Browdy and Neimark
Methotrexate derivative
 Disclosed is a compound represented by the formula: ##STR1## wherein R.sup.1 : CH.sub.2, CH.sub.2 CH.sub.2, CH.sub.2 O, CH.sub.2 S, CH.sub.2 SO; R.sup.2 : hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or a benzyl group; n: an integer of 1 to 4; R.sup.3 : COOR.sup.4, NHCOR.sup.5, CONR.sup.6 R.sup.7, PO.sub.3 H.sub.2, SO.sub.3 H. The compound shows potent antirheumatic function, psoriasis curing function and carcinostatic function and has low toxicity whereby it is available as a medicine. 
Chugai Seiyaku Kabushiki Kaisha
C C
C07F C07D
inventional inventional
Nobuaki Katushito Masahiko Yasuhisa Nobuhiro Hiroharu Keiichiro Shin Hiroshi Kenichi Hiromichi
Kato Miyamoto Mihara Takeda Ohi Matsuoka Tsuji Shimaoka Suzuki Akamatsu Nishina