Panitch Schwarze Belisario & Nadel LLP
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof
6-amino quinazoline or 3-cyano quinoline derivatives, preparation methods and pharmaceutical uses thereof are disclosed. Specifically, the present disclosure discloses novel 6-amino quinazoline or 3-cyano quinoline derivatives presented by general formula (I), or tautomers, enantiomers, diastereomers, racemates or pharmaceutically acceptable salts thereof, or metabolites, metabolic precursors or prodrugs thereof, and their uses as treatment agents especially as protein kinase inhibitors, in which each substitutent group of general formula (I) is as defined in the specification.
Jiangsu Hengrui Medicine Co., Ltd. Shanghai Hengrui Pharmaceutical Co., Ltd.
C C C C A A C A C
C07D C07D C07F C07D A61P A61K C07F A61P C07D
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Jun Xin Lijun Peng Cho Bin
Wang Li Chen Tang Wang