Tropomyosin-related kinase (TRK) inhibitors
Tropomyosin-related kinase inhibitors (Trk inhibitors) are small molecule compounds useful in the treatment of disease. Trk inhibitors can be used as pharmaceutical agents and in pharmaceutical compositions. Trk inhibitors are useful in the treatment of inflammatory diseases, autoimmune disease, defects of bone metabolism and/or cancer, and are particularly useful in the treatment of osteoarthritis (OA), pain, and pain associated with OA. Trk inhibitors are also useful for inhibiting tropomyosin-related kinase A (TrkA), tropomyosin-related kinase B (TrkB), tropomyosin-related kinase C (TrkC), and/or c-FMS (the cellular receptor for colony stimulating factor-1 (CSF-1)).
GENZYME CORPORATION
C C C C C C A C C A A A C C C C C A C A C A C C A A C A A C A A A A A A C
C07D C07D C07F C07D C07D C07D A61K C07F C07D A61K A61K A61K C07F C07D C07D C07D C07D A61P C07D A61K C07D A61P C07D C07D A61P A61K C07F A61P A61K C07D A61K A61P A61P A61K A61K A61K C07D
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Andrew Markus Gloria Michael John L. Jinyu
Scholte Metz Matthews Kothe Kane, Jr. Liu