Schwegman Lundberg & Woessner, P.A.
Heterocyclic inhibitors of monocarboxylate transporters
The invention provides heterocyclic compounds of formula A, B, and C as described herein that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
THE SCRIPPS RESEARCH INSTITUTE
C C A A A A A A A A
C07D C07D A61P A61P A61K A61K A61P A61P A61P A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Jun Yong Jitendra K. Andy S. John L. Thomas D. William R. Reji
Choi Mishra Tsai Cleveland Bannister Roush Nair