Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof
The present invention is directed to substituted certain reversed indazole compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1A, R1B, X, Y, RZ and R2 are as defined herein, which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
Merck Sharp & Dohme Corp.
C C A C A C C C C A A
C07D C07D A61K C07D A61K C07D C07D C07D C07D A61K A61K
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J. Michael Vladimir David Annunziato Barbara Hakan Blair T. Harold B. Peter H. Joey L. John Weiguo Santhosh F.
Ellis Simov Candito Pio Gunaydin Lapointe Wood Fuller Methot Acton Liu Neelamkavil