Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
The present disclosure provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I:     
Amgen Inc.
C C C A
C07D C07D C07D A61P
inventional inventional inventional inventional
Corey Alexander Michael J. Matthew P. Albert Jonathan D. Thomas T. Paul E. Jennifer R. Vu V. Jian J.
Reeves Pickrell Frohn Bourbeau Amegadzie Low Nguyen Harrington Allen Ma Chen