Liang Legal Group, PLLC
Humanized antibodies against Globo H and uses thereof in cancer treatments
A humanized anti-Globo H antibody, or an scFv or Fab fragment thereof, comprising a heavy-chain variable domain having three complementary regions consisting of HCDR1, HCDR2, and HCDR3 and a light-chain variable domain having three complementary regions consisting of LCDR1, LCDR2, and LCDR3, wherein the sequence of HCDR1 is GYISSDQILN (SEQ ID NO:4), the sequence of HCDR2 is RIYPVTGVTQYXHKFVG (SEQ ID NO:5, wherein X is any amino acid), and the sequence of HCDR3 is GETFDS (SEQ ID NO:6), wherein the sequence of LCDR1 is KSNQNLLX′SGNRRYZLV (SEQ ID NO:7, wherein X′ is F, Y, or W, and Z is C, G, S or T), the sequence of LCDR2 is WASDRSF (SEQ ID NO:8), and the sequence of LCDR3 is QQHLDIPYT (SEQ ID NO:9).
Development Center for Biotechnology
A C C C C A C C C C C
A61P C07K C07K C07K C07K A61K C07K C07K C07K C07K C07K
inventional inventional additional additional additional additional inventional inventional additional inventional additional
Chih-Yung Yu-Jung Tzu-Yin Szu-Liang Chia-Cheng
Hu Chen Lin Lai Wu