Panitch Schwarze Belisario & Nadel LLP
Oxopicolinamide derivative, preparation method therefor and pharmaceutical use thereof
The present invention relates to an oxopicolinamide derivative, a preparation method therefor and the pharmaceutical use thereof. In particular, the present invention relates to an oxopicolinamide derivative as shown in the general formula (AI), a preparation method therefor and a pharmaceutical composition comprising the derivative, and to the use thereof as a therapeutic agent, in particular as an inhibitor of blood coagulation factor XIa (Factor XIa, FXIa for short) and the use thereof in the preparation of a drug for treating diseases such as thromboembolism, wherein the definition of each substituent in the general formula (AI) is the same as defined in the description.
Jinagsu Hengrui Medicine Co., Ltd Shanghai Hengrui Pharmaceutical Co., Ltd.
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Fanglong Feng Xiaodong Weikang Gang Weimin
Yang He Li Tao Chen Wang