Sterne, Kessler, Goldstein & Fox P.L.L.C.
Compositions and methods for diagnosing and treating cancer
Monoclonal antibodies that specifically bind to an extracellular domain of human Jagged 1 and inhibit growth of a tumor comprising cancer stem cells are described. Also described is a method of treating cancer that comprises administering a therapeutically effective amount of a monoclonal anti-Jagged 1 antibody.
OncoMed Pharmaceuticals, Inc.
C C A A A
C07K C07K A61P A61K A61K
inventional inventional inventional additional additional
Maureen Timothy Austin Sanjeev
Fitch Bruhns Hoey Gurney Satyal