Knobbe Martens Olson & Bear LLP
Activated collagen scaffold materials and their special fused active restoration factors
Provided are activated collagen scaffold materials as well as their special fused active restoration factors useful for promoting tissue repair, such as bone damage repair or nerve injury repair. The special fused active restoration factors are fusion proteins comprising a collagen-binding domain (CBD) at N-/C-terminus of cytokines, wherein the collagen-binding domain is a polypeptide consisting of 7-27 amino acid residues with a conservative sequence shown in SEQ ID NO:1 at N-terminus.
Institute of Genetics and Developmental Biology Chinese Academy of Science Yantai Zhenghai Bio-Technology Co., Ltd.
A C A A A C C A C A C C C C C C A
A61P C07K A61P A61P A61L C07K C07K A61K C07K A61L C07K C07K C07K C07K C07K C07K A61P
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Wenjie Hang Bing Jianwu Wenxue
Sun Lin Chen Dai Zhao