Sughrue Mion, PLLC
Heterocyclecarboxamide derivative
A nitrogen-containing six-membered heterocyclic compound having substituents &#8212;X&#8212;A&#8212;R3, &#8212;N(R1)-(Ph substituted by R2), and &#8212;CONH2, a salt thereof, a prodrug thereof, and a Syk inhibitor containing the same as an active ingredient. (In the formula, A: a (substituted) lower alkylene, a (substituted) arylene, or the like; X: NR4, CONR4, NR4CO, O, or S; R1, R4: H, a lower alkyl, &#8212;CO-lower alkyl, or &#8212;SO2-lower alkyl; R2: H, a (substituted) lower alkyl, &#8212;O-lower alkyl, &#8212;S-lower alkyl, &#8212;O-aryl, nitro, cyano, or the like; R3: &#8212;CO2H, &#8212;CO2-lower alkyl, -lower alkylene-CO2H, &#8212;NH2, -alkylene-NH2 or the like.
Yamanouchi Pharmaceutical Co., Ltd.
C A A C A C C A
C07D A61P A61P C07D A61P C07D C07D A61P
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Takayuki Kenichi Atsushi Makoto Hiroyuki Souichirou Akiko Kazuhito
Suzuki Onda Ichikawa Takeuchi Hisamichi Kawazoe Orita Tanabe