Sughrue Mion, PLLC
Long-acting FGF21 fusion proteins and pharmaceutical composition comprising same
The present invention provides a fusion protein comprising an FGF21 mutant protein and an Fc region of an immunoglobulin. The fusion protein according to the present invention exhibits improved pharmacological efficacy, in vivo duration and protein stability, and a pharmaceutical composition comprising the fusion protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis.
YUHAN CORPORATION
A C A A C A A
A61K C07K A61P A61K C07K A61P A61P
additional inventional inventional additional additional inventional inventional
Hyun Ho Minji Ju-Young Seyoung Jong Gyun Byung Hyun Dohoon Su Youn Mi Kyeong Jun Kyung Jun Hwan
Choi Seo Park Lim Kim Choi Kim Nam Ju Lee Kim