Macrocycle derivatives useful as inhibitors of β-secretase (BACE)
The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
Janssen Pharmaceutica NV
A C C
A61P C07D C07D
inventional inventional inventional
Eric D. Ellen W. François P. Michael H. Chih Yung Charles H. Hans Allen B. Yifang
Strobel Baxter Bischoff Parker Ho Reynolds De Winter Reitz Huang