Quine I.P. Law Group, PC.
Gene cluster for production of the enediyne antitumor antibiotic C-1027
This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). The pathway comprises a nonriobsomal peptide synthetase (NRPS). Methods are provided for the biosynthesis of enediynes, enediyne analogs and other biological molecules.
The Regents of the University of California
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Scott Steven D. Wen Ben
Standage Christenson Liu Shen