K&L Gates LLP
Indolyl-substituted pyrazino[1,2-b]isoquinolines for cancer treatment
The disclosure describes compounds of formula I,wherein the wedged bonds, R1, R2, R3, R4, R5, R5a, R6, R7, R8, R9, R10, R11, R12, R13, R14, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier.
EVEREST BIOSCIENCES, INC.
C A A A A C A C
C07D A61K A61P A61P A61P C07D A61P C07D
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Martin Rikard Jenny Olov
Johansson Larsson Persson Sterner