2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, composition, and method for improving function of aortic endothelial cell
The disclosure relates to a compound, 2-(3,4-dihydroxyphenyl)ethyl 3-hydroxybutanoate, for improving aortic endothelial cell function and use thereof. The compound is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by a saturated fatty acid, and preventing an occurrence and progression of atherosclerosis. The compound is capable of reducing human aortic endothelial inflammation caused by a saturated fatty acid, for example, reducing the mRNA levels of interleukin-6 (IL-6), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by a saturated fatty acid, for example, increasing the expression of mitochondrial complex I.
XI'AN JIAOTONG UNIVERSITY
C C A
C07C C07C A61P
inventional inventional inventional
Xu-Yun Qing-Lin Cai-Yue Lin Xiao-Hong Ting-Hua Yu-Xia Jian-Kang Qing-Qing Zhen Jian-Gang Jing Ya-Chong Yong-Yao
Liu Jiang Zhu Zhao Xu Zhang Zhang Liu Ma Wang Long Lou Hu Wang