Sheppard Mullin Richter & Hampton LLP
4-hydroxy-isoquinoline compounds as HIF hydroxylase inhibitors
The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.
FibroGen, Inc.
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Min Michael P. Hongda Shaojiang Lee A. Lee R. Wen-Bin Danny Xiaoti
Wu Arend Zhao Deng Flippin Wright Ho Ng Zhou