Choate, Hall & Stewart
Multi-state genetic oscillator
Provided are methods and compositions for regulating gene expression in a cell. The invention provides recombinant multi-state genetic oscillators containing an adjustable-threshold genetic switch that is periodically activated by an oscillating amount of an activator agent. The activating agent is a gene product expressed from a promoter regulated by the adjustable-threshold switch and thus forms a feedback loop that causes periodic switching of the adjustable-threshold switch between an &#8220;on&#8221; state and an &#8220;off&#8221; state. Multi-state genetic oscillators are useful to express one or more genes of interest in a periodic manner without requiring a periodic application of an external activating agent.
Boston University
C C
C12N C12N
inventional inventional
James J. Timothy
Collins Gardner