Birch, Stewart, Kolasch & Birch, LLP
Physiologically active substances
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it 
Eisai Co., Ltd. Mercian Corporation
A A C C A C A A A C A A A A A C A A A A A A A C C A A
A61K A61P C07D C07D A61K C12P A61K A61K A61P C07D A61P A61K A61K A61P A61P C07D A61P A61P A61P A61K A61P A61P A61K C07D C07D A61P A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Kumiko Akifumi Keisuke Satoshi Koji Takao Masao Motoko Toshio Takashi Masashi Yoshihiko Mitsuo Kazuyuki Tomohiro Naoto Tomonari Naoki Jun Susumu Kiyoshi Takashi Yoshiharu Toshimitsu Masanori
Kishi Okuda Komeda Yamamoto Norihisa Yamori Iwata Matsufuji Tsuchida Sakai Yoshida Kotake Nagai Dobashi Sameshima Kawamura Yamada Asai Niijima Takeda Okamoto Nakashima Mizui Uenaka Fujita