Methotrexate derivatives
Antirheumatic agent containing as an active ingredient a compound resented by the following general formula (II): 
Chugai Seiyaku Kabushiki Kaisha
C A
C07D A61P
inventional inventional
Hiroharu Hiroshi Kazuya Noriaki Nobuaki Keiichiro Toshio
Matsuoka Suzuki Nakagomi Maruyama Kato Tsuji Kuroki