Triterpenoids with HIV maturation inhibitory activity
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS. 
VIIV HEALTHCARE UK (NO. 4) LIMITED
C A C A A C C C A
C07F A61K C07C A61K A61P C07C C07J C07F A61K
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Ny Brian Lee Yan Jacob Nicholas A. Zheng Richard A. Sing-Yuen Li Alicia Jie
Sin Venables Chen Swidorski Meanwell Liu Hartz Sit Xu Regueiro-Ren Chen