Hunton & Williams LLP
Binding assays that use human T1R2 to identify potential taste modulators
Binding assays for identifying compounds that modulate human T1R2 polypeptide associated taste are disclosed. These assays detect the specific binding of compounds to a human T1R2 polypeptide or the modulation of the specific binding of a compound that specifically binds to a human T1R2 polypeptide. The binding assays may include the use of detectable labels, e.g., radionuclides, enxymes, fluorophases, and the like. Compounds identified in these binding assays have putative application as T1R2 taste modulators, particularly sweet taste, and potentially are useful additives in compositions for human or animal consumption.
Senomyx, Inc
C C G G G G C C G
C07K C07K G01N G16B G01N G01N C07K C12Q G01N
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Shawn Lena Sergey Xiaodong Jon Elliot
O'Connell Staszewski Zozulya Li Adler