Knobbe, Martens, Olson & Bear, LLP
Activated collagen scaffold materials and their special fused active restoration factors
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:4 at N-terminus.
YANTAI ZHENGHAI BIO-TECH CO., LTD
C C A A A A C C C C A C C A C A C
C07K C07K A61P A61L A61P A61K C07K C07K C07K C07K A61P C07K C07K A61L C07K A61P C07K
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Jianwu Hang Wenxue Wenjie Bing
Dai Lin Zhao Sun Chen