Sterne, Kessler, Goldstein & Fox, P.L.L.C.
Monoclonal antibody that binds human notch2 and notch3
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
OncoMed  Pharmaceuticals, Inc.
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John A. Aaron Ken Yuan Ching Maureen Fitch Austin L. Edward Thein Htun Timothy Charles
Lewicki Sato Liu Bruhns Gurney van der Horst Hoey