Klauber & Jackson
Compositions and devices for partitioning advanced glycosylation endproducts, and methods of their use
 The present invention is directed to compositions and devices based upon the unexpected discovery that certain antibacterial proteins, in particular lysozyme and lactoferrin, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions and devices having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain. The invention further relates to compositions and devices for partitioning AGEs away from a sample. 
The Picower Institute for Medical Research
G G Y Y G A G G G A A Y A C B C A A
G01N G01N Y10S Y10S G01N A61P G01N G01N G01N A61P A61P Y10S A61K C12N B01L C07K A61K A61Q
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Helen Anthony Yong Ming
Vlassara Cerami Li