Flynn, Thiel, Boutell & Tanis, P.C.
Substituted thiazolo 3,2-a!azepine derivatives
 The present invention relates to a substituted thiazolo3,2-a!azepine derivative having inhibitory activity against angiotensin I converting enzyme and neutral endpeptidase. The above substituted thiazolo3,2-a!azepine derivative is represented by the following general formula (I): ##STR1## (wherein R1 represents a hydrogen atom or a protecting group of a thiol group; R2 represents a hydrogen atom, a lower alkyl group, an aryl group which may have a substituent, a hetroaryl group which may have a substituent, a lower alkoxyl group or a lower alkylthio group; R3, R4 and R5 may be the same or different from one another and represent each a hydrogen atom, a lower alkyl group, a lower alkoxyl group, a lower alkylthio group or the like, with the proviso that the case wherein all of R3, R4 and R5 are hydrogen atoms are excepted; PA1 R6 and R7 may be the same or different from each other and represent each a hydrogen atom or a lower alkyl group; R8 represents a hydrogen atom or a protecting group of a carboxyl group; and PA1 m and m are each independently 0 or, 1 or 2). 
Eisai Co., Ltd.
Y C A C
Y02P C07D A61K C07K
additional inventional additional inventional
Naoki Hideyuki Hitoshi Kazutoshi Masanori Mamoru Makoto Takeshi Masayuki Makoto Shinji Tomohiro Toshiyuki Yoshio
Yoneda Adachi Oinuma Miyake Mizuno Saito Okita Sudo Namiki Kotake Suda Matsushima Matsuoka Fukuda