Bis-aryl thiazole derivatives
Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by an uncoupling protein. In particular, the compounds of the invention modulate the expression and/or activity of UCP3. The subject compositions are particularly useful in the treatment of obesity and type II diabetes, and associated diseases
Amgen Inc.
C A
C07D A61K
inventional inventional
Paul Juan C. Jin-Long David N. M. Catherine
Rafferty Jaen Chen Johnston Amaral