Law Offices of Albert Wai-Kit Chan, PLLC
Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
The present invention relates to a Beclin 1-UVRAG complex structure which reveals a tightly packed coiled coil assembly with Beclin 1 and UVRAG residues complementing each other to form a stable dimeric complex. This potent physical interaction is critical for UVRAG-dependent EGFR degradation but less critical for autophagy. Targeting the Beclin 1 coiled coil domain with rationally designed stapled peptides leads to enhanced autophagy activity and EGFR degradation in non-small cell lung cancer (NSCLC) cell lines, suggesting translational value for these compounds.
The Hong Kong Polytechnic University
C A
C07K A61P
inventional inventional
Wenchao Xianxiu Yanxiang Shuai Yunjiao Xiaohua
Yang Qiu Zhao Wu He Li