Indazole and azaindazole Btk inhibitors
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein X1, X2, R1, R7, R8 and R9 are as herein described. The present invention also provides pharmaceutical compositions comprising these compounds and methods for their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
Merck Sharp & Dohme Corp.
C C A C C C C A C C C C
C07D C07D A61K C07D C07D C07D C07D A61P C07D C07D C07D C07D
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Rajan Tony Shilan Sobhana Babu Jiaqiang Younong Dahai Jian Brian M. Joseph Michael D.
Anand Siu Liu Boga Cai Yu Wang Liu Andresen Kozlowski Altman