Casimir Jones SC
Small molecule antagonists of XIAP family proteins
The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of XIAP family proteins. In particular, the present invention provides embelin and other XIAP inhibitors and methods of using these compounds as antagonists of the anti-apoptotic effects of XIAP family member proteins. The present invention also provides methods for treating diseases and pathologies (e.g., neoplastic diseases).
The Regents of the University of Michigan
C C A C C
C07C C07C A61P C07D C07C
inventional inventional inventional inventional inventional
Liang Haiying Shaomeng Jianyong Dajun Zaneta Zengjian
Xu Sun Wang Chen Yang Nikolovska-Coleska Hu