Howard & Howard Attorneys PLLC
Acrylamide compounds and use thereof for inhibiting apoptosis
The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate of the compound, and to a composition comprising the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of the compound of Formula I, or the isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; and especially use for protecting cardiomyocyte, and for preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
CHINESE PLA GENERAL HOSPITAL
C A C C A A A A A A A A A A C C
C07C A61K C07D C07D A61P A61K A61K A61P A61K A61K A61K A61K A61K A61K C07D C07D
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Zhibing Ruijun Kunluu Jie Long Lili Song Chunlei Juan Wu Guoliang Junhai Wei Xin Jie
Zheng Li He Wang Long Wang Li Liu Liu Zhong Hu Xiao Li Li Tang