Bacon & Thomas, PLLC
2-selenophene-4-quinolones as anticancer agents
2-aryl-4-quinolones are converted into phosphates by reacting with tetrabenzyl pyrophosphate to form dibenzyl phosphates thereof, which are then subject to hydrogenation to replace dibenzyl groups with H, followed by reacting with Amberlite IR-120(Na+ form) to form disodium salts. The results of preliminary screening revealed that these phosphates showed significant anti-cancer activity. A novel intermediate, 2-selenophene 4-quinolone and N,N-dialkylaminoalkyl derivatives of 2-phenyl-4-quinolones are also synthesized. These novel intermediates exhibited significant anticancer activities.
China Medical University
A A C C C C C
A61P A61P C07D C07F C07F C07D C07D
inventional inventional inventional inventional inventional inventional inventional
Kuo-Hsiung Tzong-Der Jang-Chang Tian-Shung Li-Jiau Jai-Sing Li-Chen Chih-Shiang Jing-Gung Sheng-Chu Shiow-Lin Chung-Ming Chien-Ting Shih-Ming Ching-Che Che-Ming
Lee Way Lee Wu Huang Yang Chou Chang Chung Kuo Pan Sun Chen Huang Huang Teng