Marshall, Gerstein & Borun
Method for stereoselectively inverting a chiral center of a chemical compound using an enzyme and a metal catalyst
A process for stereoselectively inverting a chiral center of a chemical compound is disclosed. The process first consists of forming a mixture of the chemical comopund, an enzymatic system, and a metal catalyst. Next, the process stereoselectively dehydrogenates a group attached to the chiral center with the enzymatic system in the presence of an oxidant to produce a dehydrogenated group, Lastly, the process hydrogenates the dehydrogenated group with the metal catalyst in the presence of a hydrogen source to stereoselectively invert the chiral center of the chemical compound.
PCBU Services, Inc.
C C C C
C12N C12N C12P C12P
inventional inventional inventional inventional
Weiguo David John Scott Paul Phillip
Liu Ager Laneman Taylor