IPro, PLLC
Engineering strain and application thereof in production of Danshensu
The present disclosure discloses an engineering strain and application thereof in joint production of Danshensu and alanine, and belongs to the technical field of bioengineering. The present disclosure constructs a three-enzyme co-expression genetic engineering strain, and realizes joint production of Danshensu and alanine. Further, the transport of a substrate is promoted and decomposition of products is reduced by knocking out or enhancing expression of related genes on E. coli genome. The genetic engineering strain provided by the present disclosure can produce optically pure D-danshensu and L-danshensu, and jointly produce pyruvic acid. The production process is simple, raw materials are easily available, impurities are fewer, and a good industrial application prospect is achieved.
Jiangnan University
C C C C C C C C C C C
C12P C12Y C12N C12N C12Y C12R C12Y C12Y C12N C12Y C12P
inventional additional inventional inventional additional additional additional additional inventional additional inventional
Yanrui Tianzhen Yujie Jinbin Xiaohui Yajun
Ding Xiong Cai Liu Zheng Bai