Reed Smith LLP
Low oxygen affinity mutant hemoglobins
Non-naturally occurring mutant hemoglobins rHb (&bgr;N108Q) and rHb (&bgr;L105W) are provided that have a lower oxygen affinity than that of native hemoglobin, but high cooperativity in oxygen binding. rHb (&bgr;N108Q) also exhibits enhanced stability against autoxidation. The mutant hemoglobins are preferably produced by recombinant DNA techniques. Such mutant hemoglobins may be used as a component of a blood substitute and hemoglobin therapeutics.
Carnegie Mellon University
A C A A
A61P C07K A61K A61P
inventional inventional additional inventional
Tsuei-Yun Ching-Hsuan Chien Tong-Jian
Fang Tsai Ho Shen