Wolf, Greenfield & Sacks, P.C.
Substituted penta-fused hexa-heterocyclic compounds, preparation method therefor, drug combination and use thereof
A type of substituted penta-fused hexa-heterocyclic compounds having selective inhibition for PIKfyve kinase, a pharmaceutically acceptable salt and pharmaceutically acceptable solvate thereof, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with PIKfyve in vivo, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.
Xiamen University
A A C C C A A A A A A C A
A61K A61P C07D C07D C07D A61K A61K A61P A61K A61K A61K C07D A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Zhixiang Baoding Jingfang Xinrui Yun Ting Xihuan Qingyan Wei Yan Xiaoyang Zhiyu Xianming Li
He Zhang Zhang Wu Chen Zhang Sun Xu Huang Liu Li Hu Deng Li