Muncy, Geissler, Olds and Lowe, P.C.
Serum miRNA marker for OPLL diagnosis and application thereof
A serum microRNA (miRNA) marker suitable for early screening and diagnosis of ossification of posterior longitudinal ligament (OPLL) and its application in the diagnostic reagent or kit for the OPLL. Biomarker miRNA-563, miRNA-196b, miRNA-10a and miRNA-129 have high diagnostic value for OPLL, and the development and application of the related serum miRNA biomarker detection reagent kit. It can be applied in the screening of ossification of posterior longitudinal ligament disease, supporting the diagnosis of OPLL more quickly and accurately, evaluate the patient's ossification condition, and may lay down the foundation for improving clinical therapeutic effect.
THE SECOND MILITARY MEDICAL UNIVERSITY
C C C C
C12Q C12Q C12Q C12Q
inventional additional additional inventional
Wen Chen Huiqiao Xiaolong Hao Yang Peng Yuanyuan
Yuan Xu Wu Shen Zhang Liu Cao Chen