Husch Blackwell LLP
Methods for preparing azoxystrobin and intermediate thereof
The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound represented by formula (3) to contact with sodium methoxide and 4,6-dichloropyrimidine, to obtain a mixture of intermediates represented by formulae (1) and (2), in the existence of a catalyst, the catalyst is an azabicyclic compound or its salt. The present invention further discloses a method for preparing azoxystrobin, comprising: controlling the intermediate represented by formula (2) provided in the present invention to react with 2-cyanophenol or its salt under the catalytic action of an azabicyclic compound or its salt, to obtain an azoxystrobin compound represented by formula (4). The method provided in the present invention has advantages including high transformation ratio, high product purity, easy and convenient operation, and environmental friendliness.
NUTRICHEM COMPANY LIMITED SHANGYU NUTRICHEM CO., LTD.
C C
C07D C07D
inventional inventional
Guobin Jianhong Wenjun Jianwei Long Wentao Xufang Yongchang
Chen Chi Wang Chen Wang Jin Deng Zhao