Ladas & Parry
Process for the preparation of monohydrated sodium phenylpyruvate
 A process for the preparation of monohydrated sodium phenylpyruvate comprises reacting benzaldehyde with the stoichiometric quantity of hydantoin in the aqueous medium in the presence of a catalytic quantity of a primary or secondary amine at high temperature, treating the reaction mixture with an excess of sodium hydroxide at high temperature, adding sodium chloride to the sodium hydroxide-treated solution, acidifying the so obtained solution with concentrated hydrochloric acid, and washing the formed precipitate with methanol. 
Development Center for Biotechnology
C C
C07C C07C
inventional inventional
Hsin Same-Ting Jin-Tann
Tsai Chen Chen