Fenwick & West LLP
Variant activin IIB receptor
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
Amgen Inc.
Xiaolan Jeonghoon Lei-Ting Tony Keith Soo-Nyung Hui-Quan
Zhou Sun Tam Kwak Han