Soluble guanylate cyclase stimulators
The invention provides compounds of the Formula (I) or a pharmaceutically acceptable salts thereof, wherein X, Y, Z, R1, R2, R4, Ra, and the subscripts m, p, and q are as described herein. The compounds or their pharmaceutically acceptable salts can modulate the body's production of cyclic guanosine monophosphate (“cGMP”), and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention also provides pharmaceutical compositions which comprise compounds of Formula (I) or pharmaceutically acceptable salts thereof. The invention also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose. 
Merck Sharp & Dohme Corp.
A C C A A A A A
A61P C07D C07D A61K A61P A61P A61P A61K
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Yi-Heng Falong Subharekha Gang Alan Yong John Cameron J. Joie Guoqing Rui Hong-Dong Shouwu Raphaelle Jianmin
Chen Jiang Raghavan Ji Whitehead Zhang Stelmach Smith Garfunkle Li Zhang Li Miao Berger Fu