Buchanan Ingersoll & Rooney PC
Specific conjugation linkers, specific immunoconjugates thereof, methods of making and uses such conjugates thereof
The present invention relates to novel linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic (trans (E)- or cis (Z)-butenedioic), or acetylenedicarboxyl group for conjugation of a cytotoxic agent, and/or one or more different functional molecules per linker to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule specifically. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
HANGZHOU DAC BIOTECH CO., LTD.
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C07D C07D A61K A61K C07D C07D C07D A61K A61P C07D A61K A61K A61K A61K A61P A61K A61K A61K A61P A61K C07D
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Qianqian Qingliang Hongsheng Linyao Chen Yuanyuan Xiaomai Minjun Huihui Shun Robert Yongxin Junxiang Wenjun Zhixiang Hangbo Chengyu Zhicang
Tong Yang Xie Zhao Lin Huang Zhou Cao Guo Gai Zhao Jia Li Guo Ye Yang Ye