McKenna Long & Aldridge LLP
Microorganisms for therapy
Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
Genelux Corporation
A A A C A A C C C A C A A A A C C C A A A A C A C A A
A61K A61P A61K C12N A61P A61K C07K C12P C12N A61K C07K A61K A61K A61P A61P C12N C12P C12N A61P A61K A61P A61K C12N A61K C12N A61P A61K
inventional inventional additional inventional inventional additional inventional inventional additional inventional inventional inventional additional inventional inventional additional inventional additional inventional inventional inventional inventional additional additional inventional inventional inventional
Aladar A. Tatyana Qian Yong A.
Szalay Timiryasova Zhang Yu