Sughrue Mion, PLLC
Bone densifying agent characterized by use of cathepsin K inhibitor with PTH
The present invention relates to an agent for increasing BMD characterized by use of a cathepsin K inhibitor as a bone resorption inhibitor in combination with a type of PTH as a bone formation stimulator. This agent for increasing BMD is useful for the treatment of osteoporosis, bone fracture, arthritis, rheumatoid arthritis, osteoarthritis, hypercalcemia, osteometastasis of carcinoma, periodontal disease, bone Paget's disease and other bone metabolic diseases. For example, as the cathepsin K inhibitor, there can be mentioned a compound of formula (W) and a salt thereof, etc.
Ono Pharmaceutical Co., Ltd.
A A A A A A A A A A A A A A A
A61K A61P A61P A61P A61P A61K A61P A61P A61K A61P A61P A61P A61K A61K A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Yasuo Ryouji Hiroyuki Hiroshi Makoto Naoki
Ochi Kayasuga Yamada Mori Tanaka Kawada