LeClairRyan
Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Sirna Therapeutics, Inc.
A A A C C C A A C
A61K A61P A61K C12N C07H C12N A61P A61K C12N
inventional inventional inventional additional inventional inventional inventional inventional additional
Marina Jeffrey Robert A. David Anthony W. Weimin Rachel Anne Aaron Vadim Yu Lu Rubina G. Steven L. Kathleen B. Thomas Joseph
Busuek Aaronson Kowtoniuk Tellers Shaw Wang Storr Momose Dudkin Yuan Tian Parmar Colletti Calati Tucker