Leydig, Voit & Mayer, Ltd.
Dibenzylamine compounds and pharmaceutical use thereof
A dibenzylamine compound represented by the formula (1)wherein R1 and R2 are each a C1-6 allyl group optionally substituted by halogen atoms and the like; R3, R4 and R5 are each a hydrogen atom, a halogen atom and the like, or R3 and R4 may form, together with carbon atoms bonded thereto, a homocyclic or heterocyclic ring optionally having substituent(s); A is —N(R7)(R8) and the like; ring B is an aryl group or a heterocyclic residue; R6 is a hydrogen atom, a halogen atom, a nitro group, a C1-6 allyl group and the like; n is an integer of 1 to 3, a prodrug thereof and a pharmaceutically acceptable salt thereof show selective and potent CETP inhibitory activity, and therefore, they can be provided as therapeutic or prophylactic agents for hyperlipidemia or arteriosclerosis and the like.
Japan Tobacco Inc.
C C C C A A C C A C C C C C A A C C A C C
C07C C07D C07C C07D A61P A61P C07C C07C A61P C07D C07D C07D C07D C07C A61P A61P C07D C07D A61P C07D C07D
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Kimiya Daisuke Hironobu Yasunori Hiroshi Hisashi Toshio
Maeda Takahashi Nagamori Suzuki Nakamura Shinkai Taniguchi