Jenkins, Wilson, Taylor & Hunt, P.A.
Pharmaceutical composition containing stem cell in which vascular endothelial growth factor is overexpressed as effective ingredient for preventing or treating neurodegenerative disease
The present invention relates to a pharmaceutical composition containing stem cells in which vascular endothelial growth factor (VEGF) is overexpressed as an effective ingredient for preventing or treating neurodegenerative diseases. The stem cells in which VEGF is overexpressed according to the present invention effectively act against the neurodegenerative disease-induced VEGF reduction of neural stem cells in the SVC to inhibit the abnormal migration of neural stem cells, suppress inflammatory responses, and restrain the accumulation of cholesterol and spingolipids in the cerebral cortex, thus restoring the behavior exercise capacity of animal models, whereby the pharmaceutical composition can be used as an effective therapeutic agent for neurodegenerative diseases.
Kyungpook National University Industry-Academic Cooperation Foundation
A A A A A A A C
A61K A61K A61K A61K A61P A61K A61K C07K
inventional inventional inventional inventional inventional inventional inventional inventional
Jae Sung Hee Kyung Min Hee
Bae Jin Park