Scully, Scott, Murphy & Presser, P.C.
Triacetyl-3-hydroxyphenyladenosine and its use for regulating blood fat
The invention discloses triacetyl-3-hydroxyphenyladenosine represented by formula (I), the preparation, the pharmaceutical composition and the use thereof. Specially, the invention discloses a new compound of 2′,3′,5′-tri-O-acetyl-N6-(3-hydroxyphenyl)adenosine. Using hypoxanthine nucleoside as starting material, the compound is prepared by acetylating with acetic anhydride, chlorinating with thionyl chloride, and being substituted with 3-hydroxy aniline. The invention also discloses the pharmaceutical composition comprising triacetyl-3-hydroxyphenyladenosine. The dosage forms of the said pharmaceutical composition include tablet, capsule, pill, injection, sustained release preparation, controlled release preparation or particulate delivery system. The medicament for treatment or precaution of hyperlipemia prepared by the compound of the invention has the advantages of significant hypolipidemic activity, less toxicity and adverse effect as well as slow metabolism in vivo.
Institute of Mataria Medica, Chinese Academy of Medical Sciences
A A C A
A61P A61K C07H A61P
inventional inventional inventional inventional
Xing Haibo Wei Linghua Kai Ping Song
Wang Zhu Li Hao Qu Zhu Wu