DLA Piper LLP (US)
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
The Johns Hopkins University School of Medicine Wisconsin Alumni Research Foundation Wyeth
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Daniel S. Neil Kathy Alexandra C. Se-Jin William N.
Greenspan Wolfman Tomkinson McPherron Lee Pappano