Chalker Flores, LLP
Live attenuated viral vaccine created by self-attenuation with species-specific artificial MicroRNA
The present invention includes a live attenuated virus and methods of making the same comprising an isolated virus comprising a viral genome that expresses one or more viral antigens; and one or more exogenous species-specific microRNAs inserted into the viral genome and expressed thereby, wherein the species-specific microRNAs are ubiquitously expressed in a viral target species cell but not in a viral propagation cell.
Texas Tech University System
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Junwei Mingtao
Li Zeng