Fish & Neave IP Group Ropes & Gray, LLP
Aryl boronate functionalized polymers for treating obesity
Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas:Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid.Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.
Genzyme Corporation
A A C C C A A C C
A61K A61K C08G C08F C08G A61P A61K C08G C08F
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Steven Craig Xinhua Stephen Randall W. Harry Chad Cori Pradeep K.
Polomoscanik Li Holmes-Farley Mandeville, III Huval Dhal