Hollander Law Firm, P.L.C.
Amine compounds and use thereof
Novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism, and cancer metastasis include compounds represented by the following general formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof:wherein each of n1, n2, and n3 is an integer of 1; each of R1, R2, R3, R4, R5, and R6 is independently a hydrogen atom; A1 is imidazole; A2 is imidazole or imidazole substituted with an alkyl group; W is a phenyl group or naphthyl group; X is CH2; D is a group represented by -Q-Y—B, wherein Q is NR12 and R12 is a hydrogen atom or an alkyl group; Y is (CH2)m3 and m3 is an integer of 2 to 4; and B is N(R25R26), wherein each of R25 and R26 are independently a hydrogen atom, a C1–C6 alkyl group or a C3–C6 cycloalkyl group.
Kureha Corporation
A C C A C C A C C A A C C A
A61P C07D C07D A61P C07D C07D A61P C07D C07D A61P A61P C07D C07D A61P
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Masahiro Kunitaka Toru Shigeru Atsushi Mikiro Haruka Shigeyuki Ryo Yoshiyuki Sei
Ono Hirose Yamazaki Suzuki Saitou Yanaka Takahashi Kikumoto Matsui Takemura Kumakura