Viksnins Harris Padys Malen LLP
Method for preparing azoxystrobin and its intermediates
The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.
Shangyu Nutrichem Co., LTD. Nutrichem Company Limited
C C
C07D C07D
inventional inventional
Wenjun Xufang Wentao Long Yongchang Guobin Jianhong Jianwei
Wang Deng Jin Wang Zhao Chen Chi Chen