Foley & Lardner LLP
Enzymatic synthesis of sulfated polysaccharides
Heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues, wherein the uronic acid is selected from iduronic and glucuronic acid, wherein the glucosamine is partially N-sulfated; by a series of selective reactions catalyzed by recombinant enzymes.
Rensselaer Polytechnic Institute The University of North Carolina at Chapel Hill
C
C12P
inventional
Jinghua Jian Fikri Y. Robert J. Ava M.
Chen Liu Avci Linhardt Munoz