LeClairRyan, a Professional Corporation
Methods of screening T1R1/T1R3 receptors for compounds that modulate umami taste signaling
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.
Senomyx, Inc.
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C07K C12Q G01N G01N G01N C12Q A01K C12Q G01N A61P G01N C07K G01N G01N
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Xiaodong Fernando Jon Elliot Sergey Lena Mark Shawn Hong
Li Echeverri Adler Zozulya Staszewski Zoller O'Connell Xu