Fish & Richardson P.C.
Macrocyclic compounds as Trk kinase inhibitors
Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Array BioPharma, Inc.
A A C Y A C A A A A A C A C A A C
A61P A61K C07D Y02A A61P C07D A61P A61P A61P A61P A61P C07D A61P C07D A61P A61P C07D
inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Qian Yutong Steven W. Gabrielle R. Hong-Woon Kevin Ronald Julia Jeongbeob
Zhao Jiang Andrews Kolakowski Yang Condroski Haas Seo