Factor XIa inhibitors
The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoaguability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
Merck Sharp & Dohme Corp.
A C C
A61P C07D C07D
inventional inventional inventional
Wanying Sung-Sau Weiguo Amjad Ying-Duo Anthony K Scott D Alan Zhuyan Rongze
Sun So Liu Ali Gao Ogawa Edmondson Hruza Guo Kuang