Klarquist Sparkman, LLP
Multicomponent vaccine for malaria providing long-lasting immune responses against plasmodia
Disclosed are immunogenic conjugates which elicit an immune response to Plasmodium proteins. In particular examples, the Plasmodium proteins include sexual stage surface proteins, circumsporozoite protein (CSP), or immunogenic portions of CSP. Also provided herein are immunogenic compositions including one or more of the disclosed immunogenic conjugates and a pharmaceutically acceptable carrier. Further provided is a method of eliciting an immune response to Plasmodium in a subject, comprising administering to the subject an immunogenic composition disclosed herein.
New York University The United States of America, as represented by the Secretary, Department of Health and Human Services
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Y02A A61K A61P A61K A61P C07K
additional inventional inventional inventional inventional inventional
Jerry Rachel Fathy Christopher P. John B. Ruth Louis Joanna Zuzana Darrell T.
Keith Schneerson Majadly Mocca Robbins Nussenzweig Miller Kubler-Kielb Biesova Liu