Foley Hoag LLP
2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
Georgetown University Duke University
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A61K A61K A61K C07D A61K A61K A61K
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Milton L. Amir H. Edward D. Yong Yingxian Mikell A. Kenneth J.
Brown Rezvani Levin Liu Xiao Paige Kellar