Process for preparing 4-(4-fluoro-3-(2-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine-7-carbonyl)benzyl)phthalazin-1(2h)-one
A preparation method for a compound represented by formula I or a pharmaceutically acceptable salt thereof, The method includes a step of reacting a compound represented by formula II  with an inorganic or organic acid selected from the group consisting of hydrochloric acid, phosphoric acid and maleic acid to provide a compound represented by formula II′  In the above formulas II and II′, R1 may be trifluoromethyl; and X may be hydrochloric acid, phosphoric acid, or maleic acid. The method also includes a step of reacting the compound represented by formula II′ with a compound represented by formula IV:  to provide the compound represented by formula I, wherein Ra is selected from hydroxyl, halogen or alkoxy. 
JIANGSU HENGRUI MEDICINE CO., LTD.
A C A
A61P C07D A61K
inventional inventional inventional
Yingjie Wenhai
Zhang Li