McDonald Hopkins LLC
6-nitro-2,3-dihydroimidazo[2,1-b]oxazoles and a process for the preparation thereof
The present invention relates to newer generation of triazoles, tetrazoles, isoxazoles, urea and sulphonamide functionalities containing 6-nitro-2,3-dihydronitroimidazooxazoles agents of formula 1, their method of preparation, and their use as drugs for treating Mycobacterium tuberculosis, MDR-TB and XDR-TB either alone or in combination with other anti-tubercular agents. In the present invention, new generation 6-nitro-2,3-dihydronitroimidazooxazoles agents also show acceptable pharmacokinetic properties and synergistic or additive effects with known anti-tubercular drugs.
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
C A A A A A A A
C07D A61K A61K A61K A61K A61K A61K A61P
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Gurunadham Inshad Ali Ram Asray Nitin Pal Amit Reddy Yempalla Sanghapal Damodhar Vikrant Singh Parvinder Pal
Munagala Khan Vishwakarma Kalia Nargotra Kushalava Sawant Rajput Singh