Parker Highlander PLLC
Methods for directed differentiation of pluripotent stem cells to immune cells
Provided herein are methods for the efficient in vitro differentiation of somatic cell-derived pluripotent stem cells to hematopoietic precursor cells, and the further differentiation of the hematopoietic precursor cells into immune cells of various myeloid or lymphoid lineages, particularly T cells, NK cells, and dendritic cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the hematopoietic precursor cells.
FUJIFILM Cellular Dynamics, Inc.
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Christie Sarah A. Bradley Wen Bo Andrew J. Maksym A. Xin Deepika
Munn Burton Swanson Wang Brandl Vodyanyk Zhang Rajesh