Panitch Schwarze Belisario & Nadel LLP
Dapagliflozin crystalline form and preparation method thereof
The present invention relates to a new crystalline form of dapagliflozin represented by formula (I). The crystalline form has a characteristic absorption peak at about 4.318 (20.45) in an X-ray powder diffraction pattern shown by angle 2 theta and interplanar spacing (value d). It can be prepared by dissolving dapagliflozin in good organic solvents, adding poor solvents, stirring to crystallization, filtering and drying. The new crystalline form of dapagliflozin of the present invention has the following superior features: good solubility, low hygroscopicity, high stability and good preparation reproducibility.
Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
C C C A A C
C07H C07H C07B A61P A61K C07D
inventional inventional additional inventional inventional inventional
Fuping Xifeng Tiancheng Xiaobi
Yuan Zhu Zhang Li