Darby & Darby
Desferrioxamine oral delivery system
 Modified amino acids and methods for their preparation and use as oral delivery systems for pharmaceutical agents are described. The modified amino acids are preparable by reacting single amino acids or mixtures of two or more kinds of amino acids with an amino modifying agent such as benzene sulfonyl chloride, benzoyl chloride, and hippuryl chloride. The modified amino acids may form encapsulating microspheres in the presence of the active agent under sphere-forming conditions. Alternatively, the modified amino acids may be used as a carrier by simply mixing the amino acids with the active agent. The preferred acylated amino acid carrier is salicyloyl-phenylalanine. The modified amino acids are particularly useful in delivering biologically active agents, e.g., desferrioxamine, insulin or cromolyn sodium, or other agents which are sensitive to the denaturing conditions of the gastrointestinal tract. 
Emisphere Technologies, Inc.
C A C C C A C C A C A C A C C C A A A A A
C07C A61K C07C C07C C07C A61K C07C C07C A61K C07C A61K C07C A61K C07C C07C C07C A61K A61K A61K A61K A61K
additional inventional inventional inventional inventional inventional inventional additional inventional additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Evgueni N. Sam J.
Barantsevitch Milstein