Henneman & Saunders
Papilloma pseudo-virus and preparation
The invention involves a papilloma pseudo-virus that can induce immune response after oral intake as well as its preparation. It is characterized in that HPV or BPV pseudo-virus are made by disrupting HPV-VLP or BPV-VLP, mixing them with plasmids (plasmids or DNA vaccine), and reassembling them into the pseudo-viruses (VLPs with plasmids inside). Oral administration of the pseudo-viruses will result in delivery to mucosal and systemic lymphoid tissues and induce immune responses for disease prevention and treatment. The pseudo-virus induces stronger immune response than DNA vaccines. Additionally, the pseudo-virus can be applied in gene therapy by bringing the therapeutic genes into lymphoid tissues in the human body.
C A A A A A C C A
C12N A61P A61P A61P A61P A61P C12N C12N A61K
inventional inventional inventional inventional inventional inventional additional additional additional
Liang Wei Jianzhong Yujun
Qiao Shi Liu Huang