Ohlandt, Greeley, Ruggiero & Perle, L.L.P
Composition comprising an extract of Tiarella polyphylla and tiarellic acid isolated therefrom having antiinflammatory, antiallergic and antiasthmatic activity
The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
Korea Research Institute of Bioscience and Biotechnology
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C07J A61P A61P A61P A23L A61K
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Byung Sun Doo Young Joo Heon Gyoon Hee Hea Young Eun Ah Jung Hee Guang Hai Bo Young Sei Ryang So Young Gun Cheol Soon Ja Kyung Seop Mi Jin Gui Hua Joong Ku Sang Ku Hyeong Kyu Ok Kyoung
Min Kim Kim Han Park Kim Kim Shen Park Oh Kim Kim Choi Ahn Kim Quan Lee Lee Lee Kwon