Human anti-factor IX/IXa antibodies
The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting the activation of-FIX and inhibiting FIX/IXa dependent coagulation.
Genentech, Inc.
C A C C A A C C A A C C A A
C07K A61K C07K C07K A61K A61P C07K C07K A61P A61P C07K C07K A61P A61P
additional additional additional additional additional inventional inventional inventional inventional inventional additional additional inventional inventional
Dan L. Brigitte Daniel Philip E. Camellia W. Shelley J. Kevin
Eaton Devaux Kirchhofer Hass Adams Suggett Judice