McDermott Will & Emery LLP
Mass analysis method and mass analysis apparatus
The present invention achieves a mass analysis method that can identify protein or peptide with high speed and high sensitivity. A mass spectrum is obtained from a standard sample of healthy person, an ion is selected from the mass spectrum as a precursor ion, and a mass spectrum of the precursor ion is obtained [(a) to (d)]. A mass spectrum is obtained from a sample of interest to be measured of patient, an ion other than the precursor ion of the standard sample is selected from the mass spectrum as a precursor ion, and a mass spectrum of the precursor ion is obtained [(g) to (k)]. Identifications on peptide/protein specific to the standard sample and the sample to be measured, and common to both are conducted [(r) to (q)], and based on the results, comparative analysis on peptide/protein of the sample to be measured (t). Without regarding an ion derived from all components of the sample to be measured as precursor ion, MS/MS spectrum is obtained and identification on a plurality of components of the sample to be measured can be conducted for a short time and with high sensitivity.
Hitachi High-Technologies Corporation
H G
H01J G01N
inventional inventional
Hiromichi Akihiro Kinya Tomoyuki
Yamashita Takeda Kobayashi Kurosawa