McAndrews, Held & Malloy
Antibodies against nerve growth factor (NGF) with enhanced in vivo stability
The present invention provides anti-nerve growth factor (NGF) antibodies that contain an IgG4 constant region comprising a stabilizing hinge region mutation and wherein the antibodies exhibit an unexpectedly long serum half life in cynomolgus monkeys. Pharmaceutical compositions comprising the anti-NGF antibodies, nucleic acids encoding the NGF antibodies, host cells for expressing the NGF antibodies and methods of using the antibodies for treating NGF-related diseases or conditions are also provided.
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Jerry A. Andrea Wei Mark Sandeep Duncan John
Hall Best Liu Maginn Dutta Casson Powell