Banner & Witcoff, Ltd.
Sustained-release composition containing tetrahydropyrido[4,3-b]indole derivatives and preparation of the derivatives
The present invention relates to a sustained-release composition containing 2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridyl)ethyl]-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof as an active ingredient, preparation thereof and the compound. The composition is suitable for oral administration by one time per day, and achieves the peak plasma concentration at 1.0 to 3 hours after oral administration. The composition is suitable for manufacturing a medicament for treatment of cognitive dysfunction syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, or senile dementia.
Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China
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C07D A61K A61P A61K A61K A61K A61P A61P
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Yunde Zhibing Song Junhai Bing Wu Xinbo
Xie Zheng Li Xiao Li Zhong Zhou