Brinks Gilson & Lione
Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
Disclosed herein are compounds of formula (I)wherein L1, L2, L3, R1, R4, R5, and R6 are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, osteoporosis, bone fracture, periodontal bone loss, orthopedic implant, alopecia, neuropathic pain, and related disorders. Pharmaceutical compositions and methods of treating conditions or disorders are also described.
CAYMAN CHEMICAL COMPANY, INC.
C A C C C
C07D A61P C07D C07D C07D
inventional inventional inventional inventional inventional
Kirk M. Adam Fred Lawrence Andriy Stephen Douglas Thomas Allen Bradlee David Gregory William James Paul
Maxey Uzieblo Ciske Kornilov Barrett Owen Germain Endres O'Malley