Casimir Jones, S.C.
Compositions and methods for treating and diagnosing cancer
The present invention relates to compositions and methods for treating, characterizing, and diagnosing cancer. In particular, the present invention provides gene expression profiles and signatures associated with solid tumor stem cells, as well as novel stem cell cancer markers useful for the diagnosis, characterization, prognosis and treatment of solid tumor stem cells. More particularly, the present invention identifies two profiles of cancer stem cells useful for the diagnosis, characterization, and treatment of cancer and cancer metastases. The invention also provides a variety of reagents such as stem cell gene signatures for use in the diagnosis and management of cancer.
OncoMed Pharmaceuticals, Inc. The Regents of the University of Michigan
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Michael F. John A. Austin L. Xinhao
Clarke Lewicki Gurney Wang