TraskBritt
Single pot conversion of artemisinin into arteether
The present invention provides a method for the preparation of arteether from artemisinin in one pot in just about 4 hours comprising reduction of artemisinin into dihydroartemisinin by less quantity of sodium borohydride in ethanol at room temperature in the presence of a novel polyhydroxy catalyst, acylation of dihydroartemisinin in the presence of an acid catalyst, extraction of arteether from an aqueous reaction mixture using 1% ethyl acetate in n-hexane followed by workup and purification of the impure arteether to yield 80-86% (w/w) pure alpha, beta arteether.
Council of Scientific and Industrial Research
C
C07D
inventional
Amit Rajendra Singh Tarun Suman P. S.
Tewari Bhakuni Singh Khanuja