Schwegman, Lundberg, Woessner & Kluth, P.A.
Heterocyclic topoisomerase poisons
The invention provides compounds of formula I: wherein R1 to R5 have any of the values defined in the specification, as well as pharmaceutically acceptable salts of the compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds, compositions, or salts to treat cancer. In embodiments, R4 and R5 taken together can be a 3, 4, or 5 membered saturated or unsaturated chain comprising members selected from the group consisting of non-peroxide oxygen, sulfur, N(X), and carbon, optionally substituted by oxo; wherein each X is independently absent or is H, 0, (C1-C4)alkyl, phenyl or benzyl; and wherein at least one of the chain members is an N&#8212;H group.
Rutgers, The State University of New Jersey
A A C A C A
A61P A61K C07D A61K C07D A61K
inventional inventional inventional inventional inventional inventional
Jung Sun Edmond J. Leroy Fong
Kim La Voie Liu