Panitch Schwarze Belisario & Nadel LLP
Pyridinecarboxamide derivatives, preparation method thereof and pharmaceutical uses thereof
Pyridinecarboxamide derivatives, preparation methods, and a pharmaceutical uses thereof are provided. In particular, pyridinecarboxamide derivatives represented by general formula (I), wherein the substituents of the formula (I) are defined in the specification are provided. Also provided are a preparation method for the pyridinecarboxamide derivatives of formula (I), a pharmaceutical composition containing the pyridinecarboxamide derivatives, and uses of the pyridinecarboxamide derivatives as therapeutic agents, especially as inhibitors of the Renal Outer Medullary Potassium channel (ROMK) and in the preparation of medicaments for treating and/or preventing hypertension and heart failure.
Jiangsu Hengrui Medicine Co., Ltd. Shanghai Hengrui Pharmaceutical Co., Ltd.
A A A C A A A A A C A
A61P A61P A61K C07D A61P A61P A61P A61P A61P C07D A61P
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Piaoyang Xin Qing
Sun Li Dong