Spencer & Frank
Peptidomimetic inhibitors of cathepsin D and plasmepsins I and II
 The present invention relates to the design and synthesis of linear and cyclic inhibitors of cathepsin D and plasmepsins I and II. The present invention also relates to the uses of these inhibitors for inhibiting invasion and metastasis of cancerous cells. The present invention further relates to the use of cathepsin D and plasmepsin I and II inhibitors for the prevention and treatment of Alzheimer's disease and malaria. 
The United States of America as represented by the Department of Health and Human Services
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A61K Y02A A61P A61P C07K C07K C07K A61P
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Sergei Pavel John Jack
Gulnik Majer Erickson Collins