Synthetic antibody mimic peptides
The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets. Some embodiments comprise peptide-drug conjugates (PDCs) comprising the mimic peptides disclosed herein. The targets of these mimic peptides include epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2), vascular endothelial growth factor (VEGF), programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1). The present disclosure comprises application of the knob-socket computational model to design antibody mimics for proteins.
Formurex, Inc.
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C07K C07K G01N C07K G01N A61K
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Dan Bhaskara Rao Hyun Sameer Yu Xiaoling Jerry
Su Jasti Joo Sachdeva Zheng Li Tsai