Oblon, McClelland, Maier & Neustadt, L.L.P.
Crosslinked hyaluronic acid composition and self-crosslinking hyaluronic acid particles
The present invention provides a crosslinked hyaluronic acid composition including self-crosslinking hyaluronic acid particles having an equilibrium swelling capacity of 3-fold to 10-fold, and an aqueous solvent, wherein a dry weight of the self-crosslinking hyaluronic acid particles based on the total volume of the crosslinked hyaluronic acid composition is 3 w/v % to 8 w/v %.The crosslinked hyaluronic acid composition of the invention uses self-crosslinking hyaluronic acid particles of which the equilibrium swelling capacity is within the above predetermined range. Accordingly, the viscosity does not sharply increase even if the concentration thereof is increased. Therefore, if the crosslinked hyaluronic acid composition is applied to an injection, it is possible to obtain a sufficient curative effect on knee osteoarthritis even with a small frequency of administration.
DENKI KAGAKU KOGYO KABUSHIKI KAISHA
A C A A Y A A A A A C
A61K C08B A61K A61K Y10T A61K A61Q A61K A61K A61P C08L
additional inventional inventional inventional additional inventional inventional additional inventional inventional inventional
Teruaki Masamichi Kenji Tadashi Daisuke Mariko Kei Yoshiaki Akio
Kakema Hashimoto Fujii Morikawa Ogasawara Takeda Takahashi Miyata Ohno