Compositions and methods for detection of sirolimus
Compounds are disclosed comprising a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, linked to a sirolimus compound at position 26 or at position 32. Such sirolimus compounds comprising an immunogenic carrier can be employed to raise both polyclonal and monoclonal antibodies to the sirolimus compound. Polyclonal antibodies are also disclosed, which are raised against a compound wherein a moiety, such as a poly(amino acid), a non-poly(amino acid) label moiety, or a non-poly(amino acid) immunogenic carrier, is linked to a sirolimus compound at position 32. The above antibodies and sirolimus compounds comprising a label can be used in assays for the detection of sirolimus compounds.
Dade Behring Inc.
A Y Y G C A C Y C A A
A61K Y10S Y10S G01N C07K A61K C07D Y10T C07D A61K A61K
inventional additional additional inventional inventional inventional inventional additional inventional inventional inventional
Cathy K. Yi Feng Hshiou-ting Jian Holger Yali
Worley Zheng Liu Chen Keim Yang