Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
The present invention relates to a compound represented by formula I′: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
Merck Sharp & Dohme Corp.
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C07D A61K A61P C07D A61K C07D A61P C07D A61K C07D A61P C07D C07D A61P A61K C07D C07D C07D C07D C07D C07D A61P A61P A61K A61K
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Jinlong Clare Andreas Dong-Ming Thomas H. Wensheng
Jiang Tudge Verras Shen Graham Liu