Nath, Goldberg & Meyer
STAT3 and ERK signal pathway inhibitor comprising mogrosides and analogs thereof
The present invention relates to a chemical and pharmaceutical technology, and in particular to a STAT3 and ERK signal pathway inhibitor and a use thereof. The present invention provides a STAT3 and ERK signal pathway inhibitor. The inhibitor mainly consists of a mogroside and/or an analog thereof. The mogroside and the analog thereof inhibit the phosphorylation of a transcription factor STAT3 and the phosphorylation of an ERK. The method for preparing the mogroside and the analog has the characteristics of simpleness, strong operability and high purity of products. The present invention further provides a use of the STAT3 and ERK signal pathway inhibitor in the preparation of drugs for treating tumors, which realizes the purposes of inhibiting the proliferation of cancer cells and promoting the apoptosis of cancer cells and has a very good inhibition effect on cancers.
BEIJING UNIVERSITY OF AGRICULTURE
A A A A A C A C C
A61K A61P A61K A61K A61K C12Q A61P C07J C07J
inventional inventional inventional inventional inventional additional inventional inventional inventional
Can Zhengzi Yan Dequan Xiaomeng Xiaozhu Lanqing Long Yuanxia Juntao Haiwen
Liu Bi Wang Dou Zhao Bi Ma Rong Sun Li Hu