Muserlian, Lucas and Mercanti
Process for producing desulfated polysaccharide, and desulfated heparin
A method of increasing proliferation of cells which comprises adding to cells a cellular proliferating amount of a primary hydroxyl group of N-acetylglucosamine selectively desulfated heparin having the following characteristics for an enzyme digestion product of the heparin:(1) contents of unsaturated disaccharides of the following formulae (a) and (b): measured by high performance liquid chromatography in the enzyme digestion product of the selectively desulfated heparin are less than 40% and 30 to 67%, respectively, (2) a content of disaccharides containing an N-substituted sulfate group is 75 to 95%, and (3) the weight average molecular weight Mw is 4,000 to 30,000 dalton.
Seikagaku Corporation
A C A A A C
A61P C08B A61K A61P A61P C08B
inventional inventional inventional inventional inventional inventional
Masayuki Saburo Keiichi
Ishihara Hara Yoshida