Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators
Novel compounds of Formula I:or an enantiomer, diastereomer, tautomer, prodrug or salt thereof, wherein m, Q, T, U, V, ring A, X, Y, R3, R4, R4a, R5a, R5b, R5c, R5d, R5e, R6a, R6b, and R6c are defined herein, are provided which are TGR5 G protein-coupled receptor modulators. TGR5 G protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring TGR5 G protein-coupled receptor modulator therapy. Thus, the disclosure also concerns compositions comprising these novel compounds and methods of treating diseases or conditions related to the activity of the TGR5 G protein-coupled receptor by using any of these novel compounds or a composition comprising any of such novel compounds.
Bristol-Myers Squibb Company
A A A A C A A A C A A C A C C A C A A A A A A C C A C A C A A A A C A A A A C
A61K A61K A61P A61P C07D A61K A61P A61K C07D A61P A61P C07F A61K C07D C07D A61K C07D A61K A61P A61K A61K A61P A61P C07D C07D A61P C07D A61P C07D A61P A61K A61K A61K C07D A61P A61K A61P A61P C07D
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Jun Saleem Steven J. Jeffrey A. William N. Lawrence J. Khehyong Haixia
Li Ahmad Walker Robl Washburn Kennedy Ngu Wang