Nixon Peabody LLP
Cationic lipids with various head groups for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with siRNA, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo.
SIRNA THERAPEUTICS, INC.
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A61K C07J C07J A61K
inventional inventional inventional inventional
Vladislav V. Matthew G. Andrea R. Weimin Jennifer R. Mark Lu
Telyatnikov Stanton Geiser Wang Davis Cameron Tian