Naphthostyrils
Disclosed are novel naphthostyrils of formula These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing such compounds, methods for the treatment and/or prevention of cancer using such compositions, and intermediates useful in the preparation of the compounds of formula I.
Hoffmann-La Roche Inc.
A C C A A A A C C A
A61P C07D C07D A61P A61P A61P A61P C07D C07D A61P
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Frederick Martin Yi Jin-Jun Apostolos Kin-Chun
Konzelmann Chen Liu Dermatakis Luk