Panitch Schwarze Bellisario & Nadel LLP
Stearoyl amino acid salt and preparation method and application thereof
A stearoyl amino acid salt having a structural formula of the general formula (I), wherein R1 is H or an aromatic base capable of being substituted by one or more substituents, or a C1-4 straight chain or an alkyl with a branched chain, the substituent being an alcoholic hydroxyl group or a phenolic hydroxyl group; and R2 is a C11-25 saturated or unsaturated aliphatic group. Also provided are methods of preparing the stearoyl amino acid salt, and methods of using the stearoyl amino acid salt. Compared to a prototype drug stearoyl amino acid, the stearoyl amino acid salt described herein has excellent physicochemical properties, good stability, high relative bioavailability, a strong drug effect and a high safety factor. It is thus expected to become a candidate for clinical treatment of neurodegenerative diseases and acute brain injury, and a clinical drug for weight loss, thus having broad application prospects.
SHANGHAI JIAOTONG UNIVERSITY SCHOOL OF MEDICINE
A C C A A A A A
A61P C07C C07C A61P A61P A61P A61P A61P
inventional inventional additional inventional inventional inventional inventional inventional
Yang Jianhua Shuangqi Hongzhuan
Lu Liu Tang Chen