Reed Smith Shaw & McClay LLP
Low oxygen affinity mutant hemoglobin
 A non-naturally occurring mutant hemoglobin (.alpha.96Val.fwdarw.Trp) is provided that has a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. The mutant hemoglobin is preferably obtained by recombinant DNA techniques. Such a mutant hemoglobin may be used as a component of a blood substitute. 
Carnegie Mellon University
A C A
A61K C07K A61P
additional inventional inventional
Hyun-Won Tong-Jian Chien
Kim Shen Ho