Osha • Liang LLP
Pyridazine derivatives and their use as therapeutic agents
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (Ia):where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Xenon Pharmaceuticals Inc.
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A61K A61P A61P A61P A61K C07D C07D A61K A61P A61P A61P A61P C07D
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Shifeng Mikhail Sultan Sengen Shaoyi Jian-Min Chi Duanjie Vandna Melwyn Nagasree Serguei Heinz W. Vishnumurthy Mark W. Zaihui Michael D. Rajender Wenbao
Liu Chafeev Chowdhury Sun Sun Fu Tu Hou Raina Abreo Chakka Sviridov Gschwend Kodumuru Holladay Zhang Winther Kamboj Li