The Nath Law Group
Crystal forms of pyrrolylheptanoic acid derivatives
The present invention provides novel crystalline forms D1 and D2 of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms D1 and D2 have X-ray powder diffraction peaks described in FIGS. 1 and 3, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.
Dong-A Pharm. Co., Ltd.
A C
A61P C07D
inventional inventional
Yong Jik Jae Keol Seong Jin Moon Sung Hong Gyu Moo Hi Si Young Jun Ho Dae Won
Kim Rhee Park Kim Lim Yoo Sung Choi Cha