Contrast reagent leakage correction in dynamic susceptibility contrast magnetic resonance imaging
Disclosed are methods and systems for calculating a contrast reagent (CR) extravasation rate constant and generating a contrast reagent leakage corrected relative cerebral blood volume (rCBV) image map of a brain region from dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) time-course image data based on pharmacokinetic first principles. In one example approach, a computerized method may include performing a linearization transform of a DSC MRI time-course equation which accounts for an intravascular contribution and an extravasating component, and calculating CR leakage from a slope of a linear portion of the transformed data.
OREGON HEALTH & SCIENCE UNIVERSITY
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William Xin
Rooney Li