Fitzpatrick, Cella, Harper & Scinto
Hetero compound
To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity. Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
Astellas Pharma Inc.
A A A A A A A A A A A C C A A A A A A C A A
A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P C07D C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Yoshito Hiromichi Masataka Hideo Sunao Kazuyuki Tatsuaki Kazuya Hironori
Abe Itani Morita Tsutsumi Imada Hattori Morokata Fujita Harada