Wolf, Greenfield & Sacks, P.C.
Substituted pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones for cancer treatment
The synthesis of various pyrazino[1′,2′:1,5]pyrrolo[2,3-B]-indole-1,4-dione analogs has been successfully implemented in the present application. From these efforts, compounds having the structure of Formula I-a or Formula I-b: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, are provided herein. These biologically active derivatives have been used to effectively treat various diseases including cancer. 
The Board of Trustees of the University of Illinois Massachusetts Institute of Technology
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Justin Mohammad Karen Paul Nicolas
Kim Movassaghi Morrison Hergenrother Boyer