Cantor Colburn LLP
Piperazinyl 3-aminopyrrolidine derivatives as a CCR2 antagonists
The present invention relates to compounds of chemical formula 1 and having CCR2 (chemokine receptor 2) antagonistic effects, and salts or isomers thereof. These compounds are very useful for treating, preventing, or relieving rheumatoid arthritis, arteriosclerosis, multiple sclerosis, asthma, and various diseases related to CCR2.wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 is the same as defined in the specification.
Yang Ji Chemical Co., Ltd.
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Min-Ho Jee Woong Jung-Ok So-Hee Seung-Woo Jung-Duk Yongho Jong-Hoon Youna
Oak Lim Lee Kang Lee Sohn Na Kim Oh