Triterpenoids with HIV maturation inhibitory activity
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is —C1-6 alkyl-halo. These compounds are useful for the treatment of HIV and AIDS. 
VIIV HEALTHCARE UK (NO. 4) LIMITED
A C C A A C C A C
A61K C07C C07J A61K A61K C07F C07C A61P C07F
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Sing-Yuen Alicia Yan Richard A. Ny Jacob Brian Lee Nicholas A. Zheng Li Jie
Sit Regueiro-Ren Chen Hartz Sin Swidorski Venables Meanwell Liu Xu Chen