Fenwick & West LLP
Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Amgen Inc.
A A A A A A A C A A A A A
A61K A61K A61P A61K A61P A61K A61K C07K A61P A61K A61P A61K A61K
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Jeonghoon Lei-Ting Tony Keith Soo-Nyung Huiquan Xiaolan
Sun Tam Kwak Han Zhou