K & L Gates LLP
Polycationic polyrotaxanes capable of forming complexes with nucleic acids
A polycation capable of forming a complex with a nucleic acid for carriage thereof. The polycation comprising at least one cyclic compound having a cavity. A polymer backbone is threaded into the cavity of the cyclic compound. A pair of bulky moieties cap the terminals of the polymer backbone to inhibit dethreading of the cyclic compound from the polymer backbone. In use, the net positive charge of said polycation enables a complex to form with nucleic acid.
National University of Singapore Agency for Science, Technology and Research
B A C C A
B82Y A61K C12N C08B A61K
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Suat Hong Kam W. Hongzhe Xin Chuan Jun
Goh Leong Li Wang Yang Li