Scully Scott Murphy & Presser
Inhibitor of FLT3 kinase and use thereof
Provided in the present invention is a novel inhibitor of FLT3 kinase, comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, ester, acid, metabolite or prodrug thereof. Also provided in the present invention are a pharmaceutical composition comprising a compound of formula (I) and a use and method for preventing or treating cell proliferative conditions and/or FLT3-related conditions, in particular for conditions responding to the inhibition of FLT3 kinase (especially FLT3/ITD mutant kinases).
HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES HEFEI COSOURCE PHARMACEUTICAL CO., LTD.
C A A A A
C07D A61K A61P A61K A61P
inventional inventional inventional inventional inventional
Zheng Kailin Wei Qingsong Jing Xixiang Jiaxin Beilei Juan Chen Aoli Hong Wenchao Cheng Li
Zhao Yu Wang Liu Liu Li Wu Wang Liu Hu Wang Wu Wang Chen Wang