Blakely Sokoloff Taylor & Zafman LLP
1,2-Phenylenediboronic acid reagents and complexes
A reagent having the general formula of General Formula I: wherein group Z comprises a spacer selected from an aliphatic chain up to about 6 carbon equivalents in length, an unbranched aliphatic chain of from about 6 to 18 carbon equivalents in length with at least one of an intermediate amide and a disulfide moiety, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the reagent with a biologically active species; and wherein group Q is one of nothing at all, an amide, a methyl amide, a methylene, an ether, a thioether, a methyl ether, and a methyl thioether moiety. Also, a conjugate, a bioconjugate and a method of conjugating.
Prolinx, Inc.
G C C C C C Y C C C C C C C C Y G C
G01N C07D C07C C07C C07D C07C Y10S C07F C07C C07C C07C C07C C07C C07J C07D Y10S G01N C07C
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Guisheng Jean P. Mark L.
Li Wiley Stolowitz