Polynucleotides encoding novel PCSK9 variants
The present invention provides novel polynucleotides encoding PCSK9b and PCSK9c polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel PCSK9b and PCSK9c polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
Bristol-Myers Squibb Company
C A C C C C Y C
C07K A61K C12Y C12Y C07K C12N Y10T C07K
inventional additional inventional inventional additional inventional additional additional
Bowman Jian John N. Gabriel A. Rex Arnold
Miao Chen Feder Mintier Parker