Compounds for improved stem cell differentiation into hepatocytes
The invention relates to the compounds of formula I and pharmaceutically acceptable salts and esters thereof, wherein R1-R11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are useful in differentiating stem cells into more mature or adult-like hepatocytes for use as drug screening platforms and in disease modeling applications.
Hoffmann-La Roche Inc.
C A C C A C C
C12N A61P C12N C12N A61P C12N C07D
additional inventional inventional additional inventional additional inventional
Eric Brian Matthew Michael Sei Miriam
Chiao Leonard Hamilton Kameoka Triyatni