Foley & Lardner LLP
Compounds, compositions and methods for reducing lipid levels
The present technology relates to compounds of Formulas (V) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase.
CVI Pharmaceuticals Limited
A A C C A
A61P A61P C07D C07D A61P
inventional inventional inventional inventional inventional
Gaoping Jingwen Haiyan Junbo
Li Liu Liu Wang