Finnegan, Henderson, Farabow, Garrett & Dunner LLP
Arylsulfonyl pyrazoline carboxamidine derivatives as 5-HT6 antagonists
This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-ht6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, irritable bowel syndrome, obesity and type-2 diabetes. The compounds have the general formula (1) wherein the symbols have the meanings given in the description.
ABBVIE BAHAMAS LIMITED
A A A A C A C A A C A A A A A A A C A A A A A A A A A A C C C A A A A A
A61P A61P A61P A61P C07D A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P A61K A61P C07D A61P A61K A61P A61P A61P A61P A61P A61K A61K A61K C07D C07D C07D A61P A61P A61P A61K A61P
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Martina A.W. Alex Wouter I. Agatha M. Martin Jennifer Arnold Cornelis G.
Van Der Neut Stoit Iwema Bakker Rensink De Haan Venhorst van Loevezijn Kruse