Pearl Cohen Zedek Latzer Baratz LLP
STAT5a and its functional tumor suppressor analogs for treatment of malignancies expressing NPM/ALK and other oncogenic kinases
The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein.
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
A G C A C A C C G A A C A G C C
A61K G01N C12Q A61K C07K A61K C12N C07K G01N A61K A61P C12N A61P G01N C07K C12N
inventional inventional inventional inventional additional inventional additional inventional additional inventional inventional inventional inventional additional inventional additional
Qian Mariusz A.
Zhang Wasik