Genentech, Inc.
Purine compounds selective for PI3K P110 delta, and methods of use
The invention provides compounds having the general formula:and stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and n are defined herein, compositions including the compounds and method of using the compounds to treat a disease or disorder mediated by the p110 delta isoform of PI3 kinase selected from immune disorders, cancer, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.
F. Hoffmann la Roche AG
A A A A A A A A A C A A A
A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Zachary Daniel P. Jun Brian
Sweeney Sutherlin Li Safina