Barnes & Thornburg
Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders. 
CAYMAN CHEMICAL COMPANY, INC.
A A A C C A A A A A A A A A A A A A A A A A A A A A C A
A61K A61L A61L C07D C07D A61L A61L A61P A61P A61K A61P A61L A61P A61P A61L A61P A61L A61P A61L A61L A61P A61L A61P A61P A61P A61P C07D A61L
inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional
James Bernard Fred Lawrence Stephen Douglas Bradlee David Gregory William Andriy Joseph Michael Adam Kirk M.
Kramer Ciske Barrett Germain Endres Komilov Colombo Uzieblo Maxey