Catechols as antimicrobial agents
Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.
Merck & Co., Inc.
C C A C C C C C A C A C
C07D C07D A61P C07D C07D C07D C07D C07D A61P C07D A61P C07D
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Gina M. Milana Michael Aaron H. Milton L. Sherman T. Jason John Dennis
Santorelli Maletic Morytko Leeman Hammond Waddell Hill Finn Keith