Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
Diacylglycerol acyltransferase inhibitors
Provided herein are compounds of the formula (I):were RI is phenyl, R2 is hydrogen, halogen or lower alkyl, X is carbon on nitrogen, and R3 is isoquinoline, -amino, or a -4- to 6-membered heterocycloalkyl ring and pharmaceutically acceptable salts thereof, which are active as DGAT inhibitors and therefore find uses in treatment of diseases associated with abnormal metabolism of trigliceride. such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
Madrigal Pharmaceuticals, Inc.
A C C A A C C C C C A C C A C
A61P C07D C07D A61P A61P C07D C07D C07D C07D C07D A61P C07D C07D A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Nicholas David Robert Yimin Matthew Michael Lee Apostle Adrian Wai-Hing
Marcopulos Bolin Qian Hamilton McDermott Cheung