Osha · Liang LLP
Piperazine derivatives and their use as therapeutic agents
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where G, J, L, M, x, y, W, V, R2, R3, R4, R5, R6, R7, R8, R8a, R9, R9a, R10, R10a, R11 and R11a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
Xenon Pharmaceuticals Inc.
A C A A A C A C A A A C C A A A A
A61P C07D A61K A61P A61P C07D A61P C07D A61P A61P A61P C07D C07D A61K A61K A61P A61P
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Shaoyi Vishnumurthy Shifeng Heinz W. Michael D. Mark W. Chi Melwyn Rajender Wenbao Serguei
Sun Kodumuru Liu Gschwend Winther Holladay Tu Abreo Kamboj Li Sviridov