Mason & Associates, PA
Thienopyrimidine compounds and salts thereof and process for the preparation of the same
Thieno[2,3-d]pyrimidine compounds of general formula (1) useful as drugs having a cGMP-specific phosphodiesterase inhibiting effect and the preparation thereof wherein Q is formula: (CH2)n&#8212;N(r1)&#8212;C(r2) (r3), CH&boxH;CH&#8212;CH&boxH;CH, or (CH2)m which is bonded to a and b; R1 is hydrogen or C1-C6 alkyl; R2 is C3-C8 cycloalkyl optionally substituted with G1, phenyl optionally substituted with G2, or a saturated or unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, O and S and being optionally substituted with G3; and R3 is a saturated or unsaturated heretocyclic group having 1 to 4 heteroatoms selected from N, O and S and being optionally substituted with G3 or (CH2)kC(&boxH;O)R4 or CH&boxH;CHC(O)R4.
Nippon Soda Co., Ltd.
C A A A C
C07D A61P A61P A61P C07D
inventional inventional inventional inventional inventional
Yasuyuki Nobuo Nobuhiro Hirokazu Seiichi Hiromi
Shiinoki Mochizuki Umeda Yamada Uchida Horikoshi