Non-A/non-B/non-C/non-D/non-E hepatitis agents and molecular cloning thereof
 Polypeptide antigens are disclosed which are immunoreactive with sera from individuals infected with non-A, non-B, non-C, non-D, non-E hepatitis. Also disclosed are corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic polypeptides. The antigens are useful in diagnostic methods for detecting the presence of N-(ABCDE) hepatitis agent infection in primates. The antigens are also useful in vaccine and antibody preparations. Methods are presented for the isolation of entire genomes corresponding to the N-(ABCDE) hepatitis agents. 
Genelabs Technologies, Inc.
C C C A
C12N C12N C07K A61K
additional additional inventional additional
Gregory R. LaVonne Marie Jungsuh P.
Reyes Young Kim