Sterne, Kessler, Goldstein & Fox P.L.L.C.
Cyclourea compounds as calcium channel blockers
The invention relates to cyclourea compounds of Formula I: or a pharmaceutically acceptable salt or solvate thereof, wherein R1-R3 and Z are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.
Purdue Pharma L.P.
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Xiaoming
Zhou