IPro, PLLC
Method for do novo biosynthesis of chondroitin sulfate
The present invention relates to a method for chondroitin sulfate biosynthesis, belongs to the field of pharmaceuticals. CS was biosynthesized by sulfating the chondroitin with C4ST or C6ST in Tris-HCl buffer assisted with 3′-phosphoadenosine 5′-phophosulfate (PAPS). C4ST and C46ST came from bioengineered Escherichia coli or Pichia pastoris. Chondroitin came from bioengineered Bacillus subtilis 168.
JIANGNAN UNIVERSITY
C C C C
C12P C12Y C12Y C12N
inventional inventional inventional inventional
Zhengxiong Jian Guocheng Zhen
Zhou Chen Du Kang