Pennie & Edmonds LLP
Vaccine containing a Shigella bacterium having an enhanced antigenic property
 Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced bacteria for use in vaccines. Also disclosed are methods for using the antigenically enhanced bacteria as well as the vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof, are provided by Shigella species. In addition to this microorganism there are other enteric bacteria, such as Campylobacter species and Helicobacter pylori, which are useful for inducing or enhancing expression of enteric bacterial antigens and/or virulence factors. 
Antex Biologics Inc.
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A61P A61K G01N C12Q A61K G01N C12R G01N C12Q C12N G01N Y02A C12N G01N Y10S Y10S Y10S A61K
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Steven Michael John Lee Richard Ives
Frey Pace Walker