Mathews, Collins Shepherd & Gould, P.A.
Polyoxypropylenepolyethylene vitamin E and preparation thereof
Disclosed is polyoxypropylenepolyoxyethylene vitamin E, represented by formula (I). It is prepared by subjecting vitamin E to polyethoxylation and then, to polypropoxylation to a proper extent. The vitamin E is of superior anti-oxidation activity with water solubility. The bent chain of the polyoxypropylenepolyoxyethylene vitamin E increases the cross-sectional area of the whole molecule, making it difficult for the molecule to penetrate into the skin. It is very safe to apply to the skin. The polyoxypropylenepolyoxyethylene vitamin E has superb surface activity by forming close bilayer vesicle structures, like phospholipids or dialkyl surfactants, so it can be advantageously used in the cosmetic industry, the food industry and the medical industry. In said formula, R1 is &#8212;(OCH2CH2)m&#8212; wherein m is an integer of 0 to 150; R2 is (a) wherein n is an integer of 1 to 200; A is (b) or (c); B is &#8212;CH3 at the 5-, 7- or 8-position of vitamin E; and p is an integer of 1 or 3.
A C
A61P C07D
inventional inventional
Jungsoo Keunja Jisoo Youngdae
Kim Park Kim Kim