Kagan Binder, PLLC
Butylphthalide-telmisartan hybrids, preparation method and application thereof
The invention discloses a butylphthalide-telmisartan heterocomplex, a preparation method and an application thereof. The invention specifically relates to an optically active ring-opening butylphthalide-telmisartan heterocomplex shown in formula I or a pharmaceutically acceptable salt or ester thereof, a preparation method thereof, a pharmaceutical composition containing the compounds, and a pharmaceutical application thereof, particularly application in prevention and treatment of neuroinflammation-related diseases, including ischemic stroke, Alzheimer's disease, brain trauma, Parkinson's disease, multiple sclerosis, depression and so on.
GUANGDONG LONGFU MEDICINE CO., LTD.
A C A C C A C A
A61P C07D A61P C07D C07D A61P C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional
Wenbin Cunfang Tao Zhangjian Weijie Tingyu Jinxiang
Zeng Wang Pang Huang Wu Huang Deng