Genentech, Inc.
Pyrazolopyrimidine JAK inhibitor compounds and methods
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.
Genentech, Inc.
C A A A A
C07D A61P A61P A61K A61P
inventional inventional inventional inventional inventional
Joseph P. Richard Bing-Yan Mark Steven R. Thomas E. Emily Paul Rohan Wendy Michael Aihe
Lyssikatos Pastor Zhu Zak Magnuson Rawson Hanan Gibbons Mendonca Liu Siu Zhou