Knobbe Martens Olson & Bear LLP
Fused ring heteroaryl compounds and their use as Trk inhibitors
The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof. The compounds can be used as an inhibitor of Trk and are useful in the treatment of pain, cancer, inflammation, neurodegenerative disease and certain infectious diseases.In some compounds of Formula I, Q is —CH═CR3C(O)NR4R5, —C≡CC(O)NR4R5, or
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inventional inventional inventional inventional
Kinam Gilnam Myung Eun Jae Il Chaewoon Je Hak Hye Kyoung Moonsoo MinWoo Hyang Cheol Hwan Soongyu Misoon Hyun Jung Jeongbeob Hankyul
Lee Lee Jung Lee Lee Kim Kim Kim Lee Choi Yoon Choi Kim Kim Seo Jeong