Fish & Richardson P.C.
Preparation of and formulation comprising a MEK inhibitor
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Novartis AG Array BioPharma, Inc.
A A A C A A A C A A A A C A A C A C A A A
A61P A61P A61P C30B A61K A61K A61P C07D A61K A61K A61K A61K C30B A61K A61K C07B A61K C07D A61K A61P A61K
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Weidong Marie-Christine Daniel Andreas Daniel Peter J. Paul Werner Heinz Marian Christoph Max
Liu Wolf Niederer Zimmermann Stengel Nichols Pachinger Misun Krell