Syndicated Law, PC.
Enhanced active agents
The teachings provide active agents that are conjugated with delivery systems that increase the half-life, and reduce the immunogenicity, of the active agents. Methods of making and using the systems are also provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.
A A A A A C A A A A A A A
A61K A61K A61P A61K A61P C07D A61K A61P A61K A61P A61K A61K A61P
inventional inventional inventional inventional inventional additional inventional inventional additional inventional inventional inventional inventional
Xiaoling William K. Mamoun M. Sravan C. Mark R. Miki S.
Li Chan Alhamadsheh Penchala Miller Park