Knobbe, Martens, Olson & Bear, LLP
1,2-bis-(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane and intermediate for the synthesis of same
The present invention provides improved processes for the synthesis of 1,4-ditosyl-1,4,7-triazacyclonone, comprising deprotecting a compound of formula (C):wherein P is tosylate or arylsulfonate, with an acidic medium to form 1,2-bis(1,4,7-triazacyclonon-1-yl)-ethane; and subsequently adding formaldehyde and formic acid to the acidic medium to form 1,2-bis-(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane (Me4-DTNE). The syntheses of intermediates are also disclosed.
Catexel Limited
C C
C07D C07D
inventional inventional
Lodewijk Wei Jianrong Ronald Xiaohong Stephen William Jean Hypolites
Van der Wolf Zhao Zhang Hage Wang Russell Koek