Cantor Colburn LLP
Substituted 1-benzyl-4-substituted piperazine analogues
Compounds of Formula I are provided, in which variables are as described herein:Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
Neurogen Corporation
C C A A C C C
C07D C07D A61P A61P C07D C07D C07D
inventional inventional inventional inventional inventional inventional inventional
Wallace C. Mary-Margaret E. James G. Dario Manuka Linda M. Kyungae Bertrand L. John M. George P. Alan J. Guiying
Pringle O'Donnell Tarrant Doller Ghosh Gustavson Lee Chenard Peterson Luke Hutchison Li