Liang Legal Group, PLLC
Immunostimulatory nanocomplex
The present invention relates to an immunostimulatory nanocomplex. The immunostimulatory nanocomplex comprises polyglutamic acid (PGA), a first positively charged substance, a second positively charged substance and a dengue viral protein for holding the dengue viral protein inside. The immunostimulatory nanocomplex is characterized by having a nonuniformally and positively charge distribution along a radial direction thereof. The nonuniformally and positively charge distribution comprises a first electrically charged portion having substantially electrical neutrality, a second electrically charged portion surrounding the first electrically charged portion, and a third electrically charged portion surrounding the second electrically charged portion. The third electrically charged portion has a third volume charge density more than a second volume charge density of the second electrically charged portion, thereby enhancing CD8(+) T-cell response and higher antibody titer after administrating an organism with the immunostimulatory nanocomplex.
National Cheng Kung University
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A61K A61K Y02A A61K A61K A61K C12N A61K A61K A61K A61K A61K A61K A61K C12N A61K
inventional inventional additional inventional additional additional additional additional additional additional inventional additional inventional additional inventional inventional
Yee-Shin Yu-Hung
Lin Chen