Heterocycles useful in the treatment of benign prostatic hyperplasia
This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the α-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
Janseen Pharmaceutica N.V.
A C C A C C C C C C C C C C C C C C
A61P C07D C07D A61P C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Haripada Cynthia William V. Catherine Frank Xiaobing Nelson C. F. Gee-Hong Richard H.
Khatuya Maryanoff Murray Prouty Villani Li Yim Kuo Hutchings