Licata & Tyrrell P.C.
Anti-ADDL monoclonal antibody and uses thereof
The present invention relates to antibodies that bind amyloid β-derived diffusible ligands, also known as ADDLs. The antibodies of the invention are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.
Merck Sharp & Dohme Corp.
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Alexander Renee C. Wei-Qin Ningyan Min Weirong Paul J. Fubao
McCampbell Gaspar Zhao Zhang Xu Wang Shughrue Wang