WPAT, P.C.
Method of identifying a candidate compound which may inhibit α9-nAchR overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells
The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or α9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that α9-nAChR has an activating protein 1 (AP1)-binding site, that the α9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the α9-nAChR promoter at the AP1-binding site, indicating that ER-induced α9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.
Taipei Medical University
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A61K A61K A61P G01N G01N G01N
inventional inventional inventional inventional inventional inventional
Ching-Shyang Chien-Hsi Yuan-Soon Li-Ching Chih-Hsiung Shih-Hsin Po-Li Hui-Wen Ying-Jan Ya-Chieh Chia-Hwa Ching-Shui Yu-Jia
Chen Chang Ho Chen Wu Tu Wei Chang Wang Chang Lee Huang Chang