Ladas & Parry LLP
Promoter and viral vector containing the same
The invention constructs an activating KRASmutant but not p53-responsive promoter and generates an E1B-55kD-deleted (ΔE1B-55kD) adenovirus, harboring a transcriptionally activating transgene and holding lytic replication ability in the tumor cells with activating KRASmutant. The adenovirus of the invention can be used in the treatment of cancers.
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C12N A61P C07K C12N C12N C12N A61K C12N A61K A61P
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Chin-Cheng Jin-Hwang
Liu Liu