Stites & Harbison PLLC
Method for preparing insulin glargine crystal
Disclosed is a method for preparing an insulin glargine (GlyA21-ArgB31-AryB32-human insulin) crystal, comprising crystallizing the insulin glargine at pH 7.0-9.0 and in a crystallization solution containing a recombinant insulin glargine, an organic solvent of a 10-30% concentration by volume, a zinc compound, a phenol derivative, a salt and an organic acid.
Gan & Lee Pharmaceuticals
C C C A C
C07K C30B C07K A61P C30B
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Jinlei Wenjie Damei
Zhang Li Wang