Armstrong Teasdale LLP
Panaxdiol-type ginsenoside derivative, preparation method therefor and use thereof
Provided are panaxdiol-type ginsenoside derivatives having structures as shown in formula I or formula II. Also provided are the uses thereof in the preparation of drugs for preventing and treating atherosclerosis. The panaxdiol-type ginsenoside derivatives have low cytotoxicities, can significantly reduce the percentages of the areas of atherosclerotic plaques in apoE−/− mice, can also effectively reduce the levels of low-density lipoprotein cholesterol and increase the levels of high-density lipoprotein cholesterol in serums of mice, and can significantly reduce the local TNF-α levels in the arteries of apoE−/− mice and have good anti-inflammatory effects; at a dose of 30 μM, the panaxdiol-type ginsenoside derivatives can significantly reduce the degrees of the formation of RAW264.7 cell-derived foam cells. In addition, the preparation methods for the panaxdiol-type ginsenoside derivatives are easy to operate and obtain high yields.
ARMY MEDICAL UNIVERSITY CHONGQING PUDI BIO-PHARMACEUTICAL CO. LTD
A C C C C C C
A61P C07J C07J C07H C07H C07J C07J
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Xiaohui Yi Yan
Li Jia Huang