Nixon Peabody LLP
Cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is susceptible to hydrolytic instability that may translate into reduced liver residence times and reduced hepatocellular toxicity. The present invention employs acetals and ketals to provide a low pH sensitive chemical handle for degradation.
SIRNA THERAPEUTICS, INC.
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Zhengwu James Matthew G. Weimin Steven L. Ivory
Deng Stanton Wang Colletti Hills