Lowe Hauptman Ham & Berner LLP
Nuclease-resistant RNA aptamer inhibiting replication of hepatitis C virus replicon
Disclosed is a nuclease-resistant RNA aptamer for inhibiting the replication of HCV replicon. This aptamer is capable of binding specifically to HCV NS5B and inhibiting the proliferation of the HCV replicon, and includes at least one sequence selected from a group consisting of SEQ ID NOS. 1 to 4, in which a fluoro group is substituted for 2′-hydroxy of both U (uracil) and C (cytosine) bases, and SEQ ID NO. 17, in which the fluoro group is substituted for the 2′-hydroxy of both the U (uracil) and the C (cytosine) bases, and which is tagged with a cholesteryl group at a 5′ end and with idT at a 3′ end. The RNA aptamer is useful in the diagnosis and treatment of HCV infection.
Bexcore Co., Ltd. Daewon Pharm. Co., Ltd.
C C C C C A C C
C12N C12N C12N C12Q C12N A61P C12N C12Q
inventional additional additional inventional additional inventional additional additional
Jong-Hoon Kyung-Sook Seong-Wook
Lim Shin Lee