Muncy, Geissler, Olds & Lowe, P.C.
Controlled release system and manufacturing method thereof
A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.
Kaohsiung Medical University
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Yin-Chih Je-Ken Mei-Ling Gwo-Jaw Hui-Ting Chih-Kuang Cherng-Chyi
Fu Chang Ho Wang Chen Wang Tzeng