Husch Blackwell LLP
In vitro and xenograft anti-tumor activity of a halogenated-xanthene against refractory pediatric solid tumors
A method of treating a pediatric cancerous solid tumor in a mammalian subject is disclosed that comprises intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor. Another contemplated method comprises the steps of intralesionally administering an amount of a halogenated xanthene or a pharmaceutically acceptable salt thereof, preferably Rose Bengal disodium, that elicits ablation of tumor cells of the administered tumor and systemically administering a tumor-inhibiting effective amount of a systemic anti-cancer medication that provides synergistic cytotoxicity with the halogenated xanthene. The two administrations can occur concurrently, or one prior to the other.
UTI Limited Partnership Provectus Pharmatech, Inc.
A A A A A A C A C A A A A
A61K A61K A61K A61K A61K A61K C07K A61K C07K A61K A61K A61P A61K
inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional
Satbir Chunfen Aru Lucy Mohit Jamie Eric A.
Thakur Zhang Narendran Swift Jain Singer Wachter