Christensen O'Connor Johnson Kindness PLLC
Conjugates of biologically active proteins having a modified in vivo half-life
Disclosed are biologically active protein conjugates that comprise a biologically active polypeptide coupled via a peptide bond to a polypeptide comprising from 2 to about 500 units of a repeating peptide motif, wherein the biologically active protein conjugate exhibits a modified plasma half-life compared to the intrinsic half-life of the unconjugated biologically active polypeptide or protein. Also disclosed are methods of making and using the conjugated proteins, as well as methods for determining whether a given conjugate exhibits a modified half life relative to the intrinsic half life of the unconjugated polypeptide.
Cell Therapeutics, Inc.
A Y C A
A61K Y02A C07K A61P
additional additional inventional inventional
David Marc Jack Stewart
Leung Besman Singer Chipman