Aryl-substituted nitrogen-containing heterocyclic compounds
Disclosed is an aryl-substituted nitrogen-containing heterocyclic compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof. This compound serves as nociceptin receptor antagonist and is useful as a pharmaceutical agent for treating diseases associated with a nociceptin receptor. (I)[in the formula, A1, A2 and A3 independently represent a carbon atom or a nitrogen atom, and one or two of A1, A2 and A3 represent a carbon atom; R1 represents a lower alkyl group or the like; R2 represents a phenyl group which may be substituted with a halogen atom or the like; R3 represents a hydrogen atom, a lower alkyl group or the like; and R4 represents a lower alkyl group or the like.]
Banyu Pharmaceutical Co., Ltd.
A C C A A A C A C A A A A A C A A A
A61P C07D C07D A61P A61P A61P C07D A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Tomohiro Osamu Hirokatsu Satoshi Hisashi Kensuke
Tsujita Okamoto Ito Ozaki Ohta Kobayashi