McCarter & English, LLP
Cytotoxic benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
ImmunoGen, Inc.
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Wei Nathan Elliott Ravi V. J. Michael Louis
Li Fishkin Chari Miller