Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis
 Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, psoriasis, uveitis and allograft rejection and in preventing the formation of atherosclerotic plaques. 
Merck Frosst Canada, Inc.
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John H. John Pierre Michel Rejean Daniel Yves Dwight
Hutchinson Scheigetz Hamel Therien Fortin Delorme Girard MacDonald