Townsend and Townsend and Crew
Optical fluorescent imaging
Compounds and methods are disclosed that are useful for noninvasive imaging in the near-infrared (NIR) spectral range. The NIR is highly sensitive for tumor detection and tracking. The application discloses targeting a tumor-enriched cell surface receptor with a ligand-conjugated fluorescent probe, which specifically allows detection of the tumor relative to the negligible animal autofluorescence.
Li-Cor, Inc.
C C C C A C A A C
C07D C08B C07K C07D A61K C09B A61K A61K C07D
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William M. D. Michael Jiyan Ananda G. Joy Xinshe Narasimhachari Daniel R.
Volcheck Olive Chen Lugade Kovar Xu Narayanan Draney