Fitzpatrick, Cella, Harper & Scinto
Apparatus and method for measuring specimen
 On a slab-like board formed of a transparent material is closely attached a wedge-shaped transparent cover member provided with a recess in a central inner portion, thereby to form a clearance. The height of the clearance between the recess and the board is configured to decrease continuously or in steps. When an immunological active substance such as a monoclonal antibody is caused to sensitize carrier particles F, and a reagent having the carrier particles F dispersed into a liquid medium mainly composed of the water is mixed with a specimen, the reaction will occur in which the flocculate is formed from plural carrier particles. When this reaction liquid is poured into the clearance through the opening, the reaction liquid penetrates in the direction having a narrower vertical spacing due to surface tension. A single carrier particle unflocculated can move deep within the recess because it is small in diameter, but the flocculate G is trapped on its way and can not move because of its size. 
Canon Kabushiki Kaisha
G Y G B B G Y G Y Y G B Y Y B G G Y G G
G01N Y10S G01N B01L B01L G01N Y10S G01N Y10S Y10S G01N B01L Y10S Y10S B01L G01N G01N Y10S G01N G01N
inventional additional additional additional additional inventional additional inventional additional additional additional additional additional additional inventional additional additional additional additional additional
Matsuomi Hidehito Takeshi Toshikazu Kazumi
Nishimura Takayama Miyazaki Ohnishi Tanaka