Schwegman Lundberg & Woessner, P.A.
Metalloprotein inhibitors
The present invention relates to metalloprotein inhibitors comprising: a. an organic substituent and at least one zinc binding group (ZBG) covalently attached thereto; or b. a ZBG substituted by a side chain wherein the ZBG is of formula (I): wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.
The Regents of the University of California
C A A A A A C A A C A
C07D A61K A61P A61P A61K A61K C07D A61P A61P C07D A61P
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David T. Seth M. Jana A.
Puerta Cohen Lewis