Heteroaryl quinazoline derivatives
Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc.(wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; R1 represents a group of a formula:(wherein R11 and R12 each independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.;R2 represents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).
MSD K.K.
A C C C A A A A A A C A
A61P C07D C07D C07D A61P A61P A61P A61K A61P A61P C07D A61K
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Akio Masanori Takuya Norikazu Tomoharu
Ohno Asai Suga Otake Iino