Harness, Dickey & Pierce, P.L.C.
Antibody drug conjugate platform using bispecific antibody
The present invention relates to an antibody drug conjugate using a bispecific antibody and its use. The antibody drug conjugate of the present invention can easily form a conjugate of an antibody and a drug without a multistep synthetic process though binding of a conjugate of a bivalent cotinine-peptide and a drug, and an anti-cotinine single chain variable fragment. In addition, the antibody drug conjugate can effectively deliver a drug to a target to which the antibody binds specifically, and can enhance a half-life of a drug in the body, thereby improving a therapeutic effect.
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
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Gunwoo Junyeong Soohyun Hyori Junho
Park Jin Kim Kim Chung