Edwards Wildman Palmer LLP
Methods related to the treatment of neurodegenerative and inflammatory conditions
The invention includes methods of neuroprotection, inducing release of neurotrophic factors, inhibiting the over-activation of innate immune cells, attenuating the toxin-induced death and/or damage of tissues, reducing inflammation, treating an inflammation-related condition, and inhibiting NADPH oxidase, that includes contacting or administering an effective amount of at least one compound of the invention that include: valproic acid, sodium butyrate, and salts thereof; opioid peptides; a peptide comprising the tripeptide GGF; and morphinans, such as naloxone, naltrexone, 3-hydroxy-morphinan and dextromethorphan.
The United States of America as represented by the Secretary, Department of Health and Human Services
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Liya Jau-Shyong Michelle Giia-Shuen Wei Po-See Guorong
Qin Hong Block Peng Zhang Chen Li