Klarquist Sparkman, LLP
Prefusion PIV F immunogens and their use
Embodiments of a recombinant human Parainfluenza Virus (hPIV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the hPIV F ectodomain trimer and methods of producing the hPIV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or inhibiting a hPIV infection in a subject by administering a effective amount of the recombinant hPIV F ectodomain trimer to the subject.
The United States of America, as represented by the Secretary, Dept. of Health and Human Services Institute for Research in Biomedicine
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Li Yongping Yaroslav Kai Aliaksandr John Peter Paul Wing-Pui Guillaume Antonio Baoshan Davide Gwo-Yu Tongqing
Ou Yang Tsybovsky Xu Druz Mascola Kwong Thomas Kong Stewart-Jones Lanzavecchia Zhang Corti Chuang Zhou