Oblon, Fisher, Spivak, McClelland & Maier
Clavulone derivatives, process for preparing the same, and use of said compounds
 Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent. 
Fujisawa Pharmaceutical Co., Ltd.
C
C07C
inventional
Iwao Yasumasa Osamu Toshitaka Yasuji Masanori Hiroyuki
Shimizu Tsukitani Hirai Manda Yamada Fukushima Kikuchi