BakerHostetler
Radiolabeled and fluorescent PARP inhibitors for imaging and radiotherapy
The present disclosure relates to compounds of Formula I and II, wherein R1-R20 and FL are defined herein. Also provided are methods of targeting alpha-radiation to poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, reducing proliferation of cancer cells, reducing proliferation of cancer cells, detecting intact and enzymatically active poly(ADP-ribose)polymerase 1 (PARP-1) enzyme expression, detecting PARP-1 enzyme expression in a subjects tissue sample, monitoring cancer treatment in a subject, or detecting a PARP-1 receptive cancer in a subject.
The Trustees of the University of Pennsylvania
C G C A C C C C G A A
C07D G01N C07F A61K C07B C07F C12Q C07F G01N A61P A61K
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Kuiying Roger A. Daniel A. Sean Robert H. Mehran
Xu Greenberg Pryma Reilly Mach Makvandi