Rossi, Kimms & McDowell LLP
Fusion proteins containing recombinant cytotoxic RNAses
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.
Immunomedics, Inc.
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Edmund A. Hans J. Sailaja S. Chien-Hsing Ken David M.
Rossi Hansen Vanama Chang Goldenberg