Mueting, Raasch & Gebhardt, P.A.
Replication competent hepatitis C virus and methods of use
The present invention provides replication competent polynucleotides that include a coding sequence encoding a hepatitis C virus polyprotein having adaptive mutations. The invention also includes methods for malting replication competent polynucleotides, identifying a compound that inhibits replication of a replication competent polynucleotide, selecting a replication competent polynucleotide, and detecting a replication competent polynucleotide.
Board of Regents, the University of Texas System
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MinKyung Stanley M.
Yi Lemon