Schwegman, Lundberg, Woessner & Kluth, P.A.
Benzimidazole topoisomerase poisons
The invention provides a topoisomerase poison of formula I: wherein R1-R8 have any of the meanings defined in the specification, or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof.
Rutgers, The State University of New Jersey
C C A C A C C A
C07D C07D A61P C07D A61P C07D C07D A61P
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Jung Sun Meera Edmond J. Leroy Fong
Kim Rangarajan LaVoie Liu