Harding, Earley, Follmer & Frailey, P.C.
Nanoparticle coated with ligand introduced with long hydrophobic chain and method for preparing same
The present invention relates to a nanoparticle having a linker connected to a long alkane or alkene chain, and a method for preparing the nanoparticle. The alkyl chain of C10-30 introduced with a ligand of the present invention can be coated on a hydrophobic nanoparticle through a noncovalent bond, enabling easy introduction of various ligands to the nanoparticle, and the nanoparticle having various functional groups prepared using the method can be applied to fluorescent detection, MRI, raman spectroscopy, optical detection, PET, SPECT, or gamma image device, and the ligand of the visualization agents can be modified to be used for new vessels detection, cancer cell detection, immunocyte detection, hepatocyte detection, cell death detection, and gene detection.
CELLBION CO., LTD.
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G01N A61K A61K G01N A61K G01N A61K A61K B82Y A61K
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Myung Chul Young Kyoung Jae Min Dong Soo June-Key
Lee Lee Jeong Lee Chung