Kilpatrick Townsend & Stockton LLP
Compositions and methods for silencing genes expressed in cancer
The present invention provides therapeutic nucleic acids such as interfering RNA (e.g., siRNA) that target the expression of genes associated with tumorigenesis and/or cell transformation, lipid particles (e.g., nucleic acid-lipid particles) comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles, e.g., for the treatment of a cell proliferative disorder such as cancer.
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES PROTIVA BIOTHERAPEUTICS, INC.
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Snorri S. Yun-Han Adam Ian
Thorgeirsson Lee Judge MacLachlan