Hamilton, Brook, Smith & Reynolds, P.C.
Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
Vitae Pharmaceuticals, Inc.
C A C C A Y A C A A A A A A C C
C07D A61P C07D C07D A61P Y02P A61P C07D A61P A61P A61P A61P A61P A61P C07D C07D
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Zhenrong David A. Robert D. Patrick T. Lawrence W. Gerard Wei Alexey V. Jing Suresh B. Salvacion Colin John J.
Xu Claremon Simpson Flaherty Dillard McGeehan Zhao Ishchenko Yuan Singh Cacatian Tice Baldwin