Wenderoth, Lind & Ponack, LLP
Endothelin antagonist peptides
 The peptide derivatives having endothelin receptor-antagonistic action or a salt thereof and medicinal compositions containing them are provided. Since peptide derivatives or a salt thereof of this invention exhibit remarkable endothelin receptor-antagonistic action with low toxicity, they are effective as medicines for prophylaxis and therapy of, for example, cardio- or cerebro-circulatory diseases hepatic diseases and/or renal diseases. 
Takeda Chemical Industries, Ltd.
C C A C
C07K C07K A61K C07K
inventional inventional additional inventional
Tetsuya Toshifumi Chieko Taiji
Ohtaki Watanabe Kitada Asami