Alston & Bird LLP
Methods and compositions for the diagnosis and treatment of cancer
The present invention relates to methods, kits, and compositions for detecting and/or diagnosing metastatic potential of cancer cells or for evaluating prognosis in a patient with cancer by detection of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule. The present invention also relates to the use of the protein expression level of an HLA class I molecule and/or the copy number variation of a polynucleotide encoding the HLA class I molecule as a prognosis biomarker and metastasis predictive biomarker of cancer.
BGI TECH SOLUTIONS CO., LTD BEIJING INSTITUTE FOR CANCER RESEARCH
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Jiantao Wenmei Longyun Zhibo Lin Youyong Rui
Cui Li Chen Gao Li Lu Xing