Eversheds Sutherland (US) LLP
Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO
This invention discloses the use of aza-tryptanthrin derivatives as an IDO1 and/or TDO inhibitors, and the derivatives are represented by the general Formula (I). The compounds represented by the Formula (I) have inhibitory effects on indoleamine-2,3-dioxygenase 1 (IDO1) and/or tryptophan-2,3-dioxygenase (TDO), and can be used for treating diseases having the pathological features of IDO1 and/or TDO-mediated tryptophan metabolism, including but not limited to tumors, autoimmune disease, infectious diseases, Alzheimer's disease, depression, anxiety.
Peking University
C A C A
C07D A61K C07D A61P
inventional inventional inventional inventional
Yu Zhongjun Dongbo Xiangbao Meiqi
Chen Li Lu Meng Zhang