Everest Intellectual Property Law Group
Leishmania as carriers for the delivery of proteins and peptides
Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.
Rosalind Franklin University of Medicine and Science
C A Y A
C12N A61K Y02A A61K
inventional additional additional inventional
Bala Krishna Jerome F. Daniel A. Kwang-Poo Shigeru Hiroya
Kolli Sah Peterson Chang Sassa Ito