Mueting, Raasch & Gebhardt, P.A.
Antibodies for the treatment of Clostridium difficile-associated infection and disease
Provided herein are reagents, compositions, and therapies with which to treat Clostridium difficile infection and related disease conditions and pathologies, such as Clostridium difficile-associated diarrhea, resulting from infection by Clostridium difficile bacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and/or toxin B of C difficile and neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided.
Progenics Pharmaceuticals, Inc.
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Dangshe Shankar Brian Andre J. Naoya Albert Gerald P. Yun Kirsten William C.
Ma Kumar Kennedy Marozsan Tsurushita Cupo Donovan Kang Nagashima Olson