Genomics Institute of the Novartis Research Foundation
N-(pyridin-2-yl)sulfonamides and compositions thereof as protein kinase inhibitors
The invention provides a novel class of compounds of Formula (I) (wherein A, Y, R2, R3, R4 and R5 are defined in the summary of the invention), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
NOVARTIS AG
A C A A C A A A
A61P C07D A61K A61P C07D A61K A61K A61K
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John E. Yongqin Zuosheng Shifeng Xia Shenlin Qiong Xing Yongping
Tellew Wan Liu Pan Wang Huang Zhang Wang Xie