McCarter & English, LLP
Cytotoxic benzodiazepine derivatives
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
IMMUNOGEN, INC.
A C A
A61K C07D A61K
inventional inventional inventional
Ravi V. J. Wei Michael Louis
Chari Li Miller