Sterne, Kessler, Goldstein & Fox P.L.L.C.
4,4-diphenylpiperidine compounds or pharmaceutically acceptable salts thereof, pharmaceutical compositions and uses thereof
The invention belongs to the field of medicine and chemical industry and relates to a 4,4-diphenylpiperidine compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same and uses thereof. In particular, the invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, and to a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof. In the present invention, the compound or pharmaceutically acceptable salt thereof and the pharmaceutical composition have significant activity in blocking an N-type calcium channel, and have good pharmacokinetic properties, can effectively relieve pain, and have a potential as a new medicament for prevention or treatment of pain, stroke, cerebral ischemia, alcohol addiction, alcoholism, kidney disease, addictive disorder caused by analgesic or tolerance disorder caused by analgesic.
Academy of Military Medical Sciences
C A A C A C A A A C A C C A A
C07D A61K A61K C07D A61P C07D A61P A61P A61P C07D A61P C07D C07D A61P A61K
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Haoshan Xiaomei Jin Jianquan Liuhong Chong Ning Juan Shuzhuo Cheng Rifang Guoxing
Wang Zhuang Li Zheng Yun Pang Wu Wang Zhang Zhang Yang Dong