Fish & Richardson P.C.
Methods for isolating and proliferating autologous cancer antigen-specific CD8+ T cells
Provided is a method for isolating and proliferating autologous cancer antigen-specific CD8+T cells, and more particularly, a method for selecting an epitope recognized by CD8+ T cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific CD8+ T cells by using a peptide of the selected epitope, and a method of massively proliferating CD8+ T cells by using the method. According to the present invention, it is possible to isolate autologous cancer antigen-specific CD8+ T cells by using the peptide of the CD8 T cell epitope of the autologous cancer antigen present in blood of individual cancer patients instead of a heterologous antigen. Therefore, by using T cells recognizing the autologous cancer antigen, it is possible to effectively select and eliminate cancer cells derived from the cancer patient's own cells. Thus, T cells can be applied to treatment and alleviation of cancer diseases without side effects.
National Cancer Center
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Don-Gil Young-Joo Byoung S. Young-Woo Sang-Jae Jin-Soo Beom-Kyu Kwang-Hui Byung-Kiu Sang-Yoon Hyeon-Seok Seung-Hoon Young-Ho Heon Hyun-Guy Ho-Sik
Lee Lee Kwon Kim Park Lee Choi Kim Park Park Eom Lee Kim Yoo Kang Oh