N-heterocyclic inhibitors of TNF-α expression
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I:Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
Bristol-Myers Squibb Company Pharmacopeia, Inc.
C A C C C C C C C C C C C C A C C C
C07D A61P C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D A61P C07D C07D C07D
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Gulzar Zahid Shawn David John J. Wei Ian Axel Jeffrey John Junjun Alaric J. Katerina James Stephen T. Edward Yvonne Kevin Joseph
Ahmed Hussain Erickson Baldwin Li Henderson Metzger Letourneau Wu Dyckman Leftheris Wen Wrobleski McDonald Shimshock Moriarty