Saul Ewing LLP
Adenoviral vectors comprising partial deletions of E3
This disclosure provides replication-incompetent adenoviral vectors useful in vaccine development and gene therapy. The disclosed vectors comprise a selective deletion of E3 and are particularly useful for preparation of vaccines development and for gene therapy using toxic transgene products that result in vector instability that occurs when the entire E3 domain is deleted.
The Wistar Institute
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Hildegund C. J. Xiang Yang
Ertl Zhou