Merchant, Gould, Smith, Edell, Welter, & Schmidt
Chimeric immunogenic gag-V3 virus-like particles of the human immunodeficiency virus (HIV)
 An unprocessed human immunodeficiency virus 2 (HIV-2) gag precursor protein, containing a deficient protease, assembles into virus-like particles by budding through the cytoplasmic domain of baculovirus-infected cells. Chimeric constructs were generated by coupling the truncated HIV-2 gag gene to the neutralizing domain (V3) or the neutralizing and CD4 binding domains (V3+CD4B) of gp120 env gene sequences obtained from HIV-1 or HIV-2. Virus-like particles were formed by chimeric gene products when the env gene sequences were linked to the 3' terminus of the gag gene. The gag-env chimeric proteins displayed immunoreactivity towards anti-gp120 rabbit antisera. 
Korea Green Cross Corporation
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C12N A61K C07K C12N C12N Y10S C07K
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Chil-Yong Lizhong
Kang Luo