Morrison & Foerster LLP
Imidazopyrizine syk inhibitors
Certain imidazopyrazines having the structure of formula (I):or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are as defined herein, and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
Gilead Connecticut, Inc.
C A A A G A C C A A G A C A C A A A A A A C A A A
C12Q A61P A61P A61P G01N A61P C07D C07D A61P A61P G01N A61P C07D A61P C07D A61P A61K A61P A61P A61P A61P C07D A61P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Seung H. James P. Douglas G. David M. Jeffrey E. Antonio J. M. Peter A. Soumya Jianjun Zhongdong Kevin S. Scott A.
Lee Harding Stafford Armistead Kropf Barbosa, Jr. Blomgren Mitra Xu Zhao Currie Mitchell