Conjugates and compositions for cellular delivery
This invention features conjugates, degradable linkers, compositions, methods of synthesis, and applications thereof, including cholesterol derived conjugates of biologically active compounds, including antibodies, antivirals, chemotherapeutics, peptides, proteins, hormones, nucleosides, nucleotides, non-nucleosides, and nucleic acids including enzymatic nucleic acids, DNAzymes, allozymes, antisense, dsRNA, siNA, siRNA, triplex oligonucleotides, 2,5-A chimeras, decoys and aptamers.
Merck Sharpe & Dohme
A A Y
A61K A61K Y02A
inventional additional additional
Tongqian Peter Chandra Weimin
Chen Haeberli Vargeese Wang