Oxotetrahydrofuran-2-yl-benzimidazole derivative
The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.
MSD K.K.
A C A A A A A A A A A A A A
A61K C07D A61P A61P A61K A61P A61P A61P A61K A61P A61P A61P A61K A61K
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Akio Norikazu Masanori Tomoharu Seiichi Makoto
Ohno Ohtake Asai Iino Inamura Ishikawa