McCarter & English, LLP
Method for enrichment and separation of spinal fluid glycoprotein, method for searching for marker for central nervous system diseases which utilizes the aforementioned method, and marker for central nervous system diseases
The purpose of the present invention is to develop: a method for selectively separating a glycoprotein derived from the central nervous system from a body fluid or a central nervous system cell; and a method for searching for an index marker for central nervous system diseases, which utilizes the aforementioned method. A protein derived from the central nervous system, which occurs in a trace amount in a body fluid or a central nervous system cell, can be selectively enriched by a two-stage separation procedure comprising removing a glycoprotein having sialic acid at a non-reducing terminal thereof from the body fluid or the central nervous system cell and then separating a glycoprotein having N-acetylglucosamine at a non-reducing terminal thereof.
National Institute of Advanced Industrial Science and Technology
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Hideki Yuzuru Hajime Kazuo Keiro Satoshi Atsushi Hiromi Masakazu Jun Hisashi Yasuhiro
Matsuzaki Ikehara Arai Fujihara Shirotani Futakawa Kuno Ito Miyajima Hirabayashi Narimatsu Hashimoto