Birch, Stewart, Kolasch & Birch, LLP
Prodrugs
Compounds of the formula I or corresponding monohydroxynucleoside derivatives wherein:R1 is hydroxy, amino or carboxy: optionally having esterified/amide bonded thereon;a C4-C22 saturated or unsaturated, optionally substituted fatty acid or alcohol, or an aliphatic L-amino acid;R2 is the residue of an aliphatic L-amino acid;L1 is a trifunctional linker group;L2 is absent or a difunctional linker group;and pharmaceutically acceptable salts thereof have favorable pharmacological properties and are antivirally active.
Medivir AB
C C C C C C C C C C C C C C
C07H C07D C07D C07D C07D C07F C07H C07D C07F C07H C07C C07F C07F C40B
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional
Stefan Nils Gunnar Xiao-Xiong Christian Hans Horst Lourdes Christer
Lindstrom Johansson Zhou Sund Wallberg Wahling Salvador Sahlberg