Edwards Wildman Palmer LLP
Pyridopyrimidine derivatives and use thereof
The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3′ OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders.
The Asan Foundation
A A A C A A A A A
A61P A61P A61K C07D A61P A61P A61P A61P A61P
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Gilnam Jeongbeob Suk Young Chul Soo Eun Kyung Jung Jin Albert Charles Han Won Choung Soo
Lee Seo Cho Lim Choi Hwang Gyorkos Cho Kim