Mammalian osteoregulins
The invention features novel osteoregulin polypeptides, nucleic acid sequences which encode the polypeptides, vectors, antibodies, hosts which express heterologous osteoregulins, and animal cells and mammals with a targeted disruption of an osteoregulin gene. These osteoregulins play a role in regulating bone homeostasis, adiposity, and the calcification of atherosclerotic plaques. Accordingly, the invention also features screening assays to identify modulators of osteoregulin activity as well as methods of treating mammals for diseases or disorders associated with osteoregulin activity.
Pfizer Inc.
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A61P A61P A61P C07K A61P A61P A01K A61P
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Lynn M. Jeffrey R. Lori C. Thomas A.
Hames De Wet Gowen Brown