Edwards Angell Palmer & Dodge LLP
Use of a peptide that interacts with αvβ3 integrin of endothelial cell
The present invention relates to the use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (TY) or asparagines-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.
Kyungpook National University Industry-Academic Cooperation Foundation
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Jae-Yong Byung-Heon Jung-Eun Sung-Jin Ju-Ock Rang-Woon Je-Yong Ha-Won In-San
Park Lee Kim Lee Nam Park Choi Jeong Kim