Knobbe, Martens, Olson & Bear, LLP
Inhibitors of macrophage migration inhibitory factor and methods for identifying the same
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures:including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
Avanir Pharmaceuticals
A A A A A C A C A A A C A A A C A A A C A A A C A
A61K A61P A61K A61P A61P C07D A61P C07D A61P A61P A61P C07D A61K A61P A61P C07D A61P A61P A61K C07D A61P A61P A61P C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Sunil Kumar Wenbin Jagadish
K C Ying Sircar