Integrin antagonist conjugates for targeted delivery to cells expressing LFA-1
The invention relates to compounds of formula (I), wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to LFA-1 integrin antagonists to target cells expressing LFA-1.
HOFFMANN-LA ROCHE INC.
C A A A C C A C C C A C A A C
C07C A61P A61K A61P C07D C07D A61P C07D C07D C07C A61K C07H A61P A61K C09B
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Robert Alan Achyutharao Matthew Michael Agnieszka
Goodnow, Jr. Sidduri Hamilton Kowalczyk