McDonnell Boehnen Hulbert & Berghoff LLP
(Oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof where the variables R1, R2, A, R4, R5, R6, R6′, n, and W are defined herein. These compounds bind to the benzodiazepine site of GABAA receptors are provided and, therefore can be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals.
Neurogen Corporation
A A A A C A
A61P A61P A61P A61P C07D A61P
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John Guiying Pamela
Peterson Li Albaugh