Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
 The present invention is directed to compound of the formula I: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R .sub.5, X, Y, and ##STR2## are as defined herein. These compounds are useful for inhibiting the activity of a metalloproteinase by contacting the metalloproteinase with an effective amount of the inventive compounds. 
Agouron Pharmaceuticals, Inc. Syntex Inc.
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Judith G. Melwyn A. Steven L. Jian Jeffrey Arlindo L. Wesley K. M. Roland J.
Deal Abreo Bender Chen Castelhano Chong Billedeau