Sughrue Mion, PLLC
Dual function proteins comprising FGF21 mutant protein and pharmaceutical composition comprising same
The present invention provides a dual function protein prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin, which has improved pharmacological efficacy, in vivo duration and protein stability. A dual function protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.
YUHAN CORPORATION
A A A C A A C C C A A A
A61P A61P A61P C07K A61P A61K C07K C07K C07K A61P A61P A61P
inventional inventional inventional inventional inventional additional inventional inventional additional inventional inventional inventional
Mi Kyeong Jun Hwan Su Youn Seyoung Minji Dohoon Seul Gi Jong Gyun Hyun Ho Sangmyoun Ju-Young
Ju Kim Nam Lim Seo Kim Kim Kim Choi Lim Park