Aminoglycoside and azole compositions and methods
The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
Utah State University
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Michelle Sanjib K. Jon Y. Cheng-wei Tom
Grilley Shrestha Takemoto Chang