Viksnins Harris Padys Malen LLP
Hindered disulfide drug conjugates
The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.
Genentech, Inc.
A A A A C A C A A A C A A A C C A C A C C C A C C
A61K A61K A61K A61K C07D A61K C07D A61K A61K A61K C07D A61K A61K A61K C07D C07D A61K C07D A61P C07D C07D C07D A61K C07D C07D
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Zhonghua Jinhua Peter John Jack Thomas
Pei Chen Dragovich Wai Sadowsky Pillow