Finnegan, Henderson, Farabow, Garrett & Dunner LLP
Compositions of rotigotine, derivatives thereof, or pharmaceutically acceptable salts of rotigotine or its derivative
The disclosure relates to a composition comprising rotigotine or a pharmaceutically acceptable salt thereof; at least one poly(lactide-co-glycolide) (PLGA); and at least one fatty acid, wherein the at least one fatty acid is at least 0.5% in weight relative to the total weight of the composition. The composition as disclosed herein has significantly reduced burse release effect. The disclosure also provides a method of treating Parkinson's disease comprising administering an effective amount of the composition as disclosed to a subject in need thereof.
SHAN DONG LUYE PHARMACEUTICAL CO., LTD.
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inventional inventional inventional inventional inventional
Kaoxiang Wanhui Aiping Jun Lifang Youxin
Sun Liu Wang Li Sun Li