Cyanamides useful as reversible inhibitors of cysteine proteases
Compounds according to the following formula (I): wherein the variables Q and R1 to R6 are as described herein, which reversibly inhibit the cysteine proteases, such as cathepsins K, S, F, L and B; pharmaceutical compositions containing such compounds, and method of treating diseases and pathological conditions exacerbated by these cysteine proteases such as, but not limited to rheumatoid arthritis, multiple sclerosis and other autoimmune diseases, osteoporosis, asthma, Alzheimer's disease, atherosclerosis and endometriosis.
Boehringer Ingelheim Pharmaceuticals Inc.
C C C
C07C C07D C07D
inventional inventional inventional
Eugene Richard Denice M. Thomas A. Peter Allen Weimin
Hickey Spero Gilmore Nemoto Liu