Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
Acylguanidine derivative or salt thereof
[Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or prevention of migraine.[Means for Resolution] It was found that an acylguanidine derivative having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5-HT2B receptor and 5-HT7 receptor. In addition, the compound of the present invention having antagonism to both of the receptors showed superior pharmacological action in comparison with the case of the single use of an antagonist selective for either one of the receptors. Based on the above, the compound of the present invention is useful in preventing and/or treating diseases in which 5-HT2B receptor and 5-HT7 receptor are concerned, particularly in treating irritable bowel syndrome (IBS) and/or preventing migraine.
Astellas Pharma Inc.
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C07D C07D C07D C07D A61P C07D C07D C07D C07D A61P C07D C07D C07D C07D A61P A61P A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Eisuke Shinobu Ayako Koichiro Hiroyoshi Hirotsune Takaho
Nozawa Akuzawa Moritomo Harada Yamada Itahana Matsuzawa