Cesari and McKenna, LLP
Phosphate ester compound of hydroxy acid substituted phenol ester, preparation method and medical use thereof
Phosphate ester compound of hydroxy acid substituted phenyl ester, preparation method and medical use thereof are provided. The title compound is shown in formula (I), in which Y═C1-4 straight carbon chain, M1 and/or M2=H, alkali metal ion, protonated amine or protonated amino acid. The compound has good water solubility and high stability in its aqueous solution, and it can release 2,6-diisopropylphenol rapidly under the action of enzymes in vivo, which has the effects of sedation, hypnosis and/or anesthesia. By protecting hydroxyl of 2,6-diisopropylphenol in compound of formula (I), the first-pass metabolic activity of 2,6-diisopropylphenol is reduced, so that the synthetic compound can be used for sedation, hypnosis and/or anesthesia.
Yichang Humanwell Pharmaceutical Co., Ltd. West China Hospital, Sichuan University
A C A C
A61P C07F A61P C07F
inventional inventional inventional inventional
Jin Jun Wensheng
Liu Yang Zhang