Osha Liang LLP
Anti-granulysin antibodies and methods of use thereof
An anti-granulysin antibody, or an scFv or Fab fragment thereof, capable of binding to an epitope region from R64 to R113 of granulysin and capable of neutralizing an activity of granulysin. The antibody may contain a sequence selected from the sequences of SEQ ID NO:82 to SEQ ID NO:195, or the antibody may contain a sequence selected from the sequences of SEQ ID NO:39 to SEQ ID NO:76. The antibody may be a monoclonal antibody. A method for treating or preventing an unwanted immune response disorder includes administering to a subject in need thereof an effective amount of an anti-granulysin antibody capable of neutralizing the activity of granulysin. The unwanted immune response disorder may be SJS, TEN, or GVHD.
Academia Sinica Development Center for Biotechnology DCB-USA LLC
A C C A C C C C A
A61P C07K C07K A61P C07K C07K C07K C07K A61P
inventional inventional additional inventional additional additional additional additional inventional
Ying-Yung Chao-Yang Yuan-Tsong Chih-Yung Woan-Eng Hung-Ling Jiann-Shiun
Lok Huang Chen Hu Chan Wang Lai