Reed Smith LLP
Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
The present disclosure provide viral compositions and methods for modulating adeno-associated virus properties including transduction efficiency, virus capsid assembly, viral genome packaging, capsid stability and intracellular processing. Engineered adeno-associated viruses with modifications in the N-terminal region of the capsid proteins VP1 or VP2 are provided which have varying effects on viral properties including transduction efficiency. Corresponding nucleic acids and amino acids are provided.
William Marsh Rice University
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Momona Byunguk Michelle Junghae Veronica
Yamagami Kang Ho Suh Gough