Finnegan, Henderson, Farabow, Garrett & Dunner
Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists
This invention concerns compounds of the general formula (1):and derivatives thereof, which are antagonists of 5-HT6 receptors, wherein the symbols have the meanings given in the description. The invention also concerns methods for the preparation of these compounds, to novel intermediates useful for their synthesis, and to uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in treating at least on disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes.
Abbvie Bahamas, Ltd.
A C C C A A C A C A A A C A C A C A C C A C A A C A A C A A C A C A C A C C A C C C C A
A61P C07D C07D C07D A61P A61P C07D A61P C07D A61P A61K A61K C07D A61P C07D A61P C07D A61P C07D C07D A61P C07D A61P A61K C07D A61P A61P C07D A61P A61P C07D A61P C07D A61P C07D A61P C07D C07D A61P C07D C07D C07D C07D A61K
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Jan Cornelis G. Wouter I. Hiskias G. Martina A. W. Arnold
Zorgdrager Kruse Iwema Bakker Keizer Van Der Neut Van Loevezijn