Intellectual Property Connections, Inc.
Baculovirus display vectors and uses thereof
A recombinant baculovirus displaying on its envelop a fusion protein is disclosed. The fusion protein comprises a heterologous antigen, and a C-terminal region of baculovirus envelope GP64 protein, which has at least 100 amino acid residues in length and lacks a B12D5 binding epitope located within the central basic region of the GP64 protein. The genome of the recombinant baculovirus comprises a transgene encoding a fusion protein that comprises a signal peptide, the heterologous antigen, and the C-terminal region of the baculovirus envelope GP64 protein, in which the antigen is located between the signal peptide and the C-terminal region of the GP64 protein. Methods for eliciting an antigen-specific immunogenic response in a subject in need thereof are also disclosed.
REBER GENETICS CO., LTD.
C A C A A A A A A A A A C A C C C A C A C A C
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Wei-I Yan-Chiou Hsiu-Kang Chia-Jung
Chou Liao Chang Chang