Sughrue, Rothwell, Mion, Zinn and Macpeak
7-(.alpha.-Acylamino-.alpha.-phenyl or thienylacetamido) cephalosporin derivatives
 A compound of the formula (I): ##STR1## wherein A is a monocyclic or polycyclic heteroaromatic ring containing at least one nitrogen atom as a hetero atom, which may be unsubstituted or substituted with one or more substituents; PA0 R is a phenyl group which can be unsubstituted or substituted or a thienyl group; PA0 T is (1) a -CH.sub.2 -S-Het group, where Het is a tetrazolopyridazine ring, a triazolopyridazine ring, or a triazolopyridine ring, (2) ##STR2## WHERE R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, (3) a -CH.sub.2 N.sub.3 group or (4) a --CH.sub.2 S--D group in which D is a group selected from the group consisting of ##STR3## where m and n each is 0 to 3; with the proviso that (A) WHEN T is the --CH.sub.2 SD group wherein D is as defined above then the HO-A- moiety is a ##STR4## where B represents the non-metallic atoms necessary to complete a pyridine ring, a pyrimidine ring or a pyrazoline ring, each of which may be unsubstituted or subsituted, and PA1 (b) when T is the --CH.sub.2 N.sub.3 group, then R is a substituted phenyl group And the non-toxic, pharmaceutically acceptable salts thereof, processes for preparing the same, and anti-microbial compositions containing the same. 
Sumitomo Chemical Company, Limited
Y A
Y02A A61K
additional inventional
Hirotada Toshiaki Takenari
Yamada Komatsu Nakagome