Arnold & Porter LLP
Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Genentech, Inc.
A G C C C A A A C G C C G C C A A A G A A C G C G G G G
A61P G01N C07K C07K C07K A61P A61K A61P C07K G01N C07K C07K G01N C07H C07K A61P A61P A61P G01N A61P A61P C07K G01N C07K G01N G01N G01N G01N
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Ellen H. Audrey William I. Austin L. Paul J.
Filvaroff Goddard Wood Gurney Godowski