4-Alkenyl- and 4-alkynyloxindoles
 Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II. 
Hoffmann-La Roche Inc.
C C C C C A A
C07D C07D C07D C07D C07D A61P A61P
inventional inventional inventional inventional inventional inventional inventional
Steven Gregory Wendy Lea Yi Apostolos Jin-Jun Kin-Chun Paige E.
Mischke Corbett Chen Dermatakis Liu Luk Mahaney