Genomics Institute of the Novartis Research Foundation
Compounds and compositions as TLR activity modulators
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors, including TLR7 and TLR8. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine (formula I) wherein: X3 is N; X4 is N Or CR3; X5 is —CR4═CR5.
Novartis AG IRM LLC
A A A C A A A A C A A A A A A A A A A C A A C A A C A
A61P A61P A61P C07D A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P C07D A61P A61P C07D A61P
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Tom Yao Hsiang Alex David Yongkai Nicholas Pranab Yefen Manmohan Xiaoyue
Wu Cortez Skibinski Li Valiante Mishra Zou Singh Zhang