Novak Druce Connolly Bove + Quigg LLP
Cycloastragenol monoglucoside, preparation, pharmaceutical composition and application thereof
This invention provides a method for preparing cycloastragenol monoglucoside CMG (cycloastragenol-6-O-β-D-glucoside), comprising the steps of: a. using astragaloside IV or Astragali extracts prepared by a conventional method as raw materials and adding an appropriate solvent thereinto to form a raw material solution; b. adding hydrolase and allowing for hydrolysis at a constant temperature to obtain a hydrolysate; c. separating the hydrolysate with macroporous adsorption resin; and d. obtaining the product by purification and separation. The present invention further provides cycloastragenol-6-O-β-D-glucoside prepared according to the method of this invention as well as its use in the preparation of a medicament for treating cardiovascular diseases and pharmaceutical compositions comprising the same.
Tianjin Institute of Pharmaceutical Research
A C C A A
A61K C12P C07J A61P A61K
inventional inventional inventional inventional inventional
Zhuanyou Peng Yingmei Weiting Shijun Lida Wulin Naxia Guangping Weiren Yuli Xiaoli
Zhao Liu Han Wang Zhang Tang Liu Zhao Xia Xu Wang Fu