Biomolecule retaining material and methods for attaching biomolecules to a surface
The present invention provides a method and material for attachment of biomolecules onto the surface of a substrate, such as microwell plates, tubes, beads, microscope slides, silicon wafers or membranes. The material includes a substrate having a surface coating including a polyamine compound. In one embodiment, the method and material are used to immobilize nucleic acid probes onto plastic materials such as microwell plates, e.g., for use in hybridization assays. In particular, the material can be used to attach a biomolecule (e.g., a nucleic acid) which in turn can be used for specific binding reactions (e.g., to hybridize a nucleic acid to its complementary strand).
Corning Incorporated
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Mark A.
Lewis