Spiroindolinone derivatives
The present invention relates to spiroindolinone derivatives of the formulaand their enantiomers and pharmaceutically acceptable salts and esters thereof wherein R1, R2, R3, R4, R5, R6, R7 and R8, are as herein described.The compounds have utility as antiproliferative agents, especially, as anticancer agents.
Hoffmann-La Roche Inc.
C A
C07D A61P
inventional inventional
Jin-Jun Qingjie Song Zhuming Li
Liu Ding Yang Zhang Chen