Klarquist Sparkman, LLP
Methods for making definitive endoderm using at least GDF-8
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.
Janssen Biotech, Inc.
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Christine Janet Pascal Ghislain Andre Jiajian
Parmenter Davis Bonnet Liu