Lex IP Meister, PLLC
Chicken antibody transformed into cysteine and site-specific conjugation using same
A framework fragment derived from a chicken antibody, in which an amino acid at a particular position is replaced by cysteine, a heavy chain variable region or a light chain variable region including the framework fragment, or an antibody including the heavy chain variable region or the light chain variable region does not induce or prevents formation of disulfide bonds between antibody molecules while maintaining activity and reactivity of the antibody. The antibody introduced with cysteine or an antigen-binding fragment thereof easily binds with a conjugation compound such as a chemotherapeutic drug, an enzyme, an aptamer, a toxin, an affinity ligand, or a detection label, thereby being applied to various fields for diagnosis or treatment of diseases.
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
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additional inventional additional additional additional inventional
Jungwon Jung Won Junho Aerin
Han Shin Chung Yoon