Polsinelli PC
Enhanced production of recombinant CRM197 in E. coli
Rediced genome or native K12 strain E. coli bacteria comprising expression vectors encoding a recombinant CRM197 protein and their use in the production of CRM 197 is provided. The CRM 197 protein may be fused to a signal sequence that directs the expressed CRM197 protein to the periplasm of the E. coli host.
SCARAB GENOMICS, LLC
C C C
C07K C12N C12N
inventional inventional inventional
David Gyorgy Eric A. Charles F. Hyunsic Robert E. Cristopher R. Terrance M. Frederick R.
Frisch Posfai Steffen Landry Choi Novy Blattner Henker Blattner