Sughrue Mion, PLLC
Method for producing antibody CH3 domain heterodimeric mutant pair using yeast mating and CH3 mutant pair produced thereby
A method for evaluating and screening a mutant inducing the high-efficiency formation of heterodimers from a human antibody heavy chain constant region mutant pair combination library in order to increase the yield of formation of human antibody heterodimeric heavy chain constant regions. A heterodimeric heavy chain constant region (heterodimeric F) library is obtained by the method. A CH3 domain mutant pair, in which the formation of the heterodimeric heavy chain constant regions is preferred in the library, forms heterodimeric heavy chain constant regions at a high yield of at least 80-90%, and also has excellent thermal stability and retains binding ability to the heavy chain constant region receptor (FcRn).
AJOU UNIVERSITY INDUSTRY—ACADEMIC COOPERATION FOUNDATION
A C C C C C C C C C C C C
A61K C07K C07K C07K C40B C07K C07K C12N C07K C07K C40B C07K C12N
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Hye Ji Yong Sung Ji Hee
Choi Kim Ha