Hunton & Williams, LLP
Heteromeric taste receptors
Heteromeric taste receptors are provided. These receptors comprise a first polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R1 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R1 polypeptide or a different GPCR; and a second polypeptide which comprises extracellular and transmembrane domains wherein the transmembrane domains are at least 95% identical to the transmembrane domains of specific T1R3 polypeptides, and the extracellular domains are at least 95% identical to the corresponding extracellular domains of the specific T1R3 polypeptide or that of a different GPCR.
Senomyx, Inc
C A G C A C C G G G G G G C
C07K A61P G01N C12Q A01K C12Q C12Q G01N G01N G01N G01N G01N G01N C07K
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Fernando Mark Hong Jon Elliot Xiaodong Sergey Lena Shawn
Echeverri Zoller Xu Adler Li Zozulya Staszewski O'Connell