Fish & Richardson
Pro-urokinase mutants
 The invention relates to thrombolytically active pro-urokinase (pro-UK) mutants comprising the amino acid sequence of native pro-UK, but including a mutation which causes the pro-UK mutants to induce less fibrinogenolysis and non-specific plasminogen activation than native pro-UK, to have at least a 10-fold lower intrinsic activity than native pro-UK, and to have substantially the same fibrin promotion and thrombolytic activity after plasmin activation compared to native pro-UK when administered to a patient. 
New England Deaconess Hospital Corporation
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A61K A61P C12N C12N C12Y C12Y
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Jian-Ning Victor
Liu Gurewich