Knobbe, Martens, Olson & Bear, LLP
Modulation of chemosensory receptors and ligands associated therewith
The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.
Senomyx, Inc.
C A A G C A C A A A C C A A C A A A C C A C C C A C A A A C C C A A A A A A A A A C C A C C
C07D A61P A61P G01N C07D A61P C07D A61P A61P A61P C07D C07D A61P A61P C07D A23L A61P A61P C07D C07D A61P C07D C07D C07D A23L C07D A61P A61P A61P C07D C07D C07D A23L A23L A23L A61P A61P A23L A61P A23L A61P C07D C07D A61P C07D C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Vincent Jeffrey Robert Feng Donald S. Guy Xinshan Hong Catherine Rachel D. A. Boris Albert Richard Marketa Xiaodong Jeffrey Joseph R. Xiao-Qing Sara Goran Qing Haitian
Darmohusodo Hammaker Zhang Karanewsky Servant Kang Zhang Tachdjian Kimmich Klebansky Zlotnik Fine Rinnova Li Yamamoto Fotsing Tang Adamski-Werner Petrovic Chen Liu