Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula Ior a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
3-Dimensional Pharmaceuticals, Inc.
A A A C A C A A A C A C A C A A C A A A A A A A A A C A C A A C A A A A A A A
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Jinsheng Kristi Sanath Heather Rae Nalin Wenxi M. Jonathan Farah Joan Hui Shelley K. Kenneth T. Jeremy M. Ehab Maxwell D. Mark
Chen Leonard Meegalla Hufnagel Subasinghe Pan Rudolph Ali Gushue Huang Ballentine Wilson Travins Khalil Cummings Wall