Tarolli, Sundheim, Covell & Tummino LLP
Systems pharmacology for treating ocular disorders
A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or Gq-protein coupled receptors or Gs- or Gq-signaling cascade in ocular cells of the subject, and/or activates Gi-protein coupled receptors, which is induced or triggered by light induced all-trans-retinal generation.
Case Western Reserve University
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Krzysztof Akiko Yu
Palczewski Maeda Chen