Baker & Hostetler LLP
Retinoid-liposomes for enhancing modulation of HSP47 expression
What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1—2 (SEQ ID NOS: 60 and 127), SERPINH1—45a (SEQ ID NOS: 98 and 165), and SERPINH1—51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
Nitto Denko Corporation
C A A A A A A A C A C A C A A C A A C A A A C A A
C12N A61P A61K A61K A61P A61P A61P A61P C12N A61P C07H A61P C12N A61P A61P C12N A61P A61P C12N A61P A61P A61P C12N A61P A61K
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Yasunobu Joseph E. Sharon Kenjiro Elena Victor Yun Richard P. Igor Violetta Mohammad Wenbin Hagar Loren A. Yoshiro
Tanaka Payne Avkin-Nahum Minomi Feinstein Knopov Liu Witte Mett Akopian Ahmadian Ying Kalinski Perelman Niitsu