Birch, Stewart, Kolasch and Birch
CNS depressant .gamma.-(secondary amino)-ortho-nitro-butyrophenones
 Novel compounds of the formula: ##STR1## wherein R is a hydrogen or fluorine atom, W is an oxygen atom or an ethylenedioxy or ethylenedithio group and Z is a certain secondary amino group, which are useful as central nervous system depressants, can be prepared by the reaction of a compound of the formula: ##STR2## wherein X is a halogen atom and R and W are each as defined above with a secondary amine of the formula: H--Z wherein Z is as defined above, in case of W being ethylenedioxy or ethylenedithio, optionally followed by hydrolysis and can be reduced to give a compound of the formula: ##STR3## wherein R and Z are each as defined above, which are useful as antipsychotic and/or analgesic agents. 
Sumitomo Chemical Company, Limited
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Keiichi Shigeho Kikuo Hisao Yasuo
Ono Inaba Sasajima Yamamoto Motoike