Chalker Flores, LLP
Compositions comprising an extract of Tiarella polyphylla or compounds isolated therefrom for preventing and treating cancer diseases
The present invention relates to an anoikis-inducing agent comprising a Tiarella polyphylla extract, a tiarellic acid compound isolated therefrom or a pharmaceutically acceptable salt thereof, which is specific to cancer cells expressing a tumor-associated antigen L6 or a homolog thereof. The Tiarella polyphylla extract, the tiarellic acid compound isolated therefrom or pharmaceutically acceptable salt thereof of the present invention leads to loss of cell adhesion to reduce cancer cell proliferation and exhibits the effect of inducing cell death in cancer cells expressing a tumor-associated antigen L6 or a homolog thereof, thereby being used for preventing and treating cancer diseases due to a tumor-associated antigen L6 or a homolog thereof.
Korea Institute of Bioscience and Biotechnology
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A23L A61P A61P A61K
inventional inventional inventional inventional
Jung-Hee Su-Yong Kyungseop Ho-Jae Soo Hyun Sei-Ryang Joongku Eun-Ah Jung Weon Soon-Ja Hyeong-Kyu Doo-Young Sangku
Kim Choi Ahn Lee Kim Oh Lee Kim Lee Choi Lee Kim Lee