Foley & Lardner
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds of the invention. The invention also relates to methods of modulating the function of protein kinases using indolinone compounds of the invention and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.
Sugen, Inc.
C A A A A A A C A A A
C07D A61P A61P A61P A61P A61P A61P C07D A61P A61P A61P
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Xiaoyuan Peng Cho Chung Chun Ruofei Jinrong Todd A. Ping
Li Tang Wei Zhang Cui Miller Huang