Bacon & Thomas, PLLC
Hydrophilic derivatives of 2-selenophene-4-quinolones as anticancer agents
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
China Medical University
A C C C C A C
A61P C07F C07D C07D C07F A61P C07D
inventional inventional inventional inventional inventional inventional inventional
Ching-Che Che-Ming Sheng-Chu Tzong-Der Jai-Sing Kuo-Hsiung Tian-Shung Chung-Ming Chih-Shiang Li-Chen Li-Jiau Jang-Chang Shih-Ming Shiow-Lin Chien-Ting Jing-Gung
Huang Teng Kuo Way Yang Lee Wu Sun Chang Chou Huang Lee Huang Pan Chen Chung