Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Difluoroprostaglandin derivatives and their use
 A fluorine-containing prostaglandin derivative of the formula (1) (or a salt thereof) and a medicine containing it, particularly, a preventive or therapeutic medicine for an eye disease: ##STR1## wherein A is a vinylene group or the like, R.sup.1 is an aryloxyalkyl group or the like, R.sup.2 and R.sup.3 are hydrogen atoms or the like, and Z is OR.sup.4 (wherein OR.sup.4 is a hydrogen atom or an alkyl group) or the like. 
Santen Pharmaceutical Co., Ltd. Asahi Glass Company Ltd.
C A C A A C
C07C A61P C07C A61P A61P C07C
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Yasushi Tadashi Eiichi Takashi Yoshitomi Hideshi Nobuaki Masaaki
Matsumura Nakajima Shirasawa Nakano Morizawa Sasakura Mori Kageyama