Tarolli, Sundheim, Covell & Tummino LLP
Compounds and methods of treating retinal degeneration
This application relates to compounds and methods of treating retinal degeneration associated with inherited rhodopsin mutations in the ocular tissue of a subject. The retinal degeneration, can include, for example, macular degeneration, a including age-related macular degeneration, Stargardt disease, and retinitis pigmentosa. The retinitis pigmentosa can include autosomal dominate retinitis pigmentosa associated with a P23H RHO mutation. A method of treating retinal degeneration in a subject includes administering to the subject a therapeutically effective amount of a compound of formula (I), wherein the compound of formula (I) acts as a chaperone of rhodopsin.
UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION CASE WESTERN RESERVE UNIVERSITY
A A A A
A61K A61P A61K A61K
inventional inventional inventional inventional
Krzysztof Yuanyuan
Palczewski Chen