Brinks Gilson & Lione
Methods of synthesizing a difluorolactam analog
The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.
CAYMAN CHEMICAL COMPANY, INC.
C A C A A A C C C
C07D A61P C07D A61P A61P A61P C07D C07D C07F
inventional inventional inventional inventional inventional inventional inventional inventional inventional
Bradlee David Joseph Michael Adam Andriy James Bernard Stephen Douglas
Germain Colombo Uzieblo Kornilov Kramer Barrett