Rosenberg, Klein, & Bilker
Method for synthesis of bifunctional chelating agents-peptides
 This invention is a novel synthesis of BCA-peptides (BCA: bifunctional chelating agents). In this method, the starting material--Fmoc-Thr(ol)-Terephthal-Acetal-Amide Resin is coupled with the various amino acids. The straight peptide-resin of D-Phe-Cys(Trt)-Phe-D-Trp(Boc)-Lys(Boc)-Thr(tBu)-Cys(Trt)-Thr(ol)-Terephtha l-Acetal-Amide Resin was obtained. This compound reacted with iodine to give disulfide-containing peptide resin of ##STR1## Cleavage of the peptide from the resin was achieved by TFA. The cleavaged peptide was protected by the reaction of octreotide with di-t-butyldicarbonate. BCA was coupled to the selectively protected octreotide. This product was obtained by reaction of protected BCA-peptides with TFA. The final product was labeled by radioisotope .sup.111 InCl.sub.3 for tumor imaging radiopharmaceuticals. 
Institute Of Nuclear Energy Research
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A61K A61K C07K A61K
inventional inventional inventional additional
Shui-Tein Kung-Tsung Lie-Hang Shyh-Yi Te-Wei Chang-Mau Gann Shiang-Rong Tian-Fu Zei-Tsan
Chen Wang Shen Chyi Lee Shing Ting Chang Huang Tsai