Sughrue, Mion, Zinn, Macpeak & Seas, PLLC
TNF-.alpha.inhibitor
 A method for the prophylaxis and treatment of diseases induced by accelerated INF-.alpha. secretion, such as rheumatoid arthritis, endotoxin shock, adult respiratory distress syndrome, thermal burn, asthma, myocardial infarction, acute phase of viral myocardiosis, etc. which comprises administering a carbostyril compound of the formula: ##STR1## wherein R.sup.1 is H or lower alkyl, and R.sup.2 is phenyl(lower)alkyl having optionally 1 to 3 lower alkoxy substituents on the phenyl ring, or a pharmaceutically acceptable salt thereof to a subject. 
Otsuka Pharmaceutical Company, Limited
A
A61K
inventional
Yukihisa Toyoki Michiaki
Ono Mori Tominaga