhai
Xie Nan Zhang Yang Xiao Chen