Klarquist Sparkman, LLP
Pharmaceutical composition for suppressing angiogenesis, and method for screening active material for suppressing angiogenesis
The present invention provides a pharmaceutical composition for suppressing angiogenesis, containing heat shock protein 27 (HSP27) or a nucleic acid encoding HSP27. In addition, the present invention provides a pharmaceutical composition for treating cancer, containing HSP27 or a nucleic acid encoding HSP27. Additionally, the present invention provides a method of suppressing the in vitro growth of endothelial cells using HSP27. Further, the present invention provides a method of screening an active material for suppressing angiogenesis or an active material for treating cancer, comprising the following steps: processing endothelial cell lines into samples, respectively; measuring the content of HSP27 in an endothelial cell line; and selecting the sample in which the content of HSP27 in an endothelial cell line is increased compared with a control group.
Korea Institute of Radiological & Medical Sciences
A G A C A G C
A61K G01N A61K C07K A61P G01N C07K
inventional inventional additional additional inventional inventional inventional
Yoon Jin Yun-Sil Kyeng-Jung Hae-June Seo-Hyun
Lee Lee Kim Lee Choi