Integrin antagonist conjugates for targeted delivery to cells expressing VLA-4
The invention relates to compounds of formula I: wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to VLA-4 integrin antagonists to target cells expressing VLA-4.
Hoffmann-La Roche Inc.
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C07D C07C C07C A61K C07D C07D
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Robert Alan Matthew Michael Achyutharao
Goodnow, Jr. Hamilton Sidduri