Pillsbury Winthrop LLP
Translation enhancer element of the human amyloid precursor protein gene
 The present invention is directed to a DNA element that enhances the translation of the human amyloid precursor protein (APP) gene. The enhancer may be incorporated into expression vectors to enhance recombinant protein production. In addition, the invention is directed to an assay that utilizes vectors containing the translation enhancer element for the purpose of identifying agents that modulate the expression of the human amyloid precursor protein. These agents will ultimately be used to suppress APP expression in patients with Alzheimer's disease. 
The Brigham and Women's Hospital, Inc.
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C12N C12N C12N C07K A61K
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Jack
Rogers