C-3 and C-17 modified triterpenoids as HIV-1 inhibitors
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I:These compounds are useful for the treatment of HIV and AIDS.
ViiV HEALTHCARE UK (NO.5) LIMITED
A C C C C
A61P C07J C07J C12N C12N
inventional inventional inventional inventional additional
Alicia Nicholas A. Beata Ira B. Sing-Yuen Brian Lee Jie Ny Jacob Yan Richard A.
Regueiro-Ren Meanwell Nowicka-Sans Dicker Sit Venables Chen Sin Swidorski Chen Hartz