Foley & Lardner LLP
Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization
The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and R6 are identical and each represent a hydrogen or fluorine atom; A is a cycle selected from the group including aryl and heteroaryl groups, wherein said groups can be substituted.
Centre National de la Recherche Scientifique (CNRS)
C C C C C C A C C C C C C C C C C C C C
C07C C07C C07C C07C C07C C07C A61P C07C C07C C07C C07C C07F C07C C07H C07C C07D C07D C07C C07C C07C
inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Abdallah Jian-Miao Jean-Daniel Jean-François Mouâd Olivier Jérôme Anne Samir Joanna
Hamze Liu Brion Peyrat Alami Provot Bignon Giraud Messaoudi Bakala