Newport IP, LLC
Modifications to polynucleotides for sequencing
This disclosure describes techniques to improve the sequencing of polynucleotides by decreasing the likelihood of errors occurring during a sequencing calibration process. In implementations, regions of polynucleotides that are used for the calibration process can be modified to reduce a number of polynucleotides that have a same nucleotide at one or more positions of the calibration regions. In some cases, the calibration regions can be modified by adding a sequence to the polynucleotides that replaces the original calibration regions. Also, the calibration regions can be modified by rearranging the nucleotides at the different positions of the calibration regions. Additionally, the calibration regions can be modified by adding sequences of varying length to the polynucleotides being sequenced to produce polynucleotides having varying length with different calibration regions.
Microsoft Technology Licensing, LLC
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G16B C12Q C12Q
inventional inventional inventional
Karin Randolph Luis H. Yuan-Jyue Lee Georg
Strauss Lopez Ceze Chen Organick Seelig