Sterne, Kessler, Goldstein & Fox P.L.L.C.
7,8-cyclicmorphinan analogs
The application is directed to compounds of Formula I-Aand pharmaceutically acceptable salts and solvates thereof, wherein Cy, R1a-R3a, R4a, and R4b are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I-A to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
Purdue Pharma L.P.
C A A A A A A C A A A
C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Laykea Donald J. Xiaoming
Tafesse Kyle Zhou