Lerner, David, Littenberg, Krumholz & Mentlik, LLP
S-(carboxymethyl)-cysteine pharmaceutical compound and preparation method and use thereof
Disclosed are an S-(carboxymethyl)-cysteine pharmaceutical compound (I), and a preparation method and use thereof. Also disclosed are an S-(carboxymethyl)-D-cysteine ammonium salt monohydrate, and use thereof in preparation of medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases, in particular in preparation of expectorants. The compounds can reduce airway resistance and production of oxides in rat COPD models, increase the level of antioxidants, and alleviate damage caused by the oxides and inflammatory mediators to lungs.
Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factroy Guangzhou Institute of Respiratory Disease
C A A C A C C
C07C A61P A61K C07C A61P C07B C07C
inventional inventional inventional inventional inventional additional inventional
Jin Binge Jinping Xianglin Hairong Nanshan Wei Wei Ping Hongying Lin Mao Shaoxuan
Feng Huang Zheng Fu Hu Zhong Wang Liao Wan Mo Zhang Chen Zhu