Substituted sulfonamide compounds
The invention is concerned with the compounds of formula (I):and salts thereof, wherein X, Y, Z, R1, R2, R3, R3′, R4, R5 and R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.
Hoffmann-La Roche Inc.
A C A C C C C C A C C C C C C C A A C A C A C A C C A A C A C
A61P C07D A61P C07D C07D C07D C07C C07D A61P C07D C07D C07D C07C C07C C07D C07D A61P A61P C07D A61P C07C A61P C07D A61P C07C C07D A61P A61P C07D A61P C07D
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Joseph P. Shaoqing Yimin Christine E. Allen John Kyungjin Lin Huifen Zhi Shawn David Sung-Sau Peter Michael Anthony Hongju
Lyssikatos Chen Qian Brotherton-Pleiss Lovey Kim Yi Chen Chen Erickson So Wovkulich Estrada Li