Buchanan Ingersoll & Rooney
Factor VIII conjugates
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
BAYER HEALTHCARE LLC
A A A A C A C A C
A61P A61P A61K A61K C07K A61P C07K A61K C07K
inventional inventional inventional additional inventional inventional inventional inventional additional
Deqian Liang Jianmin Thomas Hendri Clark Q. Jonathan S. John E. Baisong
Wang Tang Chen Barnett Tjandra Pan Strauss Murphy Mei