Fulbright & Jaworski L.L.P.
Suppression of neu overexpression using a mini-E1A gene
 The present invention relates to methods for the inhibition, of the gene product of the neu oncogene, p185 neu tyrosine kinase. Over-expression of the neu oncogene can lead to chemoresistance. The present invention discloses the functional domains of E1A responsible for the repression of neu-mediated transformation. Further the invention discloses methods for the novel use of mini-E1A in combination with chemotherapeutic drugs and/or tyrosine kinase inhibitors. Mini-E1A may be used in the treatment of cancer and other disease. 
Board of Regents, The University of Texas System
C C A A C A
C12N C07K A61K A61P C12N A61K
additional inventional additional inventional additional additional
Hua Dihua Mein-Chie
Chen Yu Hung