Difluoromethoxy compound with low bioactivation potential for the reduction of beta-amyloid production
The compound N2-(3-(difluoromethoxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(4-fluorophenyl)-N4,5,5-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine: [PLEASE INSERT CHEMICAL STRUCTURE HERE] reduces -amyloid peptide (A 42) production and has low potential for bioactivation, and may be useful in the treatment of Alzheimer's Disease and other conditions affected by -amyloid peptide (A 42) production.
Bristol-Myers Squibb Company
A A A C A
A61P A61P A61K C07D A61K
inventional inventional additional inventional inventional
Stephen E. Kenneth M. Richard E. Xiaoliang
Mercer Boy Olson Zhou