Matthias Scholl P.C.
5,6-dimethyl xanthone-4-acetic acid derivatives and method of preparing the same
A method of preparation of 5,6-dimethylxanthone-4-acetic acid (DMXAA) and derivatives thereof. The derivatives are represented by formula (I), wherein R represents totally 1 to 2 substitutes at 1, 2, 3, 7, and 8 position selected from a lower alkyl, halogen, CF3, CN, NO2, NH2, CH2COOH, OR2, OH, NHSO2R2, SR2, CH2CONHR2 or NHR2, and R2 represents a lower alkyl, or a lower alkyl having OH, NH2, or OCH3. The invention further provides a pharmaceutical composition having such derivatives used as excellent antitumor and antibacterial agents.
Grand Pharma (China) Co., Ltd.
A C A
A61P C07D A61P
inventional inventional inventional
Yan Wei Guofan Zhiqiang Bo Jianzhong Jianming Haiming Lu
Chen Li Xie Qian Yang Zhou Zhou Geng Huang