Factor XIa inhibitors
The present invention provides a compound of Formula (I); and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Merck Sharp & Dohme Corp.
C A C C
C07D A61P C07D C07D
inventional inventional inventional inventional
Ying-Duo Amjad Sung-Sau Scott D. Anthony K. Santhosh F. Alan Rongze Andrew F. Eric Weiguo Rudrajit Heping Jiafang Yi Wanying
Gao Ali So Edmondson Ogawa Neelamkavil Hruza Kuang Nolting Mertz Liu Mal Wu He Zang Sun