Sterne, Kessler, Goldstein & Fox P.L.L.C.
Antibodies to notch receptors
The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor and inhibits growth of tumor cells. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human NOTCH receptor protein and inhibits growth of tumor cells.
OncoMed Pharmaceuticals, Inc.
C C C A C C C C C C A A A C C C C C A A
C07K C07K C07K A61K C07K C07K C07K C07K C07K C07K A61P A61K A61N C07K C07K C07K C07K C07K A61K A61K
inventional additional additional additional additional inventional additional additional inventional additional inventional additional inventional additional additional inventional additional inventional inventional inventional
Wan-Ching Austin John A. Timothy Sanjeev
Yen Gurney Lewicki Hoey Satyal