Thomas, Kayden, Horstemeyer & Risley
Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
A biodegradable hyaluronic acid derivative comprising a modified hyaluronic acid repeating unit represented by the formula (HA)-[O(C═O)NH-M]p, wherein HA is a unit including N-acetyl-D-glucosamine and D-glucuronic acid, M is a modifying moiety containing a C2-16 hydrocarbyl group or a prepolymer, and p is an integer of 1 to 4. The biodegradable hyaluronic acid derivative when dissolved in a hydrophilic medium can form micelles and can be used to entrap a pharmaceutically active or bioactive molecule.
Industrial Technology Research Instittute
A A A A A C
A61K A61K A61K A61K A61K C08B
inventional inventional inventional inventional inventional inventional
Hsuen-Tseng Muh-Lan Jui-Hsiang Yu-Hua Mei-Jung Shu-Hua Bin-Hong
Chang Chen Chen Chen Liu Jan Tsai