Choate Hall & Stewart LLP
Rabconnectin-3-binding protein
A protein useful for clarifying the regulation mechanism of Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, and a method of screening for a material useful for regulating Ca2+-dependent exocytosis in particular, the activation and inactivation of Rab3A, using the above protein. By using the coimmunoprecipitation with an anti-Rab3A GEP antibody, a protein participated in the regulation of activation or inactivation of Rab3A is determined. As the protein binds to rabconnectin-3 and GDP/GTP exchange protein, it can be used for screening for a material that increases or decreases the binding.
Eisai R&D Management Co., Ltd
G C G G C G G
G01N C07K G01N G01N C07K G01N G01N
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Masakazu Yoshimi
Takeuchi Takai