Klarquist Sparkman, LLP
Animal model of Charcot-Marie-Tooth disease as HSP27 mutant (S135F) carrier
The present invention relates to a HSP27 mutation (S135F) mediated Charcot-Marie-Tooth disease (CMT) animal model. Particularly, the vector expressing mutant HSP27 protein wherein the 135th serine is substituted with phenylalanine has been injected in the mouse zygote and then the mouse harboring the expression vector was selected. The selected mouse was confirmed to display Charcot-Marie-Tooth disease phenotype, so that the animal model was expected to be efficiently used for the evaluation of the effect of Charcot-Marie-Tooth disease treating material candidates.
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION CHONG KUN DANG PHARMACEUTICAL CORP
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A61K G01N A01K C12Q C07K C12Q A01K A01K G01N G01N A01K C12Q
inventional inventional additional additional inventional additional additional additional inventional additional inventional inventional
Jin-Mo Sung Chul Byung-Ok Young Bin So-Youn Yun Tae
Park Jung Choi Hong Woo Kim