Nixon & Vanderhye
DNA sequences encoding infectious bronchitis virus spike protein
 The problem of diagnosis and typing of infectious bronchitis virus in poultry has been solved and important progress made towards an IBV vaccine by this invention. DNA complementary to the region of genomic IBV RNA which codes for a spike protein polypeptide comprising the S1 polypeptide (containing antigenic determinants) or the S2 polypeptide (containing means for anchoring the spike protein to the viral membrane) has been made. It can be carried by a cloning vector, incorporated in a host and cloned. It can also be cloned in a poxvirus which is used to transfect mammmalian cells. Such cells express an artificial spike protein polypeptide. 
National Research Development Corporation
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A61K C12Q C07K C12N
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Fiona M. Michael E. G. Matthew M. Thomas D. K.
Tomley Boursnell Binns Brown