Substituted imidazopyridine compounds as inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan-2,3-dioxygenase
Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.
IOmet Pharma Ltd. Merck Sharp & Dohme Corp.
A A A A A C A A A A A A
A61P A61P A61K A61P A61P C07D A61P A61P A61P A61P A61P A61P
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Hongjun Kun Hua Meredeth Ann Alan Phillip M. Yongxin Thomas J. Qinglin
Zhang Liu Zhou McGowan Wise Cowley Han Brown Pu