Renner, Otto, Boisselle & Sklar, LLP
Sulfonamide analogues of galiellalactone
Disclosed are sulfonamide analogues of galiellactone of formula (I) as STAT3-inhibitors for use in the treatment of a STAT3 signaling related disorder, e.g. solid cancers, hematological cancers, benign tumors, hyperproliferative diseases, inflammations, autoimmune diseases, graft or transplant rejections, delayed physiological function of grafts or transplants, neurodegenerative diseases and viral infections. The sulfonamide comprises a cyclic substituent.
GLACTONE PHARMA DEVELOPMENT AB
C C C A A C A A A A A A A A C A C
C07D C07D C07D A61P A61P C07D A61P A61P A61K A61K A61K A61K A61P A61P C07D A61K C07D
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Martin Olov
Johansson Sterner