Sheppard Mullin Richter & Hampton LLP
Isothiazole-pyridine derivatives as modulators of HIF (hypoxia inducible factor) activity
The present invention relates to novel compounds according to Formula I or II, methods, and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF). Formula (I) or (II).
FibroGen, Inc.
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A61K A61K A61P C07D A61K
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Lee A. Xiaoti Michael P. Min
Flippin Zhou Arend Wu