Cyclic peptides and use as medicines
The present invention provides a compound of formula I;or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and A-B are as defined herein, which are non-immunosuppressive, cyclophilin-binding, mPTP blockers and are therefore useful for the prevention or treatment of diseases or disorders such as HCV infection, stroke, multiple sclerosis, HBV infection, HPV infection, asthma, cancer, muscular dystrophy, sepsis, ischemia/reperfusion injury, and heart failure.
Novartis AG
A A A C A C A A A A A A A A A A A
A61P A61P A61P C07K A61K C07K A61P A61P A61P A61P A61P A61P A61K A61P A61P A61P A61K
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Aregahegn Alexey Subramanian Andrew Meiliana Xiaolin Wosenu Zachary Kevin Peichao Jiping
Yifru Rivkin Karur Weiss Tjandra Li Mergo Sweeney Lu Fu