Saliwanchik, Lloyd & Saliwanchik
Use of acacetin and related compounds as potassium channel inhibitors
This invention provides a method for treating or preventing human atrial arrhythmia (fibrillation) using the leading flavone compound acacetin, and its derivatives and analogues that inhibit the ultra-rapidly-activating delayed rectifier potassium current (IKur or IKsus), transient outward potassium (Ito), and acetylcholine-activated potassium current (IK.ACh).
The University of Hong Kong Shanghai Institute of Materia Medica, Chinese Academy of Sciences
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A61K A61P A61K
inventional inventional inventional
Hong-Bing Gui-Rong Chu-Pak Guo-Wei
Wang Li Lau Qin