Bozicevic, Field & Francis LLP
Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation&#8212;when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. Subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe, causing the emission of electromagnetic radiation. Further described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.
The Regents of the University of California
B G G Y Y Y Y Y Y Y
B82Y G01N G01N Y10T Y10T Y10T Y10T Y10T Y10T Y10T
inventional inventional inventional additional additional additional additional additional additional additional
Shimon Marcel Paul
Weiss Bruchez, Jr. Alivisatos