Michael Best & Friedrich LLP
Bryostatin analogues and methods of making and using thereof
Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
UNIVERSITY OF UTAH RESEARCH FOUNDATION
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C07D A61P C07D C07F A61K C07D C07F C07D A61K A61P C07D C07F A61P C07D
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Wei Matthew B Jonathan A Dennie Yam Gary E Carina C Anh P
Li Kraft Covel Welch Poudel Keck Sanchez Truong