Scully, Scott, Murphy & Presser, P.C.
Crystalline form I of 3,4′5-trihydroxy-stilbene-3-β-D glucoside
The present invention relates to a novel crystalline form of a Compound 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside (polydatin) and a method of preparation and use thereof, and to a pharmaceutical composition containing crystalline form I of 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside. Crystalline form I of 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside of the present invention has a stable crystalline morphology, a definite melting point and a good chemical stability. Such a novel form of 3,4′,5-trihydroxy-stilbene-3-β-D-glucoside possesses the properties required for the preparation of solid formulations and is easily tabletable and readily formable when formulated, which allows for substantial decrease in raw materials costs, more facile operations in production and easier control over quality in industrial drug production, and moreover, better convenience in storage.
Shenzhen Neptunus Pharmaceutical Holdings Co., Ltd.
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A61P C07H A61P A61P A61P A61P A61P A61P
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Hong Dan Jing Lijuan Jinhua Yong Yu Cunfang Guanghui Hui Chuangui Milai Weizhen Lin Hanlin
Chen Zhu Li Zhang Zhao Li Man Wang Yao Kang Huang Yin Zeng Yu Feng