HIV inhibiting pyrimidine derivative
 This invention concerns the use of the compounds of formula ##STR1## the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein A is CH, CR.sup.4 or N; n is 0 to 4; Q is hydrogen or --NR.sup.1 R.sup.2 ; R.sup.1 and R.sup.2 are selected from hydrogen, hydroxy, C.sub.1-12 alkyl, C.sub.1-12 alkyloxy, C.sub.1-12 alkylcarbonyl, C.sub.1-12 alkyloxycarbonyl, aryl, amino, mono- or di(C.sub.1-12 alkyl)amino, mono- or di(C.sub.1-12 alkyl)aminocarbonyl wherein each C.sub.1-12 alkyl may optionally be substituted; or R.sup.1 and R.sup.2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C.sub.1-12 alkyl)aminoC.sub.1-4 alkylidene; R.sup.3 is hydrogen, aryl, C.sub.1-6 alkylcarbonyl, optionally substituted C.sub.1-6 alkyl, C.sub.1-6 alkyloxycarbonyl,; and R.sup.4 is hydroxy, halo, optionally substituted C.sub.1-6 alkyl, C.sub.1-6 alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl, trihalomethyloxy; R.sup.5 is hydrogen or C.sub.1-4 alkyl; L is optionally substituted C.sub.1-10 alkyl, C.sub.3-10 alkenyl, C.sub.3-10 alkynyl, C.sub.3-7 cycloalkyl; or L is --X.sup.1 --R.sup.6 or --X.sup.2 -Alk-R.sup.7 wherein R.sup.6 and R.sup.7 are optionally substituted phenyl; X.sup.1 and X.sup.2 are --NR.sup.3 --, --NH--NH--, --N.dbd.N--, --O--, --S--, --S(.dbd.O)-- or --S(.dbd.O).sub.2 --; Alk is C.sub.1-4 alkanediyl; aryl is potionally substituted phenyl; Het is an optionally substituted aliphatic or aromatic heterocyclic radical; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them. 
Janssen Pharmaceutica, Inc.
C C C A C C A C A
C07D C07D C07D A61P C07D C07D A61P C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional
Jan Chih Yung Koenraad Jozef Lodewijk Marcel Marc Rene Koen Jeanne Alfons Donald William Marcel August Constant Bart Michael Joseph Paul Adriaan Jan Lucien Maria Henricus
Heeres Ho Andries De Jonge Van Aken Ludovici Janssen De Corte Kukla Janssen Koymans