Brinks Gilson & Lione
Labeling agent and methods for simultaneous sequencing and quantification of multiple peptides and proteins using the same
The present invention provides a compound that can utilize hydrogen isotope and, at the same time, can quantify multiplexed samples at one time, as well as decreasing the cost for synthesis of the labeling agent. In addition, the present invention provides a novel method for quantitatively analyzing protein and peptide analytes having different quantities form each other using the labeling agent, wherein y-type fragment ions having a high mass which comprises the analyte remained after coupling the labeling agent with the analyte and then removing a part of the labeling agent through tandem mass spectrometry are utilized to conduct the quantitative analysis.
Postach Academy-Industry Foundation
G C C G G C C C
G01N C07C C07C G01N G01N C07C C07B C07C
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Seung Koo Min Soo Hee Yoon Hye Joo Jong Cheol Yong Sik
Shin Suh Lee Yoon Seo Jung