Birch, Stewart, Kolasch & Birch, LLP
Amino acid derivative
 The present invention relates to an amino acid derivative having an angiotensin I-converting enzyme inhibition activity, a vasopressin antagonism and an atrial natriuretic peptide hydrolase inhibition activity. This amino acid derivative is represented by the following general formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or an acyl group; R.sup.2 represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, an ary group which may have a substituent, a heteroaryl group which may have a substituent, an arylalkyl group which may have a substituent or a heteroarylalkyl group which may have a substituent; PA1 m and n represent each independently an integer of 0, 1 or 2 and PA1 J represents a cyclic group having an angiotensin I-converting enzyme inhibition activity. 
Eisai Co., Ltd.
C C A A C A C A A A C C C C C C C C A
C07D C07K A61P A61K C07D A61K C07D A61K A61P A61P C07D C07D C07D C07D C07D C07D C07D C07D A61K
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Mamoru Toshiyuki Naoki Kenji Hitoshi Makoto Nobuyuki Masayuki Kazutoshi Shinji Takeshi Shigeru
Saito Matsuoka Yoneda Hayashi Oinuma Kotake Mori Namiki Miyake Suda Sudo Souda