Water-soluble formulations of m-AMSA with pyroglutamic acid
 This invention concerns novel water-soluble salts and compositions of the antitumor agent 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA). More particularly, there are provided (1) the mono- and dipyroglutamate salts of m-AMSA and (2) compositions of m-AMSA with pyroglutamic acid. The novel salts and compositions provided enable m-AMSA to be administered as an aqueous solution without the necessity of using dimethylacetamide as a pharmaceutical vehicle. 
Bristol-Myers Company
C C A
C07D C07D A61K
inventional inventional inventional
Edward C. Jivn-Ren
Shinal Chen