Rabin & Berdo, P.C.
Transgenic mouse model for dementia
Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
Korea Institute of Science and Technology
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G01N A01K C12N G01N A01K C07K A01K G01N A01K C12N C12N A01K G01N C07K C12N C12N A01K A01K
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Do Hee Ae Nim Dong Jin Seul Gi Yun Kyung Sung Su
Kim Pae Kim Shin Kim Lim