Foley & Lardner LLP
PTD-SMAD7 therapeutics
The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or chemotherapy, including but not limited to oral and gastric mucositis. Also provided are codon-optimized nucleic acids encoding for Smad7 fusion proteins.
The Regents of the University of Colorado, a body corporate
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Yosef Qinghong Xiao-Jing
Refaeli Zhang Wang