Substituted 4-pyrimidone compounds, compositions and methods of use
 The compounds are substituted isocytosines which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methoxybenzyl)-4-py rimidone and 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-benzyloxy-4-pyrimidone . 
Smith Kline & French Laboratories Limited
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inventional inventional inventional
Graham J. Thomas H. Charon R. John C.
Durant Brown Ganellin Emmett