LeClairRyan, A Professional Corporation
In vitro method using hetero-oligomeric T1R1/T1R3 taste receptors to identify umami tastants
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners. Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.
SENOMYX, INC.
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Jon Elliot Sergey Hong Xiaodong Fernando Lena Mark Shawn
Alder Zozulya Xu Li Echeverri Staszewski Zoller O'Connell