Purified extract (ATC1) isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma
The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of Pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a OVA-sensitized/challenged mouse model.
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY YUNGJIN PHARMACEUTICAL CO., LTD
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Jung-hee Hyeongkyu Sei-ryang Byung-hwan Hyuk-hwan Ji-seok Yongnam Kyung-seop Ok-kyoung Doo-young Dae-hee
Kim Lee Oh Ryoo Song Yoo Lee Ahn Kwon Kim Shin