Birch, Stewart, Kolasch & Birch, LLP
Process for preparing tetrahydroquinoline derivatives
The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof.Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.
Mitsubishi Tanabe Pharma Corporation
C A A C A A
C07D A61P A61P C07D A61P A61P
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Masaki Takanori Hitoshi Yoshinori Yoshikazu Norimitsu Takeshi Akira
Okamoto Higashijima Kubota Nakamura Mori Hayashi Hamada Sakuragi