Sheppard Mullin Richter & Hampton LLP
Construction and application of bispecific antibody HER2xCD3
The present invention provides a bispecific antibody. The bispecific antibody provided by the present invention comprises a single-chain unit and a monovalent unit, wherein the single-chain unit has a specific binding capability against a surface antigen CD3 of an immune cell; the monovalent unit has a specific binding capability against a surface antigen HER2 of a tumor cell; the single-chain unit comprises a single-chain variable fragment ScFv fused with an Fc fragment; and the monovalent unit comprises a light chain and heavy chain pair. The present invention also provides a preparation method of the bispecific antibody and pharmaceutical use of these antibodies.
Wuhan YZY Biopharma Co., Ltd.
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Jing Xiang Rui Pengfei Kesu Lingli
Zhang Zhou Wang Zhou Fan Hu