Cohen, Pontani, Lieberman & Pavane
Process for making taxane derivatives
The present invention provides a novel semi-synthetic method of producing a variety of novel taxane derivatives. The method involves the reaction of a phenylisoserine derivative with a suitably blocked Baccatin III derivative to produce a taxane substrate that may be further modified to form Pactitaxel and other potentially useful taxane derivatives.
Scinopharm Taiwan, Ltd.
C C C A
C07D C07D C07D A61P
inventional inventional inventional inventional
George Wlodzimierz Chien Hsin Yung-Fa
Schloemer Daniewski Lin Chen