WPAT, P.C.
Dnazyme for silencing the expression of EGFR
The invention provides DNAzymes which are capable to silence the expression of EGFR at allele-specific level. These allele-specific DNAzymes against EGFR T790M mutation will knockdown the expression of EGFR T790M mRNA while keeping EGFR wild-type mRNA intact. Hence, these allele-specific DNAzymes against EGFR T790M mutation may overcome T790M-derived TKI resistance accompanied with lower unwanted side effects on normal cells in lung cancer patients.
ACADEMIA SINICA National Taiwan University
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C12N C12N C12N A61K A61P C07K C12N C12N C12N A61K A61P C12N
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Shuenn-Chen Konan Cheng-Ju Chi-Yuan Wei-Yun Pan-Chyr
Yang Peck Chang Chen Lai Yang