Sterne, Kessler, Goldstein & Fox P.L.L.C.
Spirocyclic tetrahydroquinazolines
The present disclosure provides compounds represented by Formula I: wherein R3, A, A1, A2, A3, E, E1, E2, L, Q, Z, and  are as defined in the specification, and the pharmaceutically acceptable salts and solvates thereof. Compounds of Formula I are KRAS inhibitors and are thus useful to treat cancer and other diseases. 
ASCENTAGE PHARMA (SUZHOU) CO., LTD. ASCENTAGE PHARMA GROUP CORP LIMITED
C C C C A C C
C07D C07D C07D C07D A61P C07D C07D
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Chao Lingling Guozhi Jianyong Liugen
Li Jiao Tang Chen Li