Lahive & Cockfield, LLP
Methods and compositions for regulating protein-protein interactions
The invention relates to methods and compositions of WW-domains as phosphoserine and phosphothreonine binding modules. The WW-domain containing polypeptides of the invention can be used, for example, to regulate cell growth; to treat neurodegenerative diseases; to screen for substances that modulated interactions between WW-domain containing polypeptides and phosphorylated ligands; as drug targeting vehicles; to direct protein degradation; and in the treatment of certain diseases or conditions characterized by aberrant WW-domain containing polypeptides or their ligands.
Beth Israel Deaconess Medical Center
G A A A C A G C G A A A A
G01N A61K A61K A61P C07K A61K G01N C12N G01N A61K A61K A61K A61P
inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional
Xiao Zhen Kun Ping
Zhou Lu