Cantor Colburn LLP
Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
The United States of America as represented by the Department of Health and Human Services
C A G C G A A G A A A A
C07K A61K G16B C07K G16B A61K A61P G16B A61K A61P A61P A61P
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Ruin Sarangan Irving W. Jack R. Krzysztof
Moaddel Ravichandran Wainer Collins Jozwiak