Factor XIA inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
Merck Sharp & Dohme Corp.
A C C C C C C C A
A61P C07D C07D C07D C07D C07D C07D C07D A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional
Thomas Cheng Scott D. Meng Amjad Wei Santhosh F. Wanying Jiayi Eric Dong-Ming Bart Ying-Duo Yeon-Hee Weiguo
Bara Zhu Edmondson Yang Ali Zhou Neelamkavil Sun Xu Mertz Shen Harper Gao Lim Liu