Emory Patent Group
Dehydroacetic acid (DHAA) and derivative for uses in treating cancer
This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize acetoacetate-BRAF V600 mutant binding to attenuate BRAF V600 mutant tumor growth. In certain embodiments, this disclosure relates to methods of treating cancer comprising administering an effective amount of an agent to a subject in need thereof, wherein the agent is dehydroacetic acid, derivative, prodrug, or salt thereof.
Emory University The United States Government as Represented by the Department of Veterans Affairs
A
A61K
inventional
Jack Brian Jing Siyuan
Arbiser Pollack Chen Xia