Buchanan, Ingersoll & Rooney
Factor VIII conjugates
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
BAYER HEALTHCARE LLC
A A C A C A A A C
A61P A61K C07K A61K C07K A61P A61P A61K C07K
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John E. Hendri Thomas Jianmin Liang Baisong Jonathan S. Clark Q. Deqian
Murphy Tjandra Barnett Chen Tang Mei Strauss Pan Wang