Spirocyclic GPR40 modulators
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I′A or I′B:where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
Amgen Inc.
A A A C A A A A A A A C A C C C A A C C C C C C C A
A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D A61P C07D C07D C07D A61P A61P C07C C07C C07C C07C C07C C07C C07D A61P
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Jiwen Jonathan XianYun Wang Xiaohui Ming Sujen Julio C. Zhihua Zhongyu An-Rong Zice Vatee Yingcai Liusheng Marc Sean P. Paul
Liu Houze Jiao Shen Du Yu Lai Medina Ma Wang Li Fu Pattaropong Wang Zhu Vimolratana Brown Dransfield