Casimir Jones SC
Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof
The present disclosure relates generally to thienopyrimidine and thienopyridine compounds and methods of use thereof. In particular embodiments, the present disclosure provides compositions comprising thienopyrimidine and thienopyridine compounds of Formula 3: and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. 
The Regents of the University of Michigan
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A61P A61P C07D A61P A61P C07D C07D
inventional inventional inventional inventional inventional inventional inventional
Duxin Xiaoqin Mohamed Jay L. Jolanta Kevin Artem Tomasz Dmitry
Sun Li Ibrahim Hess Grembecka Greenman Plekhov Cierpicki Borkin