Sterne, Kessler, Goldstein & Fox P.L.L.C.
Substituted acethydrazide derivative, preparation method and use thereof
The present invention pertains to the field of pharmaceutical chemicals, and relates to a substituted acethydrazide derivative, preparation method and use thereof; preferably, relates to a compound of Formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention or a pharmaceutically acceptable salt thereof can effectively inhibit proline hydroxylase, stabilize HIF-α, particularly HIF-1α, and has potency in the manufacture of a medicament for treatment and/or prophylaxis and/or adjuvant therapy of anemia, acute ischemic reperfusion injury.
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
C A A C C C
C07C A61K A61K C07C C07C C07C
inventional inventional inventional inventional inventional inventional
Song Feifei Ruiyuan Zhibing Haoming Long Junhai Xiaokui Wei Yunde Wu Xingzhou Xinbo Lili
Li Li Cao Zheng Luo Long Xiao Wang Li Xie Zhong Li Zhou Wang