Hunton & Williams LLP
Heteromeric T1R2/T1R3 taste receptors
Heteromeric taste receptors are provided. These receptors comprise a first polypeptide containing extracellular domains and transmembrane domains wherein the extracellular domains are at least 95% identical to the extracellular domains of specific T1R2 polypeptides and the transmembrane domains are at least 95% identical to the corresponding transmembrane domains of the specific T1R2 polypeptide or a different GPCR; and a second polypeptide comprising extracellular and transmembrane domains wherein the extracellular domains are at least 95% identical to the extracellular domains of specific T1R3 polypeptides and the transmembrane domains are at least 95% identical to the corresponding transmembrane domains of the specific T1R3 polypeptide or a different GPCR.
Senomyx, Inc.
G G G A C C G A C C G G G C
G01N G01N G01N A01K C07K C12Q G01N A61P C12Q C12Q G01N G01N G01N C07K
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Sergey Shawn Mark Hong Lena Jon Elliot Xiaodong Fernando
Zozulya O'Connell Zoller Xu Staszewski Adler Li Echeverri