Mutant delta-9 elongases and their use in making polyunsaturated fatty acids
Mutant delta-9 elongases having the ability to convert linoleic acid [18:2, LA] to eicosadienoic acid [20:2, EDA] and/or α-linolenic [18:3, ALA] to eicosatrienoic acid [20:3, ETrA] are disclosed herein. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding mutant delta-9 elongases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant delta-9 elongases in oleaginous yeast are also disclosed.
E I du Pont de Nemours and Company
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C12Y C12N C12N C12P
inventional inventional inventional inventional
Hongxian Yougen Quinn Qun Michael W.
He Li Zhu Bostick