Knobbe Martens Olson & Bear LLP
Modulators of retinoid-related orphan receptor gamma
Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (RORγ) activity. This modulation has numerous effects, including inhibition of TH-17 cell function and/or TH-17 cell activity, and inhibition of re-stimulation of TH-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of RORγ results in stimulation of TH-17 cell function and/or activity which is beneficial for immune-enhancing compositions (e.g., vaccines).
Orphagen Pharmaceuticals
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Xiaolin Robert Bruno Scott
Li Babine Tse Thacher