Stereoselective reductive amination of ketones
Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
Bristol-Myers Squibb Company
C C C C C
C12P C12N C12N C12P C12P
inventional inventional inventional inventional inventional
Ramesh Keith John J. Steven Ronald Wen-Sen Paul A. Mary Jo Laszlo J.
Patel Ramig Venit Goldberg Hanson Li Jass Donovan Szarka