Holtz, Holtz, Goodman & Chick, P.C.
1,2-dihydroquinoline derivative having substituted phenylamino lower alkyl group and ester-introduced phenyl group as substituents
The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator.The R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represents a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a nitro group or a cyano group; X represents —C(O)—, —C(O)NR8—, —S(O)2— and the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; and P represents 0, 1, 2 or 3.
Santen Pharmaceutical Co., Ltd.
A C A A C A A A A A A A A A A A C A A A A A A A A A A C C A A A C A A
A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P A61P A61P C07D A61P A61P
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Miwa Masatomo Masato Toshiyuki Sachiko Mamoru
Takai Kato Nagatsuka Mori Kobayashi Matsuda