Womble Bond Dickinson (Us) LLP
Methods for scaling between chromatographic systems using highly compressible fluids
Methods for transferring a separation procedure from a first chromatographic system to a second one are disclosed that involve substantially matching a pressure profile. In some such methods, a length, an area, and a particle size of a first column in the first system and a flow rate in the first separation procedure are identifiable. Some such methods also involve selecting a combination of a length, an area, and a particle size of a second column in the second system and a flow rate for the second separation procedure. These methods may involve calculating a target length, a target area, or a target particle size for the second column in the second system or a target flow rate for the second separation procedure.
Waters Technologies Corporation
G B G G B G G G G G G G G
G01N B01D G01N G01N B01D G01N G01N G01N G01N G01N G01N G01N G01N
additional inventional inventional inventional inventional inventional additional additional additional additional additional additional inventional
Michael O. Joshua A. Jason F. Joseph D. Abhijit
Fogwill Shreve Hill Michienzi Tarafder