Azole amides and amines as alpha v integrin inhibitors
The present invention provides compounds of Formula (I): (Formula (I)), or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are inhibitors to αv-containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of αv-containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.
Bristol-Myers Squibb Company
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A61P A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P C07D
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Wei Pratik
Wang Devasthale