Nixon Peabody LLP
Selective oxidation of 5-methylcytosine by TET-family proteins
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
THE CHILDREN'S MEDICAL CENTER CORPORATION THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
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Suneet Kian Peng Anjana Mamta Aravind
Agarwal Koh Rao Tahiliani Iyer