Genentech, Inc.
Triazolopyridine JAK inhibitor compounds and methods
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of JAK kinase activity in a patient are disclosed.
Genentech, Inc.
C A A A A A A A A A A A A A A A A A A A A A A A A A A A A A C A A A
C07D A61P A61P A61P A61P A61P A61K A61P A61P A61P A61P A61P A61P A61P A61K A61P A61P A61P A61P A61P A61P A61P A61P A61K A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Xu Wendy Bing-Yan Xiao Zheng Joseph P. He Richard Jun Zhao Christopher Steven R. Michael
Xing Liu Zhu Yisong Jifu Lyssikatos Haiying Pastor Liang Junping Hurley Magnuson Siu