Catechols as antimicrobial agents
Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.
Cubist Pharmaceuticals, Inc. Merck & Co., Inc.
C C C C A C A C A C C C
C07D C07D C07D C07D A61P C07D A61P C07D A61P C07D C07D C07D
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Jason Gina M. John Aaron H. Sherman T. Milana Dennis Milton L. Michael
Hill Santorelli Finn Leeman Waddell Maletic Keith Hammond Morytko