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Indenoisoquinolinone derivatives, manufacturing method and medical use thereof
Indenoisoquinolinone derivatives (I), the manufacturing method and the medical use thereof, which belong to pharmaceutical chemistry and organic chemistry field, are disclosed. These compounds can be used for treating several medical symptoms related to postmenopausal syndrome, uterine fibers deterioration and aortic smooth muscle cells proliferation, especially ER-(+) depend breast cancer. Meanwhile, these compounds can also be used for treating glioma and lung cancer, and have inhibiting effect on tumor metastasis effect on tumor metastasis.
China Pharmaceutical University Nanjing Medical University Affiliated Brain Hospital
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A61P A61P A61P C07D A61P C07D C07D A61P A61P
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Yao Xiaobo Qingjiang Hong Tianlin Hua Qidong
Yao Li Liao Xiao Wang Xiang You