Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
Benzazepine derivatives with vasopressin agonistic activity
 Novel benzazepine derivative of the formula [1]: ##STR1## wherein R.sup.1 is H or halogen, A is lower alkylene, R.sup.2 and R.sup.3 are the same or different and each H, lower alkoxy, lower alkyl having optionally a lower alkoxy substituent, etc., or R.sup.2 and R.sup.3 may combine together with the nitrogen to which they bond to form a 5- to 7-membered saturated heterocyclic group which may optionally be substituted by a lower alkyl, etc., R.sup.4 is H, lower alkyl, OH, etc., R.sup.5 is --NHR.sup.6 (R.sup.6 is lower alkyl) or pyrrolidinyl, or a salt thereof, which show excellent anti-vasopressin activity, oxytocin antagonistic activity and vasopressin agonistic activity, and are useful as a vasopressin antagonist, a vasopressin agonist and an oxytocin antagonist. 
Otsuka Pharmaceutical Company, Limited
A C A C C C A C A C C A A
A61P C07D A61P C07D C07D C07D A61P C07D A61P C07D C07D A61P A61P
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Kazumi Hidenori Keizo Minoru Yoichi Michiaki Seiji Tomoichi Yoshihisa Toyoki Muneaki
Kondo Ogawa Kan Uchida Yabuuchi Tominaga Morita Shinohara Tanada Mori Kurimura