McDonnell Boehnen Hulbert & Berghoff LLP
JAK-2 modulators and methods of use
This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
Exelixis, Inc.
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Matthew Sangyup James W. Peiwen Timothy Henry William Beecroft Craig Stacy Adam Antoni Grace Brian Hugh Hongwang Patrick Tai Phat Jeff
Lee Leahy Zhou Forsyth Johnson Takeuchi Galan Mann Ridgway Du Kearney Huynh Chen