McDonnell Boehnen Hulbert & Berghoff LLP
4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use
This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R1, R2, R25, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.
Exelixis, Inc.
A A C C C A C C C C C C C C C C A C C A
A61P A61P C07D C07D C07D A61P C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D A61P C07D C07D A61P
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Sergey Arlyn Xian Robin Tammie Brian Hugh John Wai Ki Vicky Michael Naing Adam A. Henry William Beecroft Gary L. Grace Matthew Sangyup Elena S. Jeff Timothy Patrick James W. Mohamed Abdulkader Tai Phat Peiwen Lisa E. S. David Patrick Hongwang Brian Byung Gyu
Epshteyn Arcalas Shi Noguchi Ridgway Woolfrey Chan Pack Aay Galan Johnson Lewis Mann Lee Koltun Chen Forsyth Leahy Ibrahim Huynh Zhou Meyr Brown Kearney Du Kane Kim