Sterne, Kessler, Goldstein & Fox, P.L.L.C.
Method for making heteromultimeric molecules
Methods for making heteromultimeric molecules, such as bispecific antibodies, and compositions comprising these molecules are disclosed. The methods include introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered.
OncoMed Pharmaceuticals, Inc.
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C07K A61K A61K A61K C07K C12N A61K C07K C07K C07K C07K C07K C07K C07K C07K A61P C07K A61K C07K A61P
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Aaron K. Austin L.
Sato Gurney