Foley & Lardner LLP
Apparatus and methods for manipulation and optimization of biological systems
The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system. In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems.
The Regents of the University of California
C C G G Y C
C12Q C12Q G01N G01N Y02A C12M
inventional inventional additional inventional additional inventional
Pak Kin Fuqu Ren Chih-Ming
Wong Yu Sun Ho