Bozicevic, Field & Francis LLP
Anti-human ninjurin-1 (NINJ-1) antibodies and methods for detecting human NINJ-1
The present invention provides: an antibody which specifically bonds to human NINJ-1; and a fragment thereof. The antibody or the fragment thereof according to the present invention has very high bonding affinity and bonding specificity with respect to a human NINJ-1 or a homogeneous binding site of the protein, and does not exhibit cross-reactivity with NINJ-1 proteins that are derived from other organisms and have high protein similarity. Accordingly, the present invention provides significant advantages with respect to accuracy and sensitivity and the like, not only in diagnosing disease related to NINJ-1 proteins but also in inhibiting pathological conditions involving NINJ-1 proteins. In particular, the antibody provided according to the present invention has a remarkable effect of inhibiting attachment between immunocytes and human cerebral endothelial cells, and thus has an effect of treating multiple sclerosis.
ABION INC. SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
C C C G A A C
C07K C07K C07K G01N A61P A61P C07K
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Ji Hye Young Kee Seahyung Kyoung
Lee Shin Lee Song