Useful combinations of monobactam antibiotics with beta-lactamase inhibitors
A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
Basilea Pharmaceuticals AG
A A A A A A C A C A C A A C A C Y A C C A A A A A A A
A61K A61K A61P A61K A61K A61K C07D A61K C07D A61K C07D A61P A61K C07D A61K C07D Y02A A61K C07D C07D A61P A61K A61K A61K A61K A61K A61K
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Bérangère Eric Patrick Malcom G. P.
Gaucher Desarbre Roussel Page