Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
This invention relates to a series of arylsubstituted piperazines, of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease.
Ortho-McNeil Pharmaceutical, Inc.
C C C C A C C A
C07D C07D C07D C07D A61P C07D C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional
Linda Cynthia Virginia Frank Linda Allen Xiaobing William
Jolliffe Maryanoff Pulito Villani Mulcahy Reitz Li Murray