Sterne, Kessler, Goldstein & Fox PLLC
Jagged-binding agents and uses thereof
The present invention relates to Jagged-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind to an extracellular domain of human Jagged1 or human Jagged2 and modulate Jagged activity. The present invention further provides methods of using agents that modulate the activity of Jagged, such as antibodies that specifically bind Jagged, and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
OncoMed Pharmaceuticals, Inc.
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Zhimin Austin L. Alexandra Aaron Ken Timothy Charles
Ji Gurney Lazetic Sato Hoey