Saul Ewing LLP
Anaplastic lymphoma kinase (ALK) as an oncogene capable of transforming normal human cells
The present invention provides compositions and methods for transforming primary mammalian cells using an oncogenic form of ALK wherein the transformed cells display features of that of a corresponding tumor cell isolated from a cancer subject. The invention also provides a method for immortalizing normal CD4+ T lymphocytes with a lymphoma-characteristic form of ALK such as NPM-ALK.
The Trustees of the University of Pennsylvania
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Qian Fang James L. Mariusz
Zhang Wei Riley Wasik