McDermott Will & Emery LLP
Microarray with polymer-free microstructures, methods of making, and methods of use
A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.
Corium, Inc.
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A61P A61P A61B A61K A61P
inventional inventional inventional inventional inventional
Zhongli Guohua Parminder
Ding Chen Singh