Pabst Patent Group LLP
Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization
Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (DSP) into a matrix such as biodegradable poly(lactic-coglycolic acid) (PLGA) which is densely coated with hydrophilic polymer such as PEG or PLURONIC® F127, exhibit sustained release of DSP for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.
The Johns Hopkins University
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Walter J. Qing Nicholas J. Lixia Justin Scot Qingguo Bing
Stark Pan Boylan Luo Hanes Xu Wang