Muirhead & Saturnelli, LLC
Generation and use of a catalog of polypeptide-related information for chemical analyses
A method (100) for performing chemical analyses includes digesting a reference sample to obtain precursors associated with a peptide in the sample (110), separating the precursors to determine values associated with retention times of the separated precursors (120), ionizing the separated precursors to form precursor ions (130), mass analyzing the precursor ions to determine values associated with mass and with ion intensity (140), and storing a <fcfile of the polypeptide defined by the determined values (150). A subject sample is analyzed (160), and the polypeptide is detected in the subject sample in response to a match between subject-sample and profile values. An apparatus (900) for performing chemical analyses includes a chromatography module (904), a mass-spectrometry module (912), and a computer module (926).
Waters Technologies Corporation
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G01N G01N G01N G01N H01J G01N G01N C12Q G01N G01N G01N
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Marc V. Jeffrey Cruz Guo-Zhong Scott
Gorenstein Silva Li Geromanos