3-(pyridinyl-piperazin-1-yl)-phenylethyl amides as potassium channel openers
The present invention provides piperazinyl phenylethyl amides and related derivatives having the general Formula Iwherein R1, R2, R3, R4, R5, R6, A and B are as defined in the specification, or a nontoxic pharmaceutically acceptable salt, solvate or hydrate thereof which are openers or activators of KCNQ potassium channels. The present invention also provides pharmaceutical compositions comprising said piperazinyl phenylethyl amides and to the method of treatment of disorders sensitive to KCNQ potassium channel opening activity such as migraine or a migraine attack, bipolar disorders, epilepsy, acute and chronic pain, and anxiety.
Bristol-Myers Squibb Company
C A C C
C07D A61P C07D C07D
inventional inventional inventional inventional
Li-Qiang Jie Yong-Jin
Sun Chen Wu