Beusse, Wolter, Sanks & Maire PLLC
Tau protein-binding DNA aptamers with capture/detection and therapeutic utilities in tauopathy-related neurodegenerative disorders
DNA aptamers that bind to tau protein at its phosphorylatable sites are identified. These disclosed DNA aptamers not only recognize tau at specific phosphorylatable sites, but also demonstrate inhibitory effects on phosphorylation and oligomer formation of tau protein. Molecular probes based on these disclosed DNA aptamers can be used as capture or detection agents to detect the levels of tau and phosphor-tau in cerebrospinal fluid as well as for cell-based or in vivo brain imaging in live animals or human. Compositions comprising these disclosed DNA aptamers can be used to arrest or treat the progression of tauopathy associated neurodegenerative disorders.
Department of Veteran's Affairs University of Florida Research Foundation, Inc.
G C C A G G
G01N C12N C12N A61K G01N G01N
additional inventional additional inventional additional inventional
I-Ting Xiaowei Weihong Hamad Ka W.
Teng Li Tan Yadikar Wang