Foley Hoag LLP
Compositions and methods related to anti-CD19 antibody drug conjugates
In some aspects, the invention relates to an antibody-drug conjugate, comprising an anti-CD19 antibody; a linker; and an active agent. The antibody-drug conjugate may comprise a self-immolative group. The linker may comprise an O-substituted oxime, e.g., wherein the oxygen atom of the oxime is substituted with a group that covalently links the oxime to the active agent; and the carbon atom of the oxime is substituted with a group that covalently links the oxime to the antibody.
LegoChem Biosciences, Inc.
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Yong Zu Yun Hee Chul-Woong Ji Eun Ho Young Jeiwook Jeong Hee Hyo Jung
Kim Park Chung Jung Song Chae Ryu Choi