Reducing axon degeneration with proteasome inhibitors
Reduced degeneration of an axon predetermined to be subject to degenerative neuropathy in a term patient is effected by contacting the axon in situ with an effective amount of a ubiquitin-proteasome system (UPS) inhibitor sufficient to reduce degeneration of the axon; and detecting a resultant reduction in the degeneration of the axon in situ.
Children's Medical Center Corporation
A A A A A
A61K A61K A61K A61K A61K
inventional inventional inventional inventional inventional
Jing Qiwei Ryan Liqun Zhigang Eric
Wang Zhai Watts Luo He Hoopfer