Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
Substituted pyridinone compounds as MEK inhibitors
The invention provides novel substituted heterocyclic compounds represented by Formula I and Formula II, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans.
CMG PHARMACEUTICAL CO., LTD.
C C C A C C
C07D C07D C07D A61P C07D C07D
inventional inventional inventional inventional inventional inventional
Jung Shin Jeongbeob Chul Yun Choung Soo Eun Kyung Gilnam Suk Young Hye Sun Jung Jin Bongcheol Jin Sung Ki Joon
Lee Seo Rhim Kim Choi Lee Cho Jeon Hwang Kim Kim Jeon