Knobbe Martens Olson & Bear, LLP
RNA interference agents for GST-π gene modulation
This invention provides compounds, compositions and methods for modulating the expression of human GST-π using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
Nitto Denko Corporation
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C12N A61K A61P C12N
inventional inventional inventional inventional
Mohammad Jens Wenbin Hirokazu Kenjirou Jun Erika
Ahmadian Harborth Ying Takahashi Minomi Zhang Terada