McCarter & English LLP
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
Disclosed is a compound represented by Formula (Im1)or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Also disclosed are pharmaceutical compositions comprising the compound of Formula (Im1) or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formulas (Im1), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.
Vitae Pharmaceuticals, Inc. Boehringer Ingelheim International GmbH
A C A A A A A C A A
A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
David A. Linghang Katerina Zhenrong Wei Yuanjie Salvacion Suresh B. Colin M.
Claremon Zhuang Leftheris Xu Zhao Ye Cacatian Singh Tice