Renner Kenner Greive Bobak Taylor & Weber
Polyhedral oligomeric silsesquioxane (poss)-based bioactive hybrid glass as a scaffold for hard tissue engineering
A hybrid bioactive glass comprising a plurality of POSS-cages each having at least one flexible arm radiating from an Si atom of the POSS-cage, each POSS-cage being covalently linked to another POSS-cage through an Si—O—Si linkage between two flexible arms. A method of forming a hybrid bioactive glass comprising the steps of providing a plurality of POSS-cages, each having at least one reactive flexible arm radiating from an Si atom detailed by —X—Si[R1,R2,R3], wherein X is an arm extension located between the Si—O—Si linkage and an Si atom of the POSS-cage, wherein R1, R2 and R3 are also the same or different, and at least one of the R1, R2 and R3 is an alkoxide, and reacting the plurality of POSS-cages through a sol-gel method to form a covalently-linked network and incorporating Ca+2 ions therein, the sol-gel process comprising hydrolysis and polycondensation reactions of the plurality of POSS-cages.
The University of Akron
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A61L A61L A61L C08G A61L
additional inventional additional inventional inventional
Xianfeng Nita
Zhou Sahai