Compounds, compositions and methods for prevention and treatment of inflammatory and immunoregulatory disorders and diseases
Compounds are provided having the formula:wherein variables Ra, R1, R2, R3, R4, A1, A4, L, Q, X and subscript n as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
Amgen Inc.
A A A A A A A A A A A A A A A A A A C C A A A A A A C A A A
A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Jeffrey Darin Michael G. Jason A. Julio C. Jeffrey T. Jiwen An-Rong Xiaoqi Andrew P. Zice Philippe Xiaohui
Deignan Gustin Johnson Duquette Medina Mihalic Liu Li Chen Marcus Fu Bergeron Du