Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Heterocyclic compounds and antitumor drugs containing the same as the active ingredient
The present invention relates to heterocyclic compounds represented by the formula Iwherein X represents nitrogen atom or CH; R1 represents halogen atom or hydroxyl; R2 represents hydrogen atom, hydroxyl or amino; R3 represents morpholino (which may be substituted with one or two C1–C6 alkyl), pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) or NR6R7 [R6 represents C1–C6 alkyl and R7 represents piperidinyl (which may be substituted with C1–C6 alkyl)]; R4 and R5 each represents hydrogen atom or C1–C6 alkyl, with the proviso that R2 is hydrogen atom and R3 is pyrrolidinyl (which may be substituted with hydroxy C1–C6 alkyl) when R1 is hydroxyl
Zenyaku Kogyo Kabushiki Kaisha
A C A C
A61K C07D A61P C07D
inventional inventional inventional inventional
Shinichi Tetsuo Yoshio Hiroya Kenichi Toshiyuki Seiichiro
Yaguchi Watanabe Tsuchida Sasahara Saitoh Matsuno Kawashima