Cooper & Dunham LLP
Method for conversion of terminal alkenes to aldehydes using ruthenium (IV) porphyrin catalysts
Aldehydes were obtained in excellent yields from ruthenium-porphyrin-catalyzed oxidation of various terminal alkenes with 2,6-dichloropyridine N-oxide under mild conditions. The aldehydes generated from these ruthenium-catalyzed alkene oxidation reactions can be used in-situ for olefination reactions with ethyl diazoacetate in the presence of PPh3, leading to one-pot diazoacetate olefination starting from alkenes.
University of Hong Kong
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Jian Chi-Ming
Chen Che