Banner & Witcoff, Ltd.
Urea compounds and use thereof for inhibiting apoptosis
A compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, is provided. Also, a composition containing a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents, is provided. Further, use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt or solvate thereof for anti-apoptosis is provided, preventing or treating a disease or disorder associated with apoptosis; especially for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
Chinese PLA General Hospital
C A A A A A A A C A
C07C A61P A61P A61P A61P A61P A61P A61P C07D A61P
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Long Ruijun Xin Wu Song Juan Guoliang Lili Kunlun Jie Junhai Zhibing Chunlei Wei
Long Li Li Zhong Li Liu Hu Wang He Bai Xiao Zheng Liu Li