Venable
Controlling attention and memory by altering neuronal carbonic anhydrase activity
The invention provides a method for modulating attentive cognition comprising administering a compound that alters intraneuronal carbonic anhydrase activity thereby affecting establishment of a theta rhythm. The metabolic pathway of the compound preferably involves bicarbonate-mediated GABAergic depolarization. The term &#8220;attentive cognition&#8221; is meant to encompass memory formation, learning, spatial memory, and attention. The modulating may be stimulating, or the compound may have the multiple effects of inhibiting intraneuronal carbonic anhydrase activity, establishment of a theta rhythm, and memory acquisition. The invention further provides a method of modulating memory and attention comprising switching theta rhythm on and off, the switching comprising potentiating or inhibiting intraneuronal carbonic anhydrase activity.
The United States of America as represented by the Secretary of Health and Human Services
A A
A61K A61K
inventional inventional
Miao-Kun Daniel L. Wei-Qin
Sun Alkon Zhao