Cesari and McKenna LLP
Hydroxy acid ester compound of substituted phenol, preparation method and medical use thereof
Hydroxy acid compound of substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), Y═C1-4 straight carbon chain. The compound can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has sedative, hypnotic and/or anesthetic effect. By protecting the hydroxyl group of 2, 6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2, 6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis, and/or anesthesia.
West China Hospital, Sichuan University
C A C A A C C
C07C A61P C07C A61P A61P C07C C07C
inventional inventional inventional inventional inventional inventional inventional
Jun Jin Wensheng
Yang Liu Zhang