Hunton Andrews Kurth LLP
Minimal saponin analogues, synthesis and use thereof
Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.
MEMORIAL SLOAN-KETTERING CANCER CENTER
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A61K A61K C07H A61K C07H A61P C07H A61K A61K A61P
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Jeffrey R. Alberto David Y. NagaVarakishore Eric K. Jason S. Derek S.
Gardner Fernandez-Tejada Gin Pillarsetty Chea Lewis Tan