Panitch Schwarze Belisario & Nadel LLP
2-morpholin-4,6-disubstituted pyrimidine derivative, and preparation method and pharmaceutical use thereof
Disclosed is a 2-morpholin-4,6-disubstituted pyrimidine derivative as shown in formula (1) below, and a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof, and a pharmaceutical composition thereof and a use thereof, wherein the definition of each group is as shown in the description. The compound has a PI3K kinase inhibition activity, and has a relatively high inhibitive ability and a low cytotoxicity against PIK3CA mutant breast cancer cell strains T47D and MCF-7.
YANGTZE RIVER PHARMACEUTICAL GROUP CO., LTD. SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD.
A A A A A A A C A C C A A C C A A A A A A
A61P A61P A61P A61P A61P A61P A61P C07D A61P C07D C07D A61P A61K C07D C07D A61P A61P A61P A61P A61P A61P
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Zheng Sida Weiwei Fusheng Zhiyuan Xiaojing Xiangyu
Yang Shen Wang Zhou Zhang Ni He