Oakwood Law Group, LLP
Inotropic antibodies and therapeutic uses thereof
Antibodies binding to sites on the α-subunit (Na++K+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In particular, antibodies binding to the RSATEEEPPNDD (SEQ ID NO: 1) or DVEDSYGQQWTYEQR (SEQ ID NO: 2) peptides (or isoforms/derivatives thereof) of the α-subunit of the (Na++K+)-ATPase, have been found to be highly inotropic. Both the antibodies and the peptides are important for the treatment of human heart failure and other contractile disorders.
C A
C07K A61K
inventional additional
Kai Y.
Xu