Brinks Gilson & Lione
1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof
Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof.The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.
Institue of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A., China
A A A A A A A A A A A A A A A A A C A
A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P
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Peng Yongzhen Youzhi Nan Zengliang Li Cheng Hongxia Zhenzhen Juanjuan Rusheng Xiaodan Rui Rifang Yunfeng Liuhong Jiazhi
Li Li Zhang Zhao Jin Yuan Zhang Chen Wang Qin Zhao Xu Xue Yang Li Yun Yao