Panitch Schwarze Belisario & Nadel LLP
Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof
Amide derivatives and pharmaceutically acceptable salts thereof, preparation method thereof and medicinal application thereof are provided. Specifically, amide derivatives represented by general formula (I) are provided. The amide derivatives represented by general formula (I) can be used as a therapeutic agent, particularly as an inhibitor for microsomal prostaglandin E synthase-1 (mPGES-1), and also to treat and/or prevent diseases or illnesses such as inflammation and/or pain etc. The definition of each substituent group in general formula (I) is the same as the definition in the description.
Jiangsu Hengrui Medicine Co., Ltd. Shanghai Hengrui Pharmaceutical Co., Ltd.
A A A A A C C A A A A C A C C A C C A A A A C C C A A A A C C A C A A C C A
A61P A61P A61P A61P A61P C07C C07D A61P A61P A61P A61P C07D A61P C07D C07D A61P C07C C07D A61P A61P A61P A61P C07D C07C C07D A61P A61P A61P A61P C07D C07D A61P C07D A61P A61P C07D C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Bin Xin Qiyue Xianbo Fangfang Piaoyang Wei Qing
Wang Li Hu Liu Jin Sun He Dong