Process for the preparation of 2-alkyl-5-hydroxypyrimidines from 1,3-diamino-2-propanol and an alkanecarboxylic acid
 A process for the efficient manufacture of 2-alkyl-5-hydroxypyrimidines from relatively inexpensive raw materials is provided. The vapor phase condensation/cyclization of 1,3-diamino-2-propanol and an alkanecarboxylic acid produces an equilibrium mixture of 2-alkyl-5-hydroxytetrahydropyrimidine and 2-alkyl-5-(aminomethyl)oxazoline. After separation from the oxazoline, the tetrahydropyrimidine can be dehydrogenated under mild neutral conditions with manganese dioxide to produce 2-alkyl-5-hydroxypyrimidines. 
DowElanco
C
C07D
inventional
John W.
Hull, Jr.