Vorys, Sater, Seymour and Pease LLP
Composition for alleviating nephrotoxicity caused by immunosuppressive drug, comprising metformin, and composition for preventing or treating immune disease, comprising the same
Provided is a composition for alleviating nephrotoxicity caused by an immunosuppressive drug, including metformin, and a composition for preventing or treating an immune disease, including the same. Further, the composition provided can be useful in improving a treatment effect on diseases requiring immunosuppression by effectively alleviating a decline in renal function caused due to side effects of conventional immunosuppressive drugs, and can also be useful in preventing or treating organ transplant rejection, autoimmune diseases, inflammatory diseases and the like since various methods of co-administering a conventional immunosuppressive drug and metformin are suggested to reduce nephrotoxic side effects of conventional immunosuppressive drugs and maximize immunosuppressive or immunomodulatory effects.
The Catholic University of Korea Industry-Academic Cooperation Foundation
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A61K A61K A61K A61K
inventional inventional inventional inventional
Jong Young Eun Kyung Joo Yeon Jae Kyung Eun Jung Sung Hwan Sun Woo Seon Yeong Chul Woo Mi La Min Jung
Choi Kim Jhun Kim Lee Park Lim Lee Yang Cho Park