Knobbe, Martens, Olson & Bear LLP
Macrocyclic inhibitors of hepatitis C virus replication
The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
InterMune, Inc.
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A61P A61K A61K A61K A61K C07K C07K Y02A A61P C07D A61P A61K C07D A61P A61K
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Paul Weidong Scott D Michael Lawrence M Tarek Timothy Steven W Bin Pierre Bradley April Andreas Robert Yutong C. Todd
Nichols Liu Seiwert Lyon Blatt Sammakia Kercher Andrews Wang Martin Barnett Kennedy Schumacher Kaus Jiang Eary