Sughrue, Mion, Zinn, Macpeak & Seas
Purified plasminogen activator, process for its production and thrombolytic composition containing it
 A plasminogen activator obtained from a tissue cultured liquor of human normal tissue derived cells, e.g., human embryonic derived cells, human placenta derived cells etc., and having the following properties: PA1 (a) molecular weight measured by gel filtration: 63,000.+-.10,000, PA1 (b) isoelectric point: 7.0-8.5, PA1 (c) affinity to fibrin: present, PA1 (d) affinity to concanavalin A: present, PA1 (e) optimum pH: 7-9.5, and PA1 (f) stability: does not lose activity at 60.degree. C. for 10 hours but loses about 5% of activity at pH 2-3 at 98.degree. C. for a minute; a process for the production of the aforesaid plasminogen activator; and a thrombolytic composition containing the aforesaid plasminogen activator as an active ingredient are disclosed. 
Kowa Co., Ltd. Asahi Kasei Kogyo Kabushiki Kaisha
A C A
A61P C12N A61K
inventional inventional additional
Akio Toshihito Hideo
Hasegawa Mori Yoshizaki