Brinks Gilson & Lione
Indanone derivatives, pharmaceutically acceptable salts or optical isomers thereof, preparation method for same, and pharmaceutical compositions containing same as active ingredient for preventing or treating viral diseases
Disclosed are indanone derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The indanone derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
Korea Research Institute of Chemical Technology Katholieke Universiteit Leuven K.U. Leuven R & D
C A A A C A C A A A A C C A A A C A C A A C C A C A A C A C C
C07D A61P A61P A61P C07D A61P C07D A61P A61P A61P A61P C07D C07D A61P A61P A61P C07D A61P C07D A61P A61P C07D C07D A61P C07F A61P A61P C07D A61P C07C C07D
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Hendrik Jan Soo Bong Jin Soo Hae Soo Young Sik Chong Kgo Johan Hee Chun Pil Ho
Thibaut Han Shin Kim Jung Lee Neyts Jeong Kim