Edwards Angell Palmer & Dodge LLP
Organocatalyst
The present invention provides an organocatalyst of formula (I),wherein R1 is —H, —OH, —O—Si(R4)(R5)(R6) or C1-6alkoxy, in which R4, R5 and R6 are identical or different and independently selected from the group consisting of C1-6alkyl, phenyl and phenyl substituted with C1-6alkyl; R2 is —OH or ═O; X1 is one selected from the group consisting of —NH—, —S— andX2 is one selected from the group consisting of —C(═O)—, —CH2— andand X1 is different from X2. The high yield and enantioselectivity of an addition reaction are obtained by using the organocatalyst of the present invention.
National Taiwan Normal University
C C C C C C C
C07D C07C C07D C07C C07F C07D C07D
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Kwunmin Ying-Fang Chihliang Pang-Min Hsuan-Hao
Chen Ting Chang Liu Kuan