Cook Alex Ltd.
Amine derivative with potassium channel regulatory function, its preparation and use
The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences, P.L.A.
C A A A A A C A A A A A A A A A A
C07C A61P A61P A61P A61P A61P C07D A61P A61K A61P A61P A61P A61P A61P A61P A61P A61P
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Chaoliang Liuhong Hai Lin Qixiu Rifang Lijun Wenyu Huamei Xingchun Fulin Gang Rusheng Yuan Xinqiang Wei Huasong
Long Yun Wang Wang Gao Yang Liu Cui He Tang Li Hu Zhao Yan Lu Liu Feng