Occhiuti Rohlicek & Tsao LLP
Stereoselective synthesis of β-nucleosides
This invention relates to a process for stereoselectively preparing a nucleoside of the following formula:wherein R3, R4, and B are defined herein. The process includes reacting a furanose compound with a nucleobase in the presence of a halide salt. Also disclosed is another process for stereoselectively synthesizing an intermediate that can be used to make the starting compound in the first-mentioned process.
Pharmaessentia Corp.
C C C C
C07H C07H C07H C07H
inventional inventional inventional inventional
Wensen Ko-Chung
Li Lin