Birch, Stewart, Kolasch & Birch, LLP.
Piperazine derivatives of dialkyl oxindoles
The present invention is concerned with new 3,3-disubstituted indol-2-one derivatives of the general Formula (I), wherein R1 stands for hydrogen, halogen, alkyl having 1-7 carbon atom(s) or sulfonamido; R2 represents hydrogen or halogen; R3 denotes hydrogen, alkyl having 1-7 carbon atom(s) optionally carrying an aryl substituent or aryl optionally carrying one or two halogen substituent(s); R4 stands for alkyl having 1-7 carbon atom(s); R5 represents a group of the general Formula (II a) or (II b), wherein Q and W each represents nitrogen or CH; R6, R7 and R8 each stands for hydrogen, halogen, trifluoromethyl, alkyl or alkoxy having 1-7 carbon atom(s), or R6 and R7 together represent ethylenedioxy; m is 0, 1, or 2; a is a single, double or triple bond; n is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof which are useful in the treatment or prophylaxis of diseases of the central nervous system, the gastrointestinal system and the cardiovascular system.
Egis Gyogyszergyar Nyrt
A A C A C C A A A C A A A
A61P A61P C07D A61P C07D C07D A61P A61P A61P C07D A61P A61P A61P
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Krisztina Tibor Rita György András Gábor Csilla Gyula László  Gábor Nóra Endréné Gábor István Balázs József Katalin
Móricz Mezei Kapillerné Dezsöfi Lévay Egyed Gigler Leveleki Simig Hársing Sziray Flórian Szénási Gacsályi Volk Barkóczy Pallagi