Hogan & Hartson LLP
Heterocyclic inhibitors of MEK and methods of use thereof
Disclosed are compounds of the Formula Iand pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8 and R9, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
Array Biopharma Inc.
C A A C A C C C A C C C A C A A A A A C A A A C C A A C A A C A C A
C07D A61P A61K C07D A61P C07D C07D C07D A61P C07D C07D C07D A61P C07D A61P A61K A61K A61P A61K C07D A61P A61K A61K C07D C07D A61K A61P C07D A61K A61K C07D A61K C07D A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Joseph P. Hong Woon Allison L. Jeongbeob Eli James
Lyssikatos Yang Marlow Seo Wallace Blake