Foley Hoag LLP
Method of purifying cell-binding agent-cytotoxic agent conjugates with a PVDF membrane
The invention provides processes for preparing purified cell-binding agent cytotoxic agent conjugates comprising subjecting a mixture comprising a cell-binding agent cytotoxic agent conjugate and one or more impurities to a polyvinyl difluoride (PVDF) membrane to remove at least a portion of the impurities from the mixture, thereby providing a purified cell-binding agent cytotoxic agent conjugate.
IMMUNOGEN, INC.
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Xinfang Xiaoxi Kevin
Li Chen