Method of impairing movement of a CLA + memeory T-cell within or to the skin of a mammal by administering a CTACK antagonist
Agonists or antagonists of CTACK or Vic chemokines, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the CTACK or Vic chemokines are specifically capable of inducing movement of a skin cell subset. Moreover, matching of ligand with GPR2 receptor in mammals provides methods of use.
Schering Corporation
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C07K A61K C07K C07K
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Edward P. Leslie M. Elizabeth R. Sirid-Aimee Janine M. Hortensia Wei Susan A. Albert Ying Bernhard
Bowman McEvoy Oldham Kellermann Morales Soto Wang Hudak Zlotnik Liu Homey