Westerman, Hattori, Daniels & Adrian, LLP
C2-symmetrical ruthenocene diphosphine ligands only with surface chirality and their manufacture
The invention affords C2-symmetrical ruthenocene diphosphine ligands with surface chirality and their manufacture. The present invention uses (S)-(S)-1,1′-2(diphenylphosphino)-2,2′-2[(S)-4-isopropyloxazolinyl] ruthenocene as raw material and the product is prepared through two or three steps of reaction. At the action of trifluoroacetic acid, (S)-(S)-1,1′-2(diphenylphosphino)-2,2′-2[(S)-4-isopropyloxazolinyl] ruthenocene first removes oxazoline and gets ester amides compound which then carries out ester exchange or reduction alkylation and gets the product of ruthenocene diphosphine ligand with surface chirality. The ligands prepared with the structure as follows from the invention can be used in all kinds of metallic catalysis asymmetric reaction and has good reaction activity and stereoselectivity, wherein R is methyl or ethyl, R1 is linear or branched alkyl, cycloalkyl, alkoxy, aryl, aralkyl and alkyl amino.
Shanghai Jiaotong University
B B B C B B B
B01J B01J B01J C07F B01J B01J B01J
additional inventional inventional inventional additional additional inventional
Li Jian Fang Genghong Delong Wanbin
Luo Shang Xie Hua Liu Zhang