Use of daphnetin in improving function of aortic endothelial cell
The disclosure relates to a pharmaceutical composition including daphnetin, a method for improving aortic endothelial cell function, and use of daphnetin in preparation of a medicine for improving aortic endothelial cell function. The daphnetin is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The daphnetin is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid.
XI'AN JIAOTONG UNIVERSITY
A A A A A
A61P A23L A61K A61P A23V
inventional inventional inventional inventional additional
Xu-Yun Jian-Gang Jian-Kang
Liu Long Liu