Morrison Law Firm
Azulene derivatives as thromboxane A.sub.2 and prostaglandin endoperoxide receptor antagonist
 A series of new azulene analogues are disclosed, which are represented by the following formula: ##STR1## wherein: R.sub.1 is --COOH, --COOR.sub.4 (R.sub.4 represents a lower alkyl), --CH.dbd.CH--COOH, --CH.sub.2 --COOH or --SO.sub.3 H; PA0 R.sub.2 is a hydrogen atom or lower-alkyl group; PA0 R.sub.3 is a hydrogen atom, a lower alkyl or benzyl group; PA0 A is --SO.sub.2 --, ##STR2## (R.sub.5 represents a lower alkyl); B is a phenyl, a lower alkylphenyl, a lower alkoxyphenyl, nitrophenyl, trifluoroalkylphenyl, mono-or di-halogenated-phenyl, naphthyl or tetrahydroaphthyl group; PA0 Y is an alkylene or alkenylene group. The compounds of the present invention are useful as thromboxane A.sub.2 and prostagrandin endoperoxide receptor antagonists. 
Kotobuki Seiyaku Co., Ltd.
C C A C A C C A A A C
C07C C07C A61P C07F A61P C07C C07C A61P A61P A61P C07C
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Shuuichi Masayuki Akira Rei Tsuyoshi Masafumi Hiromi
Wakabayashi Yokota Tomiyama Koyama Tomiyama Yasunami Hayashi