Sterne, Kessler, Goldstein & Fox P.L.L.C.
Wnt antagonists and methods of treatment and screening
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such Wnt antagonists. In particular, the invention discloses soluble FZD, SFRP and Ror receptors and their use.
OncoMed Pharmaceuticals, Inc.
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Austin L. Sanjeev H. Satyajit Sujit Kumar
Gurney Satyal Mitra