Sughrue Mion, PLLC
Antibody binding to TFPI and composition comprising the same
The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (TFPI), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to TFPI, can activate the extrinsic pathway of blood coagulation by inhibiting TFPI. Thus, the antibody of the present invention can be effectively used for the treatment of antibody-induced hemophilia patients and for the prevention of blood coagulation disease in hemophilia-A or hemophilia-B patients.
MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
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Dong-Sik Sumin Kisu Mi Jung Jae Chan SungHo Young Seoub Ki Joon Hyung-Kwon Heechun Junhong
Kim Lee Kim Lee Park Hwang Park Cho Lim Kwak Jeong