Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5
A monoclonal antibody is provided which specifically binds to human interleukin-5. Also provided are a hybridoma which produces the monoclonal antibody; complementary DNAs which encode the heavy and light chain variable regions of the monoclonal antibody and CDRs therefrom; humanized monoclonal antibodies; and pharmaceutical compositions comprising the monoclonal antibody or anti-idiotypic antibodies directed against it, humanized monoclonal antibodies, binding fragments, binding compositions or single-chain binding proteins derived from the antibody and a physiologically acceptable carrier.
Schering Corporation
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Chuan-Chu Jon E. Stephen William T. Chung-Her John S. Paul J. Nicholas J. Mary E.
Chou Silver Tindall Windsor Jenh Abrams Zavodny Murgolo Petro