Foley Hoag LLP
Antibody-drug conjugates comprising branched linkers and methods related thereto
The present invention relates to antibody-drug conjugates (ADCs) wherein a plurality of active agents are conjugated to an antibody through at least one branched linker. The branched linker may comprise a branching unit, and two active agents are coupled to the branching unit through a secondary linker and the branching unit is coupled to the antibody by a primary linker. The active agents may be the same or different. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody. The branched linker may comprise one active agent coupled to the branching unit by a first branch and a second branch that comprises a polyethylene glycol moiety coupled to the branching unit. In certain such embodiments, two or more such branched linkers are conjugated to the antibody, e.g., 2-4 branched linkers, which may each be coupled to a different C-terminal cysteine of a heavy or light chain of the antibody.
LegoChem Biosciences, Inc.
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Ho Young Chul-Woong Hyoungrae Yeong Soo Ji Young Yong Zu Kyung Eun Su In Byung Soo Jeiwook Yun Hee Jinyeong Dong Hyun Ji Eun Sung Min Hyo Jung
Song Chung Kim Oh Min Kim Park Lee Lee Chae Park Kim Woo Jung Kim Choi