Osha • Liang LLP
Pyridyl derivatives and their use as therapeutic agents
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is —O—, —N(R1)—, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Xenon Pharmaceuticals Inc.
A A A C A A A A C A A A A A A A C A
A61P A61P A61P C07D A61P A61K A61P A61K C07D A61P A61P A61P A61P A61P A61P A61P C07D A61P
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Shifeng Mikhail A. Cindy J. Michael D. Shaoyi Vishnumurthy Zaihui Rajender Serguei Chi Melwyn Wenbao Daniel F. Mehran Seid Vandna Heinz W.
Liu Kondratenko Hudson Winther Sun Kodumuru Zhang Kamboj Sviridov Tu Abreo Li Harvey Bagherzadeh Raina Gschwend