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malR-knockout Bacillus licheniformis strain, construction method and use
Provided are malR-knockout Bacillus licheniformis strain, a construction method and a use. Using a genetic engineering method, gene, namely, the malR gene, which is in charge of conducting the transcription of the carbon metabolism transcription factor MalR, in the genome of Bacillus licheniformis DW2 is knocked out, thereby successfully obtaining Bacillus licheniformis DW2ΔmalR, from which the malR gene has been deleted. In comparison with Bacillus licheniformis DW2, the strain obtained by the construction can improve the Bacitracin yield in a fermentation broth during Bacitracin fermentation by at least 23%.
C C C
C12P C12N C07K
inventional inventional inventional
Bowen Fei Shouwen Lijun Dongbo Xiangqi Junhui
Zhang Wu Chen Lou Cai Qiu Li