Bicyclic lactams and methods of use thereof
The invention provides novel compounds having the general formula I: wherein R1, X, Z1, L, n, the A ring, the B ring, and the C ring are as described herein, pharmaceutical compositions including the compounds and methods of using the compounds. 
Genentech, Inc.
C A C C C C A C A A A A C A A C C C A A A C C A A A C
C07D A61P C07D C07D C07D C07D A61P C07D A61P A61P A61P A61P C07D A61P A61P C07D C07D C07D A61P A61P A61P C07D C07D A61P A61P A61P C07D
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Guiling Snahel Huifen Craig Gregory
Zhao Patel Chen Stivala Hamilton