DLA Piper LLP (US)
Transgenic non-human animals expressing a truncated activin type II receptor
The present invention provides a substantially purified growth differentiation factor (GDF) receptor, including a GDF-8 (myostatin) receptor, as well as functional peptide portions thereof. In addition, the invention provides a virtual representation of a GDF receptor or a functional peptide portion thereof. The present invention also provides a method of modulating an effect of myostatin on a cell by contacting the cell with an agent that affects myostatin signal transduction in the cell. In addition, the invention provides a method of ameliorating the severity of a pathologic condition, which is characterized, at least in part, by an abnormal amount, development or metabolic activity of muscle or adipose tissue in a subject, by modulating myostatin signal transduction in a muscle cell or an adipose tissue cell in the subject. The invention also provides a method of modulating the growth of muscle tissue or adipose tissue in a eukaryotic organism by administering an agent that affects myostatin signal transduction to the organism.
The Johns Hopkins University School of Medicine
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C12N A61P A01K A61P A61P A01K A61P G01N A61P A01K C12N A01K A01K A61P C12N G01N A01K A61P A61P A61K C12N A01K C07K A01K A01K A01K A01K A01K A61K C12N A01K A61P A61P A01K G01N A61P A01K C07K C07K
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Se-Jin Alexandra C.
Lee McPherron