McCarter & English, LLP
Hydrazonamide compounds that modulate Hsp90 activity
The present invention relates to substituted hydrazonamide compounds. The invention further relates to methods of inhibiting the activity of Hsρ90 in a subject in need thereof and methods for treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted hydrazonamide compound of the invention, or a pharmaceutical composition comprising such a compound.
Synta Pharmaceuticals Corp.
C C A C A C A A
C07C C07D A61P C07D A61P C07D A61P A61P
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Shijie Weiwen Dinesh U. David Joseph
Zhang Ying Chimmanamada James Burlison