Lerner, David, Littenberg, Krumholz & Mentlik, LLP
Substance having tyrosine kinase inhibitory activity and preparation method and use thereof
Disclosed in the present disclosure are substances having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substances are the compounds having the structure of general formula (I) or the geometric isomers or pharmaceutical salts thereof. Through evaluation on tyrosine kinase inhibitory activity and related experiments, the present disclosure demonstrates that these compounds have a good tyrosine kinase inhibitory activity, and may inhibit a variety of tumor cells, and thus may be developed into drugs for preventing and treating tumor diseases, especially liver cancer, lung cancer and neuroblastoma.
Institute of Radiation Medicine, China Academy of Military Medical Sciences Pla
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A61P C07D A61P A61K A61P A61K C07D A61P
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Haiyan Lu Wei Xiaoxue Lin Shouguo Tao Teng Xiaoming Jing Yiqun Changyan
Yan Li Li Wen Wang Zhang Peng Luo Yang Liu Zhan Li