Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors
The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.
Merck Frosst Canada & Co.
C A C C A A A C A A C A A C C A A C A C C C A A A C C C C C C A A C C
C07F A61P C07F C07F A61P A61P A61P C07F A61P A61P C07F A61P A61P C07F C07F A61K A61P C07F A61P C07F C07F C07F A61P A61P A61P C07F C07F C07F C07F C07F C07F A61P A61K C07F C07F
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Chun Sing Yves Claude Christopher Cheuk Kun Rejean Zhaoyin Patrick Jacques Yves Michel
Li Leblanc Dufresne Bayly Lau Fortin Wang Roy Gauthier Therien