Arnold & Porter LLP
Nucleic acids encoding receptor for IL-17 homologous polypeptides and therapeutic uses thereof
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Genentech, Inc.
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G01N C07K A61K G01N C07K C07K C12N G01N
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J. Christopher Menno Daniel Melissa A. William I. Ellen Austin Paul P. Mickey Jian Hanzhong Colin Richard Audrey Sherman Kenneth Daniel Sarah G.
Grimaldi VanLookeren Tumas Starovasnik Wood Filvaroff Gurney Godowski Williams Chen Li Watanabe Vandlen Goddard Fong Hillan Yansura Hymowitz