Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.
Merck Frosst Canada Ltd.
A A A C A C C A A C A C A A C
A61P A61P A61P C07D A61P C07D C07D A61P A61P C07D A61P C07D A61P A61P C07D
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Denis Rejean Yeeman K. Renata M. Chun Sing
Deschenes Fortin Ramtohul Oballa Li