Maier & Maier, PLLC
Emodin succinyl ester compound, preparation method therefor and application thereof
Disclosed in the present invention are an emodin succinyl ester compound, a preparation method therefor and a use thereof, the emodin succinyl ester compound having the structure as represented by formula I (R being a C1-5 alkyl group). The method provided in the present invention has a simple method course, and may effectively save time in synthesis and reduce costs, being simple to operate, being easy to implement, and being suitable for industrial production. Experiments show that the emodin succinyl ester compound of the present invention may better promote the healing of diabetic wounds than emodin, and may be used for preparing a drug for promoting the healing of diabetic wounds. Moreover, it has been confirmed by means of performing pharmacological experiments on rats suffering from experimentally mixed hyperlipidemia that the emodin succinyl ester compound of the present invention is superior to emodin, and has the advantages of having a remarkable blood fat lowering effect, being safe, being simple and convenient to administer, the raw materials being low cost and readily available, and being easy to transport and store.
JIANGSU KANION PHARMACEUTICAL CO., LTD.
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A61L A61P A61L C07C C07C A61K A61L C07C A61P C07C C07C C07C A61P C07C C07C A61K
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Xueshi Jinhui Yunlong Baofeng Wei Chaoqian Xin Zhenzhong Zhimin Yong Yanjie
Huang Wang Bai Yang Xiao Xu Li Wang Du Zhang Lv