Knobbe, Martens, Olson & Bear LLP
Compositions and methods for nanoparticle lyophile forms
This invention provides compositions for making a solid lyophile of one or more nucleic acid active agents, which can be reconstituted as a drug product. The composition can include an aqueous suspension of lipid nanoparticles in a pharmaceutically acceptable solution, wherein the lipid nanoparticles encapsulate one or more nucleic acid active agents, a dextrin compound, and a saccharide compound. The nucleic acid active agents can be RNAi molecules capable of mediating RNA interference, as well as other RNAs and oligonucleotides.
NITTO DENKO CORPORATION
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A61K C12N A61K C12N A61K A61K C12N A61K C12N A61K A61P A61K A61K A61K
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Yuwei Roger Dong Liping Haiqing Wenbin
Wang Adami Liu Wang Yin Ying