Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Benzothiophene derivatives, their preparation and use as urokinase inhibitors
 A compound of the formula ##STR1## in which R.sup.1 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy)lower)alkyl, carboxy)lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbamoyl(lower)alkyl, PA2 R.sup.2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl, PA2 R.sup.3 is hydrogen or amidino-protective group, PA2 A is lower alkylene or carbonyl, PA2 X is ##STR2## Y is --S-- or --SO.sub.2 --, Z is --S-- or --O--, PA2 or pharmaceutically acceptable salts thereof PA2 which is useful as a medicament. 
Fujisawa Pharmaceutical Co., Ltd.
A A C A A C C C A A Y
A61P A61P C07D A61P A61P C07D C07D C07D A61P A61P Y02P
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Hiroaki Akito Minoru
Mizuno Tanaka Sakurai