Greenlee, Winner and Sullivan, P.C.
Production of taxol and taxanes
A high yield, economical process for purifying taxanes from yew biomass is disclosed. The process does not require initial liquid:liquid portioning of the crude extract to separate highly polar substances. The organic solvent extract of the biomass is adsorbed onto and selectively desorbed from an adsorption resin to provide a taxane enriched eluate. Substantially pure individual taxanes may be further isolated from the eluate by hydrophobic-interaction chromatography.
Purdue Research Foundation
C
C07D
inventional
Xiao-jie Ching-jer
Tong Chang