Baker & Hostetler LLP
Use of compounds extracted from Momordica charantia L. in the manufacture of medicaments for prevention and treatment of diabetes and obesity
The present invention disclosed a medical use of cucurbitane triterpenoids represented by the following formula and isolated from Momordica charantia L. of Cucurbitaceae family in the preparation of medications for prevention and treatment of diabetes and obesity. The above cucurbitane triterpenoids may be acted as a glucose uptake stimulator, an agonist for the translocation of glucose transporter 4 (GLUT4) to the cell membrane, and an activator of adenosine monophosphate-activated protein kinase (AMPK). They may have potential for the prevention and treatment of diabetes and obesity.
The Garvan Institute of Medical Research, Australia Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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Jiming Edward Yang Minjia Tong Xiqiang David Changqiang Gregory
Ye Kraegen Ye Tan Chen Li James Ke Cooney