Holtz, Holtz, Goodman & Chick, P.C.
1,2-dihydroquinoline derivative having (substituted phenyl or substituted heterocyclic) carbonyloxy lower alkyl group and ester-introduced phenyl group as substituents
The compounds represented in general formula (1) and a salt thereof are useful for glucocorticoid receptor modulator.The R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group, a nitro group or a cyano group; X represents —C(O)—, —C(O)NR8—, —S(O)2— and the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, a lower alkoxy group which may have a substituent and the like; Y represents a lower alkylene group; Z represents a benzene ring or a heterocyclic ring; and P represents 0, 1, 2 or 3.
Santen Pharmaceutical Co., Ltd.
C A A A A C A A A A A A A C C A A A A A C A A A A A A A A A C A A A A
C07D A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P
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Sachiko Masato Masatomo Miwa Mamoru Toshiyuki
Kobayashi Nagatsuka Kato Takai Matsuda Mori