Hunton & Williams
Heteromeric taste receptors comprising T1R2/T1R3 domains
Heteromeric taste receptors are provided. These receptors comprise a first polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R2 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R2 polypeptide or a different GPCR; and a second polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R3 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R3 polypeptide or that of a different GPCR.
Senomyx, Inc.
G G C A G G
G01N G01N C07K A01K G01N G01N
inventional inventional inventional additional additional inventional
Lena Xiaodong Fernando Hong Jon Elliot Mark Shawn Sergey
Staszewski Li Echeverri Xu Adler Zoller O'Connell Zozulya