Stereoselective reductive amination of ketones
 Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme. 
Bristol-Myers Squibb Company
C C C C
C12P C12N C12P C12P
inventional inventional inventional inventional
Ramesh Laszlo J. John J. Paul A. Wen-Sen Ronald Keith Steven Mary Jo
Patel Szarka Venit Jass Li Hanson Ramig Goldberg Donovan