Heller Ehrman White & McAuliffe
Matrix metalloprotease inhibitors
 Compounds of formula (I): ##STR1## as single stereoisomers or mixtures thereof and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as interstitial collagenases, and are useful in the treatment of mammals having disease states alleviated by the inhibition of such matrix metalloproteases, for example arthritic diseases or bone resorption diseases, such as osteoporosis. 
Syntex (U.S.A.) Inc.
C C C
C07D C07D C07F
inventional inventional inventional
Stephen Hal Van Arlindo Lucas Alexander Jian Jeffrey Paul David Zhengyu Teng Jiam
Horne Wart Castelhano Krantz Chen Cannon Yuan Liak