Merchant & Gould P.C.
Cyclohexene derivative, preparation method therefor, and pharmaceutical composition for preventing or treating metabolic diseases, containing same as active ingredient
The present invention relates to: a cyclohexene derivative; a preparation method therefor; and a pharmaceutical composition for preventing or treating metabolic diseases, containing the same as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (cAMP) by activating G protein-coupled receptor 119 (GPR-119) and simultaneously exhibits weight loss and hypoglycemic effects by inducing the release of glucagon-like peptide-1 (GLP-1), which is a neuroendocrine protein, and thus can be useful as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type 1 diabetes, type 2 diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia and syndrome X.
HYUNDAI PHARM CO., LTD.
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C07D C07D A61P C07D C07D C07D C07D A61P C07D C07D C07D C07D C07D C07D C07D A61P C07D A61P C07D A61P A61P C07D
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Han Kyu Kyu Hwan Jinwoong Daehoon Jaekeol Jeongun Chang Mo Jin Hyung-Ho Jae Hyun
Lee Lee Kim Kim Rhee Hwang Son Yang Choi Kim