Millen, White, Zelano & Branigan, P.C.
Phenylamino isothiazole carboxamidines as MEK inhibitors
The invention concerns compounds which inhibit MEK and which have activity as anti-neoplastic agents. These compounds include N-substituted-3-hydroxy-5-arylamino-isothiazole-4-carboxamidines. Also included are the tautomeric isothiazol-3(2H)-ones.
Ardea Biosciences, Inc.
A C C C C C C
A61P C07D C07D C07D C07D C07D C07D
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Hassan El Andreas Huanming Zhi Stanley Robert Dinesh Varaprasad
Abdellaoui Maderna Chen Hong Lang Tam Barawkar Chamakura