Nixon Peabody LLP
Bacteriophages expressing antimicrobial peptides and uses thereof
The present invention is generally related to engineered bacteriophages expressing antimicrobial peptides or lytic enzymes or fragments thereof for targeting a broad spectrum of bacterial hosts, and for the long-term suppression of bacterial phage resistance for reducing bacterial infections. In some embodiments, bacteriophages express antimicrobial peptides or antimicrobial polypeptides (e.g. phage lytic enzymes) which are secreted from the host bacteria, or alternatively released upon lysis of the bacterial host cell. Aspects of the present invention also relate to the use of the engineered bacteriophages for the reduction of bacterial infections, both in a subject or for bioremediation purposes, in clinical settings and wound healing.
Trustees of Boston University Massachusetts Institute of Technology
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Timothy Kuan-Ta Christopher Jongsoo James J. Michael Gregory Tanguy My
Lu Yoon Collins Koeris Stephanopoulos Chau