Antidiabetic bicyclic compounds
Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
Merck & Co., Inc.
C C C A A C A A C A A A A C C C C A C A C C A
C07D C07D C07D A61P A61P C07C A61P A61P C07C A61P A61P A61P A61P C07C C07D C07D C07D A61P C07D A61P C07D C07C A61P
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Shawn P. Gui-Bai Min Lihu Jiafang Weiguo Fiona Wai Yu Songnian
Walsh Liang Ge Yang He Liu Lau Lin