Dorsey and Whitney LLP
Fused substituted aminopyrrolidine derivative
A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.
Daiichi Sankyo Company, Limited
A A A A A A C A A C A A C Y C A A A C A C A C A A
A61P A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P C07D Y02P C07D A61P A61P A61P C07D A61P C07D A61P C07D A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Masatoshi Rie Satoshi Makoto Hiroaki Toshifumi Kiyoshi Takahiro Kenichi Hisashi Takashi
Nagamochi Miyauchi Komoriya Takemura Inagaki Tsuda Nakayama Kitamura Yoshida Takahashi Odagiri