Substituted pyrimidine compounds as RAF inhibitors and methods of use
The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula Iwherein R1 isand A1, A2, A3, A4, X, Z, Z′, R1, R2, R3, R4, R5 and R6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of Raf kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
Amgen Inc.
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Elizabeth M. Daniel Martin Jeffrey Frenel F. Stephen A. Jiawang Joseph L. Gang Nick A. Thomas Qi Adrian Leonard Jian J.
Doherty Retz Petkus De Morin Hitchcock Zhu Kim Liu Paras Nixey Huang Smith Chen