Novick, Kim & Lee, PLLC
Class of bisquaternary ammonium compound as well as the preparative method and the use thereof
A two-quaternary ammonium compound has a structural formula of formula (I). L1 is a C1 to C8 alkylene group; L2 is a C1 to C8 alkylene group; Z1 is nitro group or a halogen or methoxy group; Z2 is nitro group or a halogen or methoxy group; Z3 is nitro group or a halogen or methoxy group; R═H or a C1 to C6 alkyl group; a, b, and c are independently an integer from 0-5; and M is a pharmaceutically acceptable anion, such as a bromine ion, chlorine ion, sulfonate radical, etc. A stereoisomer or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate or eutectic of the compound of formula (I) forms a composition with a pharmaceutically acceptable carrier, or forms a compounded prescription with other active components, and the composition or compounded prescription may be used in the preparation of a muscle relaxant.
WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
C A
C07D A61P
inventional inventional
Cheng Bowen Jun Wensheng Weiyi Jin Lei
Zhou Ke Yang Zhang Zhang Liu Tang