Genetically engineered Torulopsis glabrata with enhanced extracellular secretion of pyruvic acid
The present invention provides a genetically engineered Torulopsis glabrata with enhanced extracellular secretion of pyruvic acid. T. glabrata strain was obtained from China Center for Type Culture Collection with CCTCC No: M202019 and over-expressed the optimized CutA (SEQ ID NO:2) encoding stress protein. Both of the temperature tolerance of T. glabrata and extracellular concentration of pyruvate were improved by overexpressing the optimized CutA. The optimum growth temperature of genetically engineered T. glabrata was increased too. The present invention can be widely used to increase extracellular levels of pyruvate during the fermentation process.
Jiangnan University
C C C C
C12N C12N C07K C12P
inventional inventional inventional inventional
Hongwei Jingwen Guocheng Jian
Guo Zhou Du Chen