Process for making fluorinated 4-azasteroid derivatives
The present invention relates to synthetic processes useful in the preparation of fluorinated 4-azasteroid derivatives that modulate androgen receptors and have application in the treatment of conditions caused by androgen deficiency or androgen receptor hyperactivity, such as osteoporosis, periodontal disease, bone fracture, frailty, erectile dysfunction, loss of libido, androgen-dependent cancers and sarcopenia. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.
Merck & Co., Inc
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A61P A61P A61P A61P C07J A61P A61P C07D A61P C07D A61P
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Frederick W. Benjamin T. Wenjie Lushi Nobuyoshi
Hartner Dorner Li Tan Yasuda