Fenwick & West LLP
Variant activin receptor polypeptides and uses thereof
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Amgen Inc.
A A C A A A C A A A C A A A A
A61K A61P C07K A61K A61K A61K C07K A61K A61K A61K C12Y A61K A61K A61K A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
John Keith Soo-Nyung Xiaolan Lei-Ting Tony Huiquan Jeonghoon
Lu Kwak Zhou Tam Han Sun