Finnegan, Henderson, Farabow, Garrett & Dunner LLP
Alzheimer's disease diagnosis based on mitogen-activated protein kinase phosphorylation
A method of diagnosing Alzheimer's disease in a patient comprises determining whether the phosphorylation level of an indicator protein in cells of the patient after stimulus with an activator compound is abnormally elevated as compared to a basal phosphorylation level, the indicator protein being e.g. Erk1/2 and the activator compound being e.g. bradykinin.
Blanchett Rockefeller Neurosciences Institute
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Daniel L. Wei-Qin
Alkon Zhao