Imidazole derivatives useful as modulators of FAAH and as FAAH imaging agents
The present invention is directed to certain Inidazole derivatives which are useful as modulators of Fatty Acid Amide Hydrolase (FAAH) and as FAAH imaging agents. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzeimer Disease, and Parkinson's Disease.
Merck Sharp & Dohme Corp
C A A C A A A A A A A C C A A A
C07D A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P A61P A61P
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Terence G. Wenping Robert J. Linus S. Marc D. Ping
Hamill Li DeVita Lin Chioda Liu