IL-17 related mammalian cytokine polypeptides (IL-17E)
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Genentech, Inc.
C C C C A
C07H C12N C12P C12Q A61K
inventional inventional inventional inventional inventional
Paul Hanzhong Menno William I. Daniel Sherman Richard Austin P. Mickey Christopher Ellen Audrey Jian Colin Daniel Kenneth
Godowski Li VanLookeren Wood Tumas Fong Vandlen Gurney Williams Grimaldi Filvaroff Goddard Chen Watanabe Yansura Hillan