Pyrimido compounds having antiproliferative activity
Disclosed are novel pyrimido compounds that are selective inhibitors of both KDR an FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and methods of treating cancer.
Hoffman-La Roche Inc.
A A C
A61P A61P C07D
inventional inventional inventional
Yi Christophe Jin-Jun Marek Michal William Emily Aijun Kin-Chun Andrzej Robert
Chen Michoud Liu Kabat Harris Liu Luk Daniewski