Factor XIa inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Merck Sharp & Dohme Corp.
A C A A A C C A
A61K C07D A61P A61P A61K C07D C07D A61K
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Alan Remond Wanying Scott D. Amjad Sung-Sau Weiguo Ying-Duo Eric Linda L. Santhosh F.
Hruza Moningka Sun Edmondson Ali So Liu Gao Mertz Brockunier Neelamkavil