Fenwick & West LLP
Variant activin IIB receptor
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Amgen Inc.
A A C A A A A A A A A A A A A A A A C A C
A61P A61P C07K A61P A61P A61P A61P A61P A61P A61K A61P A61P A61P A61P A61P A61P A61P A61P C07K A61P C07K
inventional inventional additional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional
Jeonghoon Hui-Quan Keith Soo-Nyung Lei-Ting Tony Xiaolan
Sun Han Kwak Tam Zhou