Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
STAT3/5 activation inhibitor
An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient:wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents a groupwherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
Otsuka Pharmaceutical Co., Ltd.
A C A A A A A A A A C A C C A A A A C
A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P C07D C07D A61P A61P A61P A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Seiji Hideo Takeshi Naoto Yasuo Masaaki Mitsuhiro Takashi Kenji Yutaka Kazuhiko Kunihiko Kazuo Kazuhisa Kenji Takashi Takumi
Akamatsu Tanaka Kodama Ohi Yanagihara Motoyama Okuno Watanabe Ohnishi Ohbuchi Hayashi Kiyono Sekiguchi Sugiyama Yoshida Suzuki Sumida