Fish & Richardson P.C.
Analysis of amino acid copolymer compositions
Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e.g., glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.
Momenta Pharmaceuticals, Inc.
A A A C C C G A C
A61K A61K A61P C08G C07K C12Q G01N A61P C12Y
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Zachary Yanjie James Eric Corinne Xiangping Peter James
Shriver Jiang Anderson Bauer Zhu Ahern