Blakely, Sokoloff, Taylor & Zafman
Process for the preparation of optically active 2-[6-(substituted alkyl)-1,3-dioxan-4-yl]acetic acid derivatives
The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-β-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula (I) is useful for preparing the therapeutic agent for hyperlipidemia, such as Astrovastatin and Fluvastatin. Wherein R1 denotes a hydrogen atom, alkyl, aryl or alkylaryl, R2 and R3 which can be identical or different, are a lower alkyl or phenyl and are capable of forming a six-membered ring, R4 stands for hydroxy, amino, alkylamino, azido, cyano, halogeno, aryloxy, alkyloxy, arylalkyloxy, alkyl, alkenyl, aryl, or aminomethyl, etc.
Choongwae Pharma Corporation
C
C07D
inventional
Inhee Seungjoo
Lee Lee