Lex IP Meister, PLLC
Composition and microsphere for controlled-release of exendin, and method preparing the same
A controlled-release composition and controlled-release microspheres containing an exendin as an active ingredient, and a method of preparing the same are provided. More specifically, a controlled-release composition containing an exendin as an active ingredient, a biodegradable polymer with a specific viscosity, and coating materials, having high bioavailability and showing sustained release of the active ingredient in an effective concentration for a certain period without an excessive initial burst of the active ingredient; controlled-release microspheres containing a core including an exendin as an active ingredient and a biodegradable polymer, and a coating layer coating the core; and a method of preparing controlled-release microspheres including the steps of mixing an exendin, a biodegradable polymer, and a solvent, removing the solvent from the mixture to prepare hardened microspheres, and coating the hardened microspheres to form a coating layer on the surface of each microsphere, are provided.
PEPTRON CO., LTD
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Jung-Soo Eun-Young Yeon-Jin Mi-Jin Chae-Jin Mi-Young Ho-Il Joon-Sik Hee-Yong Ju-Han
Kim Seol Chae Baek Lim Baek Choi Kim Lee Lee