Substituted AZA-bicyclic imidazole derivatives useful as TRPM8 receptor modulators
The present invention is directed to substituted aza-bicyclic imidazole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by TRP M8, including for example, inflammatory pain, inflammatory hyperalgesia, inflammatory hypersensitivity condition, neuropathic pain, neuropathic cold allodynia, inflammatory somatic hyperalgesia, inflammatory visceral hyperalgesia, cardiovascular disease aggravated by cold and pulmonary disease aggravated by cold.
Janssen Pharmaceutica NV
C C A A C A C C A C A
C07D C07C A61P A61P C07D A61P C07D C07C A61P C07B A61P
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Daniel J. Sanath Shawn Jinsheng Mark R Scott William J Raul
Parks Meegalla Branum Chen Player Ballentine Parsons Calvo