Substituted biphenyl GPR40 modulators
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I:where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
Amgen Inc.
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Jie Margrit Yongli Daniel Jonathan Xian Yun Gayathri Wang Qiong An-Rong Julio C. Yingcai Marc Jeffrey D. Jiwen Zice Yumei Li Jian Xiaohui Liusheng Sean P. Paul John Yong-Jae Todd J. Ming Vatee SuJen
Zhang Schwarz Su Lin Houze Jiao Swaminath Shen Cao Li Medina Wang Vimolratana Reagan Liu Fu Xiong Yang Luo Du Zhu Brown Dransfield Kim Kohn Yu Pattaropong Lai