Foley & Lardner LLP
Isoform of anaplastic lymphoma kinase and its uses
The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.
Memorial Sloan Kettering Cancer Center
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G01N G01N C12Q A61K C12Y A61K G01N C12N G01N C12Q A61K C12Q A61K
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Yu Ping Thomas
Chen Chi Wiesner