Klauber & Jackson
Methods of identifying modulators of the estrogen receptor
 The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have the pharmaceutical effect of tamoxifen without the corresponding side-effects. 
Board of Trustees Operating Michigan State University
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Yu Melvin S. Sanford M.
Chen Schindler Simon