Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
Optically active cyclic alcohol compound and method for preparing the same
The present invention relates to a method for preparing an optically active cyclic alcohol compound represented by general formula [I]:[wherein R represents a hydrogen atom or a protecting group for amino group, and * represents an astymmetric carbon atom.]which comprises a step of subjecting a cyclic ketone compound represented by general formula [II]:[wherein R has the same meaning as defined above.]to asymmetric reduction (A) in the presence of an optically active oxazaborolidine compound and a boron hydride compound, or (B) in the presence of an asymmetric transition metal complex obtained from a transition metal compound and an asymmetric ligand and a hydrogen donor, and relates to said compound.
Mitsubishi Tanabe Pharma Corporation
C B C Y A B B C B B A B B C
C07D B01J C07B Y02P A61P B01J B01J C07D B01J B01J A61P B01J B01J C07D
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Akira Yoshikazu Muneki Masaki
Sakuragi Mori Kishida Okamoto