Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
Merck, Sharp & Dohme, Corp.
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A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P
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Mihirbaran Andrew W. Xiaoxiang Yusheng Guoqing Zhaoning Jared N. Ulrich
Mandal Stamford Liu Wu Li Zhu Cumming Iserloh