Nixon Peabody LLP
Compositions and methods for treating HIF-1a over-expressing cancers
Described herein are compositions that include monoclonal antibodies that specifically bind Hsp90α and methods of using the same to treat HIF-1a-overexpressing cancer. In some embodiments, the cancers are breast cancer or lung cancer. The monoclonal antibodies bind the epitope TKPIWTRNP in Hsp90α or VKHFSVEGQ in Hsp90α.
University of Southern California
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David Hangming Divya Mei Mengchen Wei
Woodley Dong Sahu Chen Zou Li