McCarter & English, LLP
Voriconazole intermediate and voriconazole synthesis method
Provided is a synthesis method for a voriconazole intermediate condensate as shown in formula II or an acid addition salt thereof. As shown in reaction formula 1, the product is prepared via compounds III and IV. The synthesis method adjusts the feeding means, and the reaction conditions are mild and controllable, thereby reducing the production of impurity A, avoiding the use of highly toxic metal lead, and eliminating the risk of highly toxic metal remaining in a drug. The product has a higher purity and significant industrial application value.
ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.
C C
C07D C07D
inventional inventional
Wenfeng Yuling Guoliang Qianghui Zhaoyang Jiegen Zhongming Hu
Huang Fang Tu Wu Meng Liu Xu Huang