Permeable glycosidase inhibitors and uses thereof
The present invention is directed to compounds and pharmaceutical formulations comprising these compounds which are useful as O-linked N-acetylglucosaminidase (O-GlcNAcase) inhibitors, and thus may be useful for the treatment of certain disorders such as Alzheimer's disease including reducing NFTs and/or hyperphosphorylated tau. The invention is also directed to use of the compounds as O-GlcNAcase imaging agents.
ALECTOS THERAPEUTICS, INC. MERCK SHARP & DOHME CORP.
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Yuanxi Jiang Ernest J. Yaode Kun Wenping Zhongyong Harold G. Eric Changwei
Zhou Chang McEachern Wang Liu Li Wei Selnick Hostetler Mu