Wayne & Ken, LLC
Baicalin magnesium compound and its preparation method and application
A baicalin magnesium compound and methods for preparing and extracting the same. The method for preparing the baicalin magnesium compound includes steps of preparation of a baicalin suspension, preparation of a magnesium ion-containing suspension, reaction and drying. The method for extracting the baicalin magnesium compound includes steps of pretreatment of macroporous resin, extraction, adsorption and elution, concentration and drying and purification. The methods restores the baicalin to the original form as found in radix scutellariae, and the baicalin magnesium compound may be used as a substitute for the baicalin in pharmaceutical applications. As compared to the baicalin, the baicalin magnesium has a greatly increased solubility, faster adsorption rate and higher oral bioavailability. The baicalin magnesium compound may also be easily formulated as a water-soluble injection or a powder injection. Pharmacological tests show that the baicalin magnesium compound is more pharmacologically active than the baicalin.
CHENGDE MEDCIAL UNIVERSITY
A C A A C C A
A61K C07H A61P A61P C07H C07H A61P
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Yixin Cuizhe Jinjun Zhixuan Guiqin Liyan Wenshan Xiaoxia Ceyu Xigang Lin Hefei
Liu Liu Liu Wang Zhao Liu Du Mao Miao Liu Zhang Xue