Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
Omeros Corporation Institute of Materials Research and Engineering
A A A A A A A A A A B A A A A A A
A61L A61L A61K A61L A61K A61L A61K A61L A61P A61L B82Y A61L A61K A61K A61K A61L A61K
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Xiping Xu Kam W. Jun
Ni Li Leong Li