Nixon Peabody LLP
Compositions and methods for treating HIF-1α over-expressing cancers
Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90α and methods of using the same to treat HIF-1α-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP (SEQ ID NO: 1) in Hsp90α or VKHFSVEGQ (SEQ ID NO: 2) in Hsp90α.
University of Southern California
C C C C C C C C C A C
C12N C12N C07K C07K C07K C07K C12N C12N C12N A61K C12N
additional additional inventional additional inventional additional additional additional additional inventional inventional
Mengchen Wei David Divya Mei Hangming
Zou Li Woodley Sahu Chen Dong