Cyclic amine bace-1 inhibitors having a heterocyclic substituent
Disclosed are novel compounds of the formulaor a pharmaceutically acceptable salt or solvate thereof, wherein        Also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating cognitive or neurodegenerative diseases with compounds of formula I.Also disclosed are pharmaceutical compositions and methods of treatment comprising compounds of formula I in combination with other agents useful in treating cognitive or neurodegenerative diseases.
Schering Corporation
C C C A C C C C C C A C A C
C07D C07D C04B A61P C07D C07D C07D C07D C07D C07D A61P C07D A61P C07D
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Guoqing Ying Ulrich Jianping Andrew Johannes H. Corey
Li Huang Iserloh Pan Stamford Voigt Strickland