McCarter & English, LLP
Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
Disclosed is a compound represented by Formula (I):or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (I) or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, monohydrate, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.
Vitae Pharmaceuticals, Inc.
A A A A A A A A C A A A A A A A C A A C A A A A A C A A C A A
A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P
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Linghang Yuanjie Wei Wei Zhenrong Colin M. David A. Suresh B. Salvacion
Zhuang Ye Zhao He Xu Tice Claremon Singh Cacatian