LeClairRyan, A Professional Corporation
Methods of detecting umami tastant-sensitive cells which express heteromeric T1R1/T1R3 receptors
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.
Senomyx, Inc.
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G01N G01N C12N C40B C12N G01N G01N
inventional additional additional inventional additional additional inventional
Mark Shawn Hong Fernando Xiaodong Jon Elliot Lena Sergey
Zoller O'Connell Xu Echeverri Li Adler Staszewski Zozulya