Morgan Lewis & Bockius, LLP
Tiacumicin production
Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
Optimer Pharmaceuticals, Inc.
A C C A C C
A61P C12N C12P A61P C12N C12R
inventional inventional inventional inventional inventional additional
Ming-His Jonathan James Yuan-Ting Chi-Jen Frank Youe-Kong Franklin W. Mei-Chiao
Chiou Duffield Chen Du Shue Okumu Wu