Knobbe, Martens, Olson & Bear LLP
Binding domains from plasmodium vivax and plasmodium falciparum erythrocyte binding proteins
The present invention provides isolated polypeptides useful in the treatment and prevention of malaria caused by Plasmodium falciparum or P. vivax. In particular, the polypeptides are derived from the binding domains of the proteins in the EBL family as well as the sialic acid binding protein (SABP) on P. falciparum merozoites. The polypeptides may also be derived from the Duffy antigen binding protein (DABP) on P. vivax merozoites.
The United States of America as represented by the Department of Health and Human Services
C A A A Y
C07K A61P A61P A61K Y02A
inventional inventional inventional additional additional
Kim Lee Xin-Zhuan Chetan Louis H. David S. Thomas E.
Sim Su Chitnis Miller Peterson Wellems