6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.
Novartis AG
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James C. Savithri Hong Martin Keith B. Susan Simon C. Weibo Victoria William Marion Liana M. Mika Jiong Anu Elizabeth J. Allan S.
Sutton Ramurthy Yang Sendzik Pfister Kaufman Ng Wang Sung Lenahan Wiesmann Klivansky Lindvall Lan Sharma Mieuli Wagman