Knobbe Martens Olson & Bear LLP
Multi-valent guanidinium compounds for enhancing molecular translocation across cellular membranes and epithelial tissues
Disclosed herein are guanidinium containing compounds consisting of a core moiety with a plurality of side chains containing guanidinium groups. Such compounds have enhanced translocation across cellular membranes and epithelial tissues. The compounds may also have a therapeutic or other biologically active moiety attached so that these moieties may be effectively transported into a cell by the guanidinium containing compound.
Nitto Denko Corporation
A C C A
A61K C07K C07K A61K
inventional inventional inventional inventional
Jian Zheng Lei
Liu Hou Yu