Wenderoth, Lind & Ponack
Sustained-release formulation and production thereof
 Sustained-release formulations which can release a water-soluble active ingredient or ingredients at the zero-order over a long period of time, comprising: PA1 a. an inert core, PA1 b. a powder-coating layer containing a water-soluble active ingredient or ingredients, PA1 c. a powder-coating layer of practically water-repellent material, and PA1 d. a film-coating layer composed of practically pH-independent and water-insoluble film-coating material. 
Shionogi & Co., Ltd.
A
A61K
inventional
Teruo Kinzaburo Toyohiko Yusuke Toshiro
Sakamoto Noda Takeda Suzuki Fujii