Sughrue Mion, PLLC
Method for preparing highly concentrated fibrinogen solution and method for preparing fibrin sealant by using thereof
A method for preparing a highly concentrated fibrinogen solution includes adding amino acid or amino acid derivatives, and/or salts to a lowly concentrated fibrinogen solution, followed by a ultra-filtration concentration. Factor XIII can be added either before or after the ultra-filtration to give a fibrin sealant component 1 containing the highly concentrated fibrinogen solution. The fibrin sealant component 1 could be preserved for a long time at room temperature and be used without a reconstitution. Fibrin sealant component 2 is a solution containing thrombin and calcium. A fibrin sealant product may be provided in a vial type in which the fibrin sealant components 1 and 2 are each filled in separate vials or in a re-filled syringe type wherein the fibrin sealant components 1 and 2 are each filled in separate syringes connected with each other to be instantly used.
GREEN CROSS HOLDINGS CORPORATION
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A61L A61P A61P A61K C07K A61P A61K
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Yong Ki-Yong Jun Sic Gun Sul Ki Hwan
Kang Kim Kim Lee Son