Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
The present application relates to: (a) compounds of Formula (I):and salts thereof, wherein R1, R2, R3, R4, R5, R6, m, n, X and Y are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.
AbbVie Inc. Reata Pharmaceuticals, Inc.
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Pamela Chitase Michael Xin Allan William Howard Christopher F. Jason David Eric Hui-Ju Gary Louis Melean Bradley William Rolf Howard
Donner Lee Rozema Jiang Krueger Roark Bender Shanley Grampovnik Anderson Chen Bolton Visnick Caprathe Wagner Heyman