Riverside Law LLP
Compositions for preventing or treating sepsis or septic shock compromising ADK protein as active ingredient
The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine kinase (ADK) protein as an active ingredient. The Mycobacterium tuberculosis-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.
KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
A A Y A C A A A
A23L A61P Y02A A61P C12Y A23V A61K A61P
inventional inventional additional inventional additional additional inventional inventional
Jung Hee Byoung Yul Sung Jae Yeong Min Seung Jun In Duk Tae Heung
Park Soh Shin Park Lee Jung Kang