CBM Patent Consulting, LLC
Anti-PD-1 monoclonal antibody and obtaining method therefor
The invention provides human monoclonal antibodies that specifically bind to PD-1 with high affinity. The anti-PD-1 monoclonal antibodies were screened from a synthetic antibody library, and affinity maturation was performed. The synthetic antibody libraries used to select for the high affinity anti-PD-1 monoclonal antibodies were made by replacing the light chain CDR1, CDR2 and CDR3 and heavy chain CDR1, CDR 2 and CDR 3 of phage libraries from the preliminary screening, and the high affinity anti-PD-1 monoclonal antibodies were selected. The human anti-PD-1 monoclonal antibodies have high affinity and inhibit the binding of PD-1 to its ligand PD-L1. The antibodies can be used for treating tumor, inflammation and autoimmune diseases.
BEIJING JINGYITAIXIANG TECHNOLOGY DEVELOPMENT CO., LTD. BEIJING DONGFANG BIOTECH CO., LTD.
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Xianhong Yanlu Yi Haiping Junjie Shuang Xiaomin
Bai Zan Bai Zhou Zhou Pei Li