Browdy and Neimark
Determination of prodrugs metabolizable by the liver and therapeutic use thereof
 A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or metabolite. Prodrugs are shown equally effective in treating diseases as the active drug itself with many benefits and without as many associated side effects. Methods for treating cancers with 5-iodo-2-pyrimidinone-deoxyribose and 5-fluoro-2-pyrimidinone are also described. 
Yale University
A G G A G A A G A C Y
A61K G01N G01N A61P G01N A61K A61P G01N A61K C07H Y02A
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional additional
Yung-Chi Chien-Neng
Cheng Chang