Howson and Howson
Cyclic regimens utilizing indoline derivatives
This invention relates to cyclic combination therapies and regimens utilizing substituted indoline derivative compounds which are antagonists of the progesterone receptor having the general structure: wherein R1 and R2 may be single substituents or fused to form spirocyclic rings, in combination with progestins, estrogens, or both. These methods of treatment may be used for contraception, for the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, or prostate, minimization of side effects, cyclic menstrual bleeding, or stimulation of food intake.
Ligand Pharmaceuticals, Inc. WYETH
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Christopher M. Reinhold H. W. Puwen Gary S. John W. Todd K. Andrew Lori L. Jay E. Lin James P.
Tegley Bender Zhang Grubb Ullrich Jones Fensome Miller Wrobel Zhi Edwards