Godfrey & Kahn, S.C.
Biosynthesis of enediyne compounds by manipulation of C-1027 gene pathway
This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). Methods are provided for the biosynthesis of enediynes, enediyne analogs and other biological molecules. This invention also provides enediyne and enediyne analogs biosynthesized by manipulation of the C-1027 gene pathway.
Wisconsin Alumni Research Foundation (WARF)
C C C C C
C12P C12P C12P C12N C12P
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Ben Wen
Shen Liu