Saul Ewing LLP
Methods and compositions for treating cancer and inflammatory diseases
The invention provides a peptide construct comprising a cell penetrating peptide and an inhibitory peptide that interferes with the interaction between E1A and CtBP. The invention also provides related pharmaceutical composition comprising such a peptide construct. Also provided is a conjugate comprising such a peptide construct and a carrier molecule. The invention also provides related pharmaceutical compositions. Also provided are related methods of inhibiting cell proliferation in an individual and methods of treating cancer in by such pharmaceutical compositions. The present application also provides methods of treating an inflammatory disease and inhibiting inflammation in an individual comprising administering to the individual an effective amount of a therapeutic agent comprising an inhibitory peptide that interferes with the interaction between E1A and CtBP.
The Regents of the University of Colorado, a body corporate
C A A C A
C07K A61P A61K C07K A61P
additional inventional additional inventional inventional
Rui Melanie Qinghong Xiao-Jing
Zhao Blevins Zhang Wang