Caesar Rivise, PC
Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION
A A A C A
A61P A23L A61K C07D A61K
inventional inventional inventional inventional inventional
Hyang-Sook Yi Kyung Joong-heui Seungyeon Sungchan So Young Hee Yoon Sun Joo Seock Yong Jin-Hee Ja Wook Sun-Hwa Miri Nam Doo Dayea Hwan Geun Sang Bum Kyu-Sun Kweon Eunhwa Jung Beom
Hoe Ko Cho Lee Cho Kim Ryu Lee Kang Park Koo Lee Choi Kim Kim Choi Kim Lee Yu Ko Son