Baker & Hostetler LLP
Base-catalyzed silylation of terminal alkyne C—H bonds
The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.
California Institute of Technology
C C C C C C
C07J C07J C07J C07J C07F C07F
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Anton Brian M. Wenbo Kerry Robert H.
Toutov Stoltz Liu Betz Grubbs