Sughrue, Mion, Zinn, Macpeak and Seas
Antimicrobial 7-(.alpha.-acylamino-.alpha.-arylacetamido)-3-(substituted methyl)cephalosporin compounds
 Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or a (C.sub.1 -C.sub.4) alkyl group, X is a straight or branched chain C.sub.1 -C.sub.4 alkylene group and R.sub.2 is a carboxyl group or a sulfo group; and the pharmaceutically acceptable salts thereof exhibit strong inhibitory activities against a wide variety of Gram-positive and Gram-negative bacteria including Psendomonas aeruginosa, indolepositive Proteus and Enterobacter aerogenes, and also have an increased and prolonged serum level in a living body. The compounds are therefore useful as antibacterial agents for the treatment of infectious diseases caused by Gram-positive and Gram-negative bacteria. 
Sumitomo Chemical Company, Ltd.
C C
C07D C07D
inventional inventional
Hiroshi Takao Hisao Hirotada Kiyokazu
Noguchi Okuda Tobiki Yamada Jimpo