Wolf, Greenfield & Sacks, P.C.
Antibody and binding fragment recognizing CACNA2D1 and use thereof
Disclosed is a method for searching, identifying, or validating a marker CACNA2D1 of tumor-initiating cells. The method comprises a step of immunizing an animal using HEP-12 cells originating from a recurrent tumor and rich in originating cells. Also disclosed is a monoclonal antibody specially recognizing CACNA2D1 or antigen-binding fragments thereof, and the use thereof for treating or preventing tumors or diseases or conditions related to CACNA2D1.
Beijing Institute for Cancer Research
G A C A G A G A C A
G01N A61K C07K A61P G01N A61K G01N A61K C12Q A61K
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Baocai Wei Limin Haibo Zhiqian
Xing Zhao Wang Han Zhang