Panitch Schwarze Belisario & Nadel LLP
Cyclohexene derivative, preparation method thereof, and pharmaceutical composition for preventing or treating metabolic disease comprising the same as active ingredient
The present invention relates to a cyclohexene derivative, a preparation method thereof, and a pharmaceutical composition for preventing or treating metabolic disease containing the cyclohexene derivative as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (cAMP) by activating G protein-coupled receptor 119 (GPR-119) and simultaneously exhibits weight loss and hypoglycemic effects by inducing the release of glucagon-like peptide-1 (GLP-1), which is a neuroendocrine protein, and thus can be useful as a pharmaceutical composition for preventing or treating metabolic diseases such as obesity, type 1 diabetes, type 2 diabetes, inadequate glucose tolerance, insulin resistance, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, dyslipidemia and syndrome X.
HYUNDAI PHARM CO., LTD.
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C07D A61K C07D A61P C07D C07D A61P A61P C07D C07D C07D C07D C07D
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Chang Mo Jin Woong Jin Jeong Un Jae Keol Jae Hyun Han Kyu Hyung Ho Kyu Hwan Dae Hoon
Son Kim Yang Hwang Rhee Kim Lee Choi Lee Kim