Finnegan, Henderson, Farabow, Garrettt & Dunner, LLP
Cationic amphiphile compositions for intracellular delivery of therapeutic molecules
 Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. By this invention, such cationic amphiphile is used in a state in which it is capable of accepting additional protons, i.e., it is not fully protonated. For purposes of this invention, cationic amphiphiles may be considered to encompass four general categories: (A) T-shaped/steroid-based amphiphiles; (B) T-shaped/non steroid-based amphiphiles; (C) non T-shaped/steroid based amphiphiles and (D) non T-shaped/non steroid-based amphiphiles. 
Genzyme Corporation
A A C C A C C A A C
A61K A61K C07J C12N A61K C07J C07J A61K A61K C07J
additional inventional inventional inventional inventional inventional inventional inventional inventional inventional
John Simon J. David J. Ronald K. Edward R. Seng H. Chau-Dung Craig S.
Marshall Eastman Harris Scheule Lee Cheng Chang Siegel