Cooley LLP
Compounds and methods for inhibiting phosphate transport
Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y and A are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Ardelyx, Inc.
C A C A A C C C C A C A A C A A A A A A
C07D A61K C07D A61K A61K C07D C07D C07D C07D A61P C07D A61K A61K C07D A61P A61P A61K A61K A61P A61K
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Marc Eric Nicholas Han-Ting Jason G. Christopher Dominique Jeffrey W. Michael R. Noah Tao
Navre Labonte Reich Chang Lewis Carreras Charmot Jacobs Leadbetter Bell Chen