Arylsubstituted piperazines useful in the treatment of benign prostatic hyperplasia
 This invention relates to a series of arylsubstituted piperazines, of Formula I ##STR1## pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the .alpha.-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this and other disease. 
Ortho-McNeil Pharmaceutical, Inc.
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Virginia Frank Allen Linda Xiaobing Linda Cynthia William
Pulito Villani Reitz Jolliffe Li Mulcahy Maryanoff Murray