McDonnell Boehnen Hulbert & Berghoff
Antimicrobial 4-oxoquinolizines
This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.
Emergent Product Development Gaithersburg Inc.
A A A A A Y C A A A
A61K A61K A61K A61K A61K Y02A C07D A61P A61K A61K
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Peter Christian Patrick Jutta Glenn Daniel
Schneider Bartels Roussel Heim Dale Milligan