McCarter & English LLP
Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
This invention relates to novel compounds of the Formula (I), (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih)1 (Ij), (Ik), (Il1-3). (Im1-3), (In1-3), (Io1-2), (Ip1-6), (Iq1-6), (Ir1-6) and (Is1-2), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Vitae Pharmaceuticals, Inc.
A A C C C C A C A A A C A C A A A A A
A61P A61P C07D C07D C07D C07D A61P C07D A61P A61P A61P C07D A61P C07D A61P A61P A61P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Salvacion Yuanjie Linghang Wei Wei Colin M. Suresh B. David A. Zhenrong
Cacatian Ye Zhuang He Zhao Tice Singh Claremon Xu