Foley & Lardner LLP
Pyrrolo[2,3-d]pyrimidines that modulate ACK1 activity
Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure:where the values of the substituents are provided herein.
Amgen Inc.
C A A A
C07D A61P A61P A61P
inventional inventional inventional inventional
Martin J. David J. Frank Paul Jinqian Rajiv Alexander D. Christopher N. Xianyun Sarah E. Stephen J.
Harrison Kopecky Kayser Faulder Liu Sharma Frenkel Farthing Jiao Lively Shuttleworth