Method of treating inflammation, allergy and asthma with a purified extract (ATC2) isolated from Pseudolysimachion rotundam var. subintegrum containing abundant amount of active ingredient
The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of Pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY YUNGJIN PHARMACEUTICAL CO., LTD
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Dae-hee Sei-ryang Doo-young Ok-kyoung Hyeongkyu Ji-seok Kyung-seop Hyuk-hwan Yongnam Byung-hwan Jung-hee
Shin Oh Kim Kwon Lee Yoo Ahn Song Lee Ryoo Kim