Fish & Richardson P.C.
Preparation of and formulation comprising a MEK inhibitor
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Array BioPharma Inc.
A A A A C A C A A A A A A A A A C C C A A
A61K A61K A61K A61K C07D A61P C30B A61P A61P A61K A61K A61K A61P A61P A61K A61K C30B C07D C07B A61K A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional
Christoph Max Daniel Andreas Daniel Weidong Marie-Christine Peter J. Werner Heinz Marian Paul
Krell Niederer Zimmermann Liu Wolf Stengel Pachinger Misun Nichols