Process for preparing single enantiomers of 5,5,5,5&#8242;,5&#8242;,5&#8242;-hexafluoroleucine and protected analogs
A process for synthesizing L and D-5,5,5,5&#8242;,5&#8242;,5&#8242;-hexafluoroleucine and protected analogs is disclosed. These compounds have utility in the preparation of fluorous peptides and proteins, which display interesting and unusual properties including strong self-association and an affinity for lipid bilayers.
The Regents of the University of Michigan Warner-Lambert Company LLC
C
C07C
inventional
Peter Laurence James T. Edward Neil
Toogood Anderson Marsh