McCarter & English LLP
Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
This invention relates to novel compounds of the Formula I, Ik, Iq1-21, Ir1-21, Is1-21, It1-7, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of cortisol in a cell or the inhibition of the conversion of cortisone to cortisol in a cell.
Vitae Pharmaceuticals, Inc. Boehringer Ingelheim International GmbH
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A61P A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
David A. Linghang Suresh B. Frank Yuanjie Matthias Katerina Salvacion Wei Colin M. Zhenrong
Claremon Zhuang Singh Himmelsbach Ye Eckhardt Leftheris Cacatian Zhao Tice Xu