Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst
Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
Boehringer Ingelheim International GmbH
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Zhi-Hui Chris Hugh Wenjie Yongda
Lu Senanayake Li Zhang