Sterne, Kessler, Goldstein & Fox P.L.L.C.
2,3-epoxy succinyl derivative, preparation method and use thereof
The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma.
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
A A A C A C C A A C A A A
A61K A61P A61K C07D A61P C07D C07D A61K A61K C07D A61P A61K A61K
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Xingzhou Song Xiaokui Xiaoye Wu Zhibing Yunde Hongliang Xinbo Junhai
Li Li Wang Zhang Zhong Zheng Xie Wang Zhou Xiao