Emory Patent Group
PGAM1 inhibitors and methods related thereto
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1 inhibitor, for example, an anthracene-9,10-dione derivative to a subject in need thereof. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, head and neck cancer, and leukemia, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.
Emory University
C A A C C C C C A
C07C A61K A61P C09B C07K C09B C07K C07C A61K
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Taro Jing Sumin
Hitosugi Chen Kang