Hultquist, PLLC
Method for producing 1,3-propanediol using microorganism variant with deletion of 2,3-butanediol synthetic gene
The present invention relates to a method for producing 1,3-propanediol using a mutant microorganism lacking a 2,3-butanediol synthetic gene, and more particularly to a mutant microorganism wherein a gene encoding lactate dehydrogenase and a gene encoding an enzyme which is involved in 2,3-butanediol synthesis are deleted in a microorganism having the ability to produce 1,3-propanediol from glycerol and wherein a gene encoding pyruvate decarboxylase and a gene encoding aldehyde dehydrogenase are introduced or amplified, and to a method of promoting the production of 1,3-propanediol while inhibiting the production of 2,3-butanediol by using the mutant microorganism. The use of the glycerol-fermenting mutant microorganism according to the present invention can significantly increase the production of 1,3-propanediol while minimizing the production of 2,3-butanediol.
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
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Sung Mok Baek Rock Jang Min Sun-Yeon Jeong-Woo Chul Ho You Ree
Lee Oh Park Heo Seo Kim Jung