Nixon & Vanderhye P.C.
Water-soluble isatin derivative, and manufacturing method and application thereof
A novel type of water-soluble isatin derivatives, and manufacturing method and application thereof. An isatin derivative comprising a phenolic hydroxy group is used as the substrates. A dimethylaminomethylene group is introduced to an ortho position of the phenolic hydroxy group to significantly improve the water solubility of a class of compounds provided by the invention. An antitumor activity study showed that the activity of the class of compounds was not reduced, and even improved. The class of compounds has great prospects for applications in developing an antitumor pharmaceutical product.
Tianjin University of Science & Technology
A C
A61P C07D
inventional inventional
Dong Yuan Peng Longfei Jing Qian Yuou
Wang Yuan Yu Miao Wang Zhang Teng