Process for the preparation of epothilone analogs
The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
Bristol-Myers Squibb Company
C A C A A A C A A A
C07D A61P C07D A61P A61P A61P C07D A61P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
John E. Shankar Zhenrong Wen Sen
Thornton Swaminathan Guo Li