Oxadiazole beta carboline derivatives as antidiabetic compounds
Beta-carboline derivatives of structural formula I are selective antagonists of the somatostatin subtype receptor 3 (SSTR3) and are useful for the treatment of Type 2 diabetes mellitus and of conditions that are often associated with this disease, including hyperglycemia, insulin resistance, obesity, lipid disorders, and hypertension. The compounds are also useful for the treatment of depression and anxiety.
Merck Sharp & Dohme Corp
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Liangqin Shrenik K. Zhong Quang T. William K. Shuwen Jian Ravi P.
Guo Shah Lai Truong Hagmann He Liu Nargund