Peptide containing conjugates for dual molecular delivery of oligonucleotides
Disclosed herein is a peptide containing conjugate comprising (P)c-(L)d-(G)e, wherein P is a peptide and each occurance of P is independently selected from Table 2; L is an optional linker and each occurance of L, if present, is independently selected from Table 3; G is a targeting ligand and each occurance of G is independently selected from Table 4; d is 0, 1, 2, 3, 4, 5 or 6; and each of c and e is independently 1, 2, 3, 4, 5 or 6. The conjugate can be administered to a subject either alone or in combination with a composition comprising R-(L)a-(G)b, wherein R is an oligonucleotide as defined herein, to inhibit expression of a gene of the subject.
Merck Sharp & Dohme Corp.
C A C C C C C C
C12N A61K C07K C12N C07K C12N C12N C07K
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Boyoung Steven L. Matthew G. Rubina G. Rob Kathleen B. Jeffery G. Weimin Thomas J. David M.
Kim Colletti Stanton Parmar Burke Calati Aaronson Wang Tucker Tellers