McCarter & English, LLP
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
Disclosed are compounds represented by Formula (I):or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof and methods of inhibiting 11β-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.
Vitae Pharmaceuticals, Inc.
A A A C A A C A A A A A A C A A A A C A A A C C A A A A A C C A C
A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P C07D A61P A61P A61P C07D C07D A61P A61P A61P A61P A61P C07D C07D A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Linghang Yuanjie David A. Zhenrong Salvacion Katerina Colin M. Suresh B. Gerard Wei Wei
Zhuang Ye Claremon Xu Cacatian Leftheris Tice Singh McGeehan Zhao He