Hamilton, Brook, Smith & Reynolds, P.C.
Piperidine renin inhibitors
The present invention is directed to aspartic protease inhibitors represented by the following structural formula (I), or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the aspartic protease inhibitors of Structural Formula (I). Methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using these aspartic protease inhibitors are also disclosed.
Vitae Pharmaceuticals, Inc.
A A C A A A A A A C A A A A A A
A61P A61P C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P
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Alexey V. Wei Salvacion Colin M. Lawrence W. Lanqi Zhenrong Gerard Suresh B. Jing Patrick T. David A. Robert D. John J.
Ishchenko Zhao Cacatian Tice Dillard Jia Xu McGeehan Singh Yuan Flaherty Claremon Simpson Baldwin