Quinazolines for PDK1 inhibition
The invention provides quinazoline compounds that are inhibitors of PDK1. Also provided are pharmaceutical compositions including the compounds, and methods of treating proliferative diseases, such as cancers, with the compounds or compositions.
Novartis AG
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Weibo Robert L. Jeffrey Jeremy M. Xiaojong M. Rama Savithri Mina Stephen E. Allan S. Johanna M. Wei Sharadha Payman Keith B. Alice Xiaodong Yasheen Simon
Wang Warne Dove Murray Wang Jain Ramurthy Aikawa Basham Wagman Jansen Shu Subramanian Amiri Pfister Rico Lin Zhou Ng