Nixon Peabody LLP
Engineered enzymatically active bacteriophages and methods of uses thereof
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.
Trustees of Boston University Massachusetts Institute of Technology
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Hideki Michihiro Mads James J Ari Timothy Kuan-Ta
Kobayashi Araki Kearn Collins Friedland Lu