Foley Hoag LLP
Conjugates comprising peptide groups and methods related thereto
In some aspects, the invention relates to an antibody-drug conjugate, comprising an antibody; a linker; and at least two active agents. In preferred embodiments, the linker comprises a peptide sequence of a plurality of amino acids, and at least two of the active agents are covalently coupled to side chains of the amino acids. The antibody-drug conjugate may comprise a self-immolative group, preferably two-self-immolative groups. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
LegoChem Biosciences, Inc.
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Ji Eun Hyo Jung Sung Min Byung Soo Kyung Eun Su In Jinyeong Ji Young Dong Hyun Chul-Woong Yeong Soo Yun Hee Yong Zu Ho Young Hyoungrae Jeiwook
Jung Choi Kim Lee Park Lee Kim Min Woo Chung Oh Park Kim Song Kim Chae