Muncy, Geissler, Olds & Lowe, P.C.
Recombinant neuraminidase and uses thereof
A recombinant neuraminidase based on amino acid sequence (SEQ ID NO: 1) of wild-type pH1N1-NA (A/Texas/05/2009) influenza virus is provided. The recombinant neuraminidase of the present invention has an ectodomain with an amino acid sequence identical to SEQ ID NO: 1 and replaced at specific positions 149, 344, 365 and 366 residue(s) with corresponding amino acids of other influenza viruses. The recombinant neuraminidase may incur cross-protective immunity and be used as universal influenza vaccine.
National Tsing Hua University
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A61K C07K C12N C12N C12N C12N C12N A61K A61P A61K A61K A61K C12N
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Suh-Chin Chia-Ying Wen-Chun
Wu Lin Liu