Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids
This invention relates to a method of preparing a compound type where at least one of R&#8242; or R&#8243; is a carboxyl group (I) by treating a compound of formula (II) with a Group I(a) or Group II(a) metal halide, with an aprotic dipolar amide-based solvent and water.
SmithKline Beecham Corporation
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Kevin Jianhao Wilford
Webb Chen Mendelson