Millen, White, Zelano & Branigan, P.C.
Certain substituted amides, method of making, and method of use thereof
The invention relates to compounds of the following Formula Iwherein R1, R2, Z, W, and D are defined herein, that inhibit Btk and therefore are useful in the treatment of diseases responsive to inhibition of Btk activity such as cancer. The invention also relates to pharmaceutical compositions comprising at least one compound of Formula I, together with at least one pharmaceutically acceptable vehicle chosen from carriers, adjuvants, and excipients, as well as methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described, and methods for determining the presence of Btk in a sample.
Genentech, Inc. CGI Pharmaceuticals, Inc.
C C A A A A A C A C C C A A A
C07D C07D A61P A61P A61P A61P A61P C07D A61P C07D C07D C07D A61P A61P A61P
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Xiaojing Scott A. Jeffrey E. Seung H. Peter A. Kevin S. Zhongdong Aaron C. Pavel E. David R. Jianjun
Wang Mitchell Kropf Lee Blomgren Currie Zhao Schmitt Zhichkin Brittelli Xu