Substituted 4-aminoquinoline derivatives as gastric acid secretion inhibitors
 Substituted 4-aminoquinoline derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl; C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-6 alkyl, phenyl C.sub.1-6 alkyl, the phenyl groups being optionally substituted; PA0 R.sup.2 is hydroxy C.sub.1-6 alkyl, C.sub.1-6 alkoxyC.sub.1-6 alkyl or two adjacent groups R.sup.2 together form a C.sub.1-4 alkylenedioxy group; PA0 R.sup.3 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, amino, C.sub.1-6 alkylthio, halogen, cyano, hydroxy, C1-6alkanoyl, or trifluromethyl; PA0 R.sup.4 is hydrogen, C.sub.1-6 alkyl, phenyl, C.sub.1-6 alkoxy, C.sub.1-6 alkylthio, C.sub.1-6 alkanoyl, amino, C.sub.1-6 alkylamino, di- C.sub.1-6 alkyl amino, halogen, or trifluromethyl; PA0 n is 1 or 2; PA0 q is 0 to 4; PA0 m is 1, 2, or 3; and PA0 p is 1, 2, 3, or 4 provided that m+p is not greater than 5; or a salt thereof are useful as inhibitors of gastric acid secretion. 
Smith Kline & French Laboratories, Ltd.
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C07D A61P C07D C07D
inventional inventional inventional inventional
Robert J. Thomas H. Colin A.
Ife Brown Leach