Sughrue, Mion, Zinn, Macpeak & Seas
Carbostyril derivatives and pharmaceutical composition containing the same
 Novel carbostyril derivatives of the formula: ##STR1## wherein X is 0 or S; Y is H or alkyl; R.sup.A is a group of the ##STR2## {wherein n is 1 or 2, A is alkylene, R.sup.1 is benzoyl having optionally 1-3 substituents, R.sup.2A is ##STR3## is (i) alkoxy, (ii) substituted or unsubstituted 5- or 6-membered heterocylic group, (iii) alkenylthio, (iv) pyrrolidinyl-alkyl--S--, (v) pyrrolidinyl-alkyl--SO--, (vi) pyrrolidinyl-alkyl--SO.sub.2 --, (vii) --O--B--NR.sup.4 R.sup.5 [B is alkylene having optionally OH, R.sup.4 is H, R.sup.5 is tricyclo[3.3.1.1]decanyl, tricyclo[3.3.1.1]decanylalkyl, etc., or R.sup.4 and R.sup.5 may together form a group of ##STR4## (R.sup.6 is substituted or unsubstituted amino)] or (viii) substituted alkoxy; m is 1 to 3]}, which have excellent vasopressin antagonistic activities and are useful as vasodilator, hypotensive agent, water diuretics, platelet agglutination inhibitor, and a vasopressin antagonistic composition containing the compound as the active ingredient. 
Otsuka Pharmaceutical Co., Ltd.
A A A A A A C A C A A C A
A61P A61P A61P A61P A61P A61P C07D A61P C07D A61P A61P C07D A61P
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Yoichi Hiroshi Michinori Kazuyoshi Kenji Hidenori Shuji Kazumi Hajime Michiaki Takafumi Hisashi
Yabuuchi Yamashita Tanaka Kitano Nakaya Ogawa Teramoto Kondo Komatsu Tominaga Fujiioka Miyamoto