Cohen, Pontani, Lieberman & Pavane
Process for the preparation of 7-alkyl-10-hydroxy-20(S)-camptothecin
The key intermediate in any synthesis of Irinotecan is 7-ethyl-10-hydroxy-20(S)-camptothecin. A process for the efficient synthesis of this intermediate is demonstrated proceeding through readily available 20(S)-camptothecin. Various other tecan compounds may be made by use of corresponding 7-alkyl-10-hydroxy-20(S)-camptothecin intermediates.
Scinopharm Taiwan, Ltd.
C A
C07D A61P
inventional inventional
Yung-Fa Kau-Ming Chien-Hsing
Chen Chen Lin