McDonnell Boehnen Hulbert & Berghoff LLP
2-pyridone antimicrobial compositions
Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.
Evolva SA
A A Y C A A A
A61K A61K Y02A C07D A61K A61P A61K
inventional inventional additional inventional inventional inventional inventional
Daniel Patrick Jutta Glen Peter Yaoquan Christian
Milligan Roussel Heim Dale Schneider Liu Bartels