Birch, Stewart, Kolasch & Birch
Process for producing halomethylcarbapenems
 A functionallized intermediate for antibacterial carbapenems, 2-halomethylcarbapenem (III) is effectively synthesized by treating 2-hydroxymethylcarbapenem (I) with a phosphorylating reagent to give 2-phosphoryloxymethylcarbapenem (II) and then treating this product with a halogenating reagent. Some carbapenems derived from the intermediate are also disclosed. ##STR1## wherein, R.sup.1 is hydrogen or substituted or unsubstituted alkyl; PA0 R.sup.2 is hydrogen or substituted or unsubstituted alkyl; PA0 R.sup.3, R.sup.4 is halogen or substituted or unsubstituted alkoxy or aryloxy; PA0 R.sup.5 is hydrogen or carboxy protecting group; and PA0 Hal is halogen. 
Shionogi & Co., Ltd.
Y C C C
Y02P C07D C07F C07D
additional inventional inventional inventional
Mitsuru Hisao Hikaru Shoichiro
Imuta Ona Itani Uyeo