Morrison & Foerster LLP
Method for preparing 2-fluoroacrylates
Disclosed is a method for preparing a 2-fluoroacrylate, comprising the steps of: (1) mixing a vinyl ether having the structure of formula A with dichloromonofluoromethane to yield a substituted cyclopropane compound having the structure of formula B; (2) mixing the substituted cyclopropane compound having the structure of formula B with R2OH to yield an acetal product having the structure of formula C, followed by hydrolysis to yield 2-fluoroacrylaldehyde having the structure of formula D; or reacting the substituted cyclopropane compound having the structure of formula B with water to yield 2-fluoroacrylaldehyde having the structure of formula D via hydrolysis; (3) oxidizing 2-fluoroacrylaldehyde having the structure of formula D to yield 2-fluoroacrylic acid having the structure of formula E; and (4) mixing 2-fluoroacrylic acid having the structure of formula E with R3OH to yield a 2-fluoroacrylate having the structure of formula F.
Linhai Tianyu Pharmaceutical Co., Ltd. Shanghai Qixun Pharmaceutical Technology Co., Ltd.
C C C C C C
C07C C07C C07C C07C C07C C07C
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Qianjie Wenbo Xiongdong Kunlun Botao Gongyong
Yu Wang Lian Qiu Li Li