Stinson LLP
Spinosad heterologous expression strain and construction method thereof and use
The invention provides a construction method of spinosad heterologous expression strain, a spinosad heterologous expression strain obtained by the method and use thereof in preparing spinosad. The method utilizes a plurality of homologous recombination to replace the erythromycin synthetic gene cluster of Saccharopolyspora erythraea with the spinosad synthetic gene cluster and the rhamnose synthetic gene cluster, such that the Saccharopolyspora erythraea produces spinosad.
Zhejiang Hisun Pharmaceutical Co., LTD.
C C
C12N C12P
inventional inventional
Hua Na Meihong Zhen Linghui Haibin Jun
Bai Li Li Yu Zheng Wang Huang