Wilson, Sonsini, Goodrich & Rosati
Methods and compositions related to a retinoid receptor-selective pathway
Provided herein are methods and compositions related to a retinoid receptor-selective pathway. As described herein, this pathway can be targeted to manipulate a tumor microenvironment. For example, the methods and compositions described herein can be used to induce apoptosis in a cancer cell. Further, the compositions described herein, including Sulindac and analogs thereof, can be used to target this pathway for the treatment or prevention of cancer in human patients.
XIAMEN UNIVERSITY SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
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C07D C07D G01N C07C C07C A61P A61K G01N G01N C07C A61P
inventional inventional inventional inventional inventional inventional inventional additional additional inventional inventional
Wen Xiao-kun Hu Pei-Qiang Ying
Liu Zhang Zhou Huang Su