Birch, Stewart, Kolasch & Birch, LLP
Bioactive substance
The present invention provides a novel bioactive substance having an antitumor activity and a process for producing it, and a medical use thereof. Namely, it provides a 12-membered ring macrolide compound represented by the following formula obtained from the incubation solution of Streptomyces sp. Mer. 11107 or a variant thereof, a pharmacologically acceptable salt thereof or a hydrate of them, and a process for producing it.
Eisai R&D Management Co., Ltd.
A C A C C A A A C A A C C A A A A A A A A C A A A A A
A61K C07D A61P C07D C07D A61K A61P A61K C07D A61P A61P C12P C07D A61P A61P A61K A61P A61P A61K A61K A61K C07D A61K A61K A61P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Yoshihiko Susumu Kiyoshi Motoko Takao Mitsuo Koji Kumiko Naoto Satoshi Akifumi Masashi Keisuke Masao Jun Yoshiharu Tomonari Kazuyuki Toshimitsu Tomohiro Toshio Takashi Masanori Takashi Naoki
Kotake Takeda Okamoto Matsufuji Yamori Nagai Norihisa Kishi Kawamura Yamamoto Okuda Yoshida Komeda Iwata Niijima Mizui Yamada Dobashi Uenaka Sameshima Tsuchida Nakashima Fujita Sakai Asai