Morrison & Foerster LLP
Method for determining fetal chromosomal abnormality
The current invention is directed to methods for noninvasive detection of fetal genetic abnormalities by large-scale sequencing of nucleotides from maternal biological sample. Further provided are methods to remove GC bias from the sequencing results according to the difference in GC content of a chromosome. The current invention not only makes the detection much more accurate but also represents a comprehensive method for fetal aneuploidy detection including sex chromosome disorders such as XO, XXX, XXY, and XYY, etc.
BGI HEALTH SERVICE CO., LTD.
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C12Q G16B G16B G16B C12Q G16B G16B
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Xianghua Yuying Fang Huifei Fuman Xiuqing
Chai Yuan Chen Chen Jiang Zhang