Licata & Tyrrell P.C.
Method for controlling the chaperone activity of peroxiredoxins using irradiation
The present invention relates to a method for increasing chaperone activity by irradiating peroxiredoxin (Prx) proteins. More particularly, the present invention may be useful for preparing recombinant proteins imparting resistance against various environmental stresses by increasing the chaperone activity of peroxiredoxin, since it has been observed that irradiated peroxiredoxin has enhanced chaperone activity characteristics, wherein an α-helix structure decreases while a β-sheet structure increases, from analysis results of a protein structure change and chaperone activity after irradiating two types of peroxiredoxins (2-Cys, 3-Cys) which are two active cysteine motifs of peroxiredoxin.
Korea Atomic Energy Research Institute
C C C A
C12N C12N C12Y A61P
inventional inventional inventional inventional
Jae Taek Seung Sik Byung Chull Eun Mi Hyoung-Woo Byung Yeoup
Lee Lee An Lee Bai Chung