LeClairRyan
Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Sirna Therapeutics, Inc.
C C A C C A A A A
C07H C12N A61K C12N C12N A61P A61K A61P A61K
inventional additional inventional inventional additional inventional inventional inventional inventional
Anthony W. Thomas Joseph Rachel Anne Steven L. Rubina G. Jeffrey Aaron Vadim Lu Yu Marina Robert A. David Weimin Kathleen B.
Shaw Tucker Storr Colletti Parmar Aaronson Momose Dudkin Tian Yuan Busuek Kowtoniuk Tellers Wang Calati