Bierman, Muserlian and Lucas
Process for producing desulfated polysaccharide, and desulfated heparin
This invention relates to a process for producing a desulfated polysaccharide, which comprises reacting a sulfated polysaccharide having a saccharide in which a primary hydroxyl group is sulfated, as a constituent sugar, with a silylating agent represented by the following formula (I) wherein R1s are the same or different and each represent a hydrogen atom or a halogen atom, R2 represents a lower alkyl group, and R3s are the same or different and each represent a lower alkyl group, an aryl group or a halogen atom, and a desulfated heparin obtained by this production process.
Seikagaku Corporation
A A A C A C
A61P A61K A61P C08B A61P C08B
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Masayuki Saburo Keiichi
Ishihara Hara Yoshida