Adsorption of immunopotentiators to insoluble metal salts
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminum salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.
GLAXOSMITHKLINE BIOLOGICALS S.A.
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Yefen Alex Xiaoyue Jianfeng Manmohan David A. G. Yongkai Kathy Timothy Z. Tom Yao-Hsiang
Zou Cortez Zhang Pan Singh Skibinksi Li Yue Hoffman Wu