Factor XIa inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more compounds of Formula (I), and methods for using the compounds of Formula (I) for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein. 
Merck Sharp & Dohme Corp.
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Joseph L. Puneet Jiayi Yu Gioconda V. Deyou Nancy J. Zhuyan Santhosh F. Amjad Anjan Rajan Remond Andrew W. Hiroki Scott D. Zahid Younong Weiguo Heping Ying-Duo Yeon-Hee
Duffy Kumar Xu Jiang Gallo-Etienne Sha Kevin Guo Neelamkavil Ali Chakrabarti Anand Moningka Stamford Sone Edmondson Hussain Yu Liu Wu Gao Lim