Jenkins, Wilson, Taylor & Hunt, P.A.
Methods and compositions comprising novel cationic lipids
Provided herein are novel cationic lipids, compositions comprising the cationic lipids, and methods of using the cationic lipids. In some claims, the cationic lipids have cytotoxic activity and can be used alone or in combination with a cytotoxic bioactive compound to kill a cell. In some of these claims, the cationic lipid enhances the cytotoxic activity of the cytotoxic bioactive compound. Methods for treating a subject afflicted with a disease or unwanted condition are provided, wherein the method comprises administering a delivery system comprising a novel cationic lipid to the subject. The invention further provides methods for making delivery systems comprising the novel cationic lipids of the invention.
The University of North Carolina at Chapel Hill
A A A A C A A C C
A61P A61P A61K A61K C07C A61P A61K C12N C07C
inventional inventional inventional inventional inventional inventional inventional inventional inventional
Shyh-Dar Michael Leaf Joyeeta Surendar Reddy Yunching Sumio
Li Hackett Huang Sen Bathula Chen Chono