Birch, Stewart, Kolasch & Birch, LLP
Physiologically active substances
The present invention provides a novel bioactive substance having an antiangiogenic effect.The chemical compound represented by the formula (1) (wherein, R1 represents hydrogen atom, aldehyde group or a lower acyl group, R2 and R3 are the same as or different from each other and represent hydrogen atom or a lower alkoxy group or are combined to represent oxygen atom, R4 represents a lower alkyl group and R5 represents hydrogen atom or a lower alkyl group, provided that compounds in which R1 is aldehyde group, R2 and R3are different from each other and are hydrogen atom or methoxy group, R4 is ethyl group and R5 is hydrogen atom are excluded), a salt thereof or a hydrate thereof was isolated from the culture broth of genus Streptomyces and the structure thereof was analyzed.
Mercian Corporation and Eisai Co., Ltd.
C C A A
C12P C07D A61P A61P
inventional inventional inventional inventional
Yoshio Rena Taro Toshiaki Nobuaki Yasuhiro Kazuyuki Masanori Tomohiro
Watanabe Kawase Semba Wakabayashi Naruse Funahashi Dobashi Fujita Sameshima