Ladas & Parry
Nitrile glycoside useful as a bioenhancer of drugs and nutrients, process of its isolation from moringa oleifera 
The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.
Council of Scientific and Industrial Research
A A C
A61K A61K C07H
inventional inventional inventional
Mahendra Pandurang Suman Preet Singh Santosh Kumar Monika Jai Shanker Anirban Ranganathan Santha Kumar Subhash Chandra Dharmendra Subash Chandra Ajit Kumar Harpreet Madan Mohan
Darokar Khanuja Srivastava Singh Arya Pal Tiruppadiripuliyur Gupta Saikia Verma Shasany Kaur Gupta