Fish & Richardson P.C.
Anti-cellular proliferative disorder polypeptide
Disclosed is a cell lytic polypeptide that has a region capable of forming an amphipathic alpha helix and a net charge of +12 or more, or that contains 3 regions, each capable of forming an amphipathic alpha helix. A nucleic acid encoding the polypeptide is also disclosed. Also within the scope of this invention are a pharmaceutical composition containing the polypeptide or nucleic acid and a pharmaceutically acceptable carrier, and a method for treating a cellular proliferative disorder.
Academia Sinica
C A A A C
C07K A61K A61K A61P C07H
inventional additional additional inventional inventional
Hueih Min
Chen