Bacon & Thomas, PLLC
Cell culture and method for screening for a compound useful in the treatment or prevention of hepatic cirrhosis
The present invention provides a cell-culturing model and a method for screening compounds which can be applied in treating or preventing hepatic cirrhosis. The cell culturing model comprises a population of hepatocytes and hepatic stellate cells (HSCs) derived from co-culturing, and at least one population of the cells comprises a nucleotide sequence fragment of a reporter gene and a cell specific regulatory sequence. The cell-culturing model of the present invention can be applied in high throughput screening for effective compounds of medication, and also in understanding the functional mechanism of the effective compounds.
Industrial Technology Research Institute
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G01N G01N G01N
additional inventional inventional
Wen-Tyng Pei-Shan Cheng-Ta Yu-Shih Rung-Jiun
Li Li Hsieh Weng Gau