Kilyk & Bowersox, P.L.L.C.
Method of identifying compounds that inhibit fertilization
A method of identifying compounds that inhibit fertilization is provided. The method can include selecting compounds that bind to equatorin protein. Two types of equatorin protein, a long form and a short form, can be present in the testis. The amino acid sequence of mouse equatorin from positions 101 to 146 including the 138th O-glycosylated threonine residue contains an epitope recognized by anti-equatorin antibody MN9 that has an effect of inhibiting fertilization. In addition, the MN9 antibody also binds to human sperm. Compounds that bind to the epitope can inhibit fertilization. Both forms of mouse equatorin can be used as well as human equatorin to identify compounds that inhibit fertilization.
National University Corporation Chiba University
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inventional inventional additional
Keiichi Chizuru Kenji Kiyotaka
Yoshida Ito Yamatoya Toshimori