Process for preparing &agr;-hydroxyamides and &agr;-ketoamides on a solid phase support
The present invention relates to a process for preparing a &agr;-hydroxyamide or &agr;-ketoamide, said process comprising the steps of:a) reacting a resin which comprises a polymer-supported isocyanide with an aldehyde in the presence of a catalyst, to form a resin-bound &agr;-hydroxyamide;b) optionally reacting said resin-bound &agr;-hydroxyamide with a reagent which is capable of oxidizing said resin-bound &agr;-hydroxyamide to a resin-bound &agr;-ketoamide; andc) reacting said resin-bound &agr;-hydroxyamide or resin-bound &agr;-ketoamide with a reagent which cleaves the nitrogen-resin bond to form a &agr;-hydroxyamide &agr;-ketoamide.
The Procter & Gamble Company
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Jian
Chen