Wilson, Sonsini, Goodrich & Rosati
Methods and compositions related to retinoid receptor-selective pathway
Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenviroment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE XIAMEN UNIVERSITY
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Ying Xiao-kun Wen Hu Pei-Qiang
Su Zhang Liu Zhou Huang