Bicyclic [5,6] imidazo pyrimodone compounds for use in the treatment of diseases or conditions mediated by Lp-PLA2
The present invention relates to bicyclic[5,6]imidazo pyrimidone compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.In one aspect, this invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof,wherein different R groups are defined in the patent application.
Glaxo Group Limited
A A C A
A61P A61P C07D A61K
inventional inventional inventional inventional
Zehong Yingxia Qing
Wan Sang Zhang