Oblon, Spivak, McClelland, Maier & Neustadt
Monoclonal anti-idiotypic antibody, method for production thereof, and hybridoma producing said antibody
 A monoclonal anti-idiotypic antibody specific to a human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor; a method for the production of the aforementioned monoclonal anti-idiotypic antibody by the steps of immunizing an animal with a human IgG.sub.1 type monoclonal antibody specific to nicotinic acetylcholine receptor, collecting antibody-producing cells from the animal, fusing the collected cells with neoplastic cells, selecting from the product of fusion a hybridoma capable of producing a monoclonal anti-idiotypic antibody specific to the human IgG.sub.1 type monoclonal antibody possessing specificity to nicotinic acetylcholine receptor, propagating the selected hybridoma thereby giving rise to said monoclonal anti-idiotypic antibody, and collecting the produced monoclonal anti-idiotypic antibody; and use of the monoclonal anti-idiotypic antibody as a reagent and as an adsorbent. 
Agency of Industrial Science and Technology Ministry of International Trade and Industry
G Y C G Y C Y A Y A
G01N Y10S C07K G01N Y10S C07K Y10S A61P Y10S A61P
inventional additional inventional inventional additional inventional additional inventional additional inventional
Masao Koichi Hideaki Yoshiaki Toshihide
Tanihara Takakura Yamada Omura Nakashima