McCoy Russell LLP
Methods for producing recombinant factor VIII chains from non-filamentous fungi, their functional reconstitution and applications thereof
A process of producing heavy chain peptide and/or light chain peptide of recombinant Factor VIII protein includes using the Pichia pastoris expression system. A process of producing a functional recombinant Factor VIII protein by reconstituting the Heavy chain and Light chain produced using said Pichia pastoris expression system. The said functional recombinant Factor VIII protein shows improved activity and therefore is used in the management of haemophilia.
CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT
C C C C
C12P C07K C07K C12N
inventional inventional inventional inventional
Vignesh Narasimhan Vijayalakshmi Mookambeswaran Krishnan Alok Satheeshkumar Padikkara Sudheer Reddy Aswatha Sukesh Chandran
Janakiraman Arunachalam Venkataraman Srivastava Kutty Reddy Nair