Ladas & Parry LLP
Recombinant virus comprising an intact tumor-therapeutic antibody with human constant regions and the use thereof
The present invention provides a recombinant virus containing a nucleotide sequence encoding a tumor-therapeutic full-length antibody with human constant regions, and uses thereof. After a nucleotide sequence of a gene encoding a tumor-therapeutic full-length antibody with human constant regions of the light chain and the heavy chain is inserted into the genome of a recombinant virus, the tumor-therapeutic full-length antibody with human constant regions can be efficiently expressed in tumor cells, thereby inhibit the growth and metastasis of tumors.
C A C A A C A C C
C12N A61K C12N A61K A61P C07K A61P C12N C07K
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Qi Mengchao Qin Qijun
Zhang Wu Yang Qian