Pennie & Edmonds
Methods for controlling human endothelial cell proliferation and effector functions using oncostatin M
 The present invention is directed to the use of a recently discovered cytokine, Oncostatin M, to control endothelial cell immunogenicity, fibrinolytic activity and proliferation, and to its use in the treatment of a variety of human vascular and immune system disorders involving the vascular endothelium. The method of the invention includes the use of mature, hybrid, modified or truncated forms of Oncostatin M as well as Oncostatin M analogs. The invention is described by way of examples in which the efficacy of such compounds is evaluated using various in vitro assay systems. 
Oncogen
A A A A
A61K A61K A61K A61K
inventional inventional inventional inventional
Paul R. Thomas J.
Gladstone Brown