Tarolli, Sundheim, Covell & Tummino LLP
Methods and compositions for modulating adhesion and migration of cadherin expressing cells
A method modulating adhesion and migration of at least one cadherin expressing cell includes administering a cadherin modulating agent to the at least one cadherin expressing cell in an amount effective to modulate cell adhesion and migration. The cadherin modulating agent includes a small molecule peptidomimetic of a peptide or cyclic peptide that comprises a cadherin cell adhesion recognition sequence. The cadherin modulating agent can promote or inhibit neurite outgrowth when applied to at least one neuron disposed on a substrate coated with a cadherin molecule.
Case Western Reserve University
G A A A G
G01N A61K A61P A61K G01N
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Susann Susan
Brady-Kalnay Burden-Gulley