Foley & Lardner LLP
Increasing levels of nicotinic alkaloids in plants
Four genes, A622, NBB1, PMT, and QPT, can be influenced for increasing nicotinic alkaloid levels in Nicotiana plants, as well as for synthesizing nicotinic alkaloids in non-nicotine producing plants and cells. In particular, overexpressing one or more of A622, NBB1, PMT, and QPT may be used to increase nicotine and nicotinic alkaloid levels in tobacco plants. Non-nicotine producing cells can be engineered to produce nicotine and related compounds by overexpressing A622 and NBB1.
22nd Century Limited, LLC
C A Y A A A
C12N A24D Y02A A24B A61K A24B
inventional inventional additional inventional inventional inventional
Takashi Masataka
Hashimoto Kajikawa