McDonnell Boehnen Hulbert & Berghoff LLP
TDO2 Inhibitors
Presently provided are inhibitors of cellularly expressed TDO2 and pharmaceutical compositions thereof, useful for modulating an activity of tryptophan 2, 3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; and treating tumor-specific immunosuppression associated with cancer.
NewLink Genetics Corporation Genentech, Inc.
A C A A A C
A61K C07D A61K A61K A61P C07D
inventional inventional additional inventional inventional inventional
Guosheng Roheeth Po-wai Zhonghua Benjamin Douglas Zuhui Venkata Sanjeev Xingyu Hima Jesse Brendan Rohan Richard Firoz Xiaokai Lewis
Wu Pavana Yuen Pei Sellers Zhang Velvadapu Kumar Lin Potturi Waldo Parr Mendonca Pastor Jaipuri Li Gazzard