Sheppard Mullin Richter & Hampton LLP
Lyophilized formulations for factor Xa antidote
The present disclosure relates to solutions and methods of preparing lyophilized formulations of factor Xa (fXa) antidotes. A suitable aqueous formulation suitable for lyophilization can include a fXa antidote, a solubilizing agent, a stabilizer, and a crystalline component, wherein the formulation does not collapse during lyophilization.
Alexion Pharmaceuticals, Inc.
A A A A C C C A
A61K A61K A61K A61K C12Y C07K C12N A61K
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Juan Phuong M. Gregory A.
Wang Nguyen Sacha