Jacobson Holman PLLC
Coordinated-control coenzyme Q10 fermentation production process based on online oxygen consumption rate and electrical conductivity
The present invention relates to an optimized fermentation process of coenzyme Q10, particularly to a fermentation process of coenzyme Q10 via flow feeding based on cooperative control of changes of online oxygen consumption rate and conductivity. During the fermentation process of coenzyme Q10 production strains, the oxygen consumption rate is controlled between 30-150 mmol/L·h and the conductivity is maintained between 3.0-30.0 ms/cm via flow feeding, so as to facilitate strain growth and the start of coenzyme Q10 synthesis and accumulation. The present invention can substantially increase output of coenzyme Q10 and greatly reduce the production cost with simple process control and strong operability, thus being applicable to large-scale industrial production.
SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD. ZHEJIANG NHU COMPANY LTD. ZHEJIANG UNIVERSITY
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C12N C12R C12N C12P C12Q
inventional additional additional inventional inventional
Weifeng Jianbo Shaofeng Hongwei Hongmei Yong Yong Yongqiang
Li Chen Chen Yu Zhang Lv Li Zhu