Shlesinger, Arkwright & Garvey LLP
Preparing method for positively-electrified charged niosome, and charged niosome
To provide a preparing method for a charged niosome which is formed of a lipid containing a diacylglycerol PEG adduct and which is capable of being excellently impregnated into the skin and stored in the skin. The preparing method for the charged niosome includes the steps of: preparing a suspension of a niosome by mixing a lipid containing a diacylglycerol PEG adduct with an aqueous solution at a temperature where the lipid is in a liquid state so that the lipid forms the niosome spontaneously; preparing a cationic-surfactant aqueous solution by mixing a cationic surfactant with an acidic aqueous solution, the cationic surfactant being chosen from a group which consists of an aliphatic amine, an aliphatic or aliphatic-amide quaternary ammonium salt, an aliphatic amideamine and an acylamino acid derivative, the hydrophobic part of the cationic surfactant containing a saturated or unsaturated normal hydrocarbon group having a carbon number of 11 to 21; and preparing a suspension of a charged niosome by mixing the suspension of the niosome with the cationic-surfactant aqueous solution and allowing the cationic surfactant to modify a surface of the niosome with a positive charge of the hydrophilic part of the cationic surfactant.
J-NETWORK, INC.
A A A A A A B A A A A A
A61K A61K A61K A61K A61K A61K B82Y A61Q A61K A61K A61K A61K
inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional
Brian Charles Tatsuro Akira
Keller Miyoshi Kodama