Sughrue Mion, PLLC
Compound capable of binding S1P receptor and pharmaceutical use thereof
A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like.wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
Ono Pharmaceutical Co., Ltd.
C C A C C C C C A C C A C C C C
C07D C07C A61P C07C C07D C07C C07C C07C A61P C07C C07C A61P C07C C07C C07C C07D
inventional inventional inventional additional inventional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Haruto Kazuhiro Kensuke Masashi Hirotaka Takeji Hiromu Hiroshi Takaki Hiroshi Shinji
Kurata Ohtsuki Kusumi Minami Mizuno Ono Habashita Saga Komiya Hagiya Nakade