Lathrop & Gage LLP
Processes for preparing JAK inhibitors and related intermediate compounds
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
Incyte Corporation Incyte Holdings Corporation
C C A C C C A A Y
C07D C07F A61P C07F C07F C07F A61P A61P Y02P
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Yongchun Brian W. Jiacheng Mei Tai-Yuen Pingli David
Pan Metcalf Zhou Li Yue Liu Meloni