Oblon, Spivak, McClelland, Maier & Neustadt, P.C.
Amidino substituted tetrahydrobenzo thiophene or furan derivatives and their use as urokinase inhibitors
 A compound of the formula: ##STR1## in which PA0 R.sup.1 is hydrogen, optionally substituted lower alkylcarbamoyl(lower)alkylidene, lower alkylidene, lower alkyl, optionally substituted ar(lower)alkyl, cyclo(lower)alkyl(lower)alkyl, protected carboxy(lower)alkyl, carboxy(lower)alkyl, hydroxy(lower)alkyl, optionally substituted lower alkylcarbamoyl(lower)alkyl, lower alkylthio(lower)alkyl, carboxy(lower)alkanoyl, protected carboxy(lower)alkanoyl, aroyl, lower alkanoyl, or optionally substituted arylcarbamoyl(lower)alkyl, PA0 R.sup.2 is hydrogen, carboxy, protected carboxy, formyl or N-(lower)alkyl-N-(lower)alkoxycarbamoyl, PA0 R.sup.3 is hydrogen or amidino-protective group, PA0 A is lower alkylene or carbonyl, PA0 X is ##STR2## PA0 Y is lower alkylene, --S-- or --SO.sub.2 --, PA0 Z is --S-- or --O--, and PA0 the line: {character pullout} is a single bond or a double bond, or pharmaceutically acceptable salts thereof, which is useful as a medicament. 
Fujisawa Pharmaceutical Co., Ltd.
Y A A C A A A C A C C
Y02P A61P A61P C07D A61P A61P A61P C07D A61P C07D C07D
additional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Minoru Akito Hiroaki
Sakurai Tanaka Mizuno