Biaryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
The present invention relates to biaryl monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A1, Q, A2, M, W, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a biaryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic. 
Merck Sharp & Dohme Corp.
A C A C C A A A A A A A A C
A61K C07D A61K C07F C07C A61K A61K A61P A61K A61K A61K A61K A61K C07D
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Xianhai Weiguo Fa-Xiang Yan Rudrajit Wanying Linda Anthony Hongwu Jinlong Yi Christopher W. Helen Y. Weidong Min Haifeng Tesfaye
Huang Liu Ding Guo Mal Sun Brockunier Ogawa Wang Jiang Zang Plummer Chen Pan Park Tang Biftu