Casimir Jones SC
Conformationally constrained Smac mimetics and the uses thereof
The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
The Regents of the University of Michigan
A C C
A61P C07D C07D
inventional inventional inventional
Jianyong Shaomeng Zaneta Haiying Chao-Yie Naoyuki G. Liang
Chen Wang Nikolovska-Coleska Sun Yang Saito Xu