Sterne, Kessler, Goldstien and Fox P.L.L.C.
Polynucleotides encoding for frizzled-binding agents and uses thereof
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
OncoMed Pharmaceuticals, Inc.
C C A C A C C C C C A G C C A C A C C C A C A C C C C A A
C07K C07K A61K C07K A61K C07K C07K C07K C07K C07K A61K G01N C07K C07K A61K C07K A61K C07K C07K C07K A61K C07K A61P C07K C07K C07K C07K A61P A61K
additional additional additional additional inventional inventional inventional additional additional additional inventional inventional additional additional inventional additional inventional additional inventional inventional inventional additional inventional additional inventional inventional additional inventional inventional
Timothy Charles Sanjeev H. Fumiko Takada Aaron Ken Austin L. Satyajit Sujit Kumar
Hoey Satyal Axelrod Sato Gurney Mitra