TRPM8 antagonists and their use in treatments
Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure:where the definitions of the variables are provided herein.
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A C C A A A A A C C A C A A C A A A A A A A A A A A C A A A C A A A C
A61P C07D C07D A61P A61P A61P A61P A61P C07D C07D A61P C07D A61P A61P C07C A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P C07D A61P A61P A61P C07D
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Qingyian Vijay Keshav Daniel B. Holger Wenge Thomas T. Scott Nobuko James Matthew R. Jian J.
Liu Gore Horne Monenschein Zhong Nguyen Harried Nishimura Brown Kaller Chen