Nixon Peabody LLP
Inhibition of HIV replication using a mutated transfer RNA primer
Modified tRNA molecules are provided which inhibit HIV-1 replication. A tRNA molecule has a modified aminoacyl acceptor stem with a 3&#8242; segment which has reduced complementarity to the HIV primer binding site can initiate aberrant reverse transcription and/or interfere with reverse transcription. tRNA molecules which are modified in regions outside the acceptor stem which interact with reverse trancriptase or the HIV-1 RNA template can also inhibit HIV-1 replication. Methods are disclosed for introducing the modified tRNA molecules into human cells.
University of California University of Rochester
C A C
C12N A61K C12N
inventional additional inventional
Xinqiang Joseph D.
Li Rosenblatt