Fish & Richardson P.C.
Preparation of and formulation comprising a MEK inhibitor
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Array BioPharma Inc.
C A A A A A A C A C A A A A A C A A C A A
C07D A61P A61P A61P A61K A61K A61K C07B A61K C30B A61K A61K A61K A61P A61K C30B A61K A61K C07D A61P A61K
inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Peter J. Christoph Max Werner Heinz Paul Marie-Christine Marian Daniel Daniel Andreas Weidong
Stengel Krell Pachinger Nichols Wolf Misun Zimmermann Niederer Liu