Sterne, Kessler, Goldstein & Fox P.L.L.C.
Brain-targeting prodrug for AMPA receptor synergist, and pharmaceutical applications thereof
Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China
A C A A A C C C
A61K C07D A61K A61P A61P C07H C07H C07D
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Xinbo Dian Junhai Zhibing Yunde Xingzhou Xiaokui Wu Song
Zhou Xiao Xiao Zheng Xie Li Wang Zhong Li