Ostrolenk, Faber, Gerb & Soffen
Amino acid and hydroxyamino acid transporter compounds for therapeutic applications, process and use
 Amino acid and hydroxyamino acid transporter compounds are provided, in which an amino acid or hydroxyamino acid as a carrier is linked via an ester linkage to a therapeutic compound, and having one of the general formulae: EQU NH.sub.3.sup.+ --AA--COO--Z.sub.1 I EQU NH.sub.3.sup.+ --HAA--OOC--Z.sub.2 II in which AA represents the amino acid or hydroxyamino acid, HAA represents the hydroxyamino acid, and Z.sub.1 and Z.sub.2 represent a therapeutic compound, or a linking compound attached to COOH or OH of the hydroxyamino acid and to the therapeutic compound, as well as a process for preparing the same, and a process for administration of the same to animals, to obtain the benefit of the therapeutic effect of the therapeutic compound. 
A C
A61K C07K
inventional inventional
Thomas A. Thomas P. Thomas E.
Ban Brown Brown