Knobbe, Martens, Olson & Bear, LLP
Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A
The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
The United States of America as represented by the Department of Health and Human Services
C C G A A A G Y C A A
C12Q C12Q G01N A61K A61K A61K G01N Y02A C07K A61K A61K
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Christine Pierre Jurg Louis H. Nobutaka Bruno Benoit Artur Joseph Dror I.
Scheidig Buffet Gysin Miller Fujii Pouvelle Gamain Scherf Smith Baruch