Seed Intellectual Property Law Group LLP
PKM2 modulators and methods for their use
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. 
TOLERO PHARMACEUTICALS, INC.
A A C C C A C C A C C C C C C C C C C
A61P A61K C07D C07D C07D A61P C07F C07D A61P C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Kenneth Mark Xiaohui Koc-Kan Yong Kevin Bret Michael David Jason Marc David Lee Scott Albert Steven Brian Jihua
Parnell Liu Ho Xu Wright Saunders Foulks Vollmer Pearce Kanner Liu