Faegre Drinker Biddle & Reath LLP
Myricetin derivative and preparing method thereof, and application of same for treating colitis, preventing and treating colitis tumorigenesis, and treating colorectal cancer
The present invention provides a myricetin derivative, a preparation method thereof, a pharmaceutical composition containing the same, an application thereof for treating colitis, preventing and treating colitis-associated tumorigenesis and treating colorectal cancer, and an application thereof in preparing a composition for modulating activities of endoplasmic reticulum stress signaling molecules. The myricetin derivative disclosed herein has excellent water solubility, and has biological activities including inhibition of colitis, prevention and treatment of colitis-associated tumorigenesis, and treatment of colorectal cancer. The preparation method disclosed herein uses myricetrin as starting material which is economical and easily available. With the merits of low cost, high yield, high product purity and suitability for large-scale industrial production, the preparation method disclosed herein represents significant market value and economic prospects.
MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD.
A C A A C Y C A
A61P C07D A61P A61K C07H Y02P C07H A61P
inventional inventional inventional inventional inventional additional inventional inventional
Huashi Liang Chong Shixiao Feng Zhiyu Wenbao Xianjun Feng
Guan Zhang Yang Wang Li Song Li Qu Wang