Birch, Stewart, Kolasch & Birch, LLP
Methods of acylating adamantane, tricyclo[5.2.1.02,6], and decalin compounds
An acylating agent of the invention includes (A) a 1,2-dicarbonyl compound or its hydroxy reductant, (B) oxygen, and (C) at least one compound selected from (c1) a metallic compound and (C2) N-hydroxyphthalimide or another imide compound. As the 1,2-dicarbonyl compound or its hydroxy reductant (A), biacetyl, 2,3-butanediolor the like canbeused. As the metallic compound (c1), cobalt acetate, or another cobalt compound, for example, can be employed. By reacting an adamantane derivative or another compound having a methine carbon atom with the acylating agent, an acyl group can be introduced to the methine carbon atom with efficiency.
Daicel Chemical Industries, Ltd.
C C C C C C C C C C
C07D C07D C07C C07C C07C C07C C07B C07C C07C C07C
inventional inventional inventional additional inventional inventional inventional inventional inventional inventional
Naruhisa Yasutaka Tatsuya
Hirai Ishii Nakano