Cesari and McKenna, LLP
Genetic variants associated with lithium response in bipolar disorder
Described herein is a method of determining lithium responsiveness in a bipolar disorder patient. The method includes obtaining a sample from a patient having bipolar disorder, and assaying the sample for the presence or absence of one or more glutamate decarboxylase-like 1 (GADL1) gene variants selected from the group consisting of a T allele of the single nucleotide polymorphism (SNP) rs17026688, a G allele of the SNP rs17026651, and GADL1 1VS8+48delG. The presence of one or more of the GADL1 gene variants indicates that the patient is responsive to lithium treatment.
Academia Sinica
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A61K C12Q C12Q C12Q C12Q
inventional additional inventional additional additional
Chien-Hsiun Andrew Tai-Ann Chau-Shoun Yuan-Tsong Ming Ta Michael
Chen Cheng Lee Chen Lee