Metabolically engineered bacterial strains having non-functional endogenous gluconate transporters
The present invention relates to engineering metabolic pathways in bacterial host cells which results in enhanced carbon flow for the production of ascorbic acid (ASA) intermediates. In particular, the invention relates to increasing the production of ASA intermediates in bacterial cells by enhancing the availability of gluconate resulting from the inactivation of endogenous gluconate transporter genes.
Danisco US Inc.
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C07K C12P C12P
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M. Harunur Fernando Manoj Timothy C.
Rashid Valle Kumar Dodge