Stabilized interleukin 2
A stable pharmaceutical preparation comprising Human interleukin-2 or a variant thereof and a stabilizing amount of histidine. A preferred formulation includes glycine and sucrose and a variant of IL-2 having a single mutation, N88R. The preferred formulation is in lyophilized form which, on reconstitution with an aqueous diluent, results in a solution having a pH ranging from about 5.0 to 6.5.
Bayer Pharmaceuticals Corporation
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A61P A61P A61K A61P
inventional inventional inventional inventional
Michael A. Rajiv Wei
Shearer Nayar Wang