Soluble guanylate cyclase stimulators
The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose. 
Merck Sharp & Dohme Corp.
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A61K A61P A61K C07D A61P A61P C07D A61P
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Subharekha John Gang Alan Yi-Heng Shouwu Cameron J. Rui Raphaelle Hong-Dong Joie Yong Jianmin Falong Guoqing
Raghavan Stelmach Ji Whitehead Chen Miao Smith Zhang Berger Li Garfunkle Zhang Fu Jiang Li