Marshall, Gerstein & Borun LLP
Polyacid-functionalized porous membranes, related methods, and related polyacid polymers
The disclosure relates to processes, related polyacid polymers, and related articles for functionalizing a porous membrane by contacting the membrane with a polyacid polymer at low pH to stably adsorb a polyacid layer on the membrane pore surface, in particular polyacid polymers including repeating units with a pendent metal-binding ligand or star polyacid polymers. The resulting functionalized membrane is characterized by a high density of free acid groups, resulting in a higher specific capacity for its intended application. The process allows functionalization of porous membranes in a very simple, one-step process, for example without a need to derivatize an adsorbed polyacid layer to impart metal-binding ligand functionality thereto. Such functional membranes may find multiple uses, including rapid, selective binding of proteins for their purification or immobilization.
BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
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Weijing Wenjing Jinlan Merlin L. Salinda
Liu Ning Dong Bruening Wijeratne