Dentons US LLP
Poly(3-hydroxypropionate-b-lactate) block copolymer using microorganisms
Provided are a novel 3-hydroxypropionate-lactate block copolymer [P(3HP-b-LA)], and a method for preparing same, comprising: a) transforming a recombinant microorganism modified to be incapable of biosynthesizing lactic acid with a vector including a 3-hydroxypropionyl-CoA biosynthesis gene and a polyhydroxyalkanoate (PHA) synthetase gene, and a vector including a lactate biosynthesis gene and a gene of an enzyme that converts lactate to lactyl-CoA; (b) synthesizing poly(3-hydroxypropionate) (P(3HP)) by culturing the recombinant microorganism using a glycerol as a carbon source; and (c) inhibiting P(3HP) production by adding IPTG and glucose, and biosynthesizing polylactate (PLA) at the end of P(3HP) synthesized in step (b) by enabling the expression of a lactate biosynthesis enzyme and an enzyme that converts lactate to lactyl-CoA. Also provided is a recombinant microorganism produced in step a).
LG Chem, Ltd.
C C C C C C C C C C C C C C C C C C
C12N C12N C12Y C12N C12N C08G C12N C12N C12Y C12Y C12N C12Y C08G C12Y C12N C12P C12Y C12Y
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Chul Woong Jung Yun Donggyun In Young Hye Ok
Kim Choi Kang Huh Kang