Kenway & Jenney
Novel penicillin derivatives
 Novel penicillin derivatives of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein R is hydrogen or hydroxy, are produced by acylating ampicillin, amoxicillin or a salt thereof with 4-hydroxy-pyrazino[2,3-f]quinoline-3-carboxylic acid or its functional derivative. They have high anti-pseudomonas activity and other antibacterial activity against gram-positive and gram-negative bacteria, and are of extremely low toxicity. 
Taisho Pharmaceutical Co., Ltd.
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inventional inventional inventional
Chihiro Yoshiaki Jiro Toshifumi
Yokoo Watanabe Sawada Asaka