Law Offices of Nisan Steinberg
Preparation for natural product trabectedin
The present invention provides a preparation method for a natural product Trabectedin. Specifically, the present invention provides a preparation method for Et-743. In the method, tyrosine is used as an initial substrate, and after 26 steps of reaction, the Et-743 is synthesized. Raw materials and agents used in the synthetic route can all easily be obtained, reaction conditions are relatively mild, and preparation in large scale can be implemented.
CE Pharm Co., Ltd.
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Weiming Dawei Zhigao
He Ma Zhang