Cyclic peptides and use as medicines
The present invention provides a compound of formula I;or a pharmaceutically acceptable salt thereof, wherein the variables R1, R2, R3, R4, R5, and A-B are defined herein, which are non-immunosuppresive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
Novartis AG
A A A A A C A A A C A A A A A A A
A61P A61K A61P A61P A61P C07K A61P A61K A61P C07K A61P A61P A61P A61K A61P A61P A61P
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Wosenu Zachary Kevin Meiliana Aregahegn Alexey Andrew Subramanian Xiaolin Peichao Jiping
Mergo Sweeney Tjandra Yifru Rivkin Weiss Karur Li Lu Fu