Foley & Lardner
Spherical single-substance particles, medicines and foodstuffs containing the particles, and method of production thereof
 The present invention relates to a process for producing a spherical particle comprising an aggregate of particles containing at least 95% of a water-soluble single substance having a viscosity of 10 mPa.s or less as determined in the form of a saturated aqueous solution, the process comprising: preparing moist spherical particles of the single substance by charging, as cores, crystalline particles or granulated particles of the single substance on a rotary disc in a processing vessel of a centrifugal tumbling granulating apparatus, wherein the granulated particles are prepared by granulating a powder of the single substance, and dispersing over the cores a powder of the single substance and simultaneously spraying on the cores a liquid such as water or the like while supplying slit air to provide a fluidized condition; and then fixation treating the moist spherical particles by drying them while spraying an aqueous solution of the single substance or the like on the spherical particles in a fluidized bed apparatus; to the spherical particle produced by the process; and to a pharmaceutical preparation and a food containing the spherical particle. 
Freund Industrial Co., Ltd. Shionogi & Co., Ltd.
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A23V B01J A23P A23L A61K B01J A23L
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Ikuo Yusuke Nagayoshi Toshiro Hisayoshi Yoshitaka
Tanai Suzuki Myo Fujii Kato Tomoda