DLA Piper LLP (US)
Hybrid cyclic libraries and screens thereof
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
The Johns Hopkins University
A A A C C C C G C C C A
A61P A61K A61K C07D C07D C07K C07D G01N C07K C07D C07D A61P
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Wei Jingxin Manisha Jun O. Shridhar Zufeng
Li Wang Das Liu Bhat Guo