Foley & Lardner LLP
Dispiropyrrolidine derivatives
A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
Daiichi Sankyo Company, Limited
A A C A C A A A A A A A A A A A A C A A
A61K A61P C07D A61P C07D A61K A61P A61P A61P A61K A61P A61K A61P A61P A61P A61P A61K C07D A61K A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Kouichi Masaki Akitake Takanori Masaki Yuuichi Keisuke Shoko Toru
Uoto Setoguchi Yamaguchi Wakabayashi Miyazaki Sugimoto Yoshida Yoshida Taniguchi