Sutherland Asbill & Brennan LLP
Protection and treatment against influenza infection
Method and composition for protection and treatment against influenza viral infection by modulating the activity of at least one essential host signaling pathways, including the Hedgehog (Hh), the Bone Morphogenetic Protein (BMP), the Notch (N) signaling pathways or combinations thereof, which activity is altered by the viral protein NS1. The method and composition comprise use of a compound that modulates at least one of these essential host signaling pathways for preventing or controlling symptoms associated with influenza viral infection. The method or composition can also be used either alone or in combination with other therapeutic agents for treating or protecting against influenza infection, and associated syndromes.
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE SCRIPPS RESEARCH INSTITUTE
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Margery Robert John Ethan Michael Meghana
Smelkinson Krug Teijaro Bier Oldstone Malur