Vertex Pharmaceuticals Incorporated
Modulators of ATP-binding cassette transporters
The present invention provides compounds of Formula I useful as modulators of ABC transporter activity,or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below.The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
Vertex Pharmaceuticals Incorporated
A A C C A A C C C C A A A C A A A C A A A C A C A C C A C C A C A C A A A A A A A A C A C A A A A C A C C A C A C C C
A61P A61P C07D C07D A61K A61K C07C C07D C07C C07C A61P A61P A61K C07D A61P A61P A61K C07C A61P A61K A61P C07D A61P C07D A61P C07C C07C A61P C07D C07D A61K C07D A61P C07C A61P A61P A61P A61K A61K A61P A61P A61P C07D A61P C07C A61P A61P A61P A61P C07D A61P C07D C07D A61P C07C A61P C07D C07C C07C
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Mark T. Ashvani K. Matthew Sara S. Peter D. J.
Miller Singh Hamilton Hadida Ruah Grootenhuis