Piperazinedione compounds
Piperazinedione compounds of the formula: Each of and <CUSTOM-CHARACTER FILE="US06635649-20031021-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00001"/> and <CUSTOM-CHARACTER FILE="US06635649-20031021-P00901.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00002"/> independently, is a single bond or a double bond; A is H or CH(RaRb) when <CUSTOM-CHARACTER FILE="US06635649-20031021-P00900.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00003"/> is a single bond, or C(RaRb) when is a double bond; Z is R3O&#8212;(Ar)&#8212;B, in which B is CH(Rc) when <CUSTOM-CHARACTER FILE="US06635649-20031021-P00901.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00004"/> is a single bond, or C(Rc) when <CUSTOM-CHARACTER FILE="US06635649-20031021-P00901.TIF" ALT="custom character" HE="20" WI="20" ID="CUSTOM-CHARACTER-00005"/> is a double bond; Ar is heteroaryl; and R3 is H, alkyl, aryl, heteroaryl, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; each of R1 and R2, independently, is H, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; and each of Ra, Rb, Rc, Rd, and Re, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl. Optionally, Ra and Rb taken together are cyclyl or heterocyclyl; and, also optionally, R1 and Ra or R1 and Rb taken together are cyclyl or heterocyclyl. Also disclosed is a method for treating tumor with the above described piperazinedione compounds.
C A C A
C07D A61P C07D A61P
inventional inventional inventional inventional
Ya-Lan Eric I. C. Huei-Ting Ya-Bing Jih-Hwa Hui-Po On Che-Ming
Chen Li Chen Fan Guh Wang Lee Teng