Tetrahydroquinazolin-4(3H)-one-related and tetrahydropyrido[2,3-D]pyrimidin-4(3H)-one-related compounds, compositions and methods for their use
Compounds are provided having the formula:wherein variables A1, A2, A3, A4, R1, R2, R3, R4, Q and L are as described herein. The subject compounds are useful for treatment of inflammatory and immune conditions and diseases. Compositions and methods of treatment using the subject compounds are also provided. For example, the subject methods are useful for treatment of inflammatory and immune disorders and disease such as multiple sclerosis, rheumatoid arthritis, psoriasis, and inflammatory bowel disease.
AMGEN SF, LLC
A A A A A A C A C C A A A A A A C A A A A A C A A A A A
A61P A61P A61P A61P A61P A61P C07D A61P C07D C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P
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Jiwen Xiaoqi Philippe Jeffrey Zice Julio C. Jason A. Michael G. Jeffrey T. Andrew P. Darin Xiaohui An-Rong
Liu Chen Bergeron Deignan Fu Medina Duquette Johnson Mihalic Marcus Gustin Du Li