EGF(A) analogues with fatty acid substituents
The invention relates to compounds derived from the EGF(A) domain of LDL-R, in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293-332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof and use a medicament. The novel EGF(A) compounds of the invention are useful as treatment e.g. in the field of cholesterol lowering, dyslipidaemia and cardiovascular disease.
Novo Nordisk A/S
A A A C A C
A61P A61K A61P C07K A61K C07K
inventional inventional inventional inventional additional inventional
Jesper F. Patrick William Henning Birgit Lars Jianhe Janos Tibor Salka Elboel
Lau Garibay Thoegersen Wieczorek Linderoth Chen Kodra Rasmussen