2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives
Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical, and Z is COOR7, tetrazolyl, CONR6R7, or CH2OR7, are potent inhibitors of MEK and, as such, are effective in treating cancer and other proliferative diseases such as inflammation, psoriasis and restenosis, as well as stroke, heart failure, and immunodeficiency disorders.
Warner-Lambert Company
C C C C C C C C C C C C C C C C C C C C C
C07D C07C C07C C07C C07C C07D C07C C07C C07D C07D C07C C07C C07C C07C C07C C07D C07C C07D C07C C07C C07D
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Donna Reynolds Annette Marian Alexander James Alan Robert David Thomas Stephen Douglas Haile Mel Conrad
Cody Doherty Bridges Saltiel Dudley Barrett Tecle Schroeder