Sterne, Kessler, Goldstein & Fox P.L.L.C.
Antibodies that bind the glutamate ligand binding region of NOTCH3
Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
OncoMed Pharmaceuticals, Inc.
C C C A C C A C A A Y C C A A C C C C C A
C07K C07K C07K A61K C07K C07K A61K C07K A61P A61K Y10S C07K C07K A61K A61K C07K C12N C07K C07K C07K A61P
additional inventional additional additional additional additional inventional additional inventional additional additional additional additional additional inventional additional additional additional additional inventional inventional
Austin L. Maureen Aaron Ken
Gurney Fitch-Bruhns Sato