Vorys, Sater, Seymour & Pease LLP
Compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient
A compound inhibiting Hsp90 and a pharmaceutical composition including the same as an active ingredient are described, which compound is represented by formula 2 and suppresses the expression of Hsp90, inhibits the accumulation of HIF-1α, the Hsp90 client protein, and efficiently inhibits the activation of VEGF. The compound displays low cytotoxicity and can be effectively used as an active ingredient of an anti-cancer agent, a diabetic retinopathy treating agent, and an anti-arthritic agent.
SNU R&DB FOUNDATION
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Hongchan Young-Ger Sang Geon Kyu-Won Ho-Young Jeong Hun Seungbeom
An Suh Kim Kim Lee Kim Lee