Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, PC
Methods of protecting against radiation injury
Administration of a modulator of cell cycle checkpoint activation, which is preferably β-lapachone, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, protects normal cells against radiation injury. The invention includes methods of preventing radiation damage. The invention also provides methods for treating conditions such as cancer with radiotherapy, by administering a modulator of cell cycle checkpoint activation to a subject, prior to administration of radiotherapy.
ArQule, Inc.
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Chiang J. Stephen A. YouZhi
Li Hill Li