Methods of administering CRF antagonists
 Substituted pyrrazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, X, Y, Z and A are as defined herein with reference to formula I; pyrazoles and pyzazolopyrimidines of the formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and A are defined herein with reference to formula VII; compounds of the formula ##STR3## wherein A, R.sub.3, R.sub.4 and R. are as defined herein with reference to formula VIII; and pyrrolopyzimidines of the formula ##STR4## wherein B1 R3, R4, R5 and R6 are as defined herein, with reference to formula IX, have corticotropin-releasing factor antagonist activity and as such are of use in the treatment of a variety of stress-related disorders. 
A A A A A A A A A A A A A A A A A
A61P A61P A61K A61K A61P A61P A61K A61P A61P A61P A61P A61K A61P A61P A61P A61P A61P
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Willard M. Gene M. Yuhpyng L.
Welch Bright Chen