Myers Bigel Sibley & Sajovec
Hepatitis A virus deletion mutants and vaccine formulations containing the same
 Disclosed are live hepatitis A virus deletion mutants having a deletion mutation in the 5' nontranslated region of the viral genome. The deletion mutation may be selected from the group consisting of (a) pY1 deletion mutations that cause the virus to retain the ability to replicate in monkey kidney cells; and (b) deletion mutations between nucleotides 140 and 144 that render the virus temperature sensitive. Advantageously, the deletion mutation may be an attenuating mutation. Pharmaceutical formulations containing such viruses are disclosed, along with the use thereof to produce antibodies useful for diagnostic purposes and for imparting protective immunity against hepatitis A virus. 
The University of North Carolina at Chapel Hill
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Y02A C12N C07K C12N A61K C12N C12N
additional inventional inventional additional additional additional additional
Stanley M. David R.
Lemon Shaffer