Sterne Kessler Goldstetin & Fox, P.L.L.C.
Pharmaceutical composition for alleviation and treatment of ischemic conditions and method for delivering the same
The present invention relates to pharmaceutical compositions for treating diseases and conditions caused by ischemia. The pharmaceutical compositions contain a conjugate of a phospholipase (PL) polypeptide and a protein transduction domain (PTD). PLC-δ plays a major role in the regulation of cytosolic calcium levels. During myocardial ischemia, cytosolic calcium accumulation mediates pathogenic changes. According to the present invention, ischemic diseases or conditions leading to hypoxia in tissues, such as the heart and the brain, can be prevented or alleviated by administration of a PTD-PL conjugate.
ForHumanTech. Co., Ltd.
C C C Y A A A A A
C12N C07K C07K Y02A A61P A61K A61P A61P A61P
inventional additional additional additional inventional additional inventional inventional inventional
Sang-Kyou Ki-Chul Seung-Kyou Yang-Soo
Lee Hwang Lee Jang