Nixon Peabody LLP
Antibody to cytolethal distending toxin of Campylobacter jejuni
Methods for preventing IBS, reducing the likelihood of developing IBS and/or treating IBS by administering COT inhibitors and/or COT neutralizers to a subject in need thereof are described. Methods of eliciting a specific immune response and methods of vaccinating a subject to prevent IBS or to reduce the likelihood of developing or having IBS are also provided. Methods of diagnosing IBS by detecting the presence or absence of COT or a COT marker in a subject are described.
CEDARS-SINAI MEDICAL CENTER
A Y C A G A G G C A G A G G G C A
A61P Y02A C07K A61K G01N A61K G01N G01N C07K A61P G01N A61P G01N G01N G01N C07K A61K
inventional additional inventional additional inventional inventional additional additional inventional inventional inventional inventional additional additional additional additional inventional
Mark Christopher
Pimentel Chang