Lathrop Gage LLP
Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
Incyte Corporation Incyte Holdings Corporation
C C C Y A C A A C
C07F C07D C07F Y02P A61P C07F A61P A61P C07F
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Michael Yongchun Jiacheng Brian W. James D. Mei David Qiyan Haisheng Pingli Tai-Yuen
Xia Pan Zhou Metcalf Rodgers Li Meloni Lin Wang Liu Yue