Viksnins Harris & Padys PLLP
1,7-diazacarbazoles and methods of use
The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
GENENTECH, INC.
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A61K A61K A61K A61K C07D C07D A61P A61K A61K A61P A61P A61K C07D
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Huifen Lewis Hazel Joan Joseph P. Charles Karen Joy Samuel Calum Simon
Chen Gazzard Dyke Lyssikatos Ellwood Williams Drobnick Kintz Macleod Goodacre