Klarquist Sparkman, LLP
Pyrrolo-pyrimidine derivative compound, preparation method therefor, and pharmaceutical composition comprising same compound as effective ingredient for preventing or treating protein kinase-related disease
The present invention relates to a novel pyrrolo-pyrimidine derivative compound, a preparation method therefor, and a pharmaceutical composition comprising the same compound as an effective ingredient for preventing or treating a protein kinase-related disease. The compound represented by Chemical Formula 1 according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an effective ingredient has outstanding inhibitory activity against LRRK2 kinase and against phosphorylation in the NIH-3T3 cell line, which is an LRRK2-expressing cell line, and NCC01 and 448T cell lines, which are both derived from patients with brain tumors. Verified to have inhibitory activity against various protein kinases in addition to LRRK2, the compound can find effective applications in the treatment or prevention of protein kinase-related diseases.
National Cancer Center Samsung Life Public Welfare Foundation Daegu-Gyeongbuk Medical Innovation Foundation
A A C A A C
A61P A61P C07D A23L A61P C07B
inventional inventional inventional inventional inventional additional
So Young Jong Bae Yi Kyung Yunho Jung Beom Do-Hyun Seungyeon Jin-Hee Sun Joo Sun-Hwa Seung Hoon Jae Hyun Nam Doo Tae-ho Dayea Eunhwa Hwan Geun Sang Bum Joong-heui Seock Yong Eunmi
Kim Park Ko Lee Son Nam Lee Park Lee Lee Lee Bae Kim Jang Kim Ko Choi Kim Cho Kang Hong