Wolf, Greenfield & Sacks, P.C.
Halofuginone analogs for inhibition of tRNA synthetases and uses thereof
The present invention provides novel analogs and derivatives of halofuginone. The invention also provides pharmaceutical and cosmetic compositions thereof and methods for using halofuginone analogs in treating chronic inflammatory diseases, autoimmune diseases, dry eye syndrome, fibrosis, scar formation, angiogenesis, viral infections, ischemic damage, transplant and implant rejection, neurodegenerative diseases, and cosmetic applications.
President and Fellows of Harvard College Children's Medical Center Corporation
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A61P A61P A61P C07F A61P A61P C07D A61P C07D C07D C07D C07D A61P A61P A61P A61P A61K A61K A61P A61K A61P A61P C07D
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Anjana Ralph Jinbo Mark S. Tracy Malcolm
Rao Mazitschek Lee Sundrud Keller Whitman