Pabst Patent Group LLP
Compositions and methods for treating pancreatitis and pain with death receptor agonists
Death receptor 5 (DR5) agonist compositions and methods for treating pancreatitis have been developed. The compositions include Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL), its analogues, and anti-DR5 agonistic antibodies. In certain embodiments, TRAIL analogs and anti-death receptor 5 agonistic antibodies have analgesic and disease modifying effects on the pancreas.
The Johns Hopkins University
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Pankaj J. Seulki Martin G. Magdalena Ogyi
Pasricha Lee Pomper Scully Park