Knobbe Martens Olson & Bear LLP
Process for the preparation of inhibitors of macrophage migration inhibitory factor
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures:including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Avanir Pharmaceuticals
A A C A A A A C C A A C C A A A A A A
A61P A61P C07D A61P A61P A61P A61P C07D C07D A61P A61P C07D C07D A61P A61P A61P A61P A61P A61P
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Robert Federico C. A. Jagadish Sunil Kumar Andrew Jerry Wenbin
Florkiewicz Gaeta Sircar K. C. Baird Anchin Ying