Klarquist Sparkman, LLP
Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia
Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.
The United States of America, as represented by the Secretary, Department of Health and Human Services New York University
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C07K A61K A61P Y02A A61P A61K
inventional inventional inventional additional inventional inventional
Louis Rachel Joanna John B. Zuzana Fathy Jerry Christopher P. Darrell T. Ruth
Miller Schneerson Kubler-Kielb Robbins Biesova Majadly Keith Mocca Liu Nussenzweig