Hunton & Williams LLP
Methods of screening T1R2/T1R3 receptors for compounds which modulate sweet taste signaling
Heteromeric taste receptors are provided. These receptors comprise a first polypeptide containing extracellular domains and transmembrane domains wherein the extracellular domains are at least 95% identical to the extracellular domains of specific T1R1 polypeptides and the transmembrane domains are at least 95% identical to the corresponding transmembrane domains of the specific T1R1 polypeptide or a different GPCR; and a second polypeptide comprising extracellular and transmembrane domains wherein the extracellular domains are at least 95% identical to the extracellular domains of specific T1R3 polypeptides and the transmembrane domains are at least 95% identical to the corresponding transmembrane domains of the specific T1R3 polypeptide or a different GPCR.
Senomyx, Inc.
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G01N G01N A01K C12Q C07K A61P G01N C07K C12Q G01N G01N C12Q G01N G01N
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Sergey Jon Elliot Xiaodong Fernando Shawn Lena Mark Hong
Zozulya Adler Li Echeverri O'Connell Staszewski Zoller Xu