McDonald Hopkins LLC
Boronic acid bearing liphagane compounds as inhibitors of P13K-α and/or β
Compounds with unique liphagane meroterpenoid scaffold having boronic acid functionality in the skeleton are described (formula 1) together with pharmacological potential of these compounds as anticancer agents. A method of preparation and inhibiting the activity of phosphoinositide-3-kinase (PI3K-alpha and beta) has been presented. In particular, the invention describes a method of inhibiting PI3K isoforms, wherein the compounds are novel structures based on liphagane scaffold with unique boronic acid functionality. The methods and uses thereof are described herein this invention.
Counsel of Scientific & Industrial Research
C A A A
C07F A61P A61P A61K
inventional inventional inventional inventional
Anjaneya Aravind Kumar Asif Khurshid Ajit Kumar Ramesh Ram Asrey Parvinder Pal Nayan Amit Aashiq Abid Hamid Sanghapal Damodhar Parduman Raj
Kolluru Qazi Saxena Mudududdla Vishwakarma Singh Chanauria Nargotra Hussain Dar Sawant Sharma