Birch, Stewart, Kolasch & Birch, LLP
Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same
The invention relates to substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.
Egis Gyogyszergyar Rt.
A A C C A C A A C
A61P A61P C07D C07D A61P C07D A61P A61P C07D
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Bernadett Martonné István György László Péter Kótay András Éva József Csilla Anikó Miklósné Hajnalka Gábor Gyula János
Markó Gacsályi Lévay Hársing Nagy Egyed Schmidt Barkóczy Leveleki Kovács Kompagne Szénási Simig Wellmann