Factor XIa inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Merck Sharp & Dohme Corp.
C C A C C C
C07D C07D A61P C07D C07D C07D
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Anthony K. Sung-Sau Zhuyan Weiguo Amjad Heping Tingting Chunsing Yu Ying-Duo Rongze Scott D.
Ogawa So Guo Liu Ali Wu Yu Li Jiang Gao Kuang Edmondson