VLP Law Group LLp
Preparation of 2-chloro-9-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-adenine
A process for making clofarabine comprising: fluorinating a compound of formula VIIwherein each R4 is independently a hydroxy protecting group, OR6 is a leaving group, with a fluorinating agent in the presence of guanidine carbonate to give a compound of formula VIII:
Scinopharm Taiwan, Ltd.
C C Y
C07H C07H Y02P
inventional inventional additional
Lijun Yung-Fa Xiaoheng Julian Paul
Mei Chen Zhang Henschke