1,2,6-substituted benzimidazoles as flap modulators
The present invention relates to compounds of Formula (I),and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1′, X1″, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
JANSSEN PHARMACEUTICA NV
C A A A A A A A C C C
C07D A61K A61P A61K A61K A61P A61K A61K C07D C07D C07D
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Curt A. Mark S. Zachary S. Wendy Alec D. Daniel J. Paul J. James P. Jing Wenying John J. M. Steven D. Virginia M.
Dvorak Tichenor Sales Eccles Lebsack Pippel Krawczuk Edwards Liu Chai Wiener Goldberg Tanis