McCarter & English, LLP
Triazole compounds that modulate HSP90 activity
The present invention relates to substituted pyrrole compounds of formula I and compositions comprising substituted tri-substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a tri-substituted’ triazole compound of the invention, or a pharmaceutical composition comprising such a compound.
Synta Pharmaceuticals Corp.
C C C A A C C A C A C
C07D C07D C07D A61P A61P C07D C07D A61P C07D A61P C07D
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Joseph Minghu Weiwen Junghyun Shijie Dinesh U.
Burlison Song Ying Chae Zhang Chimmanamada