Schlee IP International, P.C.
Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery
A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 μm droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.
Kaer Biotherapeutics Corporation
B A A A A A A A
B01D A61M A61M A61M A61M A61M A61M A61M
inventional inventional additional additional inventional inventional additional additional
Donovan B. Jinghai Guanglin
Yeates Yi Li