Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
3-Dimensional Pharmaceuticals, Inc.
A A C A A A C A A C A A C C A A A A C A A A A A C A A A A A A A A A A A C A C
A61P A61P C07D A61P A61P A61P C07F A61P A61P C07D A61P A61P C07D C07D A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07F A61P C07D
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Farah Nalin Hui Wenxi Jeremy M. Mark Ehab Kristi A. Jinsheng Joan Jonathan M. Maxwell D. Kenneth T. Shelley K. Heather Sanath
Ali Subasinghe Huang Pan Travins Wall Khalil Leonard Chen Gushue Rudolph Cummings Wilson Ballentine Hufnagel Meegalla