Fish & Richardson P.C.
Aminopyrazole derivative
A compound represented by formula (I) or a pharmacologically acceptable salt thereof, which can inhibit a fibroblast growth factor receptor (FGFR) family kinase in cancer tissues. (In the formula, A represents a 5- to 10-membered heteroaryl group, or a C6-10 aryl group; R1 and R2 independently represent H, OH, X, CN, NO2, a C1-4 haloalkyl group, a C1-6 alkyl group, or the like <R1 and R2 together form a (substituted) 3- to 10-membered heterocyclyl group or a (substituted) 5- to 10-membered heteroaryl group>; R3 represents H, a C1-5 alkyl group, a C6-10 aryl group, a C1-5 alkyl group, or a C1-4 haloalkyl group; and R4 represents H, X, a C1-3 alkyl group, a C1-4 haloalkyl group, OH, CN, NO2, or the like.)
Chugai Seiyaku Kabushiki Kaisha F. Hoffmann-La Roche AG
A A A C C C C C C A C A A A A A C A A A
A61K A61K A61K C07F C07D C07D C07D C07D C07D A61P C07D A61P A61K A61K A61K A61K C07D A61K A61P A61K
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Ikumi Naoki Toshiyuki Masayuki Kyoko Yoshito Masayuki Tadakatsu Lisha Weili Masami Hiroki Hirosato
Hyodo Taka Mio Matsushita Takami Nakanishi Ohmori Hayase Wang Zhao Kochi Nishii Ebiike