Muirhead and Saturnelli, LLC
Methods and apparatus for fractionation-based chemical analyses
A method for analyzing chemicals includes fractionating a complex sample into at least two sample portions that each include portions of two polypeptides though in different concentration ratios, digesting and performing LC/MS on each of the sample portions, and associating precursor ions observed via LC/MS with their corresponding polypeptide in response to LC/MS-provided intensity data. A set of precursor-ions that has substantially similar intensity ratios in both sample portions is determined to be associated with the same polypeptide.
Waters Technologies Corporation
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G01N H01J G01N G01N G01N G01N G01N C12Q G01N G01N G01N
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Jeffrey Cruz Guo-Zhong Scott J. Marc V.
Silva Li Geromanos Gorenstein