Sterne, Kessler, Goldstein & Fox P.L.L.C.
Rapamycin derivative, and a preparation method, pharmaceutical composition and use thereof
The present invention pertains to the field of pharmaceutical chemicals, and relates to a rapamycin derivative of Formula I, and a preparation method, pharmaceutical composition and use thereof. The compounds of the present invention overcome the defects of rapamycin in terms of water solubility and metabolic properties, and some of the compounds have an in vitro anti-tumor activity superior to rapamycin, have less toxicity to normal cells than rapamycin, and have very good druggability.
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
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Wu Xinbo Shuang Song Ruiyuan Junhai Xingzhou
Zhong Zhou Cao Li Cao Xiao Li