Cooley LLP
Compounds and methods for inhibiting phosphate transport
Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Ardelyx, Inc.
A A A C A C A A A A A A A A A
A61P A61P A61K C07D A61P C07D A61P A61P A61P A61P A61K A61P A61K A61K A61P
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
Tao Nicholas Michael R. Marc Eric Noah Jeffrey W. Dominique Han-Ting Jason G. Christopher
Chen Reich Leadbetter Navre Labonte Bell Jacobs Charmot Chang Lewis Carreras