Eckman Law Group
RNA interference agents for GST-PI gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
Nitto Denko Corporation
C A C G C C C A C C C C C C H A A C C C C C
C12N A61B C12Q G01N C12N C12N C12N A61K C07F C12N C07D C12N C12N C12N H05K A61P A61K C12N C12N C12N C12N C12N
additional inventional inventional inventional additional additional additional additional inventional additional inventional inventional additional inventional inventional inventional inventional additional additional inventional additional additional
Mohammad Jun Kenjirou Jens Hirokazu Erika Wenbin
Ahmadian Zhang Minomi Harborth Takahashi Terada Ying