Leydig, Voit & Mayer, Ltd.
Production methods of epoxytriazole derivative and intermediate therefor
An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base.wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.
Sumitomo Chemical Company, Limited
C C C C C C C C
C07D C07D C07D C07D C07D C07C C07D C07D
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Tetsuya Weiqi
Ikemoto Wang