Nixon Peabody LLP
Labeling hydroxymethylated residues
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
CHILDREN'S MEDICAL CENTER CORPORATION THE UNTTED STATES OF AMERICA AS REPRESENTED, BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
C C C C G C C C C C G C C G C C
C12Q C12N C12Q C12N G01N C12Q C12Q C12Q C12N C12Q G01N C12N C12Q G01N C12Q C12N
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Aravind Suneet Mamta Anjana Kian Peng
Iyer Agarwal Tahiliani Rao Koh