Knobbe, Martens, Olson & Bear, LLP
Aspergillus genus showing resistance to cerulenin and L-methionine analogue and a process for preparing mevinolinic acid therefrom
 The present invention relates to a novel mutant of Aspergillus terreus which shows a resistance to both cerulenin and L-methionine analogue, and a process for preparing mevinolinic acid which comprises aerobic culture of the mutant strain and recovery of mevinolinic acid. The mutant of the present invention provides a remarkably high productivity of mevinolinic acid while reducing the production of byproducts such as mevinolinic acid analogues, when compared with a wild type Aspergillus terreus isolated from soil environment in Korea, and it successfully produce mevinolinic acid by employing monosaccharides such as glucose and galactose, unlike the mother strain. 
Chong Kun Dang Corporation
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C12N C12R C12P Y10S C12P
inventional additional inventional additional inventional
Kyung-Hwan Byoung-Tack Jung-Woo Jang-Woo Chung-Il Byoung-Kook
Kim Choi Kim Park Hong Kim