CGRP receptor antagonists with tertiary amide, sulfonamide, carbamate and urea end groups
Compounds of formula I:(wherein variables A, m, n, J, Re, Rf, R4, Ea, Eb, Ec, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
Merck, Sharp & Dohme Corp.
A A A A A C A A C A A A A A A A C C C A A A C A C A
A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P C07D C07D C07D A61P A61P A61P C07D A61P C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Michael R. Melody Kathy June Harold G.
Wood McWherter Schirripa Kim Selnick