Urea-oxaziridines
Chemoselective conjugation is achieved through redox reactivity by reacting an N-transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Chemical Tagging (ReACT) strategies for methionine-based protein functionalization. Oxaziridine (Ox) compounds serve as oxidant-mediated reagents for direct functionalization by converting methionine to the corresponding sulfimide conjugation product.
The Regents of the University of California
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C07D C07D C07D C07D G01N
inventional inventional inventional inventional inventional
Christopher J. F. Dean Alec H. Patti
Chang Toste Christian Zhang