Dorsey & Whitney LLP
Sulfur-containing naphthalimide derivatives
The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.
Dalian University of Technology East China University of Science and Technology Shanghai Institute of Materia Medica, Chinese Academy of Science
C A C C C C C C
C07D A61P C09B C09B C07D C09B C07D C07D
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Liping Jian Yonggang Hong Yufang Xuhong Baoyuan Zehong
Lin Ding Li Zhu Xu Qian Qu Miao