Isoforms of mouse serotonin 5-HT2C receptor
The invention includes mouse serotonin 5-HT2c receptor isoforms having amino acid replacements at one or more positions of the natural mouse serotonin 5-HT2c receptor polypeptide sequence, specifically at one or more of positions 157, 159 and 161. The polypeptides are useful for identifying ligands which bind with the serotonin 5-HT2c receptor and modulators of the serotonin 5-HT2c, and for identifying drugs with affinity for 5-HT2 receptors which are used to treat schizophrenia, Parkinsonism, and anxiety disorders.
Merck & Co., Inc.
A Y C
A61K Y10S C07K
additional additional inventional
Jie Tong M. Leonardus H. T.
Liu Fong Van Der Ploeg