Goodwin Procter LLP
Arsenic trioxide for treatment of PIN1-associated disorders
The present invention relates to the treatment of Pin1-associated disorders (e.g., disorders characterized by elevated Pin1 activity) with arsenic trioxide, optionally in combination with a retinoic acid compound. Pin1-associated disorders may include, for example, proliferative disorders (e.g., cancers), inflammatory conditions, and autoimmune disorders associated with aberrant levels of Pin1 activity.
Beth Israel Deaconess Medical Center, Inc.
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Xiao Zhen Kun Ping
Zhou Lu