Process for preparing osteogenesis promoting substance
 A process for preparing an osteogenesis promoting substance, which comprises extracting a demineralized bone powder with a solution of chaotorpic reagent, subjecting the extracted solution to ultrafiltration to collect a fraction containing substances ranging from 1,000 to 100,000 daltons as molecular weight, dialyzing the collected fraction and collecting the water-insoluble fraction from the dialyzing liquid. The osteogenesis promoting substance prepared by the present invention is useful as a bone repairing agent and a bone grafting agent. 
Takeda Chemical Industries, Ltd.
A A A C A
A61L A61L A61L C07K A61L
inventional inventional inventional inventional additional
Iwao Keiji Kohei
Yamazaki Yoshida Notoya