Marshall, Gerstein & Borun LLP
N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
The present disclosure provides compounds having Formula I-A: and the pharmaceutically acceptable salts and solvates thereof, wherein A, X1, X2, X3 R1a, R1b E, and = are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I-A for use to treat a disease, disorder, or condition responsive to Bcl-2 protein inhibition such as cancer.
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
A A C
A61P A61P C07D
inventional inventional inventional
Jianyong Shaomeng
Chen Wang