Single chemical entities and methods for delivery of oligonucleotides
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3′ and/or 5′ end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
Merck Sharp & Dohme Corp.
A A A C A A
A61K A61K A61K C07K A61K A61K
inventional inventional inventional inventional inventional inventional
Jeffrey G. René Anthony W. Weimin Yu Stanley F. Aaron A. David M. Vasant R. Thomas J. Steven L.
Aaronson Bartz Shaw Wang Yuan Barnett Momose Tellers Jadhav Tucker Colletti