Dock-and-lock (DNL) complexes for therapeutic and diagnostic use
Disclosed herein are methods and compositions dock and lock (DNL) complexes comprising an AD moiety selected from an AKAP protein and a DDD moiety selected from a protein kinase A regulatory subunit. Also disclosed are fusion proteins comprising an AD moiety or DDD moiety attached to an effector moiety. The DDD moieties form dimers that bind to the AD moiety to form the DNL complexes. The effector moieties may be selected from a wide range of known effector moieties that produce one or more physiological effects, including but not limited to cell death. The DNL complexes may further comprise one or more diagnostic and/or therapeutic agents. The DNL complexes are of use for treating and/or diagnosing a variety of diseases or conditions.
IBC Pharmaceuticals, Inc.
C C C C A A C C A C C A C C C A C C C C A
C07K C07K C07K C07K A61K A61K C07K C07K A61K C07K C07K A61K C07K C07K C07K A61K C12N C07K C07K C07K A61K
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David M. Chien-Hsing
Goldenberg Chang