Chroman derivatives as TRPM8 inhibitors
Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure:where the definitions of the variables are provided herein.
Amgen Inc.
C C C C C C
C07D C07D C07D C07D C07D C07D
inventional inventional inventional inventional inventional inventional
Jian J. Wenge Matthew R. Kelvin Scott Daniel B. Vu Van Kaustav Vijay Keshav
Chen Zhong Kaller Sham Harried Horne Ma Biswas Gore