Baker & Hostetler LLP
Preparation of silylamines by the dehydrogeative coupling of N—H and Si—H bonds
The present invention describes chemical systems and methods for silylating N—H bonds of aliphatic amines, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to replace an N—H bond with a silyl N—Si bond.
California Institute of Technology
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Robert H. Anton Wenbo Kerry Brian M. Alexey
Grubbs Toutov Liu Betz Stoltz Fedorov