Baker & Hostetler LLP
Retinoid-liposomes for treating fibrosis
What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
Nitto Denko Corporation
A A C A C A C A A A A A C A A A A C A C C A A A A
A61K A61P C12N A61P C12N A61P C12N A61P A61P A61P A61P A61P C12N A61K A61P A61P A61P C07H A61K C12N C12N A61P A61P A61P A61P
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Elena Sharon Wenbin Hagar Yoshiro Victor Igor Loren A. Richard P. Joseph E. Yun Violetta Yasunobu Kenjiro Mohammad
Feinstein Avkin-Nahum Ying Kalinski Niitsu Knopov Mett Perelman Witte Payne Liu Akopian Tanaka Minomi Ahmadian