Sterne, Kessler, Goldstein & Fox P.L.L.C.
Diagnosis and treatment of cancer using anti-EREG antibody
Methods that entail detection of an epiregulin (EREG) protein for cancer diagnosis are disclosed. In colon cancer, lung adenocarcinoma, pancreatic cancer, stomach cancer, and kidney cancer, the gene and protein expressions of EREG were frequently found to be elevated. Antibodies that recognize an EREG protein are used for diagnosing or treating cancer in the present invention. Pharmaceutical compositions, cell proliferation inhibitors, and anticancer agents containing an EREG-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in EREG-expressing cells and methods of suppressing the proliferation of EREG-expressing cells by contacting the EREG-expressing cells with EREG-binding antibodies are also disclosed.
The University of Tokyo Chugai Seiyaku Kabushiki Kaisha
C C A A A C A G A C G A C A A C C
C07K C07K A61P A61P A61P C07K A61P G01N A61K C07K G01N A61P C07K A61P A61P C07K C07K
additional inventional inventional inventional inventional additional inventional inventional inventional additional additional inventional additional inventional inventional additional additional
Hiroyuki Kenji Hirotaka
Aburatani Yoshida Ito