Reed Smith LLP
Low oxygen affinity mutant hemoglobins
Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
Carnegie Mellon University
A A A C
A61P A61K A61P C07K
inventional additional inventional inventional
Tsuei-Yun Chien Ching-Hsuan Tong-Jian
Fang Ho Tsai Shen