Klarquist Sparkman, LLP
Differentiation of pluripotent stem cells
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
Janssen Biotech, Inc.
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Pascal Ghislain Andre Jiajian Christine Janet
Bonnet Liu Parmenter Davis