6-oxo-1,6-dihydropyridine compounds as inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formulas I and Vand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Array BioPharma Inc.
C C C C C C C C A C C C C C C A C C
C07D C07D C07D C07D C07D C07D C07D C07D A61P C07D C07D C07D C07D C07D C07D A61P C07D C07D
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Hong-Woon Jeongbeob Joseph P. James Allison L. Eli M.
Yang Seo Lyssikatos Blake Marlow Wallace