Christensen O'Connor Johnson Kindness PLLC
Phenyl C-glucoside derivatives, preparation methods and uses thereof
The present invention relates to a sodium glucose cotransporter 2 (SGLT2) inhibitor with a phenyl C-glucoside structure, its preparation method, a pharmaceutical composition containing the same, and its use in treating diabetes and preparing an anti-diabetes medicament. The invention provides a compound with the structure of general formula I and a pharmaceutically acceptable salt and prodrug ester thereof,wherein, the definitions of R5 and R6 are selected from the following:(1) R5=R6=Me; (2) R5=Me, R6=OMe; (3) R5=Me, R6=H; (4) R5=Me, R6=F; (5) R5=F, R6=H; and (6) R5=OMe, R6=H.
Tianjin Institute of Pharmaceutical Research
C A C A A C C A A
C07D A61P C07H A61K A61P C07H C07D A61K A61P
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Lida Yuli Bingni Weiren Wei Hua Chubing Guilong Shijun
Tang Wang Liu Xu Liu Shao Tan Zhao Zhang