Choate, Hall & Stewart LLP
Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.
OPKO Health, Inc.
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Frank Xing Robert K. Yuyin Victoria M. Louis Peter Liansheng Marc Ji Gerald Xiaoyong Jian George G. Fucheng Ingrid
Chen Orr Chen Sprague Castellanos Zeng Poirier Xie Werne Fu Cui Wu Zhang Mergelsberg