Hamre, Schumann, Mueller & Larson, P.C.
Recombinant antigens of porcine circovirus 2 (PCV-2) for vaccine formulations, diagnostic kit and use thereof
The present invention relates to the preparation of the recombinant antigen of the viral capsid of Porcine circovirus 2 (PCV-2) and modifications thereof, upon expression in a prokaryotic system, purification in the monomer form, recovery of virus-like particles (VLPs) and their use in vaccine formulations, diagnostic kits and a system for quantifying in vaccine lots of the PCV-2 antigen by means of a capture ELISA assay. The antigens and vaccine formulations can be used in animal's immunization in programs for combatting PCV-2-associated diseases in conventional swine breeding systems, and represent alternatives to the commercially available vaccines. The ELISA kit can be used for testing the quality of commercial and/or experimental vaccines against PCV-2.
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MG-FAPEMIG UNIVERSIDADE FEDERAL DE VIÇOSA
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C12N G01N A61K A61K C12N G01N C07K A61P A61K G01N C12N G01N
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Tiago Juliana Lopes Rangel Gustavo Costa Márcia Rogéria Antônio Abelardo Silva Sthefany Patareli Natália Luiz Fernando Pedro Marcus Pereira Mariana Costa Jackson de Roberta Thiago Souza Rafael Locatelli Josicelli Souza Amanda Martins
Jaquel Zilch Fietto Bressan De Almeida De Morais Monteiro Junior Kalks Fialho Gonzaga Lino De Souza Vidigal Fausto Andrade Teixeira Amaziles Silva Leite Onofre Salgado Crispim De Cruz Souza