Process for producing enantiomerically enriched guaifenesin
 A tertiary amine is used to catalize the stereospecific ring-opening of chiral glycidol with o-methoxyphenol to afford high yields of enantiomerically enriched guaifenesin. The optical purity of the product may be even further enhanced by recrystallization. 
Arco Chemical Technology, L.P.
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inventional inventional additional
Wilfred P. Jian Harry
Shum Chen Mazurek