Foley & Lardner
Method for radiolabeling monovalent antibody fragments
 A method for radiolabeling a monovalent Fab or Fab' antibody fragment which comprises the steps of cleaving a divalent F(ab).sub.2 or F(ab').sub.2 antibody fragment using sulfite or meta-bisulfite ions to produce a monovalent fragment having a free sulfhydryl group, and contacting the monovalent fragment with a cation of a metallic radionuclide which binds to sulfhydryl groups, without removing excess sulfite or metabisulfite. 
Immunomedics, Inc.
A G G A A C
A61K G01N G01N A61K A61K C07K
inventional inventional inventional additional additional inventional
Anastasia L. Chien-Hsing
Jones Chang