Muirhead and Saturnelli, LLC
Techniques for performing retention-time matching of precursor and product ions and for constructing precursor and product ion spectra
Techniques are described for matching a precursor ion with one or more related product ions. Input data sets are obtained from a plurality of injections. Each of the input data sets includes a same precursor ion and one or more product ions. The input data sets are normalized in accordance with a single retention time for the precursor ion. For each input data set, it is determined which product ions are within a predetermined retention time window with respect to the single retention time for the precursor ion. If a product ion is within the predetermined retention time window in at least one of the input data sets, it is determined that the product ion is related to the precursor ion. An apparatus for analyzing a sample includes a chromatography module, a mass-spectrometry module, and a control unit.
Waters Technologies Corporation
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G16C H01J G01N H01J G01N
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Marc V. Guo-Zhong Martha Degen Scott Jeffrey C.
Gorenstein Li Stapels Geromanos Silva