Kenyon & Kenyon
Regulation of cellular invasiveness
 A method for decreasing metalloproteinase activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion construct thereof. Also, a method for increasing TIMP activity in a patient that comprises the step of administering to said patient a therapeutic composition comprising the cytokine oncostatin-M, or a biologically active fragment, mutant, analog or fusion construct thereof. In addition a method for inhibiting or treating progression of a tumor in a patient that comprises the step of administering to said patient a therapeutic composition comprising oncostatin-M, or a biologically active fragment, mutant, analog, or fusion construct thereof, said method being effective to inhibit invasion by a tumor cell through an extracellular space, extracellular matrix, basement membrane, interstitial tissue or connective tissue. Also methods effective to treat inflammatory or degenerative disease, methods effective to stimulate erythropoiesis, and methods effective to regulate tissue remodeling and to promote healing of injury. 
Bristol Meyers Squibb Company McMaster University
C A A A
C07K A61K A61K A61K
inventional inventional inventional inventional
Mohammed Jack Thomas Joseph Carl D.
Shoyab Gauldie Brown Richards