6-oxo-1,6-dihydropyridine derivatives as inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula Vand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, and inflammatory conditions in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases and inflammatory conditions in mammals and pharmaceutical compositions containing such compounds.
Array BioPharma Inc.
A C A A C C A C C C A A A C A C A C C A A A A C C C A A A C A C A A
A61P C07D A61P A61P C07D C07D A61K C07D C07D C07D A61K A61K A61K C07D A61K C07D A61P C07D C07D A61K A61P A61K A61K C07D C07D C07D A61P A61P A61K C07D A61K C07D A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Hong Woon Joseph P. James Allison L. Jeongbeob Eli M.
Yang Lyssikatos Blake Marlow Seo Wallace