Eversheds Sutherland (US) LLP
Oxime cross-linked biocompatible polymer hydrogels and methods of use thereof
Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime bonds. The hydrogels are suitable for binding to and coating a tissue or cell. The hydrogels operate to reduce cellular adhesions and protein adsorption to the tissue or cell.
The Regents of the University of California
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Michael Karen Gregory Masaki
Madani Christman Grover Fujita