Triterpenoids with HIV maturation inhibitory activity
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS.
ViiV Healthcare UK (No.4) Limited
C C A A C A C C A
C07J C07C A61P A61K C07F A61K C07C C07F A61K
inventional additional inventional inventional inventional inventional inventional inventional inventional
Brian Lee Alicia Richard A. Nicholas A. Li Ny Zheng Jacob Jie Sing-Yuen Yan
Venables Regueiro-Ren Hartz Meanwell Xu Sin Liu Swidorski Chen Sit Chen