Christensen O'Connor Johnson Kindness PLLC
Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
Merck Sharp & Dohme Corp.
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G16B G16B C12N C12N G16B G16B G16B G16B C12N C12N
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Julja Guy L. Peter S. Aimee L. Ge Steven R.
Burchard Cavet Linsley Jackson Wei Bartz