Sughrue, Rothwell, Mion, Zinn and Macpeak
7-(.alpha.-(4-Hydroxy-1,5-naphthyridine-3-carbonamido)-.alpha.-ph enylacetamido) cephalosporin derivatives
 A cephalosporin derivative of formula (I): ##STR1## wherein X is an --OCOCH.sub.3 group or an --S--Het group in which Het is a 5- or 6-membered heterocyclic ring containing one to four hetero atoms selected from the group consisting of nitrogen, oxygen and sulfur atoms, which may be substituted with one or more substituents, and the non-toxic pharmaceutically acceptable salts thereof which are useful as an antimicrobial material and which are prepared by the reaction of a compound of formula (II): ##STR2## or a reactive derivative thereof, with a compound of formula (III): ##STR3## wherein X is as defined above, or a derivative thereof. 
Sumitomo Chemical Company, Ltd.
C
C07D
inventional
Hisao Kosaku Norihiko Yasuko Kenji Akio Hiroshi Hirotada Takenari Kozo Toshiaki
Tobiki Okamura Tanno Eda Irie Izawa Noguchi Yamada Nakagome Shimago Komatsu