Adsero IP
Use of EI24 gene
The present disclosure relates to a novel use of EI24, and provides a novel use of EI24 involved in the improvement of EGFR-TKI drug resistance by inhibiting IGF-1R signaling. According to the present disclosure, the presence or absence of resistance to anti-cancer drugs may be determined by detecting an expression level of EI24. In addition, resistance to anti-cancer drugs may be inhibited, delayed, or improved using EI24 or an activating agent thereof. Moreover, by regulating a pathway of EI24-mediated resistance to anti-cancer drugs, the efficacy of existing anti-cancer drugs may be enhanced, and resistance to anti-cancer drugs may be inhibited, delayed, or improved.
University-Industry Foundation, Yonsei University
C C A A C A A G G A A A A A
C12Q C12Q A61K A61K C12Q A61K A61K G01N G01N A61K A61K A61K A61K A61K
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Hye Ryun Yu-Ra Han Woong Ji-Young Jung-Min Byoung Chul
Kim Choi Lee Jang Choi Cho