Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
Composition containing medicine extremely slightly soluble in water being excellent in eluting property and method for preparation thereof
A composition containing an extremely poorly water-soluble drug and obtained by treating, with a supercritical fluid or subcritical fluid of carbon dioxide, a mixture comprising a porous silica material and the extremely poorly water-soluble drug; and its production process. The porous silica material has an average pore diameter in a range of from 1 to 20 nm, pores having diameters within ±40% of the average pore size account for at least 60% of a total pore volume of the porous silica material, and in X-ray diffractometry, the porous silica material has at least one peak at a position of diffraction angle (2θ) corresponding to a d value of at least 1 nm.The composition according to the present invention, which contains the extremely poorly water-soluble drug, is excellent in the dissolution of the extremely poorly water-soluble drug.
Kabushiki Kaisha Toyota Chuo Kenkyusho Kowa Co., Ltd.
Y A A A A
Y10S A61K A61K A61K A61K
additional inventional inventional inventional additional
Yoshiaki Toshio Hiroshi Tsutomu Hirofumi Masayuki Haruo Makoto
Fukushima Inagi Miura Kajino Takeuchi Kanishi Takahashi Kanebako