Fish & Richardson P.C.
Preparation of and formulation comprising a MEK inhibitor
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Array BioPharma, Inc. Novartis AG
A A A C A A C C A A A A C A C A A A A A A
A61P A61P A61K C07D A61P A61K C30B C07B A61K A61K A61K A61P C30B A61K C07D A61K A61K A61K A61K A61P A61K
inventional inventional inventional inventional inventional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Weidong Marie-Christine Daniel Andreas Peter J. Daniel Paul Werner Heinz Christoph Max Marian
Liu Wolf Niederer Stengel Zimmermann Nichols Pachinger Krell Misun