Cesari and McKenna, LLP
Process of preparing microspheres for sustained release having improved dispersibility and syringeability
Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent; spray drying the solution, suspension or emulsion; and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.
Peptron Co., Ltd. Daewoong Pharmaceutical Co., Ltd.
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Hee-Yong Yeon-Jin Juhan Mi-Young Seong-Kyu Eun-Ho Jung-Soo Mi-Jin Eun-Young Ho-Il
Lee Chae Lee Baek Kim Shin Kim Baek Seol Choi