Foley & Larder LLP
Radiohalide-labeled targeted diagnostics and therapeutics
Disclosed are chemical entities of formula (I) wherein R1, R2 and n are defined herein, and methods of use thereof. These chemical entities are radiative emitters and are useful, e.g., as therapeutic agents for the treatment of, or as diagnostic (e.g., imaging) agents for cancers, e.g., cancers in which PARP1 is overexpressed.
Memorial Sloan Kettering Cancer Center
C C A A C
C07D C07F A61K A61K C07D
inventional inventional inventional inventional inventional
Jason S. Giuseppe Thomas Beatriz Salinas Wolfgang Brandon
Lewis Carlucci Reiner Rodriguez Weber Carney