Canady + Lortz LLP
Pharmaceutical composition comprising dutasteride and propylene glycol monolaurate and preparation method of the same
The present invention relates to a pharmaceutical composition comprising dutasteride and propylene glycol monolaurate, which improves the stability of dutasteride, which is a poorly soluble drug as a 5-alpha reductase inhibitor, and a process for its preparation. More particularly, the present invention also relates to a capsule formulation which is smaller in size than a commercial dutasteride capsule formulation (AVODART®), but has the equivalent dissolution rate by preparing a pharmaceutical composition comprising propylene glycol monolaurate and dutasteride, which can improve the stability of the dutasteride. A dutasteride formulation having enhanced patient's compliance and improved stability and a method for producing the same are provided.
Yuyu Pharma, Inc.
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Tae Gon Young-Joon Kyeongjin Seyeon Ju-Hee
Baik Park Ahn Kim Kim