Scully, Scott, Murphy & Presser, P.C.
Irreversible bruton's tyrosine kinase inhibitor
The present invention provides an inhibitor of Bruton's tyrosine kinase, which is a compound of formula (I), or its pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug. The present invention also provides a pharmaceutical composition comprising the compound. The present invention also provides a method for inhibiting the activity of tyrosine kinase activity or for treating a disease, disorder, or condition, which would benefit from the inhibition of Bruton's tyrosine kinase(s), by using the Bruton's tyrosine kinase inhibitor, as well application of the Bruton's tyrosine kinase inhibitor for the same.
HEFEI INSTITUTES OF PHYSICAL SCIENCE, CHINESE ACADEMY OF SCIENCES
A C A C C C Y
A61P C07D A61P C07D C07D C07D Y02P
inventional inventional inventional inventional inventional inventional additional
Yongfei Li Chen Wenchao Kailin Wei Beilei Hong Qingsong Qianmao Jing Shuang Cheng Aoli
Chen Wang Hu Wang Yu Wang Wang Wu Liu Liang Liu Qi Chen Wang