Nixon & Vanderhye P.C.
Medical use of gene and vector encoding a multisubstrate deoxyribonucleoside kinase
By inserting a DNA or RNA sequence comprising a subsequence showing a homology of at least 60%, preferably at least 80%, and most preferably at least 90% of the DNA sequence of SEQ. ID. NO. 1 into a cell, that cell will obtain a broad specificity for changing nucleoside analog prodrugs to active drugs by phosphorylation. Likewise this changement will occur at a high catalytic rate. Preferably the DNA sequence is inserted into the cell by transformation with a suitable virus or another suitable vector. Such viruses and vectors also constitute a part of the present invention.
BIO VICI
C A A A C
C12N A61P A61P A61P C12N
inventional inventional inventional inventional additional
Magnus Anna
Johansson Karlsson