McDermott Will & Emery LLP
Hydrogel compositions demonstrating phase separation on contact with aqueous media
A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer or a water-soluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer. The composition also includes a second water-swellable, water-insoluble polymer that provides for a phase separating film forming composition. Active ingredients, such as a whitening agent, may be included. The composition finds utility as an oral dressing, for example, a tooth whitening composition that is applied to the teeth in need of whitening, and removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.
Corium International, Inc. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
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Parminder Danir R. Mikhail M. Sri Gary W.
Singh Bairamov Feldstein Mudumba Cleary