Lerner, David, Littenberg, Krumholz & Mentlik, LLP
O-phenyl chalcone compounds and preparation method and use thereof
Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation of microtubules in tumor cells and influencing the mitosis of the cells, and have a high antitumor activity. The compounds also have inhibitory activity against proliferation on various tumor cells, such as a human ovary cancer cell A2780, a human colon cancer cell HCT8, a human breast cancer cell MCF7, a human lung cancer cell A549, a human colon cancer cell SW480, a human nasopharyngeal carcinoma cell CNE2, a human liver cancer cell HepG2 and the like at nanomole concentrations.
Sun Yat-Sen University
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Yu Cuige Xianzhang Gesi Yinglin Xin
Chen Zhu Bu Wen Zuo Yue