Sughrue, Mion, Zinn, Macpeak & Seas
Latex for immobilization of physiologically active substances for immuno nephelometry
 A latex for immobilization of a physiologically active substance is prepared by copolymerizing a monomer mixture comprising: PA0 (a) 100 parts by weight of an aromatic vinyl monome4r; PA0 (b) 0.01 to 5 parts by weight of a vinyl monomer having a sulfonic acid group; PA0 (c) 1 to 20 parts by weight of an .alpha.,.beta.-unsaturated carboxylic acid monomer; and PA0 (d) 0.05 to 5 parts by weight of a polyfunctional monomer for internal cross-linking; in water using a water-soluble radical polymerization initiator in the absence of an emulsifying agent. An antigen or antibody or a hapten can be covalently bound to particles of the latex to form a reagent for use in immuno nephelometry. 
Nitto Denko Corporation
Y Y G C Y C C
Y10S Y10S G01N C12N Y10S C08F C12N
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Tetsuo Kenjiro Takashi Yasuo
Watanabe Mori Tsuji Kihara