Fish & Richardson P.C.
Macrocyclic compounds as trk kinase inhibitors
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Array BioPharma, Inc.
A C A A Y C A A C A A A C A A C A
A61P C07D A61P A61P Y02A C07D A61P A61P C07D A61P A61P A61P C07D A61P A61K C07D A61P
inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Gabrielle R. Kevin Ronald Steven W. Hong-Woon Jeongbeob Yutong Qian Julia
Kolakowski Condroski Andrews Yang Seo Jiang Zhao Haas