Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
The present invention relates to bicyclic aryl monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A1, L, M, W, X, Y, Z, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a bicyclic aryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of one or more beta-lactamase inhibitor compounds.
Merck Sharp & Dohme Corp
A A A C A A C C
A61K A61K A61K C07D A61P A61K C07D C07C
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Haifeng Fa-Xiang Xianhai Jinlong Yan Reynalda Keh Hongwu Wanying Weiguo
Tang Ding Huang Jiang Guo Dejesus Wang Sun Liu