Foley Hoag LLP
Compositions and methods related to anti-EGFR antibody drug conjugates
In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-epidermal growth factor receptor (“EGFR”) antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the drug; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
LegoChem Biosciences, Inc.
C A A A
C07K A61K A61K A61K
inventional inventional inventional inventional
Jeiwook Ho Young Yun Hee Yong Zu Chul-Woong Hyo Jung Jeong Hee Ji Eun
Chae Song Park Kim Chung Choi Ryu Jung