Substituted biphenyl carboxylic acids and derivatives thereof
The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, and R10 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
Ortho-McNeil Pharmaceutical, Inc.
C A C A
C07C A61P C07C A61P
inventional inventional inventional inventional
Yan Andrew Jess Cyrille Francis Valerie Alison Richard John Kathryn Mihiro Chih Yung Remedios Jeremy Adeline Svenja
Zhang Cansfield Taylor Boussard Wilson Reader Reid Harrison Smelt Sunose Ho Hernadez-Perni Major LeFormal Burckhardt