Viksnins Harris Padys Malen LLP
Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as TrkA kinase inhibitors
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R1, R2, Ra, Rb, Rc, Rd, X, Y, B, and Ring C are as defined herein, and wherein the Y—B moiety and the NH—C(═X)—NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases. 
Array BioPharma Inc.
A A A A A C C A Y C A A C A A C A A A A A A A C A C C A C A C A A A A C C
A61K A61K A61P A61K A61K C07D C07D A61P Y02A C07D A61K A61P C07D A61P A61K C07D A61K A61K A61P A61K A61K A61K A61P C07D A61P C07D C07D A61P C07D A61K C07D A61K A61P A61K A61K C07D C07D
inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Shelley James F. Yutong Steven W. Gabrielle R. Jeongbeob Kevin R. Lily Timothy Julia
Allen Blake Jiang Andrews Kolakowski Seo Condroski Huang Kercher Haas