Thiazoles and oxazoles useful as modulators of ATP-binding cassette transporters
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
Vertex Pharmaceuticals Incorporated
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C07D A61K A61K C07D A61P A61K A61P A61P A61P A61P A61P A61P A61P C07D A61P A61K A61P A61P A61P A61P C07D A61P A61P A61P C07D A61P A61P A61P A61P
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Mark Thomas Matthew Sara S. Hadida Peter Diederik Jan
Miller Hamilton Ruah Grootenhuis