Sunstein Kann Murphy & Timbers LLP
Compositions and methods for the treatment of cancer
The present invention relates to pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidine-2,5-dione compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound or pyrrolidine-2,5-dione compound of the present invention. (Ia) (Ib) (IIa) (IIIb) Where U is independently selected from: (I) or (II)where U is independently selected from:
ArQule, Inc.
A A A C A C
A61P A61P A61P C07D A61P C07D
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Jianqiang Nivedita Jason Syed Neil Mark A.
Wang Namdev Hill Ali Westlund Ashwell