Oblon, Spivak, McClelland, Maier & Neustadt
Pyrrolidine derivatives
 The invention relates to pyrrolidine derivatives having thromboxane A.sub.2 antagonism and TXA.sub.2 synthetase-inhibitory activity, of the formula ##STR1## wherein R.sup.1 is pyridyl(lower)alkyl, R.sup.2 is an acyl group selected from the group consisting of lower alkanoyl, lower alkoxycarbonyl, lower alkylsulfonyl, phenylsulfonyl, benzoyl, phenyl(lower)alkanoyl, cyclo(lower)alkyl(lower)alkanoyl, phenyl(lower)alkoxycarbonyl and phenylcarbamoyl, each of which may have 1 to 3 substituent(s) selected from the group consisting of halogen, lower alkyl, lower alkoxy, nitro and mono(or di or tri)halo(lower)alkyl, and PA0 R.sup.3 is carboxy(lower)alkyl, protected carboxy(lower)alkyl, carboxyphenyl or protected carboxyphenyl, or a pharmaceutically acceptable salt thereof. 
Fujisawa Pharmaceutical Co., Ltd.
C C A C A C A C A A A C C C C C
C07D C07D A61P C07D A61P C07D A61P C07D A61P A61P A61P C07D C07D C07D C07D C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Masashi Hirokazu Hiroyuki Akihiko
Hashimoto Tanaka Setoi Sawada