Parkhurst & Oliff
Method of producing .gamma.-globulin for intravenous injection and therapeutic agent produced thereby
 A method of producing .gamma.-globulin which can be administered intravenously without adverse reactions and loss of opsonic activity is provided. The method comprises treating .gamma.-globulin with pepsin or uropepsin in a neutral pH range of 6.0 to 7.5. The aggregates in .gamma.-globulin are selectively decomposed by the method of the present invention, while any decomposition of monomer .gamma.-globulin molecule is substantially prevented. A therapeutic agent for intravenous injection which is reduced its anticomplementary activity and is stabilized by adding uropepsin which serves simultaneously as a proteolytic enzyme and a stabilizer, to human .gamma.-globulin. Uropepsinogen can be also as a stabilizer. 
Mochida Pharmaceutical Co., Ltd.
C C A A
C12N C07K A61K A61K
inventional inventional inventional additional
Ei Yasuo Hiroshi Haruo
Mochida Suzuki Kosuzume Ohnishi