Foley & Lardner LLP
Furanopyrimidines
The present invention relates to furanopyrimidine compounds having the general Formula I:and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.
Amgen Inc.
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A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P C07D
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Frank David C. William H. Rajiv Sarah E. John Laird Teresa L. Alexander D. Christopher N. Xiaotian Martin J. Erin F. Simon A. Stephen J. Jinqian
Kayser McGowan Buckner Sharma Lively Buchanan Marshall Frenkel Farthing Zhu Harrison DiMauro Burkitt Shuttleworth Liu