Piperazinyl substituted cyclohexane-1,4-diamines
The present invention relates to piperazine substituted cyclohexane-1,4-diamine compounds of Formula (I)and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as methods of treatment.
Janssen Pharmaceutica N.V.
C A A A
C07D A61P A61P A61P
inventional inventional inventional inventional
Shengjian George Steven A. Jingchun Peter J. Virginia L.
Li Chiu Middleton Liu Connolly Pulito