Roberts Mlotkowski Safran & Cole, P.C.
Hexenone compounds and medical use thereof
The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent; and also to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, or preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, or preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
Institute of Pharmacology and Toxicology Medical Sciences P.L.A. China
C A A A C A A A A
C07D A61P A61P A61P C07D A61P A61P A61P A61P
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Guoliang Long Junhai Wu Juan Wei Kunlun Lili Xin Zhibing Song
Hu Long Xiao Zhong Liu Li He Wang Li Zheng Li