Greenberg Traurig LLP
Method for pulverizing to fine powder
The present invention has for its object to provide a method of micronizing (E)-4-[2-[2-[N-acetyl-N-(4 -methoxybenzenesulfonyl)amino]phenylethenyl]pyridine 1-oxide while maintaining its crystalline.The present invention relates to a method of micronizing the above compound characterized in that the compound is comminuted, for example, to the extent that the mean particle diameter of the compound will be 1˜25 μm with 50 μm and larger particles accounting for 2% or less with a mill of the open-circuit pulverizing type.
Nippon Shinyaku Co., Ltd.
A A A A C A A
A61J A61K A61K A61K C07D A61K A61P
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Tetuo Shuji
Yuki Watanabe