Fish & Richardson P.C.
Preparation of and formulation comprising a MEK inhibitor
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Novartis AG Array BioPharma, Inc.
C C C A C C A A A A A A A A A A A A A A A
C07D C30B C07D A61K C07B C30B A61K A61P A61K A61P A61K A61K A61P A61K A61K A61K A61P A61K A61K A61K A61P
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Marie-Christine Werner Heinz Peter J. Marian Christoph Max Paul Daniel Andreas Weidong Daniel
Wolf Pachinger Stengel Misun Krell Nichols Niederer Liu Zimmermann