Parkhurst & Oliff
Glycoproteins and processes for their production
 A glycoprotein obtained from the cells of human or non-human warm-blooded animals having an anti-tumor effect and characterized by the following properties: PA1 (a) molecular weight: in the range from 7,000 to 90,000 by Sephadex gel filtration or SDS gel electrophoresis; PA1 (b) color reactions: it exhibits a color indicating proteins in the Lowry reaction, exhibits a color indicating peptide bonds and amino acids in the ninhydrin reaction after hydrolysis with hydrochloric acid, and exhibits a color indicating sugars in the phenol-sulfuric acid reaction, the anthrone-sulfuric acid reaction, the indole-sulfuric acid reaction and the tryptophane-sulfuric acid reaction; PA1 (c) appearance and solubility: white powder soluble in water, aqueous sodium chloride and phosphate buffer, and sparingly soluble in benzene, hexane and chloroform; PA1 (d) sugar content: sugar content is 8-45%, 6-28% of the total sugar being hexoses, 1-11% being hexosamines and 1-6% being sialic acids; PA1 (e) stability: stable in an aqueous solution of pH 2.0, pH 7.0 or pH 11.0 at 4.degree. C. for 24 hours or longer and in an aqueous solution of pH 7.0 at 60.degree. C. for 3 hours or longer; and PA1 (f) cytotoxicity: it selectively damages tumor cells without substantially damaging normal cells. 
Mochida Pharmaceutical Co., Ltd.
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C07K Y10S C07K Y10S Y10S Y10S A61K
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Kazuo Haruo Yasuo Ei Nobuo
Yamaguchi Ohnishi Suzuki Mochida Mochida