King & Spalding LLP
Cyanovirin variant-polymer conjugates
The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof, and methods of preparing such conjugates. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugates of cyanovirin-N variants exhibiting antiviral activity.
Nektar Therapeutics AL, Corporation National Institute of Heatlh
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A61P A61P A61P A61P A61P C07K
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Michael J. Michael R. Barry R. M. Elizabeth Toshiyuki
Roberts Boyd O'Keefe Snell Mori