Hultquist, PLLC
Broken or folded helical peptide or peptide analog exhibiting antimicrobial activity against gram-negative bacteria, and use thereof
The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
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Sun Mi Doyeon Yan Yunhwa Seo Yeon Jaehoon Soonsil Seonju
Jin Jo Lee Choi Kim Yu Hyun Lee