Merchant & Gould
Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
Polynucleotide delivery-enhancing polypeptides are admixed or complexed with, or conjugated to, nucleic acids for enhancing delivery the nucleic acids into cells. The transported nucleic acids are active in target cells as small inhibitory nucleic acids (siNAs) that modulate expression of target genes, mediated at least in part by RNA interference (RNAi). The siNA/polypeptide compositions and methods of the invention provide effective tools to modulate gene expression and alter phenotype in mammalian cells, including by altering phenotype in a manner that eliminates disease symptoms or alters disease potential in targeted cells or subject individuals to which the siNA/polypeptide compositions are administered.
Marina Biotech, Inc.
C C A A A C C A C A C A A C C C
C12N C12N A61P A61P A61P C12N C07K A61P C12N A61K C12N A61P A61K C12N C07K C07K
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Sasha J. Lishan Michael E. Kunyuan Yuching
Mayer Chen Houston, Jr. Cui Chen