Knobbe, Martens, Olson & Bear, LLP
RNA agents for P21 gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.
Nitto Denko Corporation
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C07F C12N C12N A61K A61P C12N C12N A61K C12N C12N C12N C12N C12N C12N C12N C12Q A61B C12N C12N H05K G01N C07D
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Cima Jens Kenjirou Kwok Yin Wenbin Hirokazu
Cina Harborth Minomi Tsang Ying Takahashi