Pabst Patent Group LLP
Method of preparing well-defined polypeptides via ROP
A process of living ring-opening polymerization comprising the step of exposing α-amino acid N-carboxyanhydride monomers to an initiator having a formula NH2CH2[CH2NHCH2]nCH2NH2, wherein n is an integer with value of 1-3 to obtain amino acid polymers, including homopolymers or block copolymers. Use of triethylenetetramine, diethylenetriamine and tetraethylenepentamine exemplified. Representative examples of block copolymers include poly(benzyl-L-glutamate) and poly(benzyl-L-lysine).
KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
C C
C08G C08G
inventional inventional
Wei Yves Nikolaos
Zhao Gnanou Hadjichristidis