Greenberg Traurig, LLP
Compositions and methods for treating hemoglobinopathies
The present invention features compositions and methods for editing deleterious mutations associated with hemoglobinopathies, such as sickle cell disease (SCD). In particular embodiments, the invention provides methods for correcting mutations in a beta globin polynucleotide using modified adenosine base editors termed “ABE8” having unprecedented levels (e.g., >60-70%) of efficiency.
Beam Therapeutics Inc.
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David A. Bernd Yi Michael Ian Seung-Joo Nicole
Born Zetsche Yu Packer Slaymaker Lee Gaudelli