McNeely Hare & War, LLP
Preparation method of lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde
Disclosed is a preparation method of the lycopene intermediate 3-methyl-4,4-dialkoxy-1-butaldehyde. The preparation method comprises the following steps: (1) reacting 2-methyl-3,3-dialkoxy-1-halopropane with magnesium powder in the solvent of anhydrous tetrahydrofuran at a temperature of 45˜65° C. to generate a mixture of Grignard reagents under the protection of an inert gas; and (2) adding N,N-disubstituted carboxamide to the mixture of Grignard reagents and reacting at a temperature of 10° C.˜35° C. to obtain 3-methyl-4,4-dialkoxy-1-butaldehyde. The process route of the present invention is simple and direct, the operation is easy, the conditions are mild and the yield is good, and thus the invention has commercial value.
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory Nanjing University of Technology
C C C C
C07C C07C C07C C07C
inventional inventional inventional inventional
Chunlei Jianhui Shiqing Pingkai Dingqiang
LV Chen Pi Ouyang Lu