Foley & Lardner LLP
Reduction of flake-like aggregation in nanoparticulate active agent compositions
This invention is directed to reduction of flake-like aggregation in nanoparticulate compositions. Also encompassed by the invention are compositions comprising a nanoparticulate active agent, at least one surface stabilizer and a flake-like aggregation reducing agent, such as a buffer and a sugar. The nanoparticulate active agent compositions comprise particles of the active agent having an effective average particle size of less than about 2000 nm.
Alkermes Pharma Ireland Limited
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David M. Peter Wei Niels P.
Slifer Snyder Liu Ryde