Nixon Peabody LLP
Selective oxidation of 5-methylcytosine by TET-family proteins
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
CHILDREN'S MEDICAL CENTER CORPORATION
C C C C C G C C C C C C G C G C
C12N C12Q C12Q C12Q C12Q G01N C12Q C12N C12N C12Q C12N C12Q G01N C12N G01N C12Q
inventional additional additional inventional inventional inventional inventional additional inventional additional additional inventional inventional additional additional additional
Aravind Anjana Kian Peng Suneet Mamta
Iyer Rao Koh Agarwal Tahiliani