Myers Bigel Sibley & Sajovec, P.A.
Pyrrolopyrimidine compounds for the treatment of cancer
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an “active compound” herein) of Formula I, IA, or IB.
The University of North Carolina at Chapel Hill
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A61P A61K C07D A61P A61P C07D A61K
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Stephen Dmitri Xiaodong Weihe Jing
Frye Kireev Wang Zhang Liu