Bacon & Thomas, PLLC
2-phenyl-4-quinolones as anticancer agents
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
China Medical University
C A C C A C C
C07D A61P C07F C07F A61P C07D C07D
inventional inventional inventional inventional inventional inventional inventional
Jai-Sing Tian-Shung Li-Chen Chung-Ming Li-Jiau Tzong-Der Chien-Ting Shiow-Lin Shih-Ming Jang-Chang Che-Ming Jing-Gung Kuo-Hsiung Chih-Shiang Ching-Che Sheng-Chu
Yang Wu Chou Sun Huang Way Chen Pan Huang Lee Teng Chung Lee Chang Huang Kuo