Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
 The present invention is directed to compound of the formula I: ##STR1## PA1 wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y, and ##STR2## PA1 are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds. 
Syntex (U.S.A.) Inc. Agouron Pharmaceuticals, Inc.
C C C C C C C A C C C C C C C C
C07D C07D C07D C07K C07K C07D C07D A61K C07D C07D C07D C07K C07D C07D C07D C07D
inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional
Jian Jeffrey Melwyn A. Judith G. Arlindo L. Roland J. Wesley K. M. Steven L.
Chen Abreo Deal Castelhano Billedeau Chong Bender