Scully, Scott, Murphy & Presser, P.C.
Use of Salmonella flagellin derivative in preparation of drug for preventing and treating inflammatory bowel diseases
The application of flagellin derivative CZLC31 from Salmonella in preparation of medicines for preventing and treating inflammatory bowel disease (IBD) is introduced in this invention. The CZLC331 protein has a good preventive and therapeutic effect for IBD, such as ulcerative colitis (UC) and Crohn's disease (CD) in this invention. Therefore, this protein can be prepared into the drug for prevention and treatment of IBD. It has been found that the bad efficacy, slow onset, long course of treatment, side effects can be significantly avoided for existing clinical IBD drugs, it can reduce the patient's pain during the treatment in this invention. The rehabilitation and quality of life of the patients have been largely improved. The drug will play an important role in the prevention and treatment of IBD in this invention, and has broad application prospects.
Institute of Radiation Medicine, Academy of Military Medical Sciences, People's Liberation Army of China Suzhou Sciscape Biomedicine Science & Technology Co. Ltd.
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A61P C07K A61K A61K A61P A61K C07K Y02A A61K A61P
inventional additional additional inventional inventional inventional inventional additional inventional inventional
Junhuai Chenggang Zhihui Yanchun Yonghong Yan Weiguang Yang
Li Zhang Li Zhang Wu Gao Li Xu