Cationic lipids
 The present invention is directed to new cationic lipids and intermediates in their synthesis that are useful for transfecting nucleic acids or peptides into prokaryotic or eukaryotic cells. The lipids comprise one or two substituted arginine, lysine or ornithine residues, or derivatives thereof, linked to a lipophilic moiety. The lipids form a complex when mixed with polyanions such as nucleic acids or peptides. The complexes permit efficient transfer of polyanions into cells, usually without significant toxicity to the cells. 
Gilead Sciences, Inc.
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C12N C07C C07K C07C C07C C07C C07C C07C C07K C07J C07C A61K A61K
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Kuei-Ying George S. Randolph B. Robert A. Richard W. Mark D. Jason G. Kevin L.
Lin Lewis DePrince Mook, Jr. Wagner Matteucci Lewis Facchine