Calfee, Halter & Griswold LLP
Multi-targeted Ubenimex prodrug derivative and preparation method and use thereof
The present invention relates to the design, synthesis, and biological study of multi-targeted Ubenimex pro-drug derivative. More particularly, provided in the present invention is a compound as shown by general structural formula (I) (wherein the definition of R is shown in the description). The derivative is a multi-targeted compound obtained by binding an aminopeptidase (APN/CD13) inhibitor, Ubenimex, with some anti-tumor drugs already on the market through an ester bond or amide bond, and is suitable for use as an anti-tumor drug for the treating various malignant tumors, and is especially suitable for treating various solid tumors.
Jinan Platinum Pharmatech Co. Ltd.
A A A A A C C A A C A C A A
A61K A61K A61P A61K A61K C07D C07C A61K A61P C07D A61K C07D A61K A61K
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Jin Wenfang Xuejian Mingming Yuqi Xiaoyang Jinning Yingjie
Li Xu Wang Zou Jiang Li Hou Zhang