Pepper Hamilton LLP
Beta-sulfonamide hydroxamic acid inhibitors of tace/matrix metalloproteinase
This invention provides compounds of Formula I, having the structure:that are useful in treating diseases or disorders mediated by TNF-α, such as arthritis (rheumatoid arthritis (RA), juvenile RA, psoriatic arthritis, osteoarthritis etc), tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection, ankylosing spondylitis, psoriasis, sepsis, multiple sclerosis, Crohn's disease, degenerative cartilage loss, asthma, idiopathic pulmonary fibrosis, vasculitis, systemic lupus erythematosus, irritable bowel syndrome, acute coronary syndrome, hepatitis C, cachexia, COPD, stroke or type 2 diabetes, and for alleviation of symptoms thereof. The invention further provides methods for use of the compounds.
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Jeffrey S. Jeremy I. Yang-I Frank E. Zhong Jerauld S. George Weiheng Kaapjoo
Condon Levin Lin Lovering Li Skotnicki Diamantidis Wang Park