Wolder, Gross & Yavner
Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions
 Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl; PA1 R.sub.1 is hydrogen, halogen or trifluoromethyl; PA1 R.sub.2 is hydrogen, methyl or hydroxymethyl; PA1 R.sub.3 is hydrogen or lower alkyl; and PA1 Y is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia. The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product. 
Kyowa Hakko Kogyo Kabushiki Kaisha
C C C C C A
C07D C07D C07D C07D C07D A61P
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Hajime Keisuke Toyofumi Shunji Kazuhiro Joji
Takahashi Isozumi Yamada Ichikawa Kubo Nakamura