Michael Best & Friedrich LLP
Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof
A polycrystalline form of a dehydrophenylahistin-like compound, and a manufacturing and purification method and application thereof. A (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)deuteromethylene]piperazine-2,5-dione monohydrate crystal and a (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylene]piperazine-2,5-dione monohydrate crystal are more competitive crystalline forms with stable quality. The manufacturing and purification method is simple and easy to operate, and can effectively control the generation of a trans-isomer contaminant to obtain a high purity product. The polycrystalline form of the dehydrophenylahistin-like compound has a certain value in an application for manufacturing an antitumor pharmaceutical product.
MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD.
A C A A C
A61K C07D A61P A61P C07B
inventional inventional inventional inventional additional
Yingwei Zhongpeng Huashi Wenbao Shixiao
Hou Ding Guan Li Wang