Burns, Doane, Swecker & Mathis, LLP
Medicament containing a 2-arylpropionic acid derivative in nanosol form and its preparation
 Immediate-effect medicaments containing a pharmacologically active 2-arylpropionic acid derivate as a pharmaceutically applicable nanosol have a considerably improved action start and bioavailability of the active substance. The 2-arylpropionic acid derivates, for example ibuprofen, flurbiprofen and ketoprofen, that are scarcely soluble in an aqueous medium, are present in a gelatine-stabilized nanosol in a form that allows these active substances to be quickly and completely resorbed already in the stomach. The disclosed colloidal disperse system composed of a 2-arylpropionic acid derivate is prepared by selecting a gelatine or gelatine derivate according to their isoelectric point (IEP), so that their IEP is adapted to the charge of the 2-arylpropionic acid derivate particles, leading to a neutral charge when the gelatine or its derivate is combined with the undissolved 2-arylpropionic acid derivate at a determined pH value. The gelatine or its derivate are converted into an aqueous sol form, their pH value is set according to the IEP of the gelatine at a value that stabilizes the nanoparticles of 2-arylpropionic acid derivate at an approximately or totally neutral charge. Before or after said last step, the 2-arylpropionic acid derivate is dissolved in the aqueous gelatine sol or a solution of 2-arylpropionic acid derivate is blended with the aqueous gelatine sol. 
PAZ Arzneimittelentwicklungsgesell schaft mbH Alfatec-Pharma GmbH
G A A A A A A
G03C A61K A61K A61K A61K A61K A61K
additional inventional inventional inventional inventional inventional inventional
Jurgen Otto Helmut Jurgen Ursula Jens-Christian
Freidenreich Schuster Lukas Werry Schick Wunderlich