Oblon, Fisher, Spivak, McClelland & Maier
Novel hyaluronidase BMP-8231 and production thereof
 Hyaluronidase obtained from Streptomyces koganeiensis has the following characteristics: PA1 (a) Acts as an endo B-hexosaminidase PA1 (b) Degrades hyaluronic acid but not chondroitin sulfate A, C, or chondroitin PA1 (c) Optimum pH around 4.0 PA1 (d) Stable pH range 4.0-11.3 PA1 (e) Optimum temperature around 60.degree. C. PA1 (f) Stable a temperature below 60.degree. C. PA1 (g) Stable against proteolytic enzymes 
Fujisawa Pharmaceutical Co., Ltd.
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C12N Y10S
inventional additional
Hiroyuki Takashi Keizo
Kikuchi Fujii Yoshida