Wolf, Greenfield & Sacks, P.C.
Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
Microfluidic systems and methods are provided for fabricating complex patterns of materials, such as proteins, inorganic materials or cells, on surfaces. Complex, discontinuous patterns on surfaces can be formed incorporating or depositing multiple materials. A stamp structure has a flow path containing a series of interconnected channels. The channels include a first channel within an interior of the stamp structure, a second channel within a stamping surface of the structure defining a pattern, and a channel fluidically interconnecting the first and second channels. After contacting the stamp with a surface, a fluid is introduced into the flow path so that the fluid contacts the surface to form a pattern. In another embodiment, the stamp structure has two non-fluidically interconnected first and second flow paths defining first and second patterns of channels to produce non-continuous first and second patterns on a surface.
Children's Medical Center Corporation President and Fellows of Harvard College
Y B B C B B B B B B B B B B B B B B B B B B C C Y B B B B G B B B Y Y B B
Y10S B01L B29C C40B B01J B01J B01J B01J B01J B29C B29C B81C B01L B01L B01J B01J B01L B82Y B01L B01F B01L B01L C40B C12N Y10S B01J B33Y B01J B01L G01N B81B B82Y B01J Y10S Y10S B01J B01J
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Noo-Li Janelle R. George M. Insung S. Sui Daniel T. Donald E. Ravi
Jeon Anderson Whitesides Choi Huang Chiu Ingber Kane