Jenkins, Wilson, Taylor & Hunt, P.A.
Reversible heparin molecules and methods of making and using the same
Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
The University of North Carolina at Chapel Hill Rensselaer Polyechnic Institute NUtech Ventures
C C Y C C A A C C A
C08L C12P Y02A C08B C12P A61P A61P C12P C08B A61K
inventional inventional additional inventional inventional inventional inventional inventional inventional inventional
Yongmei Edward Robert J. Jian
Xu Harris Linhardt Liu