Wolf, Greenfield & Sacks, P.C.
Synthetic hybrid receptor and genetic circuit in bacteria to detect enteric pathogenic microorganisms
Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g., Vibrio cholerae) are also provided.
Massachusetts Institute of Technology Trustees of Boston University
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Ning Douglas Ewen James
Mao Cameron Collins