Emory University
PGAM1 inhibitors and methods related thereto
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.
Emory University
C C C C C A A A C
C09B C07K C07K C09B C07C A61P A61K A61K C07C
inventional inventional additional inventional inventional inventional inventional inventional additional
Jing Sumin Taro
Chen Kang Hitosugi