Brumbaugh, Graves, Donohue & Raymond
Method for predicting the tendency of a protein to form amphiphilic .alpha. .beta. structure
 The present invention relates to a method for predicting the tendency of a protein to form amphiphilic .alpha. or .beta. structure, wherein a series of values for U are calculated for spans of x residues, where the equation EQU U.sub..alpha.x =H.sub.x +.mu..sub..alpha.x -<pt> is used to predict regions of amphiphilic .alpha. structure and the equation EQU U.sub..beta.x =H.sub.x +.mu..sub..beta.x <pt> is used to predict regions of amphiphilic .beta. structure, and where H.sub.x is the average hydrophobicity for a span of x residues, .mu..sub.x is the hydrophobic moment, and <pt> is the position dependent turn propensity. When the values for U.sub..alpha.x and U.sub..beta.x are represented graphically, peaks are predicted to represent regions of .alpha. and .beta. structure, respectively. 
The Trustees of Columbia University in the City of New York
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C07K C07K
inventional inventional
Min Ferenc Jorge Pavel Jun
Cheung Czegledy Fischbarg Iserovich Li