Banner & Witcoff, Ltd.
Pyridazine derivatives and use thereof as medicaments for treating microRNA viral infection
Disclosed are pyridazine derivatives represented by Formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, methods of treating and/or preventing diseases or disorders associated with viral infections in patients using the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by Formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.
INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA
A A A A A C A A A A A A A A
A61P A61P A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P
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Xingzhou Xinbo Xian Song Lili Guoming Hongliang Wu Junhai Yunde Xiaokui Zhibing
Li Zhou Zhang Li Wang Zhao Wang Zhong Xiao Xie Wang Zheng