Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors
Novel compounds are provided which are 1 1-beta-hydroxysteroid dehydrogenase type I inhibitors. 1 1-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 1 1-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: W-L-Z or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein W, L are defined herein and Z is selected from the following bicyclic heteroaryl groups: (a), (b), (c), (d).
Bristol-Myers Squibb Company
A A A C A A A A A A A A A C A A A A A A
A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P
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James J. Jun Lawrence G. Haixia Stephen P. Lawrence J. Jeffrey A.
Li Li Hamann Wang O'Connor Kennedy Robl