Methods of identifying a modulator that inhibits the binding between Epstein-Barr virus induced receptor 2 and cholesterol derived ligands
The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7,25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described.
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Andreas Klaus Silvio Sebastien Charles Y. Juan Marie-Odile Carsten Andreas Richard Francois Weijun Rocco Yu Wei Birgit Sophie
Katopodis Seuwen Roggo Hannedouche Cho Zhang Roy Spanka Sailer Knochenmuss Gessier Shen Falchetto Chen Li Baumgarten Noel