Sughrue Mion, PLLC
Substituted pyrazoles as LRRK2 inhibitors
A pyrrolo(pyrazolo)pyrimidine compound of Formula 1, a pharmaceutically acceptable salt, a hydrate, a solvate, a prodrug, and an isomer, and pharmaceutical compositions containing the compound are disclosed. The compound of Formula 1 shows excellent LRRK2 inhibitory activity. Method for manufacturing the compound and uses thereof as an LRRK2 inhibitor and methods for treating or preventing degenerative brain diseases employing the compound are disclosed:
OSCOTEC INC.
C A
C07D A61P
inventional inventional
Se-Won Hwa Sil Dong-Sik Jong-Sung Jung-Ho Song-Eun Jaekyoo Jang-Sik
Kim Kim Jung Koh Kim Park Lee Choi