Choate, Hall & Stewart LLP
Anti-human 4-1BB antibodies and uses thereof
Provided are anti-human 4-1BB antibodies and fragments thereof with one or more structural features that are not found in a reference anti-human 4-1BB antibody, where said features may improve certain characteristics of the antibody relative to a reference antibody. Various in vitro and in vivo methods and reagents related to anti-human 4-1BB antibodies described herein are also provided. Methods include, for example, inducing T-cell proliferation, inducing T cell secretion of IFNγ, as well as detection, prevention, and/or therapeutic treatment of cancer using an anti-human 4-1BB antibody or fragment thereof.
Eutilex Co., Ltd.
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A61P C07K A61K C07K C07K A61K C07K C07K A61P A61K C07K A61K C07K C07K C07K C07K C07K A61K C07K
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Young Ho Ho-Sik Joong Won Byoung S. Seoung-Joo
Kim Oh Lee Kwon Lee