Sughrue Mion, PLLC
Pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing biguanide derivative compound as active ingredient
The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.
THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC CORPORATION FOUNDATION
C A A A A C
C07C A61P A61K A61K A61K C07C
inventional inventional additional additional inventional inventional
Min-Jung Eun-Kyung Chul-Woo Jae-Kyung Mi-La Seon-Yeong Dong-Yun Sung-Hee Hye-Jin Eun-Ji
Park Kim Yang Kim Cho Lee Shin Lee Son Yang