Zackson Law LLC
Compounds comprising 4-benzoylpiperidine as a sigma-1-selective ligand
Bipiperidinyl compounds and salts thereof are disclosed. The compounds include high affinity ligands for σ1 receptors. Some compounds are also highly selective for σ1 receptor compared to σ2 receptor. Compounds can comprise radioisotopes, including 18F or 11C. Radiolabeled compounds can be used as probes for imaging distribution of σ1 receptor in a subject such as a human using positron emission tomography (PET) scanning.
Washington University
A A A C A C A
A61P A61P A61K C07D A61P C07D A61P
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Stanley M. Zhude Robert H. Wei
Parsons Tu Mach Wang