Fish & Richardson P.C.
Methods for treating pulmonary fibrosis using chromenone derivatives
A composition for prevention or treatment of pulmonary fibrosis comprising chromenone derivatives represented by Formula I of the present invention or pharmaceutically acceptable salts thereof as an active ingredient, produces altered heat shock protein 27 (HSP27) dimers, thereby preventing normal HSP27 non-phosphorylated polymers from performing a chaperone function and reducing a cell protection function that chaperone originally performs. Thus the inventive composition has a remarkable inhibitory effect on pulmonary fibrosis, in particular, an irradiation-induced pulmonary fibrosis phenomenon.
EWHA University—Industry Collaboration Foundation Industry-Academic Cooperation Foundation, Yonsei University College of Medicine Pochon Cha University Industry—Academic Cooperation
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A61P A61K A61K
inventional inventional inventional
Younghwa Jae Ho Yun-Sil
Na Cho Lee