Lucas & Mercanti, LLP
Biphenyl compound or pharmaceutically acceptable salt thereof, method for preparing novel biphenyl compound or pharmaceutically acceptable salt thereof, and pharmaceutical composition containing same as active ingredient for preventing or treating diabetes complications
The present invention provides a novel biphenyl compound or pharmaceutically acceptable salts thereof, methods for preparing the same, and pharmaceutical compositions for preventing or treating diabetic complications containing the same as an active ingredient. Novel biphenyl compounds, according to the present invention, effectively suppress generation activity of advanced glycation end products, which cause diabetic complications and are a criterion for evaluating the effectiveness of a treating agent for diabetic complications, and show an excellent therapeutic effect on retina blood vessels, increased occludin, and decreased angiogenic growth factor in actual diabetic retinopathy induced retina. Thus, novel biphenyl compounds according to the present invention can be used effectively as an active ingredient in compositions for preventing or treating diabetic complications such as diabetic retinopathy.
Korea Institute of Oriental Medicine
A C A A A C A A A
A23L C07C A23C A61P A61K C07C A23V A21D A23L
inventional inventional additional inventional inventional inventional additional inventional inventional
Dong Ho Eun Jin Jung Hyun Jin Sook Yun Mi Kyu Hyung Nam-Hee Ohn Soon Young Sook Ki Mo Chan-Sik
Jung Shon Kim Kim Lee Jo Yoo Kim Kim Kim Kim