N-heterocyclic inhibitors of TNF-α expression
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
Bristol-Myers Squibb Company Pharmaceopeia, Inc.
A C C C C C C C C C C C A C C C C C
A61P C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D C07D A61P C07D C07D C07D C07D C07D
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Gulzar John J. Zahid Stephen T. James Yvonne Axel Alaric J. Wei Jeffrey John Kevin Joseph Edward Katerina Shawn David Junjun Ian
Ahmed Baldwin Hussain Wrobleski Wen Shimshock Metzger Dyckman Li Letourneau Moriarty McDonald Leftheris Erickson Wu Henderson