Bozicevic, Field & Francis LLP
Luciferin derivatives from bicyclic reactants and aminothiol derivatives and methods of use thereof
The present disclosure features a condensation reaction and a luciferin-unmasking reaction that can be carried out under physiological conditions. In general, the condensation reaction involves reacting a bicyclic reactant with an aminothiol derivative, generating a luciferin or luciferin derivative. A luciferin can provide detectable luminescence. A luciferin derivative can be unmasked to provide detectable luminescence in a luciferin-unmasking reaction. The present disclosure provides bicyclic reactants and aminothiol derivatives suitable for use in the condensation reaction. The condensation and luciferin-unmasking reactions find use in a variety of applications, which are also provided.
The Regents of the University of California
C A G A C A G C C
C07F A61K G01N A61K C07F A61K G01N C07K C07D
inventional inventional additional additional inventional additional inventional inventional inventional
Genevieve C. Elena A. Christopher J. Carolyn R.
van de Bittner Dubikovskaya Chang Bertozzi