Nixon Peabody LLP
Method to determine transcriptional regulation pathways in organisms
The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.
Trustees of Boston University
G G G
G16B G16B G16B
additional inventional inventional
Jeremiah Boris Timothy S. James J.
Faith Hayete Gardner Collins