Intellectual Property Connections, Inc.
Hepatitis B therapeutic vaccines
A fusion protein for use as a hepatitis B therapeutic vaccine is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen comprising a hepatitis B virus X protein deletion mutant that lacks amino acids (aa) at least from as 21 to as 50. The protein transduction domain is a fusion polypeptide comprising a T cell sensitizing signal-transducing peptide, a linker, and a translocation peptide. The APC-binding domain or the CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen is located at the C-terminus of the protein transduction domain.
TheVax Genetics Vaccine Co., Ltd.
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C07K C07K C12N C12N A61P A61K A61K A61K C07K A61K C07K A61K A61P C07K C07K A61K A61K C12N C07K C12N
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Fu-Hsien Jiun-Ming Yi-Chia Wei-Hsiang Kung-Lung Chia-Kuan Cheng-Yung Chia-Hao Yi-Tsui Chia-Mao Wei-Lun Hsiang-Kai
Chiang Wu Lin Lin Lee Peng Chang Kang Chiu Wu Chang Lin