Wenderoth, Lind & Ponack, L.L.P.
3-substituted-D-homo-1,3,5(10)-estratriene derivatives
 Estratriene derivatives of the following formula have a powerful inhibitory effect on estrone sulfatase and are hence useful for the prophylaxis or treatment of diseases caused by estrogens, such as breast cancer, uterine cancer, ovarian cancer, endometriosis, adenomyosis uteri and mastopathy. ##STR1## wherein one of A and B represents C.dbd.O or CH.sub.2 and the other represents O or NH; and R represents --SO.sub.2 NR.sup.1 R.sup.2 or --PO(OM).sub.2 in which R.sup.1 and R.sup.2 each independently represent a hydrogen atom or a lower alkyl group and M represents a hydrogen atom or an alkali metal; provided that, when one of A and B represents NH, the other represents C.dbd.O. 
Teikoku Hormone Mfg. Co., Ltd.
C C
C07J C07J
inventional inventional
Tomohito Shigeki Naoyuki Shigehiro Mamoru Tomoko
Fujii Iwashita Koizumi Takegawa Mieda Kawachi