Lathrop & Gage LLP
Processes for preparing JAK inhibitors and related intermediate compounds
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
Incyte Corporation
C C A C A C Y C A
C07F C07F A61P C07F A61P C07F Y02P C07D A61P
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Mei Qiyan Jiacheng Pingli Tai-Yuen Yongchun Michael David Brian W.
Li Lin Zhou Liu Yue Pan Xia Meloni Metcalf