Method of treating inflammation, allergy and asthma with a purified extract (ATC1) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient
The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of Pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.
YUNGJIN PHARMACEUTICAL CO., LTD KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
A A A A A A A A A A A A A A A
A61K A61K A61K A61K A61K A61K A61K A61K A61K A61K A61K A61K A61K A23L A61K
inventional additional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Hyuk-hwan Sei-ryang Ok-kyoung Kyung-seop Ji-seok Yongnam Dae-hee Doo-young Byung-hwan Jung-hee Hyeongkyu
Song Oh Kwon Ahn Yoo Lee Shin Kim Ryoo Kim Lee