C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-17 and C-3 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II and III:These compounds are useful for the treatment of HIV and AIDS.
Bristol-Myers Squibb Company
A A A A A A A C
A61K A61K A61K A61K A61P A61P A61K C07J
inventional inventional inventional inventional inventional inventional inventional inventional
Jacob Ny Sing-Yuen Jie Yan Brian Lee Nicholas A. Zheng Alicia
Swidorski Sin Sit Chen Chen Venables Meanwell Liu Regueiro-Ren