Catalytic domain of ADAM33 and methods of use thereof
The present invention discloses purified polypeptides that comprise an active ADAM33 catalytic domain. In addition, the present invention discloses nucleic acids that encode the polypeptides of the present invention. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active ADAM33 catalytic domain. In addition, the present invention discloses methods of using the X-ray diffractable crystals of ADAM33 in structure-based drug design to identify compounds that can modulate the enzymatic activity of ADAM33. The present invention also discloses methods of treating respiratory disorders by administering therapeutic amounts of the ADAM33 catalytic domain.
Schering Corporation
C C A C A C
C07K C07K A61P C12N A61K C07K
inventional additional inventional inventional additional additional
Hung V. Jian-Jun Li Winifred W. Vincent S. Shahriar Shane Wenyan Jun
Le Liu Xiao Prosise Madison Taremi Wang Zou