Metis IP LLC
Method of committed differentiation of human induced pluripotent stem cells into Leydig cells and application of Leydig cells
The present application provides an in-vitro committed differentiation method for inducing human induced pluripotent stem cells (hiPSCs) into Leydig cells (LCs) by neural crest stem cells (NCSCs). The hiPS-derived LCs is verified by an animal model to have the capacity of regenerating senile or injured LCs, so that a new treatment for supplementing testosterone is provided for patients suffering from hypogonadism, particularly for patients suffering from late-onset hypogonadism (LOH).
SUN YAT-SEN UNIVERSITY
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Mei Hua Peng Weiqiang
Jiang Xiang Li