Pabst Patent Group LLP
Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the nanoparticles are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.
Yale University
A A A C A A A C C C A A C A C
A61K A61K A61K C12N A61K A61K A61K C08G C12Y C08G A61K A61K C12P A61K C12N
inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional inventional
W. Mark Jie Jiangbing Zhaozhong
Saltzman Liu Zhou Jiang