Klarquist Sparkman, LLP
Imidazopyridine derivative, method for preparing same, and pharmaceutical composition containing same as active ingredient for preventing or treating cancer
The present invention relates to a novel imidazopyridine derivative, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer. The novel imidazopyridine derivative according to the present invention, a stereoisomer thereof and a pharmaceutically acceptable salt thereof can effectively inhibit cancer-related kinases, are excellent in inhibiting proliferation of cancer cells in a cancer cell line, and effectively inhibit proliferation of cancer cells (cancer cell apoptosis) in a cancer cell heterograft model, and thus can be useful as a pharmaceutical composition containing the same as an active ingredient for preventing or treating cancer.Also, the novel imidazopyridine derivative according to the present invention, the stereoisomer thereof, and the pharmaceutically acceptable salt thereof can effectively inhibit Src and Fyn, thereby being useful as a pharmaceutical composition for preventing or treating the Src and Fyn related diseases, and in particular, have been confirmed to be useful in diabetic nephropathy in animal model experiments. Therefore, the compound of the present invention can be effective as a pharmaceutical composition containing the same as an active ingredient for preventing or treating diabetic nephropathy.
DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION
A A A C C
A23L A23L A61P C07D C07D
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Joongheui Hee Yoon Shinae Nam Doo Sun-Hwa Younho Eunhwa Jin-Hee Hwan Geun Tae-Ho Seongho Seock Yong Dayea Hyunkyoung Dong Kyu Sungwoo Suk Kyoon Jae Hyun So Young Sun Joo Jung Beom Eunmi Sangbum Sang Hyun Seungyeon Yi Kyung Jaeyoung
Cho Ryu Kim Kim Lee Lee Ko Park Choi Jang Hong Kang Kim Kim Choi Lee Yoon Bae Kim Lee Son Hong Kim Min Lee Ko Song