Selective Bruton's tyrosine kinase inhibitor and use thereof
The present invention relates to a selective Bruton's tyrosine kinase (BTK) inhibitor compound, a pharmaceutical composition, preparation and use thereof in preparation of a drug. The compound of the present invention has a structure of Formula II or Formula II′:      Re is selected from H, CH3, C2-C6 alkyl, C1-C6 azaalkyl, and C1-C6 oxaalkyl, wherein CH3, C2-C6 alkyl, C1-C6 azaalkyl and C1-C6 oxaalkyl are further substituted with amino, hydroxyl, and C1-C3 alkyl;  Y1, Y2, Y3 and Y4 are independently selected from C(Rf) and N, and at least one of Y1, Y2, Y3 and Y4 is N, wherein Rf is selected from H, halogen, C1-C3 alkyl, —CF3, and —CF2H. 
HANGZHOU HERTZ PHARMACEUTICAL CO., LTD.
A A A C A A A A A A A A
A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61K A61K
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Miao Xinglu Xingguo
Hu Zhou Liu