Piperazine analogs as broad-spectrum influenza antivirals
A compound of Formula I is set forth, including pharmaceutically acceptable salts thereof:wherein Het is a 5 or 6-membered heterocycle with —N, —O, or —S adjacent to the —Ar substituent or adjacent to the point of attachment for the —Ar substituent;Ar is aryl or heteroaryl;R is —CH3, —CH2F, or —CH═CH2;W is —NO2, —Cl, —Br, —CHO, —CH═CH2, or —CN;X is —Cl, —CH3, or —CN;Y is —CH or —N; andZ is C1-C6 alkyl, C3-C6 cycloalkyl, substituted aryl, substituted heteroaryl, OR1, or NHR1, wherein R1 is selected from the group of H, aryl, heteroaryl, C1-C6 alkyl and C3-C6 cycloalkyl.This compound is useful in compositions for the prevention and treatment of influenza virus.
Bristol-Myers Squibb Company
C C C A C C A C C A C
C07D C07D C07D A61P C07D C07D A61P C07D C07D A61P C07D
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Samuel Weixu Annapurna Guo Christopher W. Bradley C. Shirong Shuhao
Gerritz Zhai Pendri Li Cianci Pearce Zhu Shi