Indole diterpene alkaloid compounds
 The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I). 
Merck & Co., Inc.
C A C C C A
C12P A61P C07D C12P C07D A61P
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Seok H. Otto D. Maria L. Robert A. Deborah L. Owen B.
Lee Hensens Garcia Giacobbe Zink McManus