Jones Day
Substituted Quinazolin-4(3H)-one compounds, compositions, and methods for their use
Compounds are provided that have the formula:where X, A4, Ra, R1, R2, R3, R4, R14, L and Q are as described herein. These compounds are useful, for example, as modulators of a chemokine receptor and for treatment of inflammatory and immunoregulatory disorders and diseases. Pharmaceutical compositions and methods of using these compounds for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes, are also provided.
Amgen SF, LLC
C A A C C A C A A A C A A C A A C A A A C A C A A C C A A A A A A A A A C C C
C07D A61P A61P C07D C07D A61P C07D A61P A61P A61P C07D A61P A61P C07D A61P A61P C07D A61P A61P A61P C07D A61P C07D A61P A61P C07D C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D C07D C07D
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Jiwen Alan Xi Liusheng Andrew P. Michael G. An-Rong Julio C.
Liu Huang Zhu Marcus Johnson Li Medina