Chalker Flores, LLP
Influenza A virus vaccines and inhibitors
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
C C A A C A C C C C A A A A C
C12N C07K A61K A61K C12N A61P C12N C12N C12N C12N A61B A61P A61K A61K C07K
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Rei-Lin Kalyan Karen Y. Robert M. Gaetano T. Edward Li-Chung Rong
Kuo Das Twu Krug Montelione Arnold Ma Xiao