Bis-aryl ethers, compositions containing such compounds and methods of treatment
 A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf. Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound. 
Merck & Co., Inc.
C C C
C12R C12N C12P
additional inventional inventional
Maria T. Rosalind G. Denis R. Annie Z. Anne Otto D. Deborah L. Gerald F. Marina Mojena M. Dolores Hans E. Leeyuan Fernando Seok H.
Diez Jenkins Patrick Zhao Dombrowski Hensens Zink Bills Sanchez Vilella Amils Huber Huang Pelaez Lee