McDonnell Boehnen Hulbert & Berghoff LLP
Benzimidazole and pyridylimidazole derivatives
This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula IThe invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
Neurogen Corporation
A C C C C C A A A C A A C C C C C C A C A C C A C C A
A61P C07D C07D C07D C07D C07D A61P A61P A61P C07D A61P A61P C07D C07D C07D C07D C07D C07D A61P C07D A61P C07D C07D A61P C07D C07D A61P
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Spiros Manuka Kevin S. George D. Jun Guolin Kyungae Pamela George P. Guiying Scott Martin Patrick Linda M. Ling Hong Alan Nian
Liras Ghosh Currie Maynard Yuan Cai Lee Albaugh Luke Li Mitchell Allen Gustavson Xie Hutchison Liu