Schwegman, Lundberg, Woessner & Kluth, P.A.
Heterocyclic topoisomerase poisons
 The invention provides a topoisomerase poison of formula I: ##STR1## wherein R.sub.1 -R.sub.8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof. 
The State of University of New Jersey, Rutgers
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A61P C07D C07D A61P C07D C07D C07D A61P
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Leroy Fong Edmond J. Meera Jung Sun
Liu LaVoie Rangarajan Kim