Lathrop & Gage LLP
Rotenone derivatives and a use thereof
The present invention relates to rotenone derivatives and a use of the same. Particularly, the present inventors identified rotenoisin A and B which are compounds with no toxicity and which are prepared by irradiation with gamma rays onto rotenone as represented by the following formula 1. It was further confirmed that the rotenone derivatives significantly inhibited pancreatic lipase activity and preadipocyte differentiation. The rotenone derivatives of the present invention can be effectively used as a composition for the prevention and treatment of obesity and as a composition for health functional food for the prevention and improvement of obesity:(In formula 1, R1 and R2 are as defined in this description).
Korea Atomic Energy Research Institute
C B C A C A
C07D B01J C07D A61K C07D A61P
inventional inventional inventional inventional inventional inventional
Sungbeom Hyoungwoo Byung Yeoup Tae Hoon Seung Sik Chul Hong
Lee Bai Chung Kim Lee Park