Arnold & Porter LLP
IL-17 receptor-like polypeptides and therapeutic uses thereof
The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Genentech, Inc.
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James Sherman Sarah G. Paul J. J. Christopher P. Mickey Kenneth J. Audrey William I. Richard Hanzhong Daniel Menno Jian Colin K. Austin L. Ellen Daniel G. Melissa A. Dorothy
Pan Fong Hymowitz Godowski Grimaldi Williams Hillan Goddard Wood Vandlen Li Tumas Van Lookeren Chen Watanabe Gumey Filvaroff Yansura Starovasnik French