Nixon Peabody LLP
Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and high, localized concentrations of one or more PMF stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known. These approaches and therapeutic methods are also useful with non-metabolic chemicals that induce proton-motive force in bacteria.
TRUSTEES OF BOSTON UNIVERSITY
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Y02A A61K A61K A61P A61K A61K A61K A61K
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James J. Mark P. Kyle R.
Collins Brynildsen Allison