Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Cyclic hexapeptide derivatives
This invention relates to new polypeptide compound represented by the general formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on β-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystic carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
Fujisawa Pharmaceutical Co. Ltd.
A A C A A
A61P A61P C07K A61P A61K
inventional inventional inventional inventional additional
Keiji Takashi Hiroaki Kenji Ayako David Hiroshi Takahiro
Matsuda Ogino Mizuno Murano Toda Barrett Matsuda Matsuya