Wilson Sonsini Goodrich & Rosati
Method for reducing blood insulin levels by reducing in vivo cathepsin L activity
Methods and compositions are provided for modulating blood insulin levels of animals by targeting the gene and gene products of cathepsins, particularly cathepsins L, K, and S, and especially cathepsin L. The method comprises: administering to the animal an agent that reduces an in vivo level of cathepsin L activity such that the blood insulin level of the animal is reduced. The method can be used to treat hyperinsulinmia and related diseases such as insulin resistance, type II diabetes, and hyperglycermia.
NewMillennium Pharmaceutical, Inc.
A C A C C C A A
A61K C12Y A61K C12Y C12Y C12N A61K A61K
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Hamilton H. Guo-ping Jingming
Yong Shi Chen