Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I or the general formula III:where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
Amgen Inc.
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Paul J. Vatee Marc Todd J. Jiwen Jonathan Ming Wang Julio Yingcai Sean P. Liusheng
Dransfield Pattaropong Vimolratana Kohn Liu Houze Yu Shen Medina Wang Brown Zhu