Klarquist Sparkman LLP
Conjugates of Plasmodium falciparum surface proteins as malaria vaccines
Conjugates of ookinete surface protein Pfs25 are provided that are efficacious as vaccines against Plasmodium falciparum, the most severe form of malaria. Conjugates of ookinete surface protein Pvs25 for use as a vaccine against Plasmodium vivax are also provided. Methods for preparing the conjugates, which comprise the ookinete surface protein bound onto itself or onto another protein by a linking group, are also provided.
The United States of America, as represented by the Secretary, Department of Health and Human Services
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Fathy Yimin Rachel Joanna John B. Louis
Majadly Wu Schneerson Kubler-Kielb Robbins Miller