Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Heterocyclic compound and antitumor agent containing the same as effective ingredient
The present invention relates to heterocyclic compounds represented by the formula I or pharmaceutically acceptable salts thereof and antitumor agents containing the heterocyclic compounds as effective components:wherein X represents nitrogen atom or CH; R1 represents CHnF3-n (wherein n is 1 or 2), hydroxy C1-C6 alkyl, NHR6 [wherein R6 represents hydrogen atom or COR (wherein R represents hydrogen atom, C1-C6 alkyl or C1-C6 alkoxy)]; R2 represents morpholino (which may be substituted with one to four C1-C6 alkyl), thiomorpholino, piperidino, pyrrolidinyl (which may be substituted with hydroxy C1-C6 alkyl), oxazolidinyl (which may be substituted with one or two C1-C6 alkyl) or tetrahydro-1,4-thiazin-1-oxo-4-yl; R3 and R4 each represent hydrogen atom or C1-C6 alkyl; and R5 represents hydrogen atom, amino or hydroxyl.
Zenyaku Kogyo Kabushiki Kaisha
C C C A C
C07D C07D C07D A61P C07D
inventional inventional inventional inventional inventional
Seiichiro Shinichi Tetsuo Toshiyuki Hiroya
Kawashima Yaguchi Watanabe Matsuno Sasahara