7,8-disubstituted pyrazolobenzodiazepines
The present invention provides compounds of formula Iwherein R1, R2, R3, R4, and R5are described herein. The invention also provides syntheses for preparation of such compounds and pharmaceutical compositions containing them. The invention further provides methods for inhibiting kinases, in particular CDK2, for inhibiting angiogenesis, and for treating cancers, in particular breast, colon, prostate, and lung cancer.
Hoffmann-La Roche Inc.
A C A A
A61P C07D A61P A61P
inventional inventional inventional inventional
Zhuming Giacomo Yi Kshitij Chhabilbhai Kin-Chun Jin-Jun Peter Michael
Zhang Pizzolato Ren Thakkar Luk Liu Wovkulich