Ropes & Gray LLP
Method of inducing anergic T helper cells
This invention also provides a method of generating antigen specific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human suppressor CD8+CD28− T cells. Methods of tent for reduction of risk of rejection of allografts and xenografts and autoimmune diseases using the human suppressor CD8+CD28− T cells so produced are also provided, as are methods of preventing rejection and autoimmune diseases, and vaccines comprising the produced suppressor T cells. Methods of diagnosis to determine whether a level of immuno-suppressant therapy requires a reduction are provided.
The Trustees of Columbia University in the City of New York
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A61K C12N G01N A61K A61K A61K
additional additional inventional additional additional inventional
Raffaello Chih-Chao Zhuoru Nicole
Cortesini Chang Liu Suciu-Foca