2-amino-quinoline derivatives useful as inhibitors of β-secretase (BACE)
The present invention is directed to novel 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of β-secretase, also known as β-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.
Janssen Pharmaceutica N.V.
A A C A C C A
A61P A61P C07D A61P C07D C07D A61P
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Christopher J. Chih Yung Ellen Yifang Chi Tina Morgan Tianbao Allen B. Ellen Charles H.
Creighton Ho Sieber-McMaster Huang Luo Ross Lu Reitz Baxter Reynolds