Heterocyclic inhibitors of monocarboxylate transporter
The invention provides compounds that inhibit monocarboxylate transporters, such as MCT1 and MCT4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of MCT1 and/or MCT4, such as cancer or type II diabetes.
The Scripps Research Institute
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C07D A61K A61P A61P A61P A61P A61P A61K C07D A61K
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Reji Andy S. William R. John L. Jitendra K. Thomas D. Jun Yong
Nair Tsai Roush Cleveland Mishra Bannister Choi