Hamilton, Brook, Smith & Reynolds, P.C.
Diaminoalkane aspartic protease inhibitors
Diaminoalkanes of below Formula I have now been found which are orally active and bind to aspartic proteases to inhibit their activity:They are useful in the treatment or amelioration of diseases associated with elevated levels of aspartic protease activity. The invention also relates to a method for the use of the compounds of Formula I in ameliorating or treating aspartic protease related disorders in a subject in need thereof comprising administering to said subject an effective amount of a compound of Formula I.
Vitae Pharmaceuticals, Inc.
C C C A A C A C C A C A A C C A A C C C C C A C C A A
C07C C07C C07D A61P A61P C07D A61P C07D C07C A61P C07D A61P A61P C07F C07D A61P A61P C07C C07D C07F C07C C07D A61P C07C C07C A61P A61P
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Zhenrong Lawrence W. Jing Patrick T. Suresh B. David A. Gerard Wei Alexey V. Jean-Pierre Robert D. John J. Salvacion Colin M.
Xu Dillard Yuan Flaherty Singh Claremon McGeehan Zhao Ishchenko Wery Simpson Baldwin Cacatian Tice