Fish & Richardson P.C.
Genetically modified non-human animal with human or chimeric PD-1
The present disclosure relates to genetically modified non-human animals that express a human or chimeric (e.g., humanized) programmed cell death protein 1 (PD-1), and methods of use thereof. In one aspect, the animals have an insertion of a sequence encoding a human or humanized programmed cell death protein 1 (PD-1) at an endogenous PD-1 gene locus. This animal model can express a PD-1 protein containing a functional domain of the human PD-1 protein, and can be used as an animal model for developing therapeutics for human diseases and disorders, and assessing the toxicity and/or the efficacy of these human therapeutics.
Biocytogen Pharmaceuticals (Beijing) Co., Ltd.
A C A A A A A C G A C A A
A01K C07H A01K A01K A01K A61P A61K C07K G01N A01K C07K A01K A01K
additional additional additional inventional additional inventional additional inventional inventional additional inventional additional additional
Rui Chaoshe Yuelei Yanan Meiling Yang Xiaofei Jiawei
Huang Guo Shen Guo Zhang Bai Zhou Yao