Revolution IP, PLLC
Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
Disclosed is an anticancer supplement agent including a benzo[d]oxazole derivative as an effective ingredient. The benzo[d]oxazole derivative, which is a nuclear factor E2-related factor 2 (Nrf2) inhibitor, is capable of inhibiting activity of Nrf2 that induces an antioxidant enzyme to remove reactive oxygen species (ROS) that kills a cancer cell, thereby increasing production of ROS. Therefore, the benzo[d]oxazole derivative can be used as an anticancer supplement agent that shows therapeutic effects in anticancer agent therapy or radiation therapy, and in this regard, the benzo[d]oxazole derivative can overcome tolerance of the cancer cell to anticancer agent therapy or radiation therapy and enhance apoptotic effects on the cancer cell.
KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
C A
C07D A61K
inventional additional
Jie Young Ky Youb Hyun Kyung In Sung Seung Yong Ji Yeon Saelooom Yuan Arang
Song Nam Choi Jung Seo Ahn Lee Yue Son