Oblon, Spivak, McClelland, Maier & Neustadt
Indole derivatives useful as testosterone 5.alpha.-reductase inhibitors
 A compound of the formula (I): ##STR1## wherein R.sup.1 is an optionally protected carboxy(lower)alkyl, R.sup.2 is a hydrogen, an optionally substituted aryl or a carboxy, PA1 X is a bond, --0--, --NH-- or a cycloalkylene, and PA1 Y is an alkylene which may be interrupted by an oxygen atom, an alkenylene or an alkadienylene, or a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a testosterone 5.alpha.-reductase inhibitor and effective against testosterone 5.alpha.-reductase-mediated diseases such as prostatism, prostatic hypertrophy, prostatic cancer, alopecia, hirsutism (e.g. female hirsutism), androgenic alopecia (or male-pattern baldness), acne (e.g. acne vulgaris, pimple), and other hyperandrogenisms. 
Fujisawa Pharmaceutical Co., Ltd.
A C A A C A C
A61P C07D A61P A61P C07D A61P C07D
inventional inventional inventional inventional inventional inventional inventional
Hirokazu Akio Satoshi Kozo Shinya
Tanaka Kuroda Okada Sawada Watanabe