Saliwanchik, Lloyd & Eisenschenk
Use of acacetin and related compounds as potassium channel inhibitors
This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.Ach).
Shanghai Institute of Materia Medica, Chinese Academy of Sciences Versitech Limited
A A A
A61K A61P A61K
inventional inventional inventional
Chu-Pak Guo-Wei Hong-Bing Gui-Rong
Lau Qin Wang Li