Occhiuti Rohlicek & Tsao LLP
Synthesis of β-nucleosides
This invention relates to a process of stereoselectively synthesizing a β-nucleoside compound of formula (I):wherein R1, R2, and B are as defined in the specification; each of R3 and R4, independently, is H or fluoro. The process includes reacting, in the presence of a transition metal salt, a tetrahydrofuran compound of formula (II):wherein R1, R2, and L are as defined in the specification, with a nucleobase derivative; and each of R3 and R4, independently, is H or fluoro.
Pharmaessentia Corp.
A C C A
A61P C07H C07H A61P
inventional inventional inventional inventional
Wensen Chi-Yuan Wei-Der Chan Kou
Li Chu Lee Hwang