Sterne, Kessler, Goldstein & Fox P.L.L.C.
Combination product comprising phentermine and topiramate, and preparation method thereof
The present invention provides a combination product, which comprises immediate release pellet of phentermine and sustained-release pellet of topiramate, wherein the pellet of topiramate includes: a) a blank pellet core; b) an active drug layer that contains topiramate and is free of binding agent, the layer being located on surface of the blank pellet core; c) a sustained-release coating layer containing ethyl cellulose and PVP K30, the sustained-release coating layer being located on external of the active drug layer. The present invention further discloses a method for preparing the combination product.
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
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Li Meiyan Xinbo Yuli Wu Song Chunsheng Zhibing Xiaokui
Shan Yang Zhou Wang Zhong Li Gao Zheng Wang