Newport IP, LLC
Polynucleotide sequencer tuned to artificial polynucleotides
Artificial polynucleotides may have different characteristics than natural polynucleotides so conventional base-calling algorithms may make incorrect base calls. However, because artificial polynucleotides are typically designed to have certain characteristics, the known characteristics of the artificial polynucleotide can be used to modify the base-calling algorithm. This disclosure describes polynucleotide sequencers adapted to sequence artificial polynucleotides by modifying a base-calling algorithm of the polynucleotide sequencer according to known characteristics of the artificial polynucleotides. The base-calling algorithm analyzes raw data generated by a polynucleotide sequencer and identifies which nucleotide base occupies a given position on a polynucleotide strand.
Microsoft Technology Licensing, LLC
G C G G
G16B C12Q G16B G16B
inventional inventional inventional inventional
Karin Luis Bichlien Robert Yuan-Jyue Hsing-Yeh Siena Dumas
Strauss Ceze Nguyen Carlson Chen Parker Ang