Lucas & Mercanti, LLP
Aryloxy phenoxy acrylic compound having HIF-1 inhibition activity, method for preparing same, and pharmaceutical composition containing same as an active ingredient
The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity not by non-selective cytotoxicity but by inhibiting the activity of HIF-1, the transcription factor playing an important role in cancer cell growth and metastasis. Accordingly, the compound or the pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumors such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.
Dongguk University Industry-Academic Cooperation Foundation Korea Research Institute of Bioscience and Biotechnology
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C07C C07C A61K A61K C07C A61K A61K A61K A61K C07C C07C A61K A61K C07C A61P C07D A61K A61K A61K A61K A61K
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Yinglan Kyeong Jung Joon Mi Sun Hwan Mook Seung-hee Song Kyu Kiho Kyung Sook Bo Kyung Chang Woo Ki Hoon
Jin Lee Lee Won Kim Lee Park Lee Chung Kim Lee Lee