Genomics Institute of the Novartis Research Foundation
Compositions and methods for modulating c-kit and PDGFR receptors
The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFRα, PDGFRβ, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFβ, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2β, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.
IRM LLC
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Donatella Xiaodong Songchun Zuosheng Juliet Shuli Xiaodong Yun Xiaolin Taebo Valentina Christopher Jon Pingda
Chianelli Wang Jiang Liu Nabakka You Liu He Li Sim Molteni Cow Loren Ren