Craig & Antonelli
Aryl ketones and production thereof
 Novel olefinic aryl ketone compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1.sub.-4 alkyl, or C.sub.1.sub.-4 alkoxy, R.sup.2 is hydrogen or halogen, and R.sup.3 and R.sup.4 are each hydrogen, halogen, C.sub.1.sub.-4 alkyl or trifluoromethyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reaction of an acetylenic alcohol of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, with formaldehyde and an amine of the formula: ##STR3## wherein R.sup.3 and R.sup.4 are each as defined above; reduction of the resultant acetylenic aryl alcohol; and oxidation of the resultant olefinic aryl alcohol. 
Sumitomo Chemical Company, Limited
C C C
C07D C07D C07D
inventional inventional inventional
Masaru Keiichi Shigeho Yoshihiro Hisao Isamu Masaharu Shigenari Junki Kikuo
Nakao Ono Inaba Tanaka Yamamoto Maruyama Takayama Katayama Katsube Sasajima