Stewart and Kolasch, Ltd.
Naphthyridine-3-carboxamido-benzylpenicillins and salts thereof
 Novel penicillins of the formula: ##SPC1## Wherein the ring A is a benzene ring or a 5 or 6-membered heteroaromatic ring containing one or two nitrogen atoms as the hetero atom, on which one or more of lower alkyl, lower alkoxy, lower alkylthio, lower haloalkyl, lower alkylenedioxy, halogen, hydroxyl, nitro, free or protected amino, lower alkylamino, di(lower)alkylamino and lower alkanoylamino may be present, Z is a nitrogen atom or a methylene group, X is an oxygen atom or a sulfur atom, Y is a hydrogen atom, a lower alkoxycarbonyl group or a lower alkanoyl group, R.sub.1 is a free or protected hydroxyl group and R.sub.2 and R.sub.3 are each a hydrogen atom or a halogen atom, and their non-toxic pharmaceutically acceptable salts, and their preparation. 
Sumitomo Chemical Company, Limited
C C
C07D C07D
inventional inventional
Hiroshi Yasuko Takenari Hisao Iwao Hirotada Toshiaki Shigeru Kozo Akio
Noguchi Eda Nakagome Tobiki Nakatsuka Yamada Komatsu Okano Shimago Izawa