McKee, Voorhees & Sease, PLC
Organic solvent method for preparing membrane protein based nanosheets and membranes based on nanosheets
The present disclosure describes compositions and methods for preparing membrane protein nanosheets and two-dimensional crystals. In particular, the methods employ a solvent. A mixture of a polymer and a membrane protein is solubilized in the solvent, applied to a substrate, and subsequently dried to form the nanosheet or two-dimensional crystal. Applicants have surprisingly found that the membrane proteins maintain their structure when exposed to solvents during the short processing time utilized.
The Penn State Research Foundation
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Manish Woochul Yu-Ming Tingwei
Kumar Song Tu Ren