Woodcock Washburn Kurtz Mackiewicz & Norris LLP
Systems and methods for imaging fluorophores
 The systems comprise source means for illuminating the fluorophores with diffuse photon density waves of a first specified wavelength, whereby the fluorophores will fluoresce re-radiated diffuse photon density waves of a second wavelength after being illuminated with the diffuse photon density waves of the first specified wavelength; detection means for detecting the re-radiated diffuse photon density waves of the second wavelength, wherein there is a phase shift between the diffuse photon density waves of the first wavelength and the diffuse photon density waves of the second wavelength; and processing means interfaced with the detection means for processing data corresponding to the phase shift and the amplitude of the re-radiated waves to determine concentration and lifetime of the fluorophores as a function of spatial position of the fluorophores in the turbid medium. 
The Trustees of the University of Pennsylvania
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A61B G01N G01N G01N
inventional inventional additional inventional
Arjun G. Britton David A. Maureen Xingde
Yodh Chance Boas O'Leary Li