Hunton & Williams LLP
Functional assays for identifying compounds that modulate T1R2/T1R3 (sweet) taste
Functional assays for identifying compounds that activate or modulate the activation of the T1R2/T1R3 (sweet) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R2/T1R3 (sweet) taste receptor or on the activation of T1R2/T1R3 sweet taste receptor by another, compound e.g., saccharin or another artificial or natural sweetener. These assays preferably are cell-based functional assays and typically use cells, e.g., HEK-293 cells that stably express a G protein such as Gα15, Gα16 or gustducin. Compounds identified in the disclosed functional assays are potentially useful as additives in compositions for human or animal consumption.
Senomyx, Inc.
C A G C G G G G A G C C C G
C07K A01K G01N C12Q G01N G01N G01N G01N A61P G01N C07K C12Q C12Q G01N
additional additional additional inventional additional additional inventional inventional inventional inventional inventional additional additional additional
Jon Elliot Sergey Fernando Lena Xiaodong Mark Hong Shawn
Adler Zozulya Echeverri Staszewski Li Zoller Xu O'Connell