Reed Smith Shaw & McClay LLP
Unmodified recombinant human adult hemoglobin production
 Methods for obtaining unmodified recombinant human normal adult hemoglobin involve a novel expression plasmid that coexpresses human .alpha.- and .beta.-globin genes and E. coli methionine aminopeptidase genes under the control of separate tac promoters. Methods are also provided for correcting an abnormal conformation of some of the heme groups incorporated in the proteins expressed by the expression plasmid. 
Carnegie Mellon University
A Y C C
A61K Y02A C07K C12N
additional additional inventional inventional
Tong-Jian Chien
Shen Ho