Variant B7 co-stimulatory molecules
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
Maxygen, Inc.
A C C A
A61P C07K C07K A61K
inventional inventional inventional additional
Juha Chia-Chun Steven R. Alexandra
Punnonen Chang Leong Lazetic