Fidelman & Wolffe
Process to separate mixtures of enantiomeric arylpropionic acids
 A process is described in which a mixture of enantiomeric arylpropionic acid is split and one of enantiomeric forms of the acid is recovered. The mixture is transformed into a diastereoisomeric salt by a reaction with a chiralic base and an inert solvent, and the desired acid enantiomer is removed from the reaction product. The transformation to a diastereoisomeric salt takes place in a polar solvent. The salt produced is recrystallized several times and the thus purified salt is split in a dilute mineral acid. 
PAZ Arzneimittel-Entwicklungsgesellschaft mbH
C
C07C
inventional
Gunther Helmut Otto
Rau Lukas Schuster