Baker & Hostetler LLP
Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
California Institute of Technology
C C C C
C07F C07F C07D C07F
inventional inventional inventional inventional
Anton Wenbo Alexey Robert H. Brian M. Kerry
Toutov Liu Fedorov Grubbs Stoltz Betz