2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
 Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen or substituent groups such as alkyl, and where R.sub.7 is hydrogen or an organic radical, and Z is COOR.sub.7, tetrazolyl, CONR.sub.6 R.sub.7, or CH.sub.2 OR.sub.7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders. 
Warner-Lambert Company
C C C C C C C C C C C C C C C C C C C C C
C07C C07D C07D C07C C07C C07C C07D C07D C07C C07C C07D C07C C07C C07D C07C C07C C07C C07C C07D C07C C07C
additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional
Donna Reynolds Stephen Douglas Alexander James David Thomas Annette Marian Mel Conrad Alan Robert Haile
Cody Barrett Bridges Dudley Doherty Schroeder Saltiel Tecle