Cozen O'Connor
Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Sirna Therapeutics, Inc.
C C C A A A C A A
C07H C12N C12N A61K A61P A61K C12N A61K A61P
inventional additional additional inventional inventional inventional inventional inventional inventional
Steven L. Jeffrey Lu Anthony W. Rubina G. Weimin Kathleen B. Thomas Joseph Marina Yu David Rachel Anne Robert A. Aaron Vadim
Colletti Aaronson Tian Shaw Parmar Wang Calati Tucker Busuek Yuan Tellers Storr Kowtoniuk Momose Dudkin