Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
Neuromedin U derivative
An object of the present invention is to provide a novel anorectic agent. Another object of the invention is to provide an NMU derivative which exhibits a high anorectic effect even when administered in a usual manner, for example, peripherally. These objects can be achieved by the compound represented by formula (I)or a salt thereof. In formula (I), Y represents a polypeptide containing an amino acid sequence set forth in SEQ ID NO.: 1 wherein 1 to 4 amino acids are substituted; X represents a methoxypolyethylene glycol; X′ is absent or represents a methoxypolyethylene glycol; and a moiety represented by formula:La-Lb-[Lc]j represents a linker.
Takeda Pharmaceutical Company Limited
A A C C
A61K A61P C07K C07K
additional inventional inventional inventional
Hiroshi Naoki Taiji
Inooka Nishizawa Asami