Holtz Holtz Goodman & Chick PC
1,2,3,4-tetrahydroquinoxaline derivative having glucocorticoid receptor binding activity
An object of the present invention is to synthesize a novel 1,2,3,4-tetrahydroquinoxaline derivative represented by formula (1) and to find a pharmacological action of the derivative. In the formula, the R1 represents a halogen, an alkyl, cycloalkyl, aryl or heterocyclic group, or the like; p represents 0 to 5; R2 represents a halogen, an alkyl, hydroxyl or alkoxy group, or the like; q represents 0 to 2; R3 represents hydrogen, an alkyl, alkenyl, alkylcarbonyl or arylcarbonyl group, or the like; R4 and R5 independently represent hydrogen, a halogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; R6 represents hydrogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; and X represents O or S.
Santen Pharmaceutical Co., Ltd.
A A C C C C A C A C C A A A A C C C
A61P A61P C07D C07D C07D C07D A61P C07D A61P C07D C07D A61P A61P A61P A61P C07D C07D C07D
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Kenji Minoru Sachiko Mamoru Masatomo Masato Miwa Toshiyuki
Kawashima Yamamoto Kobayashi Matsuda Kato Nagatsuka Takai Mori