Hogan & Hartson LLP
Heterocyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X, Y and Z are as defined in the specification. Such compounds are MEK inhibitors and are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Array BioPharma Inc.
A A A A A A A C C A C C A A A A C C A A C A A C C A A C A C A C C A A A A A A C A A A A A A C A
A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P C07D C07D A61P A61P A61P A61P C07D C07D A61P A61P C07D A61P A61P C07D C07D A61P A61P C07D A61P C07D A61P C07D C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P C07D A61P
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T. Brian Allison L. Hong Woon Jeongbeob Joseph P. James Eli
Hurley Marlow Yang Seo Lyssikatos Blake Wallace