C-28 amines of C-3 modified betulinic acid derivatives as HIV maturation inhibitors
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-28 amines of C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS. In particular, the following compounds are provided herein, including pharmaceutically acceptable salts thereof:a compound of formula Ia compound of formula IIand a compound of formula III
Bristol-Myers Squibb Company
A C A A A
A61P C07J A61P A61P A61P
inventional inventional inventional inventional inventional
Sing-Yuen Zheng Nicholas A. Jacob Yan Alicia Jie
Sit Liu Meanwell Swidorski Chen Regueiro-Ren Chen