Rankin, Hill & Clark LLP
4′-demethylepipodophyllotoxin derivative, preparation method and use thereof
A 4′-demethylepipodophyllotoxin derivative of formula (III) having anti-tumor activity is provided. After the activation of hydroxyl in position C4 of 4′-demethylepipodophyllotoxin, tetramethylpyrazine is introduced by transamination to obtain the 4′-demethylepipodophyllotoxin derivative which is preferably used to inhibit gastric cancer line BGC-823.
Hubei University of Technology
A A C A C
A61P A61K C07D A61K C07D
inventional inventional inventional inventional inventional
Wei Ya-Jie
Zhao Tang