Method for targeted degradation of intracellular proteins in vivo or ex vivo
 A method for in vivo selective targeted degradation of intracellular proteins in situ by inducing in vivo or ex vivo in cells a production of dual-function protein comprising N-terminal domain as well as a C-terminal domain or delivering the dual-function protein. The N-terminal domain of the dual-function protein destabilizes the target protein and directs its degradation when linked to it through a linker between the target protein and between the protein agent of the invention. The protein degradation directing N-terminal domain is a subregion within the first 97 amino acids corresponding to the N-terminus of protein antizyme. 
The Regents of the University of California
C C G A A C C G C C C C C C C
C07K C07K G01N A61P A61K C12N C07K G01N C07K C07K C07K C07K C07K C12N C07K
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Philip Xianqiang
Coffino Li