Kilpatrick Townsend & Stockton LLP
Antibodies to coagulation factor XIa and uses thereof
In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.
The Regents of the University of California Pfizer, Inc.
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Isaac J. Huilan Tovo Yun Shaun R. Thomas Lauren K.
Rondon Gao David Kim Coughlin Mikita Ely