Greenblum & Bernstein, P.L.C.
Amine compound and use thereof
It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(═O) or NR11; and D is a group represented by the following general formula (4) or (6).In the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7).z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.
Kureha Corporation
C C A A C A C A C C A C A C
C07D C07D A61P A61P C07D A61P C07D A61P C07D C07D A61P C07D A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Sei Ryo Kunitaka Haruka Mikiro Toru Shigeyuki Atsushi Shigeru Masahiro Yoshiyuki
Kumakura Matsui Hirose Takahashi Yanaka Yamazaki Kikumoto Saitou Suzuki Ono Takemura