Site-specific attachment of drugs or other agents to engineered antibodies with C-terminal extensions
The present invention provides antibodies (e.g., IgG antibodies) having C-terminal cysteine-containing extensions that facilitate antibody conjugation to a partner molecule (e.g. a drug, toxin, marker molecule, protein, radioisotope, or other therapeutic agent). Methods of making, screening and selecting the antibodies of the invention are provided.
Medarex, L.L.C.
C A C A A C A A A
C07K A61P C07K A61K A61K C07K A61K A61K A61K
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David Jie
King Liu