Process for the preparation of 2-alkylpyrimidines
 2-Alkylpyrimidines are prepared from 1,3-diaminopropane and an appropriate alkanecarboxylic acid in a continuous vapor phase process without isolating any of the reaction intermediates. Improvements in each reaction step, namely, the amidation, the cyclization/dehydration and the dehydrogenation, contribute to the overall success of the continuous vapor phase process. 
DowElanco
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C07D C07D
inventional inventional
John
Hull, Jr.