Jones Day
Complex of Hepatitis B virus polymerase with p11 and method for controlling movement of the complex in HepG2 cell
Disclosed is a complex of the 11 kDa Ca2+ binding protein of 11 and Hepatitis B virus polymerase (HBVPol) which moves to Promyelocytic Leukemia Nuclear Body (PMLNB). Furthermore, the present invention discloses a method for controlling movement of the HBVPol/p11 complex into the nucleus of HepG2 cell with adjusting of intracellular Ca2+ ion concentration by administrating an agent for controlling calcium ion concentration in HepG2 cells.
Korea Institute of Science and Technology
C C C A C C
C12N C12N C07K A61K C12N C07K
inventional additional inventional additional additional inventional
Dae-sik Juhyun Ye Sun
Lim Choi Han