Bacon & Thomas, PLLC
Hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120 (Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and Λ/, Λ/-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
China Medical University
A A C C C C C
A61P A61P C07F C07D C07D C07F C07D
inventional inventional inventional inventional inventional inventional inventional
Jing-Gung Shiow-Lin Li-Jiau Sheng-Chu Li-Chen Chung-Ming Kuo-Hsiung Shih-Ming Chih-Shiang Tian-Shung Jai-Sing Ching-Che Chien-Ting Che-Ming Jang-Chang Tzong-Der
Chung Pan Huang Kuo Chou Sun Lee Huang Chang Wu Yang Huang Chen Teng Lee Way