Dann, Dorfman, Herrell & Skillman
Gene cluster
Novel isolated DNA sequences which comprise all or part of a gene cluster encoding sanglifehrin synthase, processing and regulatory genes involved in the biosynthesis of a mixed non-ribosomal peptide/polyketide compound, or mutants having altered biosynthetic capability, polypeptides or mutants thereof encoded by DNA or the mutants, vectors containing the DNA or the mutants thereof, host cells transformed with the DNA, the mutants thereof, or the vector, and a method for producing sanglifehrin compounds. Compounds with cyclophilin inhibition activity used as immunosuppressants, antivirals or cardiac protection agents.
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
A A C C A A C C A A C A A
A61K A61P C07D C07K A61P A61K C12N C12P A61P A61P C12P A61P A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Wen Nan Xudong
Liu Jiang Qu