5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
The invention provides 5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one compounds that are selective inhibitors of KDR and FGFR kinases, and are useful in the treatment of cancers. The compounds have the generic structure Iwhere Ar, Ar′, and R1 are as set forth in the present specification. The invention also provides pharmaceutical compositions containing these compounds and methods for their use.
Hoffmann-La Roche Inc.
C A A
C07D A61P A61P
inventional inventional inventional
Kin-Chun Jin-Jun
Luk Liu