JHK Law
Pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing biguanide derivative compound as active ingredient
The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.
The Catholic University of Korea Industry-Academic Cooperation Foundation
C C A A A A
C07C C07C A61P A61K A61K A61K
inventional inventional inventional inventional additional additional
Jae-Kyung Dong-Yun Min-Jung Chul-Woo Mi-La Seon-Yeong Eun-Kyung Eun-Ji Sung-Hee Hye-Jin
Kim Shin Park Yang Cho Lee Kim Yang Lee Son