Cozen O'Connor
Tetragalnac and peptide containing conjugates and methods for delivery of oligonucleotides
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; 4) one or more peptides independently selected from Table 3, which may be the same or different; and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Sirna Therapeutics, Inc.
C C A C A A A A C
C07H C12N A61K C12N A61P A61P A61K A61K C12N
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Weimin Robert A. Aaron Jeffrey Rubina G. Yu Steven L. Lu Kathleen B. Anthony W. Thomas Joseph Marina Rachel Anne Vadim David
Wang Kowtoniuk Momose Aaronson Parmar Yuan Colletti Tian Calati Shaw Tucker Busuek Storr Dudkin Tellers