Aminopyrazine compounds with A2A antagonist properties
Disclosed are compounds having the structure of Formula I, or a pharmaceutically acceptable salt of any thereof, wherein: “Z”, R1 and R2 are defined herein, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.
Merck Sharp & Dohme Corp.
A C A C A A A
A61P C07D A61K C07D A61K A01N A61K
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Robert Junying Guoqing Dong Michael Pauline Hongwu Walter
Aslanian Zheng Li Xiao Berlin Ting Wang Won