Dechert LLP
Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators
The disclosure relates to Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compounds of Formula (I):and pharmaceutically acceptable derivatives thereof wherein R1, R2, Qa, Y1, Z, A, B, Qx, E, G, J, M, U, W, and a are as defined herein, compositions comprising an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Cyclic Urea- or Lactam-Substituted Quinoxaline-Type Piperidine Compound.
Purdue Pharma L.P. Shionogi & Co., Ltd.
A A A C A C A A A C A A A A A A A A A A
A61P A61P A61P C07D A61P C07D A61P A61P A61P C07D A61P A61P A61P A61P A61P A61P A61P A61P A61P A61P
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Tatsuhiko Naoki Xiaoming
Ueno Tsuno Zhou