Oblon, McClelland, Maier & Neustadt, L.L.P.
Tetrahydrooxepinopyridine compound
[Problem] Provided is a compound having a positive allosteric modulating activity (PAM activity) on an α7 nicotinic acetylcholine receptor (α7 nACh receptor).[Means for Solution] The present inventors have studied on a PAM activity on an α7 nACh receptor, and they have found that a tetrahydrooxepinopyridine compound has a PAM activity on an α7 nACh receptor, thereby completing the present invention. The tetrahydrooxepinopyridine compound of the present invention has a PAM activity on an α7 nACh receptor and can be expected as an agent for preventing or treating dementia, cognitive impairment, schizophrenia, Alzheimer's disease, CIAS, negative symptoms of schizophrenia, inflammatory diseases, or pain.
Astellas Pharma Inc.
A A C A A C A A
A61P A61P C07D A61P A61P C07D A61P A61P
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Akio Shuichirou Koichi Satoshi Junichi Keisuke Takashi Satoshi Yuka Shinya Shimpei Hiroshi Ryo Yohei Shigeki
Kamikawa Kakimoto Yonezawa Miyamoto Shishikura Tamaki Ogiyama Aoki Koizumi Nagashima Kawakami Yamada Sato Koganemaru Kunikawa