Knobbe Martens Olson & Bear LLP
Macrocyclic inhibitors of hepatitis C virus replication
The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
InterMune, Inc.
Y C A A A C A A A A C C A A A
Y02A C07D A61P A61P A61K C07K A61K A61K A61P A61K C07D C07K A61K A61K A61P
additional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional
Bradley Yutong Bin Steven W. Robert C. Todd Scott D. Michael Pierre Paul Andreas Lawrence M. Tarek Timothy April Weidong
Barnett Jiang Wang Andrews Kaus Eary Seiwert Lyon Martin Nichols Schumacher Blatt Sammakia Kercher Kennedy Liu