Inhibitors of C-FMS kinase
The invention is directed to compounds of Formula I:wherein Z, X, J, R2 and W are as set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase. The compounds of formula I are useful for treating a variety of disorders including autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and psoriasis.
Janssen Pharmaceutica, N.V.
A A A C A A A C C A A A A A A C A A C A A C C A A C A A A A C
A61P A61P A61P C07D A61P A61P A61P C07D C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P C07D C07D A61P A61P C07D A61P A61P A61P A61P C07C
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Carl R. Mark Shelley K. Jinsheng Renee Louise Sanath K. Kenneth
Illig Wall Ballentine Chen DesJariais Meegalla Wilson