Syndicated Law
Polyene diester antibiotics
The present invention discloses a new polyene diester and its preparation. This polyene diester has a structure of Formula 1, which is used as prodrugs by introducing diester group to polyene antibiotics, and these prodrugs exhibit antifungal or antiviral activities through releasing parent polyenes by esterase in vivo. The new derivatives have good antimicrobial activity and better safety. These new derivatives are useful for the antifungal and antiviral treatment. PA-COOR Formula 1
Shanghai Institute of Pharmaceutical Industry
A A A C
A61P A61K A61P C07H
inventional inventional inventional inventional
Li Wang Wenmei
Ji'an Shuhui Wang