Compounds inhibiting leucine-rich repeat kinase enzyme activity
The present invention is directed to azaindazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
Merck Sharp & Dohme Corp.
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Wei Thomas J. John A. Michael Hong Kallol Jack D. Xing Ronald K. Duane
Li Greshock McCauley Miller Liu Basu Scott Dai Chang DeMong