McCarter & English, LLP
Crystalline forms of ARN-509, preparation method and use thereof
The present disclosure relates to novel crystalline forms of ARN-509 (structure shown in formula I), processes for preparation of the novel crystalline forms, pharmaceutical composition of the novel crystalline forms, and uses of the novel crystalline forms for preparing drug products of androgen receptor antagonists and for treating prostate cancer. The crystalline forms of ARN-509 provided by the present disclosure have one or more improved properties compared with the prior art, and is of great value to the future optimization and development of drugs.
Crystal Pharmaceutical (Suzhou) Co., Ltd.
C C A
C07D C07B A61P
inventional additional inventional
Minhua Xiaoting Chaohui Yuhao Jiale Yanfeng
Chen Zhai Yang Chen Qian Zhang