Tarolli, Sundheim, Covell & Tummino LLP
Methods and compositions for treating cancer
A method of treating cancer in a subject includes administering to the subject a therapeutically effective amount of an agent that specifically binds to or complexes with a proteolytically cleaved extracellular fragment of an immunoglobulin (Ig) superfamily cell adhesion molecule (CAM) or its receptor that is expressed by a cancer cell or another cell in the cancer cell microenvironment. The agent inhibits the cell adhesion function of the cleaved extracellular fragment or its receptor.
CASE WESTERN RESERVE UNIVERSITY
C C A A C A A C
C07K C12N A61K A61N C12N A61P A61K C12Y
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Susann
Brady-Kalnay