McCarter & English, LLP
Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
This invention relates to novel compounds of the Formula Ik, Im1, Im2, Im5, In1, In2, In5, Io1, Io2, Io5, Ip1, Ip3, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Vitae Pharmaceuticals, Inc. Boehringer Ingelheim International GmbH
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A61P A61P C07D A61P A61P A61P A61P C07D A61P A61P
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Wei Linghang Katerina Salvacion Suresh B. Colin M. David A. Zhenrong Yuanjie
Zhao Zhuang Leftheris Cacatian Singh Tice Claremon Xu Ye