Leydig Voit and Mayer Ltd
Modified anthrax toxin protective antigen
Disclosed is a Bacillus anthracis protective antigen (PA) comprising a PA amino acid sequence, wherein one or more of amino acid residues I207, I210, E654, I656, R659, M662, Y681, and L687, as defined by reference to SEQ ID NO: 1, are, independently, substituted, with the proviso that amino acid residue I207 is not substituted with alanine and amino acid residue I210 is not substituted with alanine. Related compositions, nucleic acids, recombinant expression vectors, host cells, populations of cells, methods of treating or preventing cancer in a mammal, and methods of inhibiting the growth of a target cell are also disclosed.
The United States of America as represented by the Secretary Department of Health and Human Services
A A A C A A
A61K A61P A61K C07K A61K A61K
additional inventional inventional inventional additional inventional
Jie Kuang-Hua Alexander N. Diane E. Stephen H. Shi-Hui Thomas H.
Liu Chen Wein Peters Leppla Liu Bugge