Compositions and soft tissue replacement methods
The invention relates to compositions comprising a silk fibroin material, adipose tissue and a compound of the structurewhere X1 and X5 are independently CH or N; X7 is NH, O or S; X8 and X9 are independently CH or N; R13 is an optionally substituted aryl or optionally substituted heteroaryl and R14 is C1-6 alkyl, optionally substituted aryl or optionally substituted heteroaryl. The composition is administered to a site of a soft tissue condition including those of breast tissue. The silk fibroin material can be in the form of a silk hydrogel, a silk film, a silk scaffold, a silk sheet, a silk porous material or a silk fiber. The silk fibroin material can be substantially sericin free.
Allergan, Inc.
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Gregory H. Guang-Liang Dennis E. Wha Bin Adam L. Rebecca L. Jingsong
Altman Jiang Van Epps Im Collette Horan Chen