Viksnins Harris Padys Malen LLP
1 -((3S,4R)-4-(3-fluorophenyl)-1-(2-methoxyethyl)pyrrolidin-3-yl)-3-(4-methyl-3-(2-methylpyrimidin-5-yl)-1-phenyl-1H-pyrazol-5-yl)urea as a TrkA kinase inhibitor
Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.
Array BioPharma Inc.
A A A A A A A A A A A A A A C A A A C A A A A A C A C A A A A A A A Y A A A C Y
A61P A61P A61P A61P A61P A61P A61P A61K A61P A61K A61P A61P A61P A61P C07D A61P A61P A61P C07D A61P A61P A61P A61P A61P C07D A61P C07D A61P A61P A61P A61P A61K A61P A61P Y02A A61P A61P A61P C07D Y02P
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Weidong Shelley Brian Zackary Steven W. Daniel John
Liu Allen Baer Crane Andrews Watson