Jenkins, Wilson, Taylor & Hunt, P.A.
Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same
3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.
The Board of Trustees of the University of Illinois The University of North Carolina at Chapel Hill
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A01K C12N C12N A61K A61K C12N
additional additional inventional additional additional additional
Vaibhav Guoqing Deepak Michael B. Jian Anders Jinghua
Tiwari Xia Shukla Duncan Liu Malmstrom Chen