Burgess, Ryan & Wayne
Crystal of monohydrate of heterocyclic bis(phosphonic acid) derivative
 Crystal D or E of 1-hydroxy-2-(imidazo[1,2-a]pyridin-3-yl)ethane -1,1-bis(phosphonic acid) monohydrate having specified lattice spacing and relative intensity in the powder X-ray diffraction spectrum obtained by using Cu-K.alpha. radiation and a dehydration peak temperature of 135.degree. to 149.degree. C. or 160.degree. to 170.degree. C. according to TG-DSC thermogravimetric analysis; and to a solid pharmaceutical preparation containing the same. The crystals are useful for producing a stable solid pharmaceutical preparation of the above compound which has an excellent drug efficacy for diseases wherein increased bone resorption participates, such as osteoporosis. 
Yamanouchi Pharmaceutical Co., Ltd.
C
C07F
inventional
Yoshisaburo Yasuo Makoto Mamoru Noriya
Kaneko Isomura Takeuchi Hamada Yamamoto