Bozicevic, Field & Francis LLP
Genetically modified mouse lacking diacylglycerol acyltransferase-1 (DGAT-1) activity
Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.
The United States of America as represented by the Department of Veterans Affairs The Regents of the University of California The J. David Gladstone Institutes
G A C G C C
G01N A61K C12N G01N C12P C12N
additional additional inventional inventional inventional inventional
Robert V. Sylvaine Hubert C. Steven J. Sandra K.
Farese, Jr. Cases Chen Smith Erickson