Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Guanidine derivatives as inhibitors of Na.sup.+ /H.sup.+ exchange in cells
 Guanidine derivatives of the formula: ##STR1## wherein Y is C--R.sup.1 PA2 (in which R.sup.1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) PA1 R.sup.2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., PA1 R.sup.3 is hydrogen, lower alkoxy, hydroxy, protected hydroxy, etc., PA1 Z is C--R.sup.4 PA2 (in which R.sup.4 is hydrogen, carboxy, protected carboxy, nitro, halogen, hydroxy(lower)alkyl, etc.,), and PA1 W is R.sup.12 PA2 (in which R.sup.12 is hydrogen, lower alkoxy, nitro, hydroxy or protected hydroxy) and pharmaceutically acceptable salts thereof which are useful as a medicament which are useful in inhibiting Na.sup.+ /H.sup.+ exchange in cells and in the prevention of cardiovascular diseases, cerebrovascular diseases, renal diseases, arteriosclerosis and shock. 
Fujisawa Pharmaceutical Co., Ltd.
C C A C C C A C C C A C C C C A A C
C07D C07D A61P C07D C07D C07D A61P C07C C07D C07D A61P C07D C07D C07D C07D A61P A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Atsushi Hiroaki Yoshikazu Kumi Hisashi
Kuno Mizuno Inoue Yamasaki Takasugi