Cooper & Dunham LLP
Universal methylation profiling methods
This invention provides methods of derivatizing a double-stranded DNA comprising contacting double-stranded DNA with a CpG methyltransferase and an s-adenosylmethionine analog. This invention also provides methods of sequencing DNA to determine methylation patterns.
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
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Jingyue John R. Timothy H. Xiaoxu
Ju Edwards Bestor Li