Greenblum & Bernstein, P.L.C.
Medicaments comprising sialic acid derivatives as active ingredients
A medicament for treatment of a viral infection which comprises as an active ingredient a compound represented by the following formula (I) or its Pharmaceutically acceptable salt, or a hydrate thereof or a solvate thereof. wherein R1 represents hydrogen atom or a C1-6 alkyl group; R2 represents an optionally substituted phenyl group, a C1-20 alkyl group, a C1-20 alkenyl group, or&#8212;(CH2)k&#8212;[NH&#8212;(CH2)m&#8212;NH]n&#8212;Y or &#8212;(CH2)k&#8212;[NH&#8212;(CH2CH2O)m-1&#8212;CH2CH2NH]n&#8212;Y in which Y represents phosphatidylethanolamine residue or polyglutamic acid residue, k and m independently represent an integer of from 2 to 10, n represents 0 or 1, provided that when n represents 1, Y represents phosphatidylethyl group; R3 represents hydrogen atom or an optionally substituted hydroxyl group; R4 represents hydrogen atom, a halogen atom, azide group, an optionally substituted amino group, or an optionally substituted hydroxyl group; and R5, R6, R7 and R8 independently represent an optionally substituted hydroxyl group.
Riken
A A
A61K A61P
inventional inventional
Chi-Huey Yasuo Osamu
Wong Suzuki Kanie