Dinsmore & Shohl LLP
ROS-activated compounds as selective anti-cancer therapeutics
Provided are compounds according to the following Formula I:The Formula I compounds are activated in the presence of reactive oxygen species (ROS) and are therefore selective anti-cancer therapeutics for cancers associated with elevated ROS. Also provided are methods and pharmaceutical compositions for treating cancers associated with increased ROS.
Cincinnati Children's Hospital Medical Center University of Cincinnati
C A A A C C C A A C C A A C C C A
C07D A61K A61K A61K C07C C07C C07C A61K A61K C07C C07C A61K A61K C07C C07C C07C A61K
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James C. Guorui Tiffany Edward J.
Mulloy Li Bell-Horwath Merino